Details of the Target

General Information of Target

Target ID LDTP12608
Target Name Phosphatidylinositol-3-phosphatase SAC1 (SACM1L)
Gene Name SACM1L
Gene ID 22908
Synonyms
KIAA0851; SAC1; Phosphatidylinositol-3-phosphatase SAC1; EC 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAPALKHWRTTLERVEKFVSPLYFTDCNLRGRLFGASCPVAVLSSFLTPERLPYQEAV
QRDFRPAQVGDSFGPTWWTCWFRVELTIPEAWVGQEVHLCWESDGEGLVWRDGEPVQGLT
KEGEKTSYVLTDRLGERDPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSRAELAV
FHRDVHMLLVDLELLLGIAKGLGKDNQRSFQALYTANQMVNVCDPAQPETFPVAQALASR
FFGQHGGESQHTIHATGHCHIDTAWLWPFKETVRKCARSWVTALQLMERNPEFIFACSQA
QQLEWVKSRYPGLYSRIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQE
FGKMCSEFWLPDTFGYSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHHTFFWEGLDGSRV
LVHFPPGDSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTMLDRLKRLS
NTDGLPRVQLSSPRQLFSALESDSEQLCTWVGELFLELHNGTYTTHAQIKKGNRECERIL
HDVELLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQMVAEEAMCHYEDIR
SHGNTLLSAAAAALCAGEPGPEGLLIVNTLPWKRIEVMALPKPGGAHSLALVTVPSMGYA
PVPPPTSLQPLLPQQPVFVVQETDGSVTLDNGIIRVKLDPTGRLTSLVLVASGREAIAEG
AVGNQFVLFDDVPLYWDAWDVMDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPN
SRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARVRSSQATYEIQFGHLQRPTHYN
TSWDWARFEVWAHRWMDLSEHGFGLALLNDCKYGASVRGSILSLSLLRAPKAPDATADTG
RHEFTYALMPHKGSFQDAGVIQAAYSLNFPLLALPAPSPAPATSWSAFSVSSPAVVLETV
KQAESSPQRRSLVLRLYEAHGSHVDCWLHLSLPVQEAILCDLLERPDPAGHLTLRDNRLK
LTFSPFQVLSLLLVLQPPPH
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3.
Uniprot ID
Q9NTJ5
Ensemble ID
ENST00000389061.10
HGNC ID
HGNC:17059

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.Q302H .
RL952 SNV: p.G562R DBIA    Probe Info 
U118MG SNV: p.A52T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.62  LDD0402  [1]
A-EBA
 Probe Info  		3.32  LDD0215  [2]
TH211
 Probe Info  		Y272(9.53)  LDD0257  [3]
TH216
 Probe Info  		Y272(20.00)  LDD0259  [3]
OPA-S-S-alkyne
 Probe Info  		K483(4.06)  LDD3494  [4]
Probe 1
 Probe Info  		Y449(11.40)  LDD3495  [5]
BTD
 Probe Info  		C445(0.75)  LDD2109  [6]
AHL-Pu-1
 Probe Info  		C445(2.10)  LDD0173  [7]
HPAP
 Probe Info  		3.26  LDD0064  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
DBIA
 Probe Info  		C389(3.56); C392(3.56)  LDD0080  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C445(0.00); C389(0.00); C392(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
WYneN
 Probe Info  		C445(0.00); C392(0.00); C389(0.00)  LDD0021  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		C445(0.00); C392(0.00); C389(0.00)  LDD0005  [14]
NHS
 Probe Info  		K483(0.00); K10(0.00)  LDD0010  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
Acrolein
 Probe Info  		C23(0.00); C392(0.00); C445(0.00); C389(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C445(0.00); C23(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C445(0.00); C23(0.00); C389(0.00); C392(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		11.90  LDD0443  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.11  LDD1740  [21]
C091
 Probe Info  		10.13  LDD1782  [21]
C092
 Probe Info  		16.45  LDD1783  [21]
C094
 Probe Info  		31.12  LDD1785  [21]
C134
 Probe Info  		20.97  LDD1816  [21]
C159
 Probe Info  		7.67  LDD1839  [21]
C218
 Probe Info  		11.96  LDD1892  [21]
C231
 Probe Info  		14.32  LDD1904  [21]
C235
 Probe Info  		19.03  LDD1908  [21]
C289
 Probe Info  		31.34  LDD1959  [21]
C349
 Probe Info  		9.71  LDD2010  [21]
C350
 Probe Info  		22.63  LDD2011  [21]
C362
 Probe Info  		25.46  LDD2023  [21]
C388
 Probe Info  		47.18  LDD2047  [21]
C390
 Probe Info  		20.68  LDD2049  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		12.58  LDD0477  [22]
FFF probe2
 Probe Info  		19.80  LDD0463  [22]
FFF probe3
 Probe Info  		10.35  LDD0464  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
Photoindomethacin
 Probe Info  		N.A.  LDD0154  [23]
OEA-DA
 Probe Info  		7.43  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C445(0.90)  LDD2117  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C445(2.10)  LDD0173  [7]
 LDCM0214  AC1 HCT 116 C389(1.05); C392(1.00); C445(0.95)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C389(1.13); C392(1.26); C445(0.84)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C389(1.04); C392(1.04); C445(0.80)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C389(0.92); C392(1.03); C445(0.87)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C389(1.02); C392(0.99); C445(0.73)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C389(0.93); C392(0.97); C445(0.75)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C389(1.04); C392(1.05); C445(0.79)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C389(0.91); C392(0.93); C445(0.76)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C389(1.05); C392(1.14); C445(0.92)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C389(0.91); C392(0.93); C445(0.76)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C389(0.99); C392(0.96); C445(0.90)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C389(1.03); C392(1.00); C445(0.98)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C389(1.03); C392(1.05); C445(0.77)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C389(1.02); C392(0.98); C445(0.82)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C389(0.94); C392(1.01); C445(0.84)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C389(0.94); C392(0.96); C445(0.63)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C389(0.79); C392(0.92); C445(1.06)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C389(1.00); C392(0.95); C445(0.76)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C389(0.84); C392(0.95); C445(0.66)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C389(0.93); C392(1.04); C445(0.70)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C389(0.96); C392(1.00); C445(0.82)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C389(1.03); C392(1.09); C445(0.94)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C389(1.02); C392(1.03); C445(0.86)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C389(1.13); C392(1.34); C445(1.02)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C389(0.99); C392(1.09); C445(0.74)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C389(1.41); C392(1.19); C445(1.09)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C389(1.06); C392(1.13); C445(0.87)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C389(1.06); C392(0.96); C445(1.02)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C389(1.14); C392(1.07); C445(0.98)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C389(1.03); C392(1.08); C445(0.89)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C389(1.24); C392(1.19); C445(0.76)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C389(1.24); C392(1.22); C445(0.78)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C389(1.00); C392(1.09); C445(1.11)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C389(1.14); C392(1.21); C445(1.06)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C389(0.99); C392(1.09); C445(0.98)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C389(1.18); C392(1.21); C445(0.96)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C389(1.16); C392(1.18); C445(0.91)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C389(1.04); C392(1.16); C445(0.92)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C389(0.92); C392(1.10); C445(0.86)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C389(0.98); C392(1.11); C445(0.90)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C389(1.04); C392(1.11); C445(0.80)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C389(1.03); C392(1.09); C445(0.79)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C389(1.01); C392(1.07); C445(0.71)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C389(1.10); C392(1.19); C445(0.76)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C389(0.99); C392(1.01); C445(0.80)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C389(1.09); C392(1.15); C445(0.73)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C389(1.03); C392(1.14); C445(0.69)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C389(1.24); C392(1.26); C445(0.76)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C389(0.81); C445(0.85); C392(0.96)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C445(0.54); C389(0.78); C392(0.94)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C445(0.70); C389(0.87); C392(0.93)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C445(0.60); C389(0.83); C392(0.94)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C445(0.56); C389(0.71); C392(1.03)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C445(0.43); C389(0.89); C392(1.07)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C445(0.55); C389(0.92); C392(0.98)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C445(0.79); C392(1.09); C389(1.10)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C445(0.74); C389(0.89); C392(1.09)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C445(0.68); C389(0.79); C392(1.16)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C445(0.51); C389(0.69); C392(0.82)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C445(0.53); C389(0.89); C392(1.08)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C389(0.80); C392(0.92); C445(0.71)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C389(0.83); C392(0.92); C445(0.55)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C389(0.97); C392(1.27); C445(0.73)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C389(1.04); C392(1.21); C445(0.80)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C392(0.96); C445(1.03); C389(1.05)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C445(0.81); C389(0.90); C392(0.91)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C445(0.93); C389(0.94); C392(0.99)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C445(0.92); C392(1.04); C389(1.09)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C392(0.91); C389(0.97); C445(1.03)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C389(0.87); C445(0.95); C392(0.97)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C389(1.07); C445(1.09); C392(1.16)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C392(0.86); C389(0.93); C445(1.02)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C392(1.08); C389(1.10); C445(1.11)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C392(0.93); C445(0.99); C389(1.13)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C445(0.81); C392(0.99); C389(0.99)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C445(0.82); C392(0.82); C389(0.90)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C392(0.78); C445(0.84); C389(0.88)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C445(0.77); C392(0.81); C389(0.87)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C445(0.99); C392(1.07); C389(1.10)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C445(0.74); C392(0.84); C389(0.86)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C445(0.83); C392(0.94); C389(0.97)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C445(0.62); C389(0.96); C392(0.97)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C445(0.71); C392(0.90); C389(1.00)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C445(0.64); C392(0.89); C389(0.97)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C392(0.93); C389(0.94); C445(1.19)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C392(1.02); C389(1.05); C445(1.33)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C392(1.14); C389(1.17); C445(1.25)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C392(1.07); C389(1.08); C445(1.25)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C392(1.05); C389(1.06); C445(1.08)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C445(0.97); C392(1.05); C389(1.09)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C445(0.96); C389(0.97); C392(0.98)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C389(1.07); C392(1.09); C445(1.18)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C445(0.98); C389(0.99); C392(1.01)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C392(0.99); C389(1.01); C445(1.06)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C392(0.97); C389(0.98); C445(1.11)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C445(0.88); C392(0.99); C389(1.01)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C392(0.89); C389(0.96); C445(0.97)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C389(0.98); C445(1.03); C392(1.05)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C389(0.98); C445(0.99); C392(1.01)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C445(0.70); C389(0.79); C392(0.92)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C445(0.95); C392(1.05); C389(1.11)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C392(0.80); C445(0.80); C389(0.84)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C392(0.86); C389(0.99); C445(1.34)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C389(0.91); C392(0.93); C445(1.02)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C445(0.78); C392(0.83); C389(0.88)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C389(0.83); C445(0.85); C392(0.87)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C445(0.80); C392(0.84); C389(0.91)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C445(0.72); C389(0.92); C392(1.00)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C445(0.82); C389(0.92); C392(1.11)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C445(0.69); C389(0.85); C392(0.98)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C445(0.73); C389(0.80); C392(1.05)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C445(0.69); C392(1.02); C389(1.07)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C445(0.79); C389(0.83); C392(1.08)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C445(0.71); C389(0.80); C392(1.11)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C389(0.77); C445(0.85); C392(0.94)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C389(0.87); C445(0.90); C392(1.00)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C445(0.86); C389(0.88); C392(1.02)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C445(0.73); C389(0.96); C392(1.17)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C445(0.75); C389(0.80); C392(1.07)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C445(0.62); C389(0.79); C392(1.07)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C445(0.82); C392(0.89); C389(0.94)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C445(0.74); C392(0.87); C389(1.00)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C445(0.87); C389(1.10); C392(1.16)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C445(0.63); C389(0.86); C392(0.88)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C445(0.93); C389(1.11); C392(1.13)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C445(0.76); C389(1.00); C392(1.04)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C445(0.62); C389(0.97); C392(1.00)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C445(0.68); C389(1.10); C392(1.18)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C445(0.63); C389(0.95); C392(1.11)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C445(0.78); C392(0.89); C389(0.98)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C445(0.66); C389(0.84); C392(0.85)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C445(0.84); C389(0.92); C392(0.98)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C445(0.83); C389(0.96); C392(1.03)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C445(0.79); C392(1.02); C389(1.06)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C445(0.78); C392(0.88); C389(1.01)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C392(1.06); C389(1.07); C445(1.09)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C445(0.71); C389(0.95); C392(1.06)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C445(0.75); C392(0.86); C389(0.96)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C445(0.77); C392(0.83); C389(0.99)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C445(0.81); C392(0.93); C389(1.09)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C445(0.89); C389(0.97); C392(1.00)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C392(1.02); C445(1.07); C389(1.19)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C392(0.82); C445(0.98); C389(1.12)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C445(0.76); C392(0.81); C389(1.06)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C389(1.07); C392(1.31); C445(1.40)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C445(0.74); C392(0.81); C389(1.00)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C445(0.76); C392(0.81); C389(0.92)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C392(0.78); C389(0.85); C445(0.95)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C392(0.83); C389(1.00); C445(1.02)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C389(0.92); C392(0.95); C445(0.99)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C392(0.86); C445(0.92); C389(0.97)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C445(0.74); C392(0.80); C389(0.89)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C445(0.56); C389(0.93); C392(0.99)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C445(0.94); C389(1.01); C392(1.03)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C389(1.20); C392(1.14); C445(1.00)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C445(0.90); C389(0.99); C392(1.00)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C445(0.60); C389(1.15); C392(1.23)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C23(0.00); C445(0.00); H467(0.00); C392(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C392(0.93); C389(0.97); C445(1.28)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C445(0.70); C392(0.95); C389(1.08)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C445(0.86); C392(1.00); C389(1.00)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C445(0.68); C392(0.93); C389(0.97)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C392(0.93); C389(0.94); C445(0.98)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C445(1.00); C392(1.15); C389(1.16)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C445(0.91); C392(0.94); C389(0.94)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C392(0.90); C445(0.91); C389(0.92)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C445(0.78); C392(0.79); C389(0.90)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C445(0.79); C389(0.92); C392(1.01)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C445(0.76); C392(0.93); C389(0.95)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C392(0.79); C389(0.81); C445(0.83)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C445(0.71); C392(0.88); C389(1.01)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C445(0.72); C392(0.89); C389(1.01)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C389(0.83); C392(0.87); C445(0.88)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C392(0.91); C389(0.98); C445(1.11)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C445(0.67); C392(0.92); C389(1.01)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C392(0.82); C445(0.82); C389(0.87)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C445(0.80); C392(0.91); C389(0.92)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C445(0.81); C389(0.97); C392(0.97)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C445(0.85); C392(1.04); C389(1.05)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C445(1.01); C389(1.02); C392(1.04)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C392(0.90); C389(0.92); C445(1.00)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C445(0.71); C392(0.94); C389(0.95)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C389(1.08); C392(1.09); C445(1.13)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C392(0.52); C445(0.68); C389(0.81)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C389(0.85); C445(0.94); C392(0.98)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C445(0.77); C389(0.96); C392(1.02)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C445(0.75); C389(0.86); C392(1.00)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C445(1.11); C389(1.29); C392(1.43)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C389(0.81); C445(0.87); C392(0.94)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C445(0.95); C389(1.10); C392(1.19)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C445(0.71); C389(0.79); C392(0.96)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C445(0.79); C389(0.99); C392(1.02)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C392(0.92); C389(0.94); C445(0.96)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C445(0.80); C389(0.90); C392(0.90)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C392(0.73); C445(0.85); C389(0.93)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C445(0.78); C392(0.84); C389(0.97)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C445(0.68); C392(0.84); C389(1.00)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C445(0.66); C392(0.83); C389(0.97)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C392(0.92); C389(1.00); C445(1.23)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C445(0.55); C392(0.70); C389(0.88)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C445(0.55); C392(0.75); C389(0.96)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C445(0.57); C392(0.82); C389(1.03)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C445(0.65); C392(0.82); C389(0.87)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C389(0.93); C392(0.70); C445(0.59)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C389(0.83); C392(0.70); C445(0.63)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C389(0.92); C392(0.71); C445(0.70)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C389(0.93); C392(0.74); C445(0.72)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C389(0.88); C392(0.69); C445(0.55)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C389(0.98); C392(0.79); C445(0.59)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C389(1.03); C392(0.95); C445(1.09)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C389(0.92); C392(0.83); C445(0.74)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C389(0.87); C392(0.79); C445(0.94)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C389(0.73); C392(0.71); C445(0.77)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C389(0.72); C392(0.74); C445(0.86)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C389(0.74); C392(0.71); C445(0.78)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C389(0.71); C392(0.73); C445(0.78)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C389(0.72); C392(0.73); C445(0.97)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C389(0.79); C392(0.80); C445(0.85)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C389(0.77); C392(0.77); C445(0.81)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C389(0.98); C392(0.83); C445(1.00)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C389(0.71); C392(0.72); C445(0.78)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C389(0.76); C392(0.78); C445(0.86)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C389(0.72); C392(0.77); C445(0.80)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C389(0.78); C392(0.77); C445(0.80)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C389(0.76); C392(0.78); C445(0.79)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C389(0.78); C392(0.75); C445(0.77)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C389(1.26); C392(1.21); C445(0.90)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C389(1.28); C392(1.17); C445(0.82)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C389(1.21); C392(1.12); C445(0.86)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C389(1.04); C392(0.96); C445(0.95)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C389(1.06); C392(0.95); C445(1.01)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C389(1.13); C392(1.08); C445(0.92)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C389(1.25); C392(1.32); C445(1.01)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C389(1.29); C392(1.26); C445(0.86)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C389(1.11); C392(1.18); C445(0.84)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C389(1.22); C392(1.06); C445(0.79)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C389(1.23); C392(1.07); C445(1.02)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C389(1.06); C392(0.94); C445(0.90)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C389(1.19); C392(1.05); C445(0.91)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C389(1.18); C392(1.11); C445(0.81)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C389(1.22); C392(1.15); C445(1.04)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C389(0.96); C392(0.86); C445(0.83)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C389(1.04); C392(1.01); C445(0.82)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C389(1.06); C392(1.07); C445(0.92)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C389(1.00); C392(1.01); C445(0.87)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C389(0.79); C392(0.92); C445(0.79)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C389(0.84); C392(0.95); C445(0.65)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C389(1.10); C392(1.18); C445(0.81)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C389(1.05); C392(1.07); C445(0.60)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C389(0.97); C392(0.95); C445(0.66)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C389(1.04); C392(1.03); C445(0.66)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C389(0.84); C392(0.86); C445(0.66)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C389(1.06); C392(1.01); C445(0.83)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C389(0.87); C392(0.87); C445(0.68)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C389(0.92); C392(0.92); C445(0.73)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C389(1.08); C392(1.04); C445(0.93)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C389(0.98); C392(1.01); C445(0.67)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C389(1.01); C392(1.00); C445(0.67)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C389(0.88); C392(0.89); C445(0.71)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C389(0.89); C392(0.90); C445(0.93)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C389(0.91); C392(0.91); C445(0.78)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C389(0.84); C392(0.84); C445(0.65)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C389(0.95); C392(0.90); C445(0.69)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C389(0.83); C392(0.89); C445(0.73)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C389(0.83); C392(0.87); C445(0.74)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C389(0.94); C392(0.89); C445(0.62)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C389(0.86); C392(0.84); C445(0.83)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C389(0.81); C392(0.79); C445(0.53)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C389(0.80); C392(0.79); C445(0.67)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C389(0.83); C392(0.83); C445(0.86)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C389(0.93); C392(0.91); C445(0.77)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C389(0.89); C392(0.92); C445(0.72)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C389(0.91); C392(0.91); C445(0.57)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C389(0.95); C392(0.89); C445(0.88)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C389(0.98); C392(0.96); C445(0.97)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C389(1.04); C392(0.98); C445(0.93)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C389(1.03); C392(1.01); C445(0.87)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C389(1.13); C392(1.07); C445(1.02)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C389(0.97); C392(0.90); C445(0.78)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C389(0.95); C392(0.95); C445(0.79)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C389(0.94); C392(0.97); C445(0.84)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C389(0.96); C392(0.97); C445(0.80)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C389(1.00); C392(0.98); C445(0.78)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C389(1.02); C392(1.04); C445(0.90)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C445(1.10); C199(1.16); C23(1.05); C392(1.03)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C445(1.49)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C445(1.48); 1.61; C344(3.06)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C445(1.29)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C445(0.31); 2.93  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C445(1.31)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C445(0.89); 1.26; C344(1.54)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C445(1.38); 2.77; C344(1.81)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C445(3.93); C344(0.04)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C445(0.94); 1.65; C344(0.86)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C445(0.74); 1.13  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C445(0.93); 0.94  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C445(0.59); 1.70; C344(1.22)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C445(1.03); 1.71; C344(1.49)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C445(0.92); 1.31  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C445(1.31)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C389(1.20); C392(1.20); C445(0.74)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C445(1.10); 1.30  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C445(1.56)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C389(0.79); C392(0.69); C445(0.70)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C445(1.35); 1.57; C344(2.84)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C445(1.16); 1.04; C344(0.35)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C445(1.42); 4.84; C344(0.09)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C445(2.95)  LDD2188  [26]
 LDCM0107  IAA HeLa C23(0.00); H467(0.00); C392(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C389(3.56); C392(3.56)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C389(4.34); C392(4.34)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C389(2.11); C392(2.11)  LDD0082  [10]
 LDCM0109  NEM HeLa H341(0.00); H467(0.00)  LDD0224  [18]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C445(0.75)  LDD2109  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C445(1.00)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C445(0.57)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C445(0.98)  LDD2127  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C445(1.10)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C445(0.96)  LDD2137  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C389(1.00); C389(0.25); C392(0.25)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C344(0.76); C445(0.65); C389(0.27); C392(0.27)  LDD2207  [27]
 LDCM0014  Panhematin hPBMC 3.26  LDD0064  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Flavin-containing monooxygenase 3 (FMO3) FMO family P31513
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Dehydrogenase/reductase SDR family member 7 (DHRS7) Short-chain dehydrogenases/reductases (SDR) family Q9Y394
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
UDP-sugar transporter protein SLC35A5 (SLC35A5) Nucleotide-sugar transporter family Q9BS91
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Protrudin (ZFYVE27) . Q5T4F4
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atypical chemokine receptor 2 (ACKR2) G-protein coupled receptor 1 family O00590
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coatomer subunit gamma-1 (COPG1) COPG family Q9Y678
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Protein kish-B (TMEM167B) KISH family Q9NRX6
Transcription termination factor 2, mitochondrial (MTERF2) MTERF family Q49AM1
Outer dense fiber protein 4 (ODF4) . Q2M2E3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.