Details of the Target

General Information of Target

Target ID LDTP15481
Target Name Transmembrane protein 87A (TMEM87A)
Gene Name TMEM87A
Gene ID 25963
Synonyms
Transmembrane protein 87A; Elkin1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARAAPLLAALTALLAAAAAGGDAPPGKIAVVGAGIGGSAVAHFLQQHFGPRVQIDVYEK
GTVGGRLATISVNKQHYESGAASFHSLSLHMQDFVKLLGLRHRREVVGRSAIFGGEHFML
EETDWYLLNLFRLWWHYGISFLRLQMWVEEVMEKFMRIYKYQAHGYAFSGVEELLYSLGE
STFVNMTQHSVAESLLQVGVTQRFIDDVVSAVLRASYGQSAAMPAFAGAMSLAGAQGSLW
SVEGGNKLVCSGLLKLTKANVIHATVTSVTLHSTEGKALYQVAYENEVGNSSDFYDIVVI
ATPLHLDNSSSNLTFAGFHPPIDDVQGSFQPTVVSLVHGYLNSSYFGFPDPKLFPFANIL
TTDFPSFFCTLDNICPVNISASFRRKQPQEAAVWRVQSPKPLFRTQLKTLFRSYYSVQTA
EWQAHPLYGSRPTLPRFALHDQLFYLNALEWAASSVEVMAVAAKNVALLAYNRWYQDLDK
IDQKDLMHKVKTEL
Target Bioclass
Transporter and channel
Family
LU7TM family, TMEM87 subfamily
Subcellular location
Golgi apparatus membrane
Function
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel. In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo.
Uniprot ID
Q8NBN3
Ensemble ID
ENST00000307216.10
HGNC ID
HGNC:24522

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S528F DBIA    Probe Info 
G415 SNV: p.G241V .
HEL9217 Deletion: p.M424VfsTer51; p.F426EfsTer2 DBIA    Probe Info 
JM1 SNV: p.L255I .
PF382 SNV: p.Y182H .
RKO SNV: p.M424V .
RL952 SNV: p.K109R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		25.97  LDD0318  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C431(1.01); C89(1.09)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		C89(0.00); C431(0.00)  LDD2156  [5]
PAL-AfBPP Probe
Click To Hide/Show 116 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		20.68  LDD1740  [6]
C041
 Probe Info  		9.32  LDD1741  [6]
C055
 Probe Info  		20.39  LDD1752  [6]
C056
 Probe Info  		32.45  LDD1753  [6]
C059
 Probe Info  		6.36  LDD1756  [6]
C063
 Probe Info  		11.24  LDD1760  [6]
C064
 Probe Info  		16.00  LDD1761  [6]
C067
 Probe Info  		5.10  LDD1763  [6]
C070
 Probe Info  		14.42  LDD1766  [6]
C072
 Probe Info  		9.00  LDD1768  [6]
C082
 Probe Info  		25.11  LDD1774  [6]
C085
 Probe Info  		17.63  LDD1777  [6]
C087
 Probe Info  		20.39  LDD1779  [6]
C107
 Probe Info  		7.21  LDD1794  [6]
C108
 Probe Info  		8.22  LDD1795  [6]
C112
 Probe Info  		37.79  LDD1799  [6]
C134
 Probe Info  		27.67  LDD1816  [6]
C135
 Probe Info  		13.83  LDD1817  [6]
C139
 Probe Info  		12.64  LDD1821  [6]
C141
 Probe Info  		31.12  LDD1823  [6]
C143
 Probe Info  		43.71  LDD1825  [6]
C145
 Probe Info  		10.78  LDD1827  [6]
C147
 Probe Info  		10.78  LDD1829  [6]
C169
 Probe Info  		55.72  LDD1849  [6]
C170
 Probe Info  		21.26  LDD1850  [6]
C201
 Probe Info  		24.76  LDD1877  [6]
C206
 Probe Info  		19.16  LDD1881  [6]
C208
 Probe Info  		7.57  LDD1883  [6]
C210
 Probe Info  		57.68  LDD1884  [6]
C211
 Probe Info  		13.93  LDD1885  [6]
C212
 Probe Info  		5.46  LDD1886  [6]
C213
 Probe Info  		19.16  LDD1887  [6]
C216
 Probe Info  		5.90  LDD1890  [6]
C217
 Probe Info  		5.62  LDD1891  [6]
C218
 Probe Info  		35.75  LDD1892  [6]
C219
 Probe Info  		18.00  LDD1893  [6]
C220
 Probe Info  		31.12  LDD1894  [6]
C223
 Probe Info  		8.63  LDD1897  [6]
C225
 Probe Info  		16.22  LDD1898  [6]
C226
 Probe Info  		15.45  LDD1899  [6]
C228
 Probe Info  		45.25  LDD1901  [6]
C229
 Probe Info  		17.75  LDD1902  [6]
C231
 Probe Info  		64.00  LDD1904  [6]
C232
 Probe Info  		55.72  LDD1905  [6]
C233
 Probe Info  		28.25  LDD1906  [6]
C234
 Probe Info  		8.75  LDD1907  [6]
C235
 Probe Info  		63.12  LDD1908  [6]
C237
 Probe Info  		5.13  LDD1910  [6]
C238
 Probe Info  		16.22  LDD1911  [6]
C239
 Probe Info  		5.78  LDD1912  [6]
C240
 Probe Info  		14.12  LDD1913  [6]
C243
 Probe Info  		43.11  LDD1916  [6]
C246
 Probe Info  		55.72  LDD1919  [6]
C249
 Probe Info  		28.25  LDD1922  [6]
C258
 Probe Info  		6.06  LDD1931  [6]
C264
 Probe Info  		36.00  LDD1935  [6]
C265
 Probe Info  		22.63  LDD1936  [6]
C269
 Probe Info  		6.73  LDD1939  [6]
C270
 Probe Info  		11.55  LDD1940  [6]
C278
 Probe Info  		58.49  LDD1948  [6]
C280
 Probe Info  		15.03  LDD1950  [6]
C281
 Probe Info  		7.36  LDD1951  [6]
C282
 Probe Info  		43.11  LDD1952  [6]
C284
 Probe Info  		29.86  LDD1954  [6]
C285
 Probe Info  		32.67  LDD1955  [6]
C286
 Probe Info  		5.94  LDD1956  [6]
C287
 Probe Info  		30.27  LDD1957  [6]
C288
 Probe Info  		18.38  LDD1958  [6]
C289
 Probe Info  		50.56  LDD1959  [6]
C290
 Probe Info  		10.63  LDD1960  [6]
C293
 Probe Info  		39.67  LDD1963  [6]
C296
 Probe Info  		27.28  LDD1966  [6]
C299
 Probe Info  		10.70  LDD1968  [6]
C305
 Probe Info  		18.00  LDD1974  [6]
C307
 Probe Info  		5.86  LDD1975  [6]
C310
 Probe Info  		26.54  LDD1977  [6]
C322
 Probe Info  		11.08  LDD1988  [6]
C326
 Probe Info  		16.45  LDD1990  [6]
C342
 Probe Info  		5.66  LDD2004  [6]
C343
 Probe Info  		36.25  LDD2005  [6]
C346
 Probe Info  		10.20  LDD2007  [6]
C348
 Probe Info  		37.27  LDD2009  [6]
C349
 Probe Info  		52.35  LDD2010  [6]
C350
 Probe Info  		89.88  LDD2011  [6]
C353
 Probe Info  		16.00  LDD2014  [6]
C354
 Probe Info  		10.06  LDD2015  [6]
C362
 Probe Info  		41.64  LDD2023  [6]
C363
 Probe Info  		22.63  LDD2024  [6]
C364
 Probe Info  		21.26  LDD2025  [6]
C366
 Probe Info  		14.12  LDD2027  [6]
C367
 Probe Info  		8.28  LDD2028  [6]
C376
 Probe Info  		11.55  LDD2036  [6]
C380
 Probe Info  		6.68  LDD2039  [6]
C382
 Probe Info  		13.93  LDD2041  [6]
C390
 Probe Info  		99.73  LDD2049  [6]
C391
 Probe Info  		31.56  LDD2050  [6]
C392
 Probe Info  		4.92  LDD2051  [6]
C393
 Probe Info  		6.15  LDD2052  [6]
C396
 Probe Info  		6.54  LDD2055  [6]
C399
 Probe Info  		25.63  LDD2058  [6]
C403
 Probe Info  		47.84  LDD2061  [6]
C407
 Probe Info  		22.01  LDD2064  [6]
C419
 Probe Info  		14.72  LDD2074  [6]
C420
 Probe Info  		15.89  LDD2075  [6]
C423
 Probe Info  		7.11  LDD2078  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe12
 Probe Info  		20.00  LDD0473  [7]
FFF probe13
 Probe Info  		17.73  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
FFF probe15
 Probe Info  		17.69  LDD0478  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0465  [7]
FFF probe9
 Probe Info  		20.00  LDD0485  [7]
JN0003
 Probe Info  		20.00  LDD0484  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]
OEA-DA
 Probe Info  		19.95  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C431(1.01); C89(1.09)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C431(0.90); C89(1.24)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C89(0.95)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C89(0.89)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C89(0.83)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C89(0.97)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C89(0.93)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C89(0.89)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C89(0.88)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C89(1.01)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C89(0.97)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C89(0.90)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C431(1.00); C89(1.20)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C89(0.92)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C89(0.92)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C89(0.92)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C89(0.83)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C89(0.86)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C89(0.88)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C89(0.94)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C89(0.95)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C89(0.92)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C89(0.88)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C431(0.97); C89(1.14)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C89(0.98)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C89(0.84)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C89(0.91)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C89(0.95)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C89(0.82)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C89(0.90)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C89(0.91)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C89(0.95)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C431(1.44); C89(1.27)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C431(0.93); C89(0.96)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C431(1.10); C89(0.99)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C431(1.02); C89(0.92)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C431(1.45); C89(1.15)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C431(0.97); C89(1.06)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C431(1.08); C89(1.14)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C431(0.92); C89(1.16)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C431(0.93); C89(1.09)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C431(1.01); C89(1.15)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C431(1.06); C89(1.17)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C431(1.14); C89(1.13)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C431(1.21); C89(1.22)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C431(1.07); C89(1.23)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C431(1.02); C89(1.19)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C431(1.69); C89(1.08)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C431(0.88); C89(0.89)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C431(0.78); C89(0.99)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C431(0.64); C89(1.07)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C431(0.84); C89(1.35)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C431(0.86); C89(0.92)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C89(1.04); C431(1.21)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C431(0.99); C89(1.44)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C431(1.07); C89(1.12)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C431(0.88); C89(1.09)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C431(0.59); C89(1.15)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C431(0.74); C89(1.05)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C431(0.81); C89(1.23)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C431(0.98); C89(1.08)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C431(0.68); C89(1.18)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C431(0.51); C89(1.09)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C431(0.99); C89(1.05)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C431(0.93); C89(1.08)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C89(1.06); C431(1.23)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C431(0.99); C89(1.10)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C431(1.00); C89(1.15)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C89(0.88); C431(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C431(0.84); C89(0.85)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C89(0.99); C431(1.09)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C431(0.91); C89(1.10)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C89(1.02); C431(1.17)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C431(0.86); C89(1.46)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C431(0.97); C89(1.40)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C431(0.82); C89(1.19)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C431(0.84); C89(1.29)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C431(1.23); C89(1.41)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C431(1.17); C89(1.22)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C431(1.01); C89(1.37)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C431(0.96); C89(1.27)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C431(1.02); C89(1.45)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C431(0.96); C89(1.17)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C431(1.01); C89(1.02)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C431(0.76); C89(1.05)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C431(0.75); C89(0.90)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C89(0.80); C431(1.19)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C89(0.84); C431(0.95)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C89(0.86); C431(1.00)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C431(1.31); C89(1.32)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C89(0.87); C431(1.55)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C89(0.87); C431(0.94)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C89(0.97); C431(1.24)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C89(0.89); C431(1.13)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C89(0.75); C431(1.14)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C89(0.86); C431(1.32)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C431(0.88); C89(1.01)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C431(0.81); C89(1.07)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C89(0.93); C431(1.16)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C431(0.96); C89(1.25)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C89(1.23); C431(1.28)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C431(1.01); C89(1.12)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C431(0.90); C89(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C431(0.90); C89(0.99)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C89(1.15); C431(1.16)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C89(1.04); C431(1.15)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C431(1.09); C89(1.15)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C89(1.13); C431(1.27)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C89(0.85)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C89(1.10)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C89(0.99)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C431(0.78); C89(1.11)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C89(1.04)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C89(1.11)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C89(1.52)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C89(1.15)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C89(1.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C89(1.21)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C89(1.41)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C89(1.18)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C89(1.14); C431(1.35)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C89(0.92); C431(1.33)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C431(1.15); C89(1.16)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C89(0.92); C431(1.20)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C89(0.95); C431(1.08)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C89(1.03); C431(1.20)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C89(1.46); C431(1.49)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C89(1.16); C431(1.85)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C89(1.24); C431(1.60)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C89(1.03); C431(1.27)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C89(0.85); C431(1.15)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C89(0.94); C431(1.16)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C89(0.97); C431(1.26)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C431(1.23); C89(1.25)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C89(1.04); C431(1.23)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C89(0.95); C431(1.02)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C89(1.04); C431(1.61)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C431(1.20); C89(1.37)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C431(1.11); C89(1.14)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C89(1.14); C431(1.33)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C89(1.07); C431(1.18)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C89(1.04); C431(1.25)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C89(0.97); C431(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C89(1.05); C431(1.30)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C89(1.12); C431(1.25)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C89(1.12); C431(1.47)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C89(1.20); C431(1.43)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C89(1.01); C431(1.12)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C89(1.06); C431(1.15)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C89(0.90); C431(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C89(0.93); C431(1.03)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C89(1.11); C431(1.39)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C89(1.00)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C89(0.88)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C431(0.96); C89(1.06)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C431(1.06); C89(1.21)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C431(1.21); C89(1.29)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C431(0.75); C89(0.90)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C431(0.84); C89(0.97)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C431(1.06); C89(1.22)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C431(0.84); C89(1.22)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C89(1.21); C431(1.30)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C89(1.09); C431(1.15)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C89(1.05); C431(1.15)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C89(0.92); C431(1.00)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C431(0.87); C89(0.91)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C89(1.01); C431(1.33)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C89(1.05); C431(1.53)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C431(1.02); C89(1.03)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C431(0.93); C89(0.93)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C431(1.18); C89(1.25)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C89(1.09); C431(1.15)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C431(0.79); C89(1.33)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C89(1.24); C431(1.33)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C431(0.76); C89(1.31)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C431(0.79); C89(1.06)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C431(0.79); C89(1.08)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C89(0.88); C431(1.39)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C89(0.84); C431(0.99)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C89(0.86); C431(1.09)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C431(0.65); C89(0.85)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C89(0.98); C431(1.09)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C431(0.64); C89(0.88)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C431(1.01); C89(1.04)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C89(0.98); C431(1.20)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C89(1.04); C431(1.16)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C89(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C89(1.15)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C89(0.91)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C89(1.19)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C431(0.85); C89(0.97)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C431(0.95); C89(1.07)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C89(1.04); C431(1.08)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C89(1.03)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C89(0.87)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C89(0.97)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C89(0.95)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C431(0.73); C89(0.90)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C89(0.89)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C89(1.12)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C89(1.44)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C89(1.01)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C89(1.17)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C89(1.18)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C89(1.31)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C89(1.01)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C89(1.02)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C89(1.04)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C431(0.68); C89(0.93)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C89(1.15)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C431(1.25); C89(1.02)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C431(0.90); C89(0.93)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C431(1.14); C89(0.90)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C431(1.21); C89(0.94)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C431(0.98); C89(1.14)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C431(1.18); C89(0.91)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C431(1.23); C89(0.95)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C431(1.29); C89(0.93)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C431(0.95); C89(0.89)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C431(1.16); C89(1.00)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C431(1.53); C89(0.93)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C431(1.38); C89(1.11)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C431(1.30); C89(0.95)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C431(0.99); C89(1.00)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C431(1.59); C89(1.05)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C431(1.10); C89(1.04)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C431(1.02); C89(1.13)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C431(0.90); C89(1.03)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C431(1.05); C89(1.01)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C431(0.81); C89(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C431(1.12); C89(1.00)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C431(1.13); C89(0.98)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C431(1.01); C89(0.98)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C431(0.92); C89(0.99)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C431(1.05); C89(1.05)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C431(1.11); C89(1.02)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C431(0.90); C89(1.04)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C431(1.26); C89(0.99)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C431(1.34); C89(0.94)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C431(1.26); C89(0.98)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C431(1.19); C89(0.98)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C431(1.09); C89(0.99)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C431(1.38); C89(1.07)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C431(1.37); C89(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C431(1.13); C89(1.00)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C431(2.07); C89(1.15)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C431(1.18); C89(1.12)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C431(1.13); C89(1.16)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C431(1.34); C89(1.07)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C431(1.16); C89(1.11)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C431(1.10); C89(0.90)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C431(1.26); C89(1.10)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C431(1.28); C89(1.08)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C431(1.39); C89(1.13)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C431(1.30); C89(1.04)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C431(1.07); C89(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C431(1.07); C89(1.01)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C431(1.04); C89(1.33)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C431(0.74); C89(1.56)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C431(0.84); C89(1.03)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C431(0.98); C89(1.42)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C431(0.78); C89(0.96)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C431(1.16); C89(1.22)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C431(0.94); C89(1.08)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C431(1.08); C89(1.56)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C431(1.02); C89(1.29)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C431(0.83); C89(1.27)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C431(1.02); C89(1.38)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C431(1.02); C89(1.39)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C431(0.71); C89(1.46)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C431(0.68); C89(1.43)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C431(1.08); C89(1.55)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C431(0.75); C89(0.87)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C431(0.87); C89(1.24)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C431(0.78); C89(1.09)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C431(0.76); C89(0.99)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C431(0.95); C89(0.98)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C431(0.94); C89(0.96)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C431(0.87); C89(1.14)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C431(0.81); C89(1.02)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C431(0.99); C89(1.45)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C431(0.91); C89(1.36)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C431(1.02); C89(1.16)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C431(1.00); C89(1.03); C128(0.91)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C431(1.56); C89(1.05)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C431(1.05); C89(1.02)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C89(0.93); C128(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C89(0.98); C128(0.96)  LDD1497  [10]
 LDCM0024  KB05 HMCB C89(5.15)  LDD3312  [11]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840