Details of the Target

General Information of Target

Target ID LDTP05655
Target Name A-kinase anchor protein 13 (AKAP13)
Gene Name AKAP13
Gene ID 11214
Synonyms
BRX; HT31; LBC; A-kinase anchor protein 13; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL
MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN
RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG
EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG
LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK
LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI
SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL
EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT
QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP
GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA
VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME
LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG
SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK
QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD
SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN
RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP
FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSL
EVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSA
ISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWK
SGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVV
GPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPT
VIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMS
NTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRII
DSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFP
CLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKF
CGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRI
LQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQ
MFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV
ISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDED
EGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPT
HSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVS
LPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQ
VVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ
RQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREEL
QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSF
FPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQ
SQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3. Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy. Has no guanine nucleotide exchange activity on CDC42, Ras or Rac. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes. Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol. Required for normal adaptive cardiac hypertrophy in response to pressure overload. Plays a role in osteogenesis.
Uniprot ID
Q12802
Ensemble ID
ENST00000361243.6
HGNC ID
HGNC:371
ChEMBL ID
CHEMBL4523643

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.A2585S DBIA    Probe Info 
HCT15 SNV: p.P2419H DBIA    Probe Info 
HEC1 SNV: p.R1995W DBIA    Probe Info 
HUH1 SNV: p.L2283S DBIA    Probe Info 
HUH7 SNV: p.E1261D DBIA    Probe Info 
IGROV1 Deletion: p.I2372SfsTer10 DBIA    Probe Info 
JHH7 SNV: p.Q2171R .
JURKAT SNV: p.E1519G; p.R2359Ter .
L428 SNV: p.S944Ter DBIA    Probe Info 
LN18 SNV: p.Q397P DBIA    Probe Info 
LNCaP clone FGC SNV: p.Q283R DBIA    Probe Info 
LOXIMVI SNV: p.D1452G DBIA    Probe Info 
LS180 SNV: p.A663T DBIA    Probe Info 
MFE319 SNV: p.D905E DBIA    Probe Info 
NALM6 SNV: p.E691K; p.R2200C DBIA    Probe Info 
NCIH1703 SNV: p.Q93Ter DBIA    Probe Info 
NCIH446 SNV: p.S1453C DBIA    Probe Info 
OVK18 SNV: p.E502K DBIA    Probe Info 
RKO Deletion: p.K2504RfsTer50 DBIA    Probe Info 
SKHEP1 SNV: p.L255S DBIA    Probe Info 
SSP25 SNV: p.M1538I DBIA    Probe Info 
TE11 SNV: p.P1150T DBIA    Probe Info 
TOV21G SNV: p.E2638D DBIA    Probe Info 
U2OS SNV: p.K2741Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		3.16  LDD0066  [2]
STPyne
 Probe Info  		K135(10.00)  LDD0277  [3]
BTD
 Probe Info  		C972(0.84)  LDD2099  [4]
DA-P3
 Probe Info  		28.60  LDD0179  [5]
AHL-Pu-1
 Probe Info  		C662(8.27); C536(10.91); C1169(2.83)  LDD0168  [6]
DBIA
 Probe Info  		C732(5.50)  LDD0209  [7]
HHS-475
 Probe Info  		Y235(1.01)  LDD0264  [8]
HHS-465
 Probe Info  		Y235(3.58)  LDD2237  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K2191(0.00); K2197(0.00); K2741(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		C44(0.00); C732(0.00); C2142(0.00); C418(0.00)  LDD0162  [13]
NAIA_4
 Probe Info  		C272(0.00); C536(0.00); C683(0.00); C732(0.00)  LDD2226  [14]
WYneN
 Probe Info  		C2142(0.00); C2163(0.00); C418(0.00); C732(0.00)  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
TFBX
 Probe Info  		C732(0.00); C1232(0.00); C2101(0.00); C44(0.00)  LDD0148  [16]
VSF
 Probe Info  		C683(0.00); C1232(0.00)  LDD0007  [15]
YN-1
 Probe Info  		N.A.  LDD0447  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
AOyne
 Probe Info  		14.00  LDD0443  [20]
NAIA_5
 Probe Info  		C2101(0.00); C418(0.00); C14(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C662(8.27); C536(10.91); C1169(2.83)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C709(3.32); C662(10.71); C400(2.20)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C972(0.87); C934(1.03); C683(0.79); C2142(1.09)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C972(0.93); C934(0.94); C683(1.06); C2142(1.00)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C972(0.90); C934(0.98); C683(0.90); C2142(1.03)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C972(0.93); C934(1.02); C683(0.91); C2142(0.91)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C972(0.98); C934(1.03); C683(1.04); C2142(1.04)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C972(0.96); C934(1.04); C683(1.02); C1276(1.04)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C972(1.10); C934(1.10); C683(0.92); C2142(0.99)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C972(0.99); C934(1.06); C683(1.09); C2142(0.87)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C972(1.27); C934(1.42); C683(1.83); C2142(1.06)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C972(0.89); C934(0.93); C683(0.98); C2142(0.96)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C972(1.00); C934(1.07); C683(0.95); C2142(0.92)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C972(1.04); C934(1.01); C683(1.11); C2142(0.96)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C972(1.03); C934(1.11); C683(1.00); C2142(1.06)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C972(1.03); C934(1.06); C683(1.03); C1276(1.07)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C972(1.16); C934(1.04); C683(1.09); C2142(1.03)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C972(1.00); C934(1.06); C683(0.97); C2142(0.88)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C972(0.89); C934(0.99); C683(0.77); C2142(0.96)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C972(0.94); C934(0.99); C683(1.19); C2142(1.13)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C972(0.95); C934(1.05); C683(0.86); C2142(0.98)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C972(0.99); C934(1.05); C683(1.00); C2142(1.06)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C972(0.90); C934(0.96); C683(0.82); C2142(1.10)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C972(0.95); C934(1.00); C683(1.09); C2142(0.92)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C972(0.95); C934(1.07); C683(1.10); C1276(1.10)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C972(1.04); C934(1.04); C683(1.56); C2142(0.98)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C972(1.08); C934(1.27); C683(0.96); C2142(0.87)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C972(0.99); C934(1.03); C683(0.90); C2142(0.99)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C972(0.97); C934(1.10); C683(1.18); C2142(1.10)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C972(1.01); C934(1.15); C683(1.07); C2142(0.99)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C972(1.00); C934(0.90); C683(1.06); C2142(1.07)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C972(0.95); C934(1.08); C683(0.80); C2142(0.98)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C972(0.96); C934(1.12); C683(0.93); C1276(1.20)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C972(0.85); C934(0.93); C683(0.98); C2142(0.96)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C972(1.03); C934(1.01); C683(0.98); C2142(1.00)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C972(0.98); C934(1.16); C683(1.04); C2142(0.89)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C972(0.98); C934(1.01); C683(0.86); C2142(1.13)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C972(0.94); C934(1.13); C683(0.86); C2142(1.05)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C972(1.02); C934(1.11); C683(0.99); C2142(1.04)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C972(1.10); C934(0.97); C683(1.02); C2142(1.01)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C972(1.05); C934(1.06); C683(0.88); C2142(1.01)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C972(0.99); C934(1.02); C683(0.92); C1276(1.13)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C972(1.09); C934(1.11); C683(1.19); C2142(1.02)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C972(0.95); C934(1.04); C683(1.01); C2142(1.01)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C972(1.02); C934(0.92); C683(1.01); C2142(1.03)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C972(0.92); C934(0.96); C683(0.86); C2142(0.90)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C972(0.91); C934(1.02); C683(0.74); C2142(1.18)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C972(0.95); C934(1.09); C683(0.95); C2142(1.00)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C972(1.07); C934(1.03); C683(0.95); C2142(1.04)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C972(1.06); C934(1.14); C683(0.81); C2142(0.96)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C972(1.07); C934(1.04); C683(1.19); C1276(1.10)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C972(1.12); C934(1.08); C683(1.15); C2142(1.04)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C972(0.90); C934(1.06); C683(1.15); C2142(0.97)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C972(0.92); C934(0.96); C683(1.06); C2142(0.99)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C972(0.89); C934(1.02); C683(1.19); C2142(1.02)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C972(0.97); C934(0.99); C683(0.75); C2142(0.98)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C972(0.93); C934(1.01); C683(1.04); C2142(1.02)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C972(1.08); C934(0.99); C683(1.03); C2142(1.02)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C972(1.00); C934(1.12); C683(0.87); C2142(0.96)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C972(1.04); C934(1.05); C683(1.13); C1276(1.05)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C972(1.04); C934(0.98); C683(0.81); C2142(0.91)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C972(0.92); C934(0.95); C683(0.84); C1276(1.10)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C972(1.01); C934(0.97); C683(1.13); C2142(0.96)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C972(1.06); C934(1.02); C683(1.01); C2142(0.96)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C972(0.95); C934(1.04); C683(1.11); C2142(0.99)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C972(1.01); C934(0.97); C683(1.01); C2142(1.02)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 11.76  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C1232(0.00); C732(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C418(20.00); C1232(2.20); C2101(0.82); C2101(0.75)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C972(0.82); C934(0.87); C683(1.12); C1276(1.06)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C972(0.84); C934(0.84); C683(0.85); C2142(1.22)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C972(1.00); C934(0.98); C683(1.15); C2142(1.12)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C972(1.03); C934(1.05); C683(0.99); C1276(1.20)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C972(0.92); C934(0.93); C683(1.03); C1276(1.05)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C972(1.01); C934(1.10); C683(1.05); C2142(0.97)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C972(0.98); C934(0.95); C683(0.89); C2142(1.06)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C972(1.01); C934(1.09); C683(1.11); C1276(1.03)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C972(0.99); C934(1.03); C683(0.97); C1276(1.04)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C972(1.01); C934(1.11); C683(1.07); C2142(0.97)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C972(1.09); C934(1.09); C683(1.21); C2142(0.93)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C972(0.93); C934(1.03); C683(0.92); C1276(0.98)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C972(0.92); C934(0.89); C683(1.17); C1276(1.18)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C972(0.91); C934(0.94); C683(0.95); C1276(0.88)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C972(0.83); C934(1.05); C683(0.96); C2142(0.94)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C972(0.98); C934(1.04); C683(1.28); C2142(1.20)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C972(0.98); C934(1.15); C683(0.98); C1276(0.98)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C972(0.89); C934(0.94); C683(1.02); C1276(0.97)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C972(0.93); C934(1.11); C683(0.98); C2142(0.92)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C972(1.00); C934(1.13); C683(0.92); C2142(1.03)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C972(1.03); C934(1.13); C683(1.05); C1276(1.02)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C972(0.97); C934(1.04); C683(1.03); C1276(1.00)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C972(0.93); C934(1.03); C683(1.10); C2142(0.94)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C972(1.02); C934(0.94); C683(1.34); C2142(1.08)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C972(0.95); C934(1.04); C683(1.12); C2142(1.05)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C972(0.99); C934(1.06); C683(1.07); C1276(1.06)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C972(0.94); C934(1.00); C683(1.06); C1276(1.06)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C972(0.89); C934(1.01); C683(1.15); C2142(1.05)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C972(0.92); C934(1.03); C683(1.09); C2142(1.18)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C972(0.99); C934(1.01); C683(1.05); C1276(0.88)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C972(1.00); C934(1.07); C683(1.12); C1276(1.11)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C972(0.91); C934(1.06); C683(1.11); C2142(0.97)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C972(1.05); C934(1.04); C683(1.20); C2142(1.19)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C972(0.97); C934(1.02); C683(1.12); C1276(1.13)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C972(0.93); C934(0.95); C683(1.01); C1276(0.96)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C972(0.88); C934(0.97); C683(1.21); C2142(1.08)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C972(0.97); C934(0.99); C683(1.30); C2142(1.03)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C972(0.95); C934(0.96); C683(0.99); C2142(1.11)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C972(0.88); C934(0.98); C683(1.19); C2142(1.01)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C972(0.98); C934(1.00); C683(1.06); C2142(1.34)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C972(0.91); C934(0.93); C683(1.06); C1276(1.04)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C972(0.96); C934(1.04); C683(1.11); C2142(1.03)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C972(1.13); C934(0.99); C683(1.04); C2142(1.24)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C972(0.98); C934(0.98); C683(0.88); C2142(1.15)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C972(0.95); C934(1.00); C683(1.04); C1276(1.11)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C972(1.05); C934(1.04); C683(1.02); C2142(1.06)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C972(0.97); C934(1.06); C683(0.99); C1276(0.86)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C972(1.02); C934(1.07); C683(0.93); C1276(1.01)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C972(0.95); C934(1.07); C683(1.12); C2142(0.91)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C972(1.12); C934(0.97); C683(1.33); C2142(1.06)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C972(0.95); C934(1.01); C683(0.89); C2142(0.84)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C972(0.82); C934(0.90); C683(1.07); C2142(1.06)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C972(0.97); C934(0.94); C683(0.97); C2142(0.82)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C972(0.95); C934(1.01); C683(1.27); C2142(1.15)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C972(0.97); C934(1.05); C683(0.98); C2142(1.05)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C972(1.02); C934(0.89); C683(0.93); C2142(0.99)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C972(1.01); C934(1.06); C683(0.95); C2142(1.14)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C972(1.01); C934(1.09); C683(1.05); C1276(1.15)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C972(1.14); C934(1.07); C683(0.85); C2142(0.97)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C972(1.02); C934(1.08); C683(1.03); C1276(0.90)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C972(1.07); C934(1.02); C683(1.04); C2142(0.99)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C972(0.96); C934(0.89); C683(1.12); C2142(1.12)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C972(1.07); C934(1.04); C683(1.90); C2142(1.07)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C972(1.04); C934(1.01); C683(1.03); C2142(0.97)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C972(0.99); C934(0.94); C683(0.99); C2142(1.00)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C972(0.99); C934(0.95); C683(1.11); C2142(1.01)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C972(1.00); C934(1.08); C683(1.10); C2142(1.06)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C972(1.17); C934(0.98); C683(0.92); C2142(1.12)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C972(1.19); C934(1.09); C683(1.00); C2142(1.03)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C972(1.01); C934(1.08); C683(1.00); C1276(1.06)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C972(1.18); C934(1.16); C683(1.08); C2142(0.97)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C972(0.88); C934(0.97); C683(1.00); C1276(0.86)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C972(0.95); C934(0.95); C683(0.84); C2142(0.95)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C972(0.95); C934(0.99); C683(1.02); C1276(1.14)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C972(0.94); C934(0.98); C683(0.98); C2142(1.09)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C972(0.86); C934(1.00); C683(1.00); C2142(1.11)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C972(0.81); C934(0.83); C683(0.95); C2142(1.01)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C972(0.95); C934(1.06); C683(1.03); C2142(1.20)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C972(0.94); C934(1.06); C683(1.21); C2142(1.05)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C972(1.22); C934(0.96); C683(1.29); C2142(1.08)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C972(0.93); C934(1.04); C683(0.99); C2142(1.17)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C972(1.02); C934(1.00); C683(1.08); C1276(1.07)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C972(0.81); C934(0.88); C683(0.93); C2142(1.04)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C972(1.20); C934(1.07); C683(1.60); C2142(0.98)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C972(0.99); C934(1.09); C683(1.08); C1276(0.87)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C972(1.00); C934(1.04); C683(0.99); C1276(0.99)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C972(0.99); C934(1.13); C683(1.23); C2142(0.88)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C972(0.92); C934(1.03); C683(1.10); C2142(1.29)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C972(0.99); C934(1.15); C683(1.18); C2142(1.09)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C972(0.98); C934(1.03); C683(1.28); C2142(1.01)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C972(0.96); C934(0.98); C683(1.36); C2142(1.27)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C972(0.99); C934(1.06); C683(0.98); C2142(1.11)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C972(1.18); C934(0.98); C683(1.09); C2142(1.17)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C972(0.90); C934(1.00); C683(1.22); C2142(1.13)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C972(1.05); C934(1.10); C683(0.90); C2142(1.09)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C972(1.01); C934(1.03); C683(1.03); C1276(1.05)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C972(1.42); C934(1.19); C683(1.35); C2142(1.01)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C972(0.89); C934(0.91); C683(0.89); C1276(0.91)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C972(0.88); C934(0.94); C683(1.08); C1276(1.04)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C972(1.03); C934(0.98); C683(1.18); C2142(1.07)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C972(0.90); C934(0.82); C683(0.91); C2142(1.05)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C972(0.91); C934(0.93); C683(0.99); C2142(1.14)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C972(0.93); C934(0.92); C683(1.32); C2142(1.18)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C972(0.73); C934(0.76); C683(0.86); C2142(1.39)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C972(0.91); C934(1.00); C683(1.04); C2142(0.98)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C972(1.16); C934(1.04); C683(1.03); C2142(1.08)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C972(1.04); C934(1.00); C683(0.99); C2142(1.00)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C972(0.87); C934(0.91); C683(0.96); C1276(1.16)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C972(1.01); C934(0.97); C683(0.90); C2142(1.01)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C972(0.91); C934(1.01); C683(0.96); C1276(0.90)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C972(0.97); C934(1.05); C683(0.96); C1276(0.89)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C972(0.92); C934(1.12); C683(1.01); C2142(0.88)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C972(0.98); C934(1.09); C683(1.03); C2142(0.99)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C972(0.96); C934(1.08); C683(0.96); C2142(0.90)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C972(1.02); C934(0.85); C683(0.91); C2142(1.12)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C972(0.83); C934(0.80); C683(0.92); C2142(1.06)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C972(0.92); C934(1.00); C683(1.21); C2142(1.04)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C972(0.99); C934(1.07); C683(1.03); C2142(1.08)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C972(1.11); C934(0.95); C683(1.36); C2142(1.18)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C972(1.16); C934(1.11); C683(0.77); C2142(1.12)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C972(0.96); C934(0.99); C683(1.04); C1276(1.19)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C972(1.12); C934(1.00); C683(0.95); C2142(0.94)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C972(0.92); C934(1.03); C683(1.07); C1276(0.96)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C972(0.95); C934(0.97); C683(1.04); C1276(1.11)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C972(0.90); C934(1.06); C683(1.12); C2142(0.95)  LDD1697  [22]
 LDCM0634  CY-0357 Hep-G2 C2101(0.86)  LDD2228  [14]
 LDCM0028  Dobutamine HEK-293T 9.11  LDD0180  [5]
 LDCM0027  Dopamine HEK-293T 28.60  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C972(1.09); C934(1.20); C683(1.09); C2142(0.93)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C732(1.70)  LDD1702  [4]
 LDCM0625  F8 Ramos C732(0.74); C1232(1.28)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C732(2.08)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C732(20.00)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C732(1.45); C1232(1.23)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C732(1.15); C1232(1.07)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C732(1.28); C1232(0.90)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C732(1.22); C1232(1.80)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C732(1.08); C1232(0.82)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C732(1.40); C1232(1.17)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C732(1.03); C1232(0.95)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C732(0.83); C1232(0.70)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C732(1.53); C1232(1.51)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C732(1.15); C1232(1.25)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C732(6.17)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C972(0.82); C934(0.94); C683(1.07); C2142(0.92)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C732(1.19); C1232(1.07)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C732(1.61); C1232(1.18)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C972(1.04); C934(1.07); C683(1.07); C1276(0.92)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C732(1.37); C1232(1.20)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C732(1.19); C1232(1.29)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C732(1.59); C1232(1.00)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C732(1.49)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y235(1.01)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y235(1.06)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y235(1.34)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y235(1.30)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y235(1.06)  LDD0268  [8]
 LDCM0022  KB02 HEK-293T C709(1.15); C418(0.94); C2685(0.91); C972(0.99)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C732(5.50)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C2689(1.95); C418(1.42)  LDD3310  [24]
 LDCM0109  NEM HeLa N.A.  LDD0231  [19]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C972(0.84)  LDD2099  [4]
 LDCM0029  Quercetin HEK-293T 14.31  LDD0181  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) Transglutaminase family P21980
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840