Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C221 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP02223 | Cathepsin B (CTSB) | 26.2 | ||||
| LDTP13620 | Lysosomal thioesterase PPT2 (PPT2) | 16.6 | ||||
| LDTP00316 | Ribonuclease T2 (RNASET2) | 16.3 | ||||
| LDTP09256 | Putative phospholipase B-like 2 (PLBD2) | 16.0 | ||||
| LDTP01241 | Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) | 15.0 | ||||
| LDTP10888 | Legumain (LGMN) | 14.5 | ||||
| LDTP02141 | Alpha-galactosidase A (GLA) | 14.3 | ||||
| LDTP16032 | Retinoid-inducible serine carboxypeptidase (SCPEP1) | 14.3 | ||||
| LDTP02799 | N-acetylglucosamine-6-sulfatase (GNS) | 14.1 | ||||
| LDTP02074 | Aldehyde dehydrogenase, mitochondrial (ALDH2) | 13.3 | ||||
| LDTP00428 | Tripeptidyl-peptidase 1 (TPP1) | 12.7 | ||||
| LDTP02169 | Beta-hexosaminidase subunit alpha (HEXA) | 12.1 | ||||
| LDTP13358 | Leucyl-cystinyl aminopeptidase (LNPEP) | 10.3 | ||||
| LDTP02006 | Tissue alpha-L-fucosidase (FUCA1) | 10.3 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 10.2 | ||||
| LDTP02539 | Lysosomal acid phosphatase (ACP2) | 9.8 | ||||
| LDTP04572 | Dipeptidyl peptidase 1 (CTSC) | 9.6 | ||||
| LDTP02486 | Lysosomal alpha-glucosidase (GAA) | 9.4 | ||||
| LDTP04388 | Palmitoyl-protein thioesterase 1 (PPT1) | 9.3 | ||||
| LDTP09874 | Endoplasmic reticulum protein SC65 (P3H4) | 9.2 | ||||
| LDTP02505 | Lysosomal protective protein (CTSA) | 9.1 | ||||
| LDTP11215 | Plasma alpha-L-fucosidase (FUCA2) | 8.9 | ||||
| LDTP04634 | Alpha-N-acetylglucosaminidase (NAGLU) | 8.3 | ||||
| LDTP15988 | Probable serine carboxypeptidase CPVL (CPVL) | 8.2 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 7.3 | ||||
| LDTP05905 | Acid ceramidase (ASAH1) | 7.2 | ||||
| LDTP01372 | Carboxypeptidase D (CPD) | 7.1 | ||||
| LDTP08476 | 5'-3' exonuclease PLD3 (PLD3) | 6.2 | ||||
| LDTP08265 | N-alpha-acetyltransferase 40 (NAA40) | 6.1 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 6.0 | ||||
| LDTP02216 | Beta-hexosaminidase subunit beta (HEXB) | 5.9 | ||||
| LDTP02837 | Beta-galactosidase (GLB1) | 5.8 | ||||
| LDTP13131 | 7-dehydrocholesterol reductase (DHCR7) | 5.4 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11615 | Protein tweety homolog 3 (TTYH3) | 16.0 | ||||
| LDTP02215 | Prosaposin (PSAP) | 15.1 | ||||
| LDTP02071 | Amyloid-beta precursor protein (APP) | 13.1 | ||||
| LDTP16813 | Tetraspanin-3 (TSPAN3) | 11.4 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 10.9 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 9.8 | ||||
| LDTP06034 | Lysosome membrane protein 2 (SCARB2) | 8.8 | ||||
| LDTP02655 | Lysosome-associated membrane glycoprotein 2 (LAMP2) | 8.6 | ||||
| LDTP01969 | Transferrin receptor protein 1 (TFRC) | 7.5 | ||||
| LDTP00321 | Podocalyxin (PODXL) | 7.5 | ||||
| LDTP02586 | Cation-independent mannose-6-phosphate receptor (IGF2R) | 7.4 | ||||
| LDTP11826 | Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) | 7.2 | ||||
| LDTP05538 | Prolow-density lipoprotein receptor-related protein 1 (LRP1) | 6.9 | ||||
| LDTP12451 | Integral membrane protein 2C (ITM2C) | 6.6 | ||||
| LDTP02562 | Lysosome-associated membrane glycoprotein 1 (LAMP1) | 6.5 | ||||
| LDTP06499 | V-type proton ATPase subunit S1 (ATP6AP1) | 6.1 | ||||
| LDTP04459 | H(+)/Cl(-) exchange transporter 3 (CLCN3) | 5.9 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 5.5 | ||||
| LDTP10958 | Sigma non-opioid intracellular receptor 1 (SIGMAR1) | 5.4 | ||||
| LDTP00541 | NPC intracellular cholesterol transporter 1 (NPC1) | 5.2 | ||||
Immunoglobulin
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04720 | IgG receptor FcRn large subunit p51 (FCGRT) | 10.9 | ||||
| LDTP02491 | HLA class I histocompatibility antigen, C alpha chain (HLA-C) | 5.0 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11674 | Extracellular glycoprotein lacritin (LACRT) | 99.7 | ||||
| LDTP03571 | Lipocalin-1 (LCN1) | 99.7 | ||||
| LDTP11009 | Opiorphin prepropeptide (OPRPN) | 15.7 | ||||
| LDTP07703 | Seizure 6-like protein 2 (SEZ6L2) | 14.8 | ||||
| LDTP05491 | Amyloid beta precursor like protein 2 (APLP2) | 12.6 | ||||
| LDTP05558 | Galectin-3-binding protein (LGALS3BP) | 12.0 | ||||
| LDTP19021 | EF-hand calcium-binding domain-containing protein 14 (EFCAB14) | 9.4 | ||||
| LDTP01821 | Cystatin-A (CSTA) | 9.1 | ||||
| LDTP08689 | Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) | 8.8 | ||||
| LDTP12352 | CD320 antigen (CD320) | 8.7 | ||||
| LDTP00779 | Trans-Golgi network integral membrane protein 2 (TGOLN2) | 8.5 | ||||
| LDTP14458 | Tetraspanin-6 (TSPAN6) | 8.2 | ||||
| LDTP02927 | Ganglioside GM2 activator (GM2A) | 7.9 | ||||
| LDTP13114 | C-type mannose receptor 2 (MRC2) | 6.5 | ||||
| LDTP09054 | Golgi membrane protein 1 (GOLM1) | 6.2 | ||||
| LDTP04142 | Galectin-7 (LGALS7; LGALS7B) | 6.0 | ||||
| LDTP09920 | Golgi apparatus protein 1 (GLG1) | 5.2 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 5.2 | ||||