Details of the Target

General Information of Target

Target ID LDTP07973
Target Name Histone H2A type 3 (H2AC25)
Gene Name H2AC25
Gene ID 92815
Synonyms
H2AW; HIST3H2A; Histone H2A type 3; H2A-clustered histone 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
Target Bioclass
Other
Family
Histone H2A family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q7L7L0
Ensemble ID
ENST00000366695.3
HGNC ID
HGNC:20507

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y40(7.35)  LDD0260  [1]
AZ-9
 Probe Info  		E92(1.09)  LDD2208  [2]
NHS
 Probe Info  		K120(0.00); K96(0.00); K119(0.00)  LDD0010  [3]
OSF
 Probe Info  		N.A.  LDD0029  [4]
SF
 Probe Info  		K96(0.00); K126(0.00); K120(0.00); Y40(0.00)  LDD0028  [4]
STPyne
 Probe Info  		K96(0.00); K119(0.00); K120(0.00)  LDD0009  [3]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		T60(0.00); L56(0.00); A54(0.00); E62(0.00)  LDD0024  [5]
LD-F
 Probe Info  		L56(0.00); E62(0.00); A54(0.00); T60(0.00)  LDD0015  [5]
TM-F
 Probe Info  		E57(0.00); L56(0.00); T60(0.00)  LDD0020  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Ubiquitin-conjugating enzyme E2 B (UBE2B) Ubiquitin-conjugating enzyme family P63146
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652