Details of the Target

General Information of Target

Target ID LDTP13114
Target Name C-type mannose receptor 2 (MRC2)
Gene Name MRC2
Gene ID 9902
Synonyms
CLEC13E; ENDO180; KIAA0709; UPARAP; C-type mannose receptor 2; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD antigen CD280
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSS
HITMSSSAFPASPKQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNY
QQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLT
YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQ
DAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV
SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV
LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW
YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE
GEFQRLAAQSGLYESEEL
Target Bioclass
Other
Subcellular location
Membrane
Function
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Uniprot ID
Q9UBG0
Ensemble ID
ENST00000303375.10
HGNC ID
HGNC:16875

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		14.29  LDD0318  [2]
STPyne
 Probe Info  		K1142(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C335(10.10)  LDD0209  [4]
5E-2FA
 Probe Info  		H519(0.00); H552(0.00); H770(0.00)  LDD2235  [5]
m-APA
 Probe Info  		H552(0.00); H519(0.00)  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C521(0.00); C1234(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C481(0.00); C532(0.00); C704(0.00)  LDD0037  [6]
Acrolein
 Probe Info  		C1243(0.00); C1153(0.00)  LDD0217  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
Methacrolein
 Probe Info  		C521(0.00); C1243(0.00); C1153(0.00); C481(0.00)  LDD0218  [7]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		14.32  LDD1782  [8]
C092
 Probe Info  		17.27  LDD1783  [8]
C115
 Probe Info  		10.13  LDD1802  [8]
C149
 Probe Info  		9.85  LDD1830  [8]
C170
 Probe Info  		26.17  LDD1850  [8]
C171
 Probe Info  		6.36  LDD1851  [8]
C182
 Probe Info  		5.03  LDD1860  [8]
C186
 Probe Info  		8.88  LDD1864  [8]
C215
 Probe Info  		5.74  LDD1889  [8]
C221
 Probe Info  		6.54  LDD1895  [8]
C223
 Probe Info  		6.82  LDD1897  [8]
C281
 Probe Info  		7.01  LDD1951  [8]
C302
 Probe Info  		11.24  LDD1971  [8]
C310
 Probe Info  		22.63  LDD1977  [8]
C313
 Probe Info  		14.52  LDD1980  [8]
C314
 Probe Info  		11.24  LDD1981  [8]
C318
 Probe Info  		5.35  LDD1984  [8]
C383
 Probe Info  		11.47  LDD2042  [8]
C390
 Probe Info  		31.78  LDD2049  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1098(0.71); C521(0.75); C927(0.75)  LDD0812  [9]
 LDCM0215  AC10 HEK-293T C927(1.20)  LDD0813  [9]
 LDCM0216  AC100 HEK-293T C1098(1.83)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C1098(1.55)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C1098(1.15)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C1098(1.48)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C1098(1.61)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C1098(1.05)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C1098(1.05)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C1098(1.53)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C1098(1.15)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C1098(1.06)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C927(1.08)  LDD0824  [9]
 LDCM0227  AC110 HEK-293T C1098(1.47)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C1098(1.66)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C1098(2.13)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C1098(0.77); C521(1.36); C927(1.11)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C1098(0.70); C521(1.62); C927(1.31)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C1098(1.22); C521(1.06); C927(0.96)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C1098(0.79); C521(1.24); C927(1.19)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C1098(0.82); C521(0.76); C927(0.88)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C1098(1.19); C521(2.02); C927(1.62)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C1098(1.59); C521(1.71); C927(1.63)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C927(0.94)  LDD0835  [9]
 LDCM0238  AC120 HEK-293T C1098(0.68); C521(1.08); C927(1.03)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C1098(0.83); C521(1.98); C927(1.46)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C1098(0.95); C521(1.84); C927(1.39)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C1098(1.26); C521(1.83); C927(1.55)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C1098(1.10); C521(1.68); C927(1.39)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C1098(0.87); C521(1.67); C927(1.36)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C1098(1.30); C521(2.00); C927(1.62)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C1098(1.35); C521(2.49); C927(1.91)  LDD0843  [9]
 LDCM0246  AC128 HEK-293T C521(0.66); C927(0.86)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C521(0.84); C927(1.01)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C521(0.71); C927(0.97)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C521(0.55); C927(0.92)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C521(0.65); C927(0.95)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C521(0.83); C927(1.00)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C521(0.74); C927(1.23)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C521(0.43); C927(0.75)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C521(0.69); C927(0.83)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C521(0.58); C927(0.87)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C521(0.48); C927(0.85)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C521(0.34); C927(0.78)  LDD0856  [9]
 LDCM0259  AC14 HEK-293T C927(1.19)  LDD0857  [9]
 LDCM0260  AC140 HEK-293T C521(0.67); C927(1.08)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C521(1.03); C927(1.06)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C521(0.91); C927(1.03)  LDD0860  [9]
 LDCM0263  AC143 HEK-293T C1098(0.57)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C1098(0.85)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C1098(0.89)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C1098(0.96)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C1098(0.95)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C1098(0.97)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C1098(0.76)  LDD0867  [9]
 LDCM0270  AC15 HEK-293T C927(1.18)  LDD0868  [9]
 LDCM0271  AC150 HEK-293T C1098(1.05)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C1098(1.22)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C1098(1.00)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C1098(1.03)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C1098(0.81)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C1098(0.98)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C1098(0.95)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C1098(0.61)  LDD2165  [9]
 LDCM0276  AC17 PaTu 8988t C1098(0.80); C1107(0.80); C235(1.24); C942(0.82)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C1098(0.87); C1107(0.87); C235(0.90); C942(0.54)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C1098(1.08); C1107(1.08); C235(0.74); C942(0.72)  LDD1157  [9]
 LDCM0279  AC2 HEK-293T C1098(1.07); C521(1.01); C927(1.01)  LDD0877  [9]
 LDCM0280  AC20 PaTu 8988t C1098(0.73); C1107(0.73); C235(0.70); C942(0.56)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C1098(0.92); C1107(0.92); C235(1.01); C942(0.42)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C1098(0.85); C1107(0.85); C235(1.01); C942(0.38)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C1098(0.78); C1107(0.78); C235(0.49); C942(0.46)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C1098(0.84); C1107(0.84); C235(0.66); C942(1.25)  LDD1163  [9]
 LDCM0285  AC25 HEK-293T C1098(1.25); C521(0.64)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C1098(1.13); C521(1.00)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C1098(1.22); C521(1.18)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C1098(1.35); C521(0.66)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C1098(1.16); C521(1.27)  LDD0887  [9]
 LDCM0290  AC3 HEK-293T C1098(0.87); C521(0.79); C927(0.79)  LDD0888  [9]
 LDCM0291  AC30 HEK-293T C1098(1.25); C521(1.09)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C1098(1.05); C521(1.03)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C1098(1.08); C521(1.56)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C1098(1.15); C521(1.33)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C1098(1.15); C521(1.05)  LDD0893  [9]
 LDCM0296  AC35 PaTu 8988t C927(1.15); C351(0.89); C359(0.89); C521(1.05)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C927(0.84); C351(0.88); C359(0.88); C521(0.99)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C927(1.06); C351(0.70); C359(0.70); C521(1.05)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C927(0.86); C351(0.97); C359(0.97); C521(1.17)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C927(0.84); C351(0.68); C359(0.68); C521(1.04)  LDD1179  [9]
 LDCM0301  AC4 HEK-293T C1098(0.76); C521(0.92); C927(0.92)  LDD0899  [9]
 LDCM0302  AC40 PaTu 8988t C927(0.93); C351(0.52); C359(0.52); C521(0.95)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C927(1.11); C351(0.70); C359(0.70); C521(0.76)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C927(1.68); C351(0.81); C359(0.81); C521(0.98)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C927(1.34); C351(0.80); C359(0.80); C521(1.10)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C927(0.87); C351(0.42); C359(0.42); C521(0.75)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C927(1.25); C351(0.87); C359(0.87); C521(1.11)  LDD1186  [9]
 LDCM0308  AC46 HEK-293T C1098(1.50)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C1098(1.43)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C1098(1.17)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C1098(1.10)  LDD0909  [9]
 LDCM0312  AC5 HEK-293T C1098(1.03); C521(0.92); C927(0.92)  LDD0910  [9]
 LDCM0313  AC50 HEK-293T C1098(1.03)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C1098(0.94)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C1098(0.87)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C1098(1.18)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C1098(0.92)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C1098(1.59)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C1098(1.38)  LDD0917  [9]
 LDCM0320  AC57 HEK-293T C927(1.00)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C927(0.97)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C927(0.70)  LDD0920  [9]
 LDCM0323  AC6 HEK-293T C927(1.26)  LDD0921  [9]
 LDCM0324  AC60 HEK-293T C927(0.89)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C927(0.70)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C927(0.83)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C927(0.89)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C927(0.73)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C927(0.84)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C927(0.91)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C927(1.15)  LDD0929  [9]
 LDCM0332  AC68 HEK-293T C1098(0.91); C521(0.81); C927(0.93)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C1098(0.81); C521(0.83); C927(0.84)  LDD0931  [9]
 LDCM0334  AC7 HEK-293T C927(1.06)  LDD0932  [9]
 LDCM0335  AC70 HEK-293T C1098(1.09); C521(0.61); C927(0.55)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C1098(0.95); C521(0.46); C927(0.40)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C1098(1.13); C521(0.68); C927(0.68)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C1098(0.89); C521(0.53); C927(0.50)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C1098(1.36); C521(0.96); C927(0.97)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C1098(0.89); C521(0.51); C927(0.49)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C1098(0.82); C521(0.41); C927(0.40)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C1098(1.21); C521(0.40); C927(0.39)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C1098(0.75); C521(1.16); C927(1.08)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C1098(1.07); C521(0.58); C927(0.53)  LDD0942  [9]
 LDCM0345  AC8 HEK-293T C927(1.32)  LDD0943  [9]
 LDCM0346  AC80 HEK-293T C1098(1.18); C521(0.63); C927(0.58)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C1098(1.21); C521(0.75); C927(0.75)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C1098(1.52); C521(1.08); C927(0.96)  LDD0946  [9]
 LDCM0349  AC83 HEK-293T C1098(0.82); C521(2.16); C927(2.16)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C1098(1.08); C521(2.89); C927(2.89)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C1098(0.99); C521(3.14); C927(3.14)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C1098(1.11); C521(2.45); C927(2.45)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C1098(1.21); C521(2.61); C927(2.61)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C1098(1.29); C521(3.95); C927(3.95)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C1098(1.29); C521(2.97); C927(2.97)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C1098(0.92); C521(1.78); C927(1.78)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C1098(0.79); C521(1.76); C927(1.76)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C1098(0.79); C521(2.17); C927(2.17)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C1098(0.71); C521(2.12); C927(2.12)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C1098(1.29); C521(2.35); C927(2.35)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C1098(1.18); C521(2.34); C927(2.34)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C1098(0.77); C521(1.72); C927(1.72)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C1098(1.41); C521(3.84); C927(3.84)  LDD0962  [9]
 LDCM0365  AC98 HEK-293T C1098(1.12)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C1098(1.28)  LDD0964  [9]
 LDCM0248  AKOS034007472 HEK-293T C927(1.27)  LDD0846  [9]
 LDCM0356  AKOS034007680 HEK-293T C927(1.43)  LDD0954  [9]
 LDCM0275  AKOS034007705 HEK-293T C927(1.49)  LDD0873  [9]
 LDCM0108  Chloroacetamide HeLa C1243(0.00); C481(0.00); C1153(0.00)  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C521(0.86)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C521(0.81)  LDD0685  [9]
 LDCM0369  CL100 HEK-293T C1098(0.76); C521(1.01); C927(1.01)  LDD0967  [9]
 LDCM0370  CL101 HEK-293T C927(1.31)  LDD0968  [9]
 LDCM0371  CL102 HEK-293T C927(1.24)  LDD0969  [9]
 LDCM0372  CL103 HEK-293T C927(1.32)  LDD0970  [9]
 LDCM0373  CL104 HEK-293T C927(1.49)  LDD0971  [9]
 LDCM0374  CL105 PaTu 8988t C1098(1.06); C1107(1.06); C235(0.78); C942(1.15)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C1098(1.04); C1107(1.04); C235(0.73); C942(1.22)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C1098(0.80); C1107(0.80); C235(1.22); C942(1.13)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C1098(1.00); C1107(1.00); C235(1.11); C942(0.87)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C1098(0.82); C1107(0.82); C235(0.73); C942(0.75)  LDD1257  [9]
 LDCM0379  CL11 HCT 116 C521(0.68)  LDD0696  [9]
 LDCM0380  CL110 PaTu 8988t C1098(0.77); C1107(0.77); C235(0.76); C942(0.80)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C1098(0.71); C1107(0.71); C235(0.48); C942(0.43)  LDD1260  [9]
 LDCM0382  CL112 HEK-293T C1098(1.01); C521(1.51)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C1098(1.03); C521(0.84)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C1098(1.09); C521(1.23)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C1098(1.18); C521(1.10)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C1098(1.20); C521(1.39)  LDD0984  [9]
 LDCM0387  CL117 PaTu 8988t C927(1.36); C351(0.76); C359(0.76); C521(0.84)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C927(1.78); C351(1.29); C359(1.29); C521(1.40)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C927(1.15); C351(0.82); C359(0.82); C521(1.00)  LDD1268  [9]
 LDCM0390  CL12 HCT 116 C521(0.48)  LDD0707  [9]
 LDCM0391  CL120 PaTu 8988t C927(0.96); C351(0.74); C359(0.74); C521(0.85)  LDD1270  [9]
 LDCM0392  CL121 HEK-293T C1098(1.35)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C1098(1.51)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C1098(1.20)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C1098(1.54)  LDD0993  [9]
 LDCM0396  CL125 HEK-293T C927(1.03)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C927(0.82)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C927(1.13)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C927(0.98)  LDD0997  [9]
 LDCM0400  CL13 HCT 116 C521(0.88)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C521(0.95)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C521(0.90)  LDD0719  [9]
 LDCM0403  CL16 HEK-293T C1098(1.04); C521(0.49)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C1098(0.92); C521(0.44)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C1098(1.02); C521(0.77)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C1098(1.09); C521(0.62)  LDD1004  [9]
 LDCM0407  CL2 HCT 116 C521(0.74)  LDD0724  [9]
 LDCM0408  CL20 HEK-293T C1098(1.26); C521(0.75)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C1098(1.55); C521(1.01)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C1098(0.84); C521(0.68)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C1098(1.33); C521(0.53)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C1098(1.34); C521(0.91)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C1098(0.99); C521(0.74)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C1098(0.97); C521(0.65)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C1098(1.27); C521(1.00)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C1098(1.08); C521(1.17)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C1098(1.75); C521(0.68)  LDD1015  [9]
 LDCM0418  CL3 HCT 116 C521(0.93)  LDD0735  [9]
 LDCM0419  CL30 HEK-293T C1098(1.14); C521(1.08)  LDD1017  [9]
 LDCM0420  CL31 HCT 116 C521(1.70)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C521(0.97)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C521(1.40)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C521(1.34)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C521(1.11)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C521(1.60)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C521(1.21)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C521(1.09)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C521(0.84)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C521(1.82)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C521(1.11)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C521(1.15)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C521(0.99)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C521(1.10)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C521(2.49)  LDD0752  [9]
 LDCM0436  CL46 PaTu 8988t C351(0.98); C359(0.98); C521(0.96)  LDD1315  [9]
 LDCM0437  CL47 PaTu 8988t C351(0.97); C359(0.97); C521(0.83)  LDD1316  [9]
 LDCM0438  CL48 PaTu 8988t C351(0.68); C359(0.68); C521(0.79)  LDD1317  [9]
 LDCM0439  CL49 PaTu 8988t C351(1.05); C359(1.05); C521(1.12)  LDD1318  [9]
 LDCM0440  CL5 HCT 116 C521(1.43)  LDD0757  [9]
 LDCM0441  CL50 PaTu 8988t C351(0.66); C359(0.66); C521(1.00)  LDD1320  [9]
 LDCM0442  CL51 PaTu 8988t C351(0.72); C359(0.72); C521(0.86)  LDD1321  [9]
 LDCM0443  CL52 PaTu 8988t C351(0.77); C359(0.77); C521(0.99)  LDD1322  [9]
 LDCM0444  CL53 PaTu 8988t C351(0.50); C359(0.50); C521(1.04)  LDD1323  [9]
 LDCM0445  CL54 PaTu 8988t C351(0.94); C359(0.94); C521(1.18)  LDD1324  [9]
 LDCM0446  CL55 PaTu 8988t C351(0.81); C359(0.81); C521(1.04)  LDD1325  [9]
 LDCM0447  CL56 PaTu 8988t C351(0.58); C359(0.58); C521(0.80)  LDD1326  [9]
 LDCM0448  CL57 PaTu 8988t C351(0.33); C359(0.33); C521(0.75)  LDD1327  [9]
 LDCM0449  CL58 PaTu 8988t C351(0.54); C359(0.54); C521(1.05)  LDD1328  [9]
 LDCM0450  CL59 PaTu 8988t C351(0.29); C359(0.29); C521(0.67)  LDD1329  [9]
 LDCM0451  CL6 HCT 116 C521(0.82)  LDD0768  [9]
 LDCM0452  CL60 PaTu 8988t C351(0.33); C359(0.33); C521(0.79)  LDD1331  [9]
 LDCM0453  CL61 HCT 116 C521(1.33)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C521(1.15)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C521(1.27)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C521(0.98)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C521(0.89)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C521(1.09)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C521(1.05)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C521(1.04)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C521(1.00)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C521(0.79)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C521(1.19)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C521(1.31)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C521(0.88)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C521(0.59)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C521(0.88)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C521(0.84)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C521(0.89)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C521(0.75)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C521(1.21)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C521(1.21)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C521(1.38)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C521(1.11)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C521(1.77)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C521(1.16)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C521(1.64)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C521(1.70)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C521(1.51)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C521(1.65)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C521(1.59)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C521(1.49)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C521(1.08)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C521(0.78)  LDD0802  [9]
 LDCM0486  CL91 HEK-293T C1098(0.61); C521(0.97); C927(0.97)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C1098(0.77); C521(0.83); C927(0.83)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C1098(0.67); C521(0.75); C927(0.75)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C1098(0.58); C521(1.17); C927(1.17)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C1098(0.92); C521(1.37); C927(1.37)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C1098(0.95); C521(1.17); C927(1.17)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C1098(0.95); C521(1.07); C927(1.07)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C1098(0.90); C521(0.97); C927(0.97)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C1098(0.61); C521(1.10); C927(1.10)  LDD1092  [9]
 LDCM0495  E2913 HEK-293T C983(1.04); C228(1.17)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C521(1.64)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C521(1.65)  LDD0744  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 42-MG-BA C521(1.64)  LDD2244  [11]
 LDCM0023  KB03 Jurkat C335(10.10)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C927(4.43)  LDD3310  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [7]

References

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Mass spectrometry data entry: PXD025140
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840