Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Photocelecoxib  Probe Info 
Probe concentration 250 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
Experiment Method
SIM-PAL
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04876  Actin, cytoplasmic 1 (ACTB) V96
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E99
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E100
 LDTP04876  Actin, cytoplasmic 1 (ACTB) V163
 LDTP04876  Actin, cytoplasmic 1 (ACTB) Y166
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E167
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E316
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E364
 LDTP01803  Adenosine deaminase (ADA) D296
 LDTP01803  Adenosine deaminase (ADA) L298
 LDTP01803  Adenosine deaminase (ADA) F300
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) I389
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) E391
 LDTP02198  Cathepsin D (CTSD) I321
 LDTP02198  Cathepsin D (CTSD) G323
 LDTP05947  Cullin-2 (CUL2) V384
 LDTP02567  DNA topoisomerase 1 (TOP1) E702
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) E268
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) V289
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) V405
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) E413
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) F415
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) L174
 LDTP09396  Minor histocompatibility antigen H13 (HM13) E68
 LDTP08050  Myosin-14 (MYH14) E1139
 LDTP03764  Myosin-9 (MYH9) N1284
 LDTP03764  Myosin-9 (MYH9) L1819
 LDTP03764  Myosin-9 (MYH9) E1820
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) N1054
 LDTP01704  Phosphatidylserine lipase ABHD16A (ABHD16A) T195
 LDTP01704  Phosphatidylserine lipase ABHD16A (ABHD16A) R199
 LDTP05052  S-phase kinase-associated protein 1 (SKP1) G129
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) F53
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) V68
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) D69
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) P72
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) E279
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) K280
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) P364
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) N489
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05084  Hemoglobin subunit alpha (HBA1; HBA2) A22
 LDTP05084  Hemoglobin subunit alpha (HBA1; HBA2) E24
 LDTP05084  Hemoglobin subunit alpha (HBA1; HBA2) A29
 LDTP05084  Hemoglobin subunit alpha (HBA1; HBA2) E31
 LDTP05084  Hemoglobin subunit alpha (HBA1; HBA2) R32
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) H94
 LDTP05236  Phosphatidylinositol transfer protein alpha isoform (PITPNA) E33
 LDTP05236  Phosphatidylinositol transfer protein alpha isoform (PITPNA) G36
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) N32
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) E33
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) T72
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) E294
 LDTP05235  Transcription factor A, mitochondrial (TFAM) E130
Other
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05655  A-kinase anchor protein 13 (AKAP13) R1254
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) F242
 LDTP14951  Beta-actin-like protein 2 (ACTBL2) E108
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) L56
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) Y58
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) E62
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) I63
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) L64
 LDTP08450  Histone H2A type 2-B (H2AC21) A54
 LDTP08450  Histone H2A type 2-B (H2AC21) V55
 LDTP08450  Histone H2A type 2-B (H2AC21) L56
 LDTP08450  Histone H2A type 2-B (H2AC21) E57
 LDTP08450  Histone H2A type 2-B (H2AC21) Y58
 LDTP08450  Histone H2A type 2-B (H2AC21) L59
 LDTP08450  Histone H2A type 2-B (H2AC21) T60
 LDTP08450  Histone H2A type 2-B (H2AC21) E62
 LDTP08450  Histone H2A type 2-B (H2AC21) L64
 LDTP02390  Histone H2A.Z (H2AZ1) E65
 LDTP01054  Histone H2B type 1-K (H2BC12) H50
 LDTP01054  Histone H2B type 1-K (H2BC12) S65
 LDTP01054  Histone H2B type 1-K (H2BC12) V67
 LDTP01054  Histone H2B type 1-K (H2BC12) D69
 LDTP01054  Histone H2B type 1-K (H2BC12) G76
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) Y42
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) S58
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Y52
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E54
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E64
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) D69
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) A70
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) T72
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Y73
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E75
 LDTP02164  Nucleophosmin (NPM1) G90
 LDTP02164  Nucleophosmin (NPM1) E93
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) E103
 LDTP02218  Profilin-1 (PFN1) A46
 LDTP02218  Profilin-1 (PFN1) E47
 LDTP09086  Protein FAM98A (FAM98A) L112
 LDTP04510  Rho GDP-dissociation inhibitor 1 (ARHGDIA) V162
 LDTP04510  Rho GDP-dissociation inhibitor 1 (ARHGDIA) E163
 LDTP04511  Rho GDP-dissociation inhibitor 2 (ARHGDIB) E160
 LDTP04511  Rho GDP-dissociation inhibitor 2 (ARHGDIB) A162
 LDTP02205  Tubulin beta chain (TUBB) E69
 LDTP02205  Tubulin beta chain (TUBB) E288
 LDTP02037  Tubulin beta-4A chain (TUBB4A) E123
 LDTP02037  Tubulin beta-4A chain (TUBB4A) S138

References

1 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094