Details of the Target

General Information of Target

Target ID LDTP02927
Target Name Ganglioside GM2 activator (GM2A)
Gene Name GM2A
Gene ID 2760
Synonyms
Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIV
PGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIP
TGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKR
LGCIKIAASLKGI
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Lysosome
Function
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
TTD ID
T51499
Uniprot ID
P17900
DrugMap ID
TTGOFW6
Ensemble ID
ENST00000357164.4
HGNC ID
HGNC:4367

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.76  LDD0054  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C138(1.15)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [4]
PAL-AfBPP Probe
Click To Hide/Show 90 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		10.56  LDD1714  [5]
C022
 Probe Info  		17.03  LDD1728  [5]
C040
 Probe Info  		7.52  LDD1740  [5]
C041
 Probe Info  		5.78  LDD1741  [5]
C045
 Probe Info  		15.03  LDD1744  [5]
C053
 Probe Info  		6.28  LDD1751  [5]
C063
 Probe Info  		18.13  LDD1760  [5]
C070
 Probe Info  		10.20  LDD1766  [5]
C073
 Probe Info  		6.50  LDD1769  [5]
C087
 Probe Info  		7.11  LDD1779  [5]
C091
 Probe Info  		11.31  LDD1782  [5]
C092
 Probe Info  		27.10  LDD1783  [5]
C106
 Probe Info  		56.89  LDD1793  [5]
C107
 Probe Info  		11.24  LDD1794  [5]
C108
 Probe Info  		16.91  LDD1795  [5]
C112
 Probe Info  		37.27  LDD1799  [5]
C115
 Probe Info  		6.28  LDD1802  [5]
C130
 Probe Info  		6.82  LDD1812  [5]
C134
 Probe Info  		24.42  LDD1816  [5]
C143
 Probe Info  		14.93  LDD1825  [5]
C149
 Probe Info  		6.68  LDD1830  [5]
C159
 Probe Info  		10.48  LDD1839  [5]
C160
 Probe Info  		7.73  LDD1840  [5]
C161
 Probe Info  		15.56  LDD1841  [5]
C163
 Probe Info  		6.23  LDD1843  [5]
C164
 Probe Info  		5.66  LDD1844  [5]
C170
 Probe Info  		35.51  LDD1850  [5]
C171
 Probe Info  		9.58  LDD1851  [5]
C186
 Probe Info  		23.26  LDD1864  [5]
C197
 Probe Info  		7.41  LDD1873  [5]
C201
 Probe Info  		99.73  LDD1877  [5]
C206
 Probe Info  		26.72  LDD1881  [5]
C208
 Probe Info  		13.74  LDD1883  [5]
C211
 Probe Info  		13.83  LDD1885  [5]
C213
 Probe Info  		18.51  LDD1887  [5]
C220
 Probe Info  		21.71  LDD1894  [5]
C221
 Probe Info  		7.94  LDD1895  [5]
C223
 Probe Info  		14.42  LDD1897  [5]
C225
 Probe Info  		6.28  LDD1898  [5]
C226
 Probe Info  		5.50  LDD1899  [5]
C228
 Probe Info  		19.97  LDD1901  [5]
C231
 Probe Info  		14.12  LDD1904  [5]
C237
 Probe Info  		7.26  LDD1910  [5]
C243
 Probe Info  		14.32  LDD1916  [5]
C246
 Probe Info  		26.54  LDD1919  [5]
C249
 Probe Info  		21.86  LDD1922  [5]
C264
 Probe Info  		21.11  LDD1935  [5]
C265
 Probe Info  		14.22  LDD1936  [5]
C270
 Probe Info  		8.11  LDD1940  [5]
C277
 Probe Info  		11.71  LDD1947  [5]
C278
 Probe Info  		77.17  LDD1948  [5]
C280
 Probe Info  		12.91  LDD1950  [5]
C281
 Probe Info  		12.38  LDD1951  [5]
C282
 Probe Info  		24.42  LDD1952  [5]
C284
 Probe Info  		26.72  LDD1954  [5]
C287
 Probe Info  		10.48  LDD1957  [5]
C293
 Probe Info  		25.11  LDD1963  [5]
C296
 Probe Info  		22.16  LDD1966  [5]
C302
 Probe Info  		9.85  LDD1971  [5]
C305
 Probe Info  		14.03  LDD1974  [5]
C310
 Probe Info  		20.68  LDD1977  [5]
C314
 Probe Info  		15.78  LDD1981  [5]
C326
 Probe Info  		7.78  LDD1990  [5]
C334
 Probe Info  		4.96  LDD1997  [5]
C339
 Probe Info  		6.68  LDD2002  [5]
C343
 Probe Info  		23.92  LDD2005  [5]
C346
 Probe Info  		16.45  LDD2007  [5]
C348
 Probe Info  		12.73  LDD2009  [5]
C349
 Probe Info  		18.00  LDD2010  [5]
C350
 Probe Info  		70.03  LDD2011  [5]
C355
 Probe Info  		29.04  LDD2016  [5]
C362
 Probe Info  		67.18  LDD2023  [5]
C363
 Probe Info  		18.25  LDD2024  [5]
C364
 Probe Info  		24.08  LDD2025  [5]
C376
 Probe Info  		8.69  LDD2036  [5]
C378
 Probe Info  		5.94  LDD2037  [5]
C382
 Probe Info  		14.22  LDD2041  [5]
C383
 Probe Info  		11.24  LDD2042  [5]
C386
 Probe Info  		7.16  LDD2045  [5]
C390
 Probe Info  		75.58  LDD2049  [5]
C407
 Probe Info  		20.39  LDD2064  [5]
C419
 Probe Info  		15.35  LDD2074  [5]
C420
 Probe Info  		12.82  LDD2075  [5]
C425
 Probe Info  		15.78  LDD2080  [5]
C429
 Probe Info  		19.56  LDD2084  [5]
C431
 Probe Info  		23.59  LDD2086  [5]
FFF probe12
 Probe Info  		20.00  LDD0473  [6]
FFF probe9
 Probe Info  		20.00  LDD0470  [6]
LD-F
 Probe Info  		D156(0.00); L157(0.00)  LDD0015  [7]
TM-F
 Probe Info  		L157(0.00); D156(0.00); P155(0.00)  LDD0020  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C138(1.15)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C138(0.96)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C136(0.57); C138(0.57)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C136(0.75); C138(0.75)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C136(0.81); C138(0.81)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C136(0.85); C138(0.85)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C136(1.20); C138(1.20)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C136(0.99); C138(0.99)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C136(0.69); C138(0.69)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C136(0.94); C138(0.94)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C136(0.68); C138(0.68)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C136(1.22); C138(1.22)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C138(1.02)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C136(0.68); C138(0.68)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C136(0.75); C138(0.75)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C136(0.82); C138(0.82)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C136(0.92); C138(0.92)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C136(1.08); C138(1.08)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C136(1.09); C138(1.09)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C136(1.69); C138(1.69)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C136(1.18); C138(1.18)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C136(1.16); C138(1.16)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C136(1.22); C138(1.22)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C138(1.07)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C136(1.12); C138(1.12)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C136(1.04); C138(1.04)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C136(0.80); C138(0.80)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C136(1.18); C138(1.18)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C136(1.02); C138(1.02)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C136(0.91); C138(0.91)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C136(0.95); C138(0.95)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C136(0.93); C138(0.93)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C136(1.40); C138(1.40)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C136(1.10); C138(1.10)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C136(0.90); C138(0.90)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C136(1.10); C138(1.10)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C136(0.92); C138(0.92)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C136(0.93); C138(0.93)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C136(0.89); C138(0.89)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C136(1.02); C138(1.02)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C136(0.83); C138(0.83)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C136(0.98); C138(0.98)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C136(0.74); C138(0.74)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C136(0.80); C138(0.80)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C138(1.08)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C136(0.72); C138(0.72)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C136(0.77); C138(0.77)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C136(0.87); C138(0.87)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C136(1.53); C138(1.25)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C138(0.97); C136(1.25)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C138(1.61); C136(2.42)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C138(1.07); C136(1.21)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C138(1.19); C136(1.53)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C138(1.51); C136(1.76)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C138(1.24); C136(1.28)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C138(0.93)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C138(1.29); C136(1.71)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C138(1.12); C136(1.16)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C138(1.12); C136(1.28)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C138(1.40); C136(1.63)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C136(1.86); C138(1.38)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C136(1.53); C138(1.18)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C136(1.23); C138(1.13)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C136(1.85); C138(1.42)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C136(1.28); C138(1.28)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C136(0.93); C138(0.93)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C136(0.81); C138(0.81)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C138(1.09)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C136(1.17); C138(1.17)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C136(1.05); C138(1.05)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C136(1.06); C138(1.06)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C136(1.45); C138(1.45)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C136(1.67); C138(1.67)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C136(2.63); C138(1.89)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C136(1.36); C138(1.25)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C136(1.39); C138(1.28)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C136(1.58); C138(1.31)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C136(1.42); C138(1.22)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C138(1.08)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C136(1.84); C138(1.40)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C136(2.23); C138(1.61)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C136(1.52); C138(1.26)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C136(1.68); C138(1.36)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C136(1.26); C138(1.18)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C136(0.87); C138(0.87)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C136(0.78); C138(0.78)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C136(1.18); C138(1.18)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C136(0.84); C138(0.84)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C136(0.79); C138(0.79)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C138(1.24)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C136(0.70); C138(0.70)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C136(0.65); C138(0.65)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C136(0.68); C138(0.68)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C136(0.54); C138(0.54)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C136(0.83); C138(0.83)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C136(0.85); C138(0.85)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C136(0.56); C138(0.56)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C136(0.77); C138(0.77)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C136(0.71); C138(0.71)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C136(0.82); C138(0.82)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C138(1.22)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C136(0.85); C138(0.85)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C136(0.80); C138(0.80)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C136(0.70); C138(0.70)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C136(0.72); C138(0.72)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C136(1.05); C138(1.05)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C136(0.57); C138(0.57)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C136(0.64); C138(0.64)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C136(0.85); C138(0.93)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C136(0.82); C138(0.89)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C136(0.77); C138(0.80)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C138(0.86)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C136(0.55); C138(0.65)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C136(0.82); C138(0.83)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C136(0.69); C138(0.81)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C136(0.63); C138(0.73)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C136(0.64); C138(0.76)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C136(0.83); C138(0.86)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C136(0.79); C138(0.80)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C136(0.49); C138(0.56)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C136(1.03); C138(1.08)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C136(1.44); C138(1.49)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C138(0.78)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C136(0.99); C138(1.09)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C136(1.04); C138(1.05)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C136(0.71); C138(0.81)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C136(0.68); C138(0.89)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C136(0.78); C138(1.08)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C136(0.60); C138(0.76)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C136(0.71); C138(0.89)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C136(0.78); C138(0.84)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C136(0.64); C138(0.81)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C136(0.85); C138(0.96)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C138(0.89)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C136(0.67); C138(0.79)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C136(0.98); C138(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C136(0.75); C138(0.86)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C136(1.18); C138(1.18)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C136(0.79); C138(0.79)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C136(0.95); C138(0.95)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C136(1.06); C138(1.06)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C136(0.98); C138(0.98)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C136(0.87); C138(0.87)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C136(0.76); C138(0.76)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C136(0.89); C138(0.89)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C136(1.16); C138(1.16)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C136(1.08); C138(1.08)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C136(1.45); C138(1.45)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C136(1.07); C138(1.07)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C136(1.23); C138(1.23)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C136(1.20); C138(1.20)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C136(1.42); C138(1.42)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C136(0.74); C138(0.74)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C136(0.75); C138(0.75)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C138(0.84)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C138(1.03)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C138(0.94)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C136(0.68); C138(0.68)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C136(0.72); C138(0.72)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C138(1.19)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C138(0.82)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C138(0.99)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C138(1.06)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C138(1.07)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C136(1.21); C138(1.21)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C136(1.27); C138(1.27)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C136(0.94); C138(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C136(1.63); C138(1.63)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C136(0.87); C138(0.87)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C136(0.82); C138(0.82)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C136(1.49); C138(1.49)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C136(0.97); C138(0.97)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C136(1.21); C138(1.19)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C136(1.41); C138(1.17)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C136(1.61); C138(1.48)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C136(1.73); C138(1.46)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C136(1.81); C138(1.50)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C136(0.62); C138(0.62)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C136(0.60); C138(0.60)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C136(0.56); C138(0.56)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C136(0.61); C138(0.61)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C136(0.56); C138(0.56)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C136(0.82); C138(0.82)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C136(0.76); C138(0.76)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C136(0.93); C138(0.93)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C136(0.95); C138(0.95)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C136(1.01); C138(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C136(1.00); C138(1.06)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C136(0.85); C138(0.91)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C136(0.89); C138(0.92)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C136(0.89); C138(0.89)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C136(0.83); C138(0.83)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C136(0.61); C138(0.61)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C136(0.73); C138(0.76)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C136(0.94); C138(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C136(0.70); C138(0.83)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C136(0.73); C138(0.82)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C136(0.90); C138(0.90)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C136(0.71); C138(0.80)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C136(0.68); C138(0.77)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C136(0.61); C138(0.76)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C136(0.60); C138(0.71)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C136(0.68); C138(0.83)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C136(0.77); C138(0.84)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C136(0.86); C138(0.93)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C136(0.83); C138(0.92)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C136(0.66); C138(0.77)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C136(0.64); C138(0.74)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C136(0.71); C138(0.71)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C136(0.73); C138(0.81)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C136(0.52); C138(0.52)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C136(0.32); C138(0.32)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C136(0.37); C138(0.37)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C136(0.27); C138(0.27)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C136(0.36); C138(0.36)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C136(0.43); C138(0.43)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C136(0.39); C138(0.39)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C136(0.38); C138(0.38)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C136(0.75); C138(0.75)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C136(0.33); C138(0.33)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C136(0.52); C138(0.52)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C136(0.25); C138(0.25)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C136(0.25); C138(0.25)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C136(0.25); C138(0.25)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C136(0.22); C138(0.22)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C138(1.29)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C138(1.30)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C138(1.15)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C138(1.20)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C136(0.73); C138(0.73)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C138(1.53)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C138(1.43)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C138(1.26)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C138(0.82)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C138(1.41)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C138(0.96)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C138(1.04)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C138(1.21)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C138(1.46)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C138(1.07)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C136(0.77); C138(0.77)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C138(1.41)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C136(1.31); C138(1.31)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C136(1.18); C138(1.18)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C136(2.36); C138(2.36)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C136(1.14); C138(1.14)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C136(1.19); C138(1.19)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C136(1.58); C138(1.58)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C136(1.24); C138(1.24)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C136(1.05); C138(1.05)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C136(1.88); C138(1.88)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C136(0.65); C138(0.65)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C136(1.77); C138(1.77)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C136(1.50); C138(1.50)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C136(1.25); C138(1.25)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C136(1.18); C138(1.18)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C136(1.29); C138(1.29)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C138(1.08)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C138(1.06)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C138(1.07)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C138(1.28)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C136(1.02); C138(0.80)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C138(1.26)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C138(1.07)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C138(1.08)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C138(1.29)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C138(1.15)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C138(1.19)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C138(1.43)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C138(1.26)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C138(1.18)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C138(1.33)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C136(0.97); C138(0.55)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C138(1.13)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C138(0.94)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C138(0.87)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C138(1.07)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C138(1.02)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C138(0.93)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C138(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C138(1.16)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C138(1.00)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C138(1.06)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C136(1.08)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C136(1.39); C138(1.39)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C136(0.29); C138(0.29)  LDD0744  [3]
 LDCM0008  Tranylcypromine SH-SY5Y 2.76  LDD0054  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lauric Acid Small molecular drug DB03017
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biw-8962 Antibody D0N6TD
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Alfoscerate Small molecular drug DB04660
Lpc-ether Small molecular drug DB03633
Myristic Acid Small molecular drug DB08231
Platelet Activating Factor Small molecular drug DB02261

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402