Details of the Probe

General Information of Probe

Probe ID	LDPC0020
Probe Name	TM-F
Probe Type	PAL-AfBPP Probe
Structure
Structure	2D MOL
Ro5 Violations (Lipinski): 0	Molecular Weight (mw)	358.445
	Lipid-water partition coefficient (xlogp)	2.9615
	Rotatable Bond Count (rotbonds)	7
	Hydrogen Bond Donor Count (hbonddonor)	0
	Hydrogen Bond Acceptor Count (hbondacc)	4
Chemical Identifiers	Formula C22H22N4O Canonical SMILES C#CCN(CC1N=N1)C(=O)C1CN(C(c2ccccc2)c2ccccc2)C1 InChI InChI=1S/C22H22N4O/c1-2-13-25(16-20-23-24-20)22(27)19-14-26(15-19)21(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h1,3-12,19-21H,13-16H2 InChIKey XSDFVIIHRGLTET-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

8 Enzyme Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
Actin, cytoplasmic 1 (ACTB)	LDTP04876	P98; H101; E100	LDD0020
ATP synthase subunit beta, mitochondrial (ATP5F1B)	LDTP02150	A388; G393; A397	LDD0020
Palmitoyl-protein thioesterase 1 (PPT1)	LDTP04388	E78; V88; D79	LDD0020
Protein disulfide-isomerase (P4HB)	LDTP02188	P141; V157	LDD0020
Retinoid-inducible serine carboxypeptidase (SCPEP1)	LDTP16032	A256; I259; M258	LDD0020
Tubulin alpha-1A chain (TUBA1A)	LDTP07907	E71; V68; D76	LDD0020
Tubulin alpha-3D chain (TUBA3D)	LDTP02453	Q256; E254; T253	LDD0020
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)	LDTP06901	G38; W37; G50	LDD0020
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⏷ Show the Full List of 8 Enzyme

7 Transporter and channel Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
ADP/ATP translocase 3 (SLC25A6)	LDTP02609	G120; S119; G124	LDD0020
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)	LDTP03284	T81; G80; L85	LDD0020
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	LDTP05510	E196; D197; Y188; E198	LDD0020
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)	LDTP02724	G65; Y71	LDD0020
Putative lipid scramblase CLPTM1 (CLPTM1)	LDTP01745	E336; E333	LDD0020
Voltage-dependent anion-selective channel protein 1 (VDAC1)	LDTP03132	E36; V184; E40; L39	LDD0020
Voltage-dependent anion-selective channel protein 2 (VDAC2)	LDTP04071	Y236; D214; V217; L238	LDD0020
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⏷ Show the Full List of 7 Transporter and channel

11 Other Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
Ganglioside GM2 activator (GM2A)	LDTP02927	L157; D156; P155	LDD0020
Histone H2A type 2-C (H2AC20)	LDTP06627	T60; L59; L64; I63	LDD0020
Histone H2A type 3 (H2AC25)	LDTP07973	E57; L56; T60	LDD0020
Histone H2A.V (H2AZ2)	LDTP07908	L59; L67; A56; V66	LDD0020
Histone H3.2 (H3C15; H3C14; H3C13)	LDTP07899	E106; G103; D107	LDD0020
Membralin (TMEM259)	LDTP14939	L260; E258; F259	LDD0020
Mitochondrial import receptor subunit TOM22 homolog (TOMM22)	LDTP12565	E104; V99; E102	LDD0020
Nucleobindin-1 (NUCB1)	LDTP05375	T64; D65	LDD0020
Prohibitin-2 (PHB2)	LDTP10924	A65; G67; H69	LDD0020
Protein LYRIC (MTDH)	LDTP08224	T34; E35	LDD0020
Transmembrane protein 256 (TMEM256)	LDTP19689	Q31	LDD0020
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⏷ Show the Full List of 11 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification

Experiment 1 Reporting the Labelling Profiles of This Probe

REF [1]

Probe concentration

200 uM

Quantitative Method

Isotope tag

In Vitro Experiment Model

Model Type

Living cell

Derived Tissue

Peripheral blood

Disease Model

Normal

Model Name

Human normal cells (HEK-293T)

Interaction Atlas ID

LDD0020

References

1	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652