Details of the Target

General Information of Target

Target ID LDTP04876
Target Name Actin, cytoplasmic 1 (ACTB)
Gene Name ACTB
Gene ID 60
Synonyms
Actin, cytoplasmic 1; EC 3.6.4.-; Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Target Bioclass
Enzyme
Family
Actin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Uniprot ID
P60709
Ensemble ID
ENST00000493945.6
HGNC ID
HGNC:132
ChEMBL ID
CHEMBL2062353

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.36  LDD0402  [2]
P1
 Probe Info  		10.00  LDD0452  [3]
P2
 Probe Info  		10.00  LDD0453  [3]
P3
 Probe Info  		8.38  LDD0454  [3]
P8
 Probe Info  		10.00  LDD0455  [3]
7-N3
 Probe Info  		1.18  LDD0281  [4]
TH211
 Probe Info  		Y91(20.00); Y294(17.74); Y166(17.50); Y306(15.06)  LDD0257  [5]
TH214
 Probe Info  		Y198(20.00); Y91(20.00); Y53(19.87); Y306(17.35)  LDD0258  [5]
TH216
 Probe Info  		Y169(20.00); Y362(20.00); Y240(17.81); Y53(16.43)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K50(20.00); K291(20.00); K326(20.00); K284(8.84)  LDD2217  [7]
ONAyne
 Probe Info  		K113(0.00); K291(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K191(0.96); K61(2.51); K291(2.73); K113(2.75)  LDD3494  [9]
Probe 1
 Probe Info  		Y53(66.58); Y166(11.61); Y169(9.59); Y188(127.74)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C257(0.00); C217(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C217(1.11); C285(0.99); C272(1.00); C257(1.01)  LDD0460  [11]
EA-probe
 Probe Info  		C257(0.91); C217(0.81)  LDD2210  [12]
HHS-482
 Probe Info  		Y166(1.01); Y169(0.85); Y188(1.45); Y198(0.94)  LDD0285  [13]
HHS-475
 Probe Info  		Y240(0.75); Y53(0.77); Y294(0.78); Y198(0.78)  LDD0264  [14]
HHS-465
 Probe Info  		Y166(5.81); Y169(7.36); Y188(10.00); Y198(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C257(1.15); C272(1.15)  LDD0078  [16]
5E-2FA
 Probe Info  		H275(0.00); H40(0.00); H87(0.00); H88(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		K328(0.00); K113(0.00); K61(0.00); K50(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K328(0.00); K113(0.00); K61(0.00); K50(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C285(0.00); C272(0.00); C257(0.00); C17(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C285(0.00); C17(0.00); C257(0.00); C272(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C217(0.00); C257(0.00); C17(0.00); C285(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C17(0.00); C217(0.00); C285(0.00); C272(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C285(0.00); C272(0.00); C257(0.00); C17(0.00)  LDD0037  [19]
2PCA
 Probe Info  		K238(0.00); R312(0.00); R95(0.00); K18(0.00)  LDD0034  [22]
ATP probe
 Probe Info  		K291(0.00); K328(0.00); K18(0.00); K50(0.00)  LDD0035  [23]
AZ-9
 Probe Info  		D25(0.00); D311(0.00); E241(0.00)  LDD0395  [24]
JW-RF-010
 Probe Info  		C17(0.00); C285(0.00); C217(0.00); C257(0.00)  LDD0026  [25]
NAIA_4
 Probe Info  		C257(0.00); C272(0.00); C17(0.00)  LDD2226  [26]
TFBX
 Probe Info  		C17(0.00); C217(0.00); C285(0.00); C257(0.00)  LDD0027  [25]
WYneN
 Probe Info  		C285(0.00); C257(0.00); C17(0.00); C217(0.00)  LDD0021  [27]
WYneO
 Probe Info  		C17(0.00); C285(0.00)  LDD0022  [27]
aHNE
 Probe Info  		N.A.  LDD0001  [27]
Compound 10
 Probe Info  		C257(0.00); C272(0.00); C285(0.00)  LDD2216  [28]
Compound 11
 Probe Info  		C257(0.00); C272(0.00)  LDD2213  [28]
IPM
 Probe Info  		C272(0.00); C285(0.00)  LDD0005  [27]
NHS
 Probe Info  		K61(0.00); K326(0.00); K113(0.00); K315(0.00)  LDD0010  [27]
OSF
 Probe Info  		Y198(0.00); Y53(0.00); Y306(0.00); H40(0.00)  LDD0029  [29]
PF-06672131
 Probe Info  		N.A.  LDD0017  [30]
SF
 Probe Info  		Y166(0.00); Y91(0.00); Y294(0.00); K291(0.00)  LDD0028  [29]
VSF
 Probe Info  		C285(0.00); C17(0.00)  LDD0007  [27]
Phosphinate-6
 Probe Info  		C272(0.00); C374(0.00); C217(0.00); C17(0.00)  LDD0018  [31]
Ox-W18
 Probe Info  		W340(0.00); W356(0.00)  LDD2175  [32]
1c-yne
 Probe Info  		K18(0.00); K50(0.00); K315(0.00); K291(0.00)  LDD0228  [33]
Acrolein
 Probe Info  		C17(0.00); K18(0.00)  LDD0217  [34]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [34]
Methacrolein
 Probe Info  		N.A.  LDD0218  [34]
AOyne
 Probe Info  		11.10  LDD0443  [35]
NAIA_5
 Probe Info  		C272(0.00); C285(0.00); C257(0.00); C17(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.59  LDD0472  [36]
FFF probe13
 Probe Info  		6.05  LDD0475  [36]
FFF probe14
 Probe Info  		5.88  LDD0477  [36]
FFF probe3
 Probe Info  		5.68  LDD0465  [36]
JN0003
 Probe Info  		5.35  LDD0469  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
Diazir
 Probe Info  		C17(0.00); E253(0.00); E99(0.00); E107(0.00)  LDD0011  [27]
BD-F
 Probe Info  		V163(0.00); E99(0.00); A97(0.00); P164(0.00)  LDD0024  [39]
LD-F
 Probe Info  		E226(0.00); D222(0.00)  LDD0015  [39]
TM-F
 Probe Info  		P98(0.00); H101(0.00); E100(0.00)  LDD0020  [39]
Photocelecoxib
 Probe Info  		V96(0.00); E99(0.00); E100(0.00); V163(0.00)  LDD0019  [40]
Photoindomethacin
 Probe Info  		G251(0.00); E253(0.00)  LDD0154  [40]
Photonaproxen
 Probe Info  		E100(0.00); E167(0.00); H161(0.00); D24(0.00)  LDD0157  [40]
STS-1
 Probe Info  		N.A.  LDD0068  [41]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C217(0.85); C257(0.92); C272(1.42)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C217(0.50); C257(0.77); C272(0.82)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C217(12.51); C257(17.92); C272(5.05)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C217(1.16); C257(1.27); C272(0.96)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C217(1.02); C257(1.05); C272(0.97)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C217(0.70); C257(0.70); C272(0.87)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C217(0.91); C257(1.14); C272(1.35)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C217(0.89); C257(0.80); C272(0.77)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C217(0.71); C257(0.73); C272(0.61)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C217(0.56); C257(0.29); C272(0.87)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C217(1.34); C257(0.82); C272(0.57)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C217(1.48); C257(0.67); C272(0.67)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C217(0.45); C257(0.90); C272(1.05)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C217(1.05); C257(0.67); C272(0.82)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C217(1.21); C257(0.78); C272(0.76)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C217(1.04); C257(0.39); C272(0.76)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C217(0.76); C257(0.89); C272(0.92)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C217(1.10); C257(0.90); C272(0.94)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C217(0.73); C257(0.54); C272(0.86)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C217(0.65); C257(0.64); C272(0.90)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C217(1.01); C257(0.81); C272(1.07)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C217(1.00); C257(0.92); C272(0.92)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C217(0.83); C257(0.77); C272(0.78)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C217(0.64); C257(1.04); C272(1.10)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C217(0.86); C257(1.17); C272(1.45)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C217(0.92); C257(0.98); C272(0.92)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C217(0.53); C257(0.93); C272(0.87)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C217(1.08); C257(1.12); C272(1.01)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C217(1.23); C257(1.05); C272(1.01)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C217(0.83); C257(0.86); C272(0.78)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C217(0.82); C257(0.58); C272(0.73)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C217(0.84); C257(0.58); C272(0.70)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C217(0.27); C257(0.16); C272(0.21)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C217(1.17); C257(0.72); C272(0.53)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C217(0.83); C257(0.44); C272(0.42)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C217(1.19); C257(0.84); C272(0.65)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C217(0.82); C257(0.61); C272(0.52)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C217(0.78); C257(0.47); C272(0.42)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C217(0.66); C257(0.35); C272(0.38)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C217(0.57); C257(0.36); C272(0.39)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C217(0.75); C257(0.70); C272(0.61)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C217(0.80); C257(0.68); C272(0.57)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C217(0.68); C257(0.46); C272(0.45)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C217(0.81); C257(0.45); C272(0.36)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C217(0.56); C257(0.79); C272(0.94)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C217(0.62); C257(0.34); C272(0.31)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C217(0.72); C257(0.46); C272(0.42)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C217(0.97); C257(0.65); C272(0.52)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C217(1.36); C257(0.99); C272(0.88)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C257(0.84); C272(0.88); C217(1.02)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C272(1.06); C217(1.10); C257(1.27)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C257(0.82); C272(0.97); C217(1.02)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C257(0.51); C217(0.76); C272(0.79)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C257(0.10); C217(0.17); C272(0.67)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C257(0.53); C217(0.65); C272(0.83)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C217(0.44); C257(0.81); C272(0.87)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C257(1.12); C272(1.14); C217(1.62)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C272(0.94); C257(0.98); C217(1.12)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C257(0.51); C217(0.64); C272(1.03)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C257(0.08); C217(0.13); C272(0.64)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C217(1.09); C257(0.63); C272(0.95)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C217(1.77); C257(0.85); C272(0.89)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C217(1.32); C257(0.98); C272(0.87)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C217(1.65); C257(1.40); C272(1.20)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C257(1.33); C272(1.33); C217(1.50)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C217(0.79); C257(1.20); C272(1.20)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C257(1.06); C272(1.06); C217(1.58)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C257(0.77); C217(0.81); C272(1.10)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C217(1.43); C257(1.47); C272(1.47)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C257(1.31); C272(1.31); C217(1.65)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C217(1.10); C257(1.26); C272(1.26)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C257(1.22); C272(1.22); C217(1.53)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C257(1.11); C272(1.11); C217(1.61)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C272(0.64); C257(0.68); C217(1.07)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C272(0.69); C257(0.80); C217(0.82)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C257(0.74); C272(0.75); C217(0.87)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C272(0.87); C217(0.88); C257(1.05)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C257(0.70); C272(0.89); C217(0.98)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C217(0.62); C257(0.70); C272(0.94)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C217(0.70); C257(0.77); C272(0.89)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C257(0.72); C272(0.84); C217(0.93)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C257(0.48); C217(0.59); C272(0.68)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C257(0.52); C217(0.69); C272(0.72)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C217(0.52); C257(0.61); C272(1.09)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C217(1.77); C257(2.78); C272(2.78)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C217(0.84); C257(0.89); C272(0.89)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C257(0.82); C272(0.82); C217(1.23)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C257(0.94); C272(0.94); C217(1.22)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C257(0.92); C272(0.92); C217(1.12)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C217(0.59); C257(0.60); C272(0.97)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C257(0.48); C272(0.48); C217(0.49)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C257(0.75); C272(0.75); C217(1.00)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C257(0.58); C272(0.58); C217(0.85)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C257(0.72); C272(0.72); C217(1.19)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C257(0.57); C272(0.57); C217(0.63)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C257(0.38); C272(0.38); C217(0.44)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C257(0.83); C272(0.83); C217(1.09)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C257(0.65); C272(0.65); C217(1.10)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C257(0.63); C272(0.63); C217(1.28)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C257(0.21); C272(0.21); C217(0.26)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C217(0.55); C257(0.61); C272(1.03)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C257(0.19); C272(0.19); C217(0.39)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C257(1.34); C272(1.34); C217(1.76)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C257(0.77); C272(0.77); C217(1.04)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C257(0.40); C272(0.40); C217(0.66)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C257(0.43); C272(0.43); C217(0.54)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C257(0.16); C272(0.16); C217(0.36)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C257(0.06); C272(0.06); C217(0.14)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C257(0.39); C272(0.53); C217(1.06)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C257(0.30); C272(0.53); C217(1.09)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C257(0.17); C272(0.36); C217(0.66)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C217(0.45); C257(0.61); C272(0.62)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C257(0.34); C272(0.53); C217(1.85)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C257(0.39); C272(0.53); C217(1.70)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C257(0.10); C272(0.30); C217(0.70)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C257(0.32); C272(0.55); C217(1.33)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C257(0.15); C272(0.36); C217(0.68)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C257(0.23); C272(0.40); C217(0.91)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C257(0.30); C272(0.45); C217(2.09)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C257(0.03); C217(0.22); C272(0.34)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C257(0.57); C272(0.62); C217(0.84)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C257(0.57); C217(0.79); C272(0.87)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C217(0.46); C257(0.84); C272(1.00)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C257(0.20); C217(0.33); C272(0.52)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C257(0.68); C272(0.73); C217(0.87)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C257(0.49); C272(0.79); C217(0.86)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C257(0.08); C217(0.18); C272(0.45)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C257(0.11); C217(0.21); C272(0.58)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C257(0.04); C217(0.09); C272(0.31)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C257(0.33); C272(0.52); C217(0.54)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C257(0.31); C272(0.65); C217(0.69)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C272(0.70); C257(0.72); C217(0.92)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C257(0.64); C272(0.75); C217(0.78)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C217(0.54); C257(1.30); C272(1.61)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C257(0.48); C272(0.62); C217(0.71)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C257(0.39); C217(0.49); C272(0.61)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C257(0.04); C217(0.07); C272(0.28)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C257(0.26); C272(0.49)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C257(0.51); C272(0.71)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C272(1.24); C257(1.30)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C272(0.77); C257(0.82)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C272(1.13); C257(1.29)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C272(0.98); C257(1.14)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C257(0.54); C272(0.58)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C272(1.09); C257(1.38)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C257(0.21); C272(0.37)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C257(0.32); C272(0.35)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C272(1.24); C257(1.54)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C272(2.98); C257(3.77)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C272(0.99); C257(1.15)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C272(0.72); C257(0.78)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C257(0.63); C272(0.83)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C257(0.04); C217(0.05); C272(0.30)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C272(0.85); C217(0.98); C257(1.39)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C217(0.67); C257(0.83); C272(0.90)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C217(0.92); C257(1.13); C272(1.36)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C217(0.23); C257(0.41); C272(0.55)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.04  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C257(1.15); C272(1.15)  LDD0078  [16]
 LDCM0102  BDHI 8 Jurkat C257(1,125.59); C272(1,125.59)  LDD0204  [42]
 LDCM0630  CCW28-3 231MFP C272(2.39); C257(1.55); C217(1.18)  LDD2214  [43]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [34]
 LDCM0632  CL-Sc Hep-G2 C17(2.86); C257(2.01); C285(0.82); C257(0.28)  LDD2227  [26]
 LDCM0367  CL1 HCT 116 C257(0.78); C272(0.88); C217(1.00)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C257(0.40); C217(0.70); C272(0.75)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C257(0.61); C217(0.64); C272(1.03)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C217(0.50); C257(0.72); C272(0.83)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C217(0.59); C272(0.85); C257(0.88)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C217(0.54); C257(1.12); C272(1.20)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C217(0.60); C257(0.95); C272(0.98)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C257(0.66); C272(0.66); C217(1.00)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C257(0.74); C272(0.74); C217(0.79)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C257(0.46); C272(0.46); C217(0.58)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C217(0.49); C257(0.53); C272(0.53)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C257(0.93); C272(0.93); C217(1.06)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C257(0.22); C217(0.33); C272(0.41)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C257(0.67); C272(0.67); C217(0.80)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C217(1.03); C257(1.34); C272(1.34)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C272(0.89); C257(0.93); C217(0.97)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C257(0.76); C217(0.82); C272(0.98)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C257(0.79); C217(0.89); C272(1.18)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C217(0.85); C257(0.87); C272(1.11)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C257(0.56); C217(0.69); C272(0.87)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C257(0.14); C272(0.14); C217(0.14)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C217(0.75); C257(0.91); C272(0.91)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C217(0.61); C257(0.87); C272(0.87)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C257(0.15); C217(0.27); C272(0.37)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C257(0.64); C272(0.64); C217(1.01)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C217(1.03); C257(1.13); C272(1.13)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C257(0.66); C272(0.66); C217(0.92)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C257(0.30); C272(0.30); C217(0.56)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C257(0.25); C272(0.25); C217(0.44)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C257(0.56); C272(0.60); C217(20.00)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C257(0.61); C272(0.68); C217(1.17)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C257(0.51); C272(0.63); C217(20.00)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C257(0.21); C272(0.42); C217(0.75)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C257(0.63); C272(0.67); C217(0.84)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C257(0.58); C272(0.66); C217(0.98)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C217(0.29); C272(0.64); C257(0.71)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C257(0.81); C272(0.81); C217(0.92)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C217(1.01); C257(1.02); C272(1.02)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C257(0.87); C272(0.87); C217(1.23)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C217(1.00); C257(1.13); C272(1.13)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C272(0.85); C257(0.87); C217(1.04)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C217(0.62); C257(0.77); C272(0.77)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C257(0.37); C272(0.37); C217(0.44)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C257(0.12); C272(0.12); C217(0.13)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C217(0.83); C257(1.15); C272(1.15)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C257(0.39); C272(0.39); C217(0.40)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C217(0.50); C257(0.42); C272(0.42)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C217(0.81); C257(1.37); C272(1.37)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C217(0.83); C257(1.37); C272(1.37)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C217(0.74); C257(0.79); C272(0.79)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C217(0.65); C257(0.60); C272(0.60)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C217(1.04); C257(0.85); C272(0.92)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C217(1.01); C257(1.15); C272(1.15)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C217(0.80)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C217(0.98)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C217(1.03)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C217(0.42)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C217(0.38)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C217(0.57)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C217(0.30)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C217(0.34)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C217(0.89); C257(0.70); C272(0.72)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C217(0.58)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C217(0.58)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C217(0.08)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C217(0.23)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C217(0.68)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C217(0.49)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C217(1.75); C257(1.41); C272(0.99)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C217(1.52); C257(1.23); C272(0.97)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C217(2.40); C257(1.76); C272(1.22)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C217(2.01); C257(1.40); C272(1.01)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C217(0.89); C257(0.73); C272(0.68)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C217(1.61); C257(1.30); C272(0.92)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C217(1.48); C257(1.17); C272(0.81)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C217(1.61); C257(1.28); C272(0.97)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C217(2.10); C257(1.41); C272(1.53)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C217(2.21); C257(1.41); C272(1.02)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C217(1.98); C257(1.49); C272(1.06)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C217(1.34); C257(1.13); C272(1.06)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C217(1.55); C257(1.21); C272(1.06)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C217(1.97); C257(1.57); C272(1.07)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C217(1.15); C257(1.17); C272(0.94)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C217(1.02); C257(1.04); C272(0.84)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C217(1.43); C257(1.19); C272(0.86)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C217(0.61); C257(1.11); C272(0.86)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C217(0.56); C257(0.84); C272(0.64)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C217(0.86); C257(0.81); C272(0.68)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C217(0.51); C257(0.64); C272(0.70)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C217(0.57); C257(0.90); C272(0.91)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C217(0.33); C257(0.35); C272(0.60)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C217(0.49); C257(0.65); C272(0.91)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C217(0.61); C257(0.92); C272(0.93)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C217(1.14); C257(1.36); C272(1.06)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C217(0.50); C257(0.45); C272(0.44)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C217(0.55); C257(1.06); C272(0.91)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C217(0.60); C257(0.87); C272(0.88)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C217(0.72); C257(1.14); C272(0.97)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C217(0.71); C257(1.17); C272(1.07)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C217(0.48); C257(0.81); C272(0.80)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C217(0.87); C257(0.81); C272(0.92)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C217(0.73); C257(1.19); C272(1.14)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C217(0.72); C257(0.83); C272(0.92)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C217(0.53); C257(0.33); C272(0.82)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C217(0.29); C257(0.21); C272(0.39)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C217(1.04); C257(0.99); C272(1.08)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C217(0.83); C257(0.71); C272(0.97)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C217(0.26); C257(0.13); C272(0.78)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C217(0.43); C257(0.24); C272(0.93)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C217(0.14); C257(0.08); C272(0.65)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C217(0.88); C257(0.68); C272(0.79)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C217(1.19); C257(1.83); C272(1.67)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C217(1.01); C257(0.72); C272(1.03)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C217(0.42); C257(0.26); C272(0.71)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C217(0.09); C257(0.06); C272(0.54)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C217(0.75); C257(0.55); C272(0.57)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C217(0.85); C257(0.79); C272(1.14)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C217(0.72); C257(0.59); C272(0.82)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C217(0.66); C257(0.74); C272(0.92)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C217(0.71); C257(0.75); C272(0.87)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C217(0.55); C257(0.64); C272(0.94)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C217(0.56); C257(0.62); C272(0.87)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C217(0.61); C257(0.71); C272(1.09)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C217(0.68); C257(0.69); C272(0.98)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C217(0.56); C257(0.62); C272(0.99)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C217(0.62); C257(0.65); C272(0.96)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C17(0.76)  LDD2228  [26]
 LDCM0175  Ethacrynic acid HeLa C257(0.91); C217(0.81)  LDD2210  [12]
 LDCM0625  F8 Ramos C17(0.46); C257(0.76); C285(1.22); C217(0.32)  LDD2187  [44]
 LDCM0572  Fragment10 Ramos C17(0.99); C285(0.59); C217(2.79); 1.42  LDD2189  [44]
 LDCM0573  Fragment11 Ramos C17(0.16); C257(0.38); C285(0.00); C217(0.06)  LDD2190  [44]
 LDCM0574  Fragment12 Ramos C17(1.60); C257(1.03); C285(0.77); C217(0.39)  LDD2191  [44]
 LDCM0575  Fragment13 Ramos C17(1.15); C257(0.96); C285(0.82); C217(0.72)  LDD2192  [44]
 LDCM0576  Fragment14 Ramos C17(0.86); C257(1.58); C285(0.76); C217(0.90)  LDD2193  [44]
 LDCM0579  Fragment20 Ramos C17(1.67); C257(0.84); C285(0.81); C217(1.66)  LDD2194  [44]
 LDCM0580  Fragment21 Ramos C17(1.15); C257(0.79); C285(2.82); C217(1.62)  LDD2195  [44]
 LDCM0582  Fragment23 Ramos C17(1.12); C257(1.23); C285(1.02); C217(2.12)  LDD2196  [44]
 LDCM0578  Fragment27 Ramos C17(0.77); C257(18.51); C285(0.87); C217(0.83)  LDD2197  [44]
 LDCM0586  Fragment28 Ramos C17(0.78); C257(0.44); C285(0.22); C217(0.68)  LDD2198  [44]
 LDCM0588  Fragment30 Ramos C17(1.20); C257(0.64); C285(0.67); C217(0.73)  LDD2199  [44]
 LDCM0589  Fragment31 Ramos C17(1.20); C257(0.68); C285(1.86); C217(0.90)  LDD2200  [44]
 LDCM0590  Fragment32 Ramos C17(0.67); C257(2.76); C285(0.61); C217(2.97)  LDD2201  [44]
 LDCM0468  Fragment33 HCT 116 C217(0.57); C257(0.77); C272(1.17)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos C17(1.62); C257(6.56); C285(0.76); C217(0.54)  LDD2203  [44]
 LDCM0566  Fragment4 Ramos C17(0.80); C257(0.33); C285(0.88); C217(0.59)  LDD2184  [44]
 LDCM0427  Fragment51 HCT 116 C217(0.11)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C17(0.79); C257(2.71); C285(0.66); C217(0.87)  LDD2204  [44]
 LDCM0614  Fragment56 Ramos C17(0.78); C257(0.49); C285(0.73); C217(0.63)  LDD2205  [44]
 LDCM0569  Fragment7 Ramos C17(0.96); C257(0.21); C285(0.77); C217(0.62)  LDD2186  [44]
 LDCM0571  Fragment9 Ramos C17(0.77); C257(5.34); C285(0.78); C217(1.09)  LDD2188  [44]
 LDCM0116  HHS-0101 DM93 Y240(0.75); Y53(0.77); Y294(0.78); Y198(0.78)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y337(0.60); Y240(0.62); Y198(0.65); Y169(0.66)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y53(0.71); Y198(0.72); Y91(0.73); Y166(0.81)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y69(0.55); Y337(0.63); Y91(0.72); Y240(0.73)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y169(0.52); Y240(0.52); Y166(0.69); Y91(0.69)  LDD0268  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [34]
 LDCM0123  JWB131 DM93 Y166(1.01); Y169(0.85); Y188(1.45); Y198(0.94)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y166(0.44); Y169(1.32); Y188(0.46); Y198(0.85)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y166(0.93); Y169(0.86); Y188(0.79); Y198(0.97)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y166(2.40); Y169(3.23); Y188(6.16); Y198(2.58)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y166(2.30); Y169(1.76); Y188(2.64); Y198(1.87)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y166(0.67); Y169(1.79); Y188(1.05); Y198(0.89)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y166(0.38); Y169(0.63); Y188(0.55); Y198(0.67)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y166(0.77); Y169(0.94); Y188(0.70); Y198(0.84)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 C257(0.00); C217(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C257(2.20); C272(1.12); C217(1.29)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C257(4.50); C272(1.19); C217(1.89)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C257(2.90); C272(2.14); C217(1.88)  LDD0082  [16]
 LDCM0109  NEM HeLa N.A.  LDD0223  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C17(0.71)  LDD2207  [45]
 LDCM0131  RA190 MM1.R C257(1.17); C272(1.17)  LDD0304  [46]
 LDCM0021  THZ1 HeLa S3 C217(1.11); C285(0.99); C272(1.00); C257(1.01)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cystic fibrosis transmembrane conductance regulator (CFTR) ABCC family P13569
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Actin, cytoplasmic 2 (ACTG1) Actin family P63261
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Nitric oxide synthase 3 (NOS3) NOS family P29474
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Serine protease HTRA3 (HTRA3) Peptidase S1C family P83110
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Dual specificity protein phosphatase 19 (DUSP19) Protein-tyrosine phosphatase family Q8WTR2
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Amyloid-beta precursor protein (APP) APP family P05067
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-1 (CFL1) Actin-binding proteins ADF family P23528
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Destrin (DSTN) Actin-binding proteins ADF family P60981
Transgelin-2 (TAGLN2) Calponin family P37802
Adenylyl cyclase-associated protein 2 (CAP2) CAP family P40123
Profilin-1 (PFN1) Profilin family P07737
Translationally-controlled tumor protein (TPT1) TCTP family P13693
Emerin (EMD) . P50402
Myosin regulatory light chain 12B (MYL12B) . O14950
Neutrophil cytosol factor 1 (NCF1) . P14598
Protein FAN (NSMAF) . Q92636
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695
Quercetin Small molecular drug DB04216

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases. ACS Chem Biol. 2021 Aug 20;16(8):1401-1412. doi: 10.1021/acschembio.1c00192. Epub 2021 Jul 19.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
28 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
29 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
30 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
31 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
32 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
33 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
34 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
35 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
40 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
41 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
42 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
43 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
44 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
45 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
46 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.