Details of the Target

General Information of Target

Target ID LDTP04142
Target Name Galectin-7 (LGALS7; LGALS7B)
Gene Name LGALS7; LGALS7B
Gene ID 3963
Synonyms
PIG1; Galectin-7; Gal-7; HKL-14; PI7; p53-induced gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEV
VFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVR
LVEVGGDVQLDSVRIF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Uniprot ID
P47929
Ensemble ID
ENST00000314980.5
HGNC ID
HGNC:6568
ChEMBL ID
CHEMBL5008

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C221
 Probe Info  		5.98  LDD1895  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-glutamine gamma-glutamyltransferase 5 (TGM5) Transglutaminase family O43548
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) . Q15750
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
Single-stranded DNA-binding protein, mitochondrial (SSBP1) . Q04837

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-d-glucose Small molecular drug DB02379
Beta-d-galactosamine . DB02678

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587