General Information of Experiment

Probe Name Photoindomethacin  Probe Info 
Probe concentration 250 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
Experiment Method
SIM-PAL
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cells (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP12543  14 kDa phosphohistidine phosphatase (PHPT1) E39
 LDTP12543  14 kDa phosphohistidine phosphatase (PHPT1) K48
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) C158
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) K138
 LDTP04876  Actin, cytoplasmic 1 (ACTB) G251
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E253
 LDTP02198  Cathepsin D (CTSD) P319
 LDTP02198  Cathepsin D (CTSD) G323
 LDTP02198  Cathepsin D (CTSD) Y325
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) M333
 LDTP01127  Rho-associated protein kinase 2 (ROCK2) E464
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04391  T-complex protein 1 subunit delta (CCT4) V460
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP02164  Nucleophosmin (NPM1) E93
 LDTP02691  Plastin-2 (LCP1) F371
 LDTP10924  Prohibitin-2 (PHB2) S39

References

1 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094