Details of the Target

General Information of Target

Target ID LDTP05084
Target Name Hemoglobin subunit alpha (HBA1; HBA2)
Gene Name HBA1; HBA2
Gene ID 3039
Synonyms
; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain) [Cleaved into: Hemopressin]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Globin family
Function
Involved in oxygen transport from the lung to the various peripheral tissues.; [Hemopressin]: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
TTD ID
T49493
Uniprot ID
P69905
DrugMap ID
TTQO71U
Ensemble ID
ENST00000251595.11
HGNC ID
HGNC:4823
ChEMBL ID
CHEMBL2887

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.79  LDD0215  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K17(7.24); K41(4.74); K57(3.64)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K17(3.74)  LDD3494  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2234  [5]
2PCA
 Probe Info  		K17(0.00); R32(0.00); K41(0.00)  LDD0034  [6]
Acrolein
 Probe Info  		H51(0.00); H21(0.00)  LDD0217  [7]
TER-AC
 Probe Info  		N.A.  LDD0426  [8]
HHS-482
 Probe Info  		Y43(8.25)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		20.00  LDD0477  [10]
FFF probe4
 Probe Info  		20.00  LDD0466  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
Photocelecoxib
 Probe Info  		A22(0.00); E24(0.00); A29(0.00); E31(0.00)  LDD0019  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H51(0.00); H46(0.00)  LDD0222  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Nitric oxide synthase 3 (NOS3) NOS family P29474
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit beta (HBB) Globin family P68871
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-hemoglobin-stabilizing protein (AHSP) AHSP family Q9NZD4
Hemoglobin subunit delta (HBD) Globin family P02042
Hemoglobin subunit epsilon (HBE1) Globin family P02100
Hemoglobin subunit gamma-2 (HBG2) Globin family P69892
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 20 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iron Small molecular drug D0Y3TM
Iron Dextran Small molecular drug D08OKJ
Pentaerythritol Tetranitrate Small molecular drug DB06154
Copper . DB09130
Ferric Derisomaltose . DB15617
Ferric Pyrophosphate Citrate . DB13995
Ferrous Ascorbate . DB14490
Ferrous Fumarate . DB14491
Ferrous Gluconate . DB14488
Ferrous Glycine Sulfate . DB14501
Ferrous Succinate . DB14489
Ferrous Sulfate Anhydrous . DB13257
Nitrous Acid . DB09112
Oxygen . DB09140
Sodium Ferric Gluconate Complex . DB09517
Voxelotor . D09RII
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Efaproxyn Small molecular drug D03HVV
Hemoglobin Raffimer . D0H4CB
Polyheme . D00IWL
Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ctx110 Gene therapy D09VBN
5-hydroxymethyl-2-furfural Small molecular drug D0E9BF
Fbs-0701 Small molecular drug D0D8TE
Hqk-1001 Small molecular drug D0E6SB
Oxy-111a . D00YBW
Investigative
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,3,5-benzenetricarboxylic Acid Small molecular drug D0F2WQ
2,6-dicarboxynaphthalene Small molecular drug D06KMP
2-[(2-methoxy-5-methylphenoxy)Methyl]Pyridine Small molecular drug D0TM1Z
26-dicarboxynaphthalene Small molecular drug DB08262
4-[(5-methoxy-2-methylphenoxy)Methyl]Pyridine Small molecular drug D0A1GE
Efaproxiral Small molecular drug DB08486
Ferric Pyrophosphate Small molecular drug DB09147
Heme Small molecular drug D0UU1I
Sebacic Acid Small molecular drug D05QIT
Sebacic Acid Small molecular drug DB07645
Trimesic Acid Small molecular drug DB08632
2-[4-({[(35-dichlorophenyl)Amino]Carbonyl}Amino)Phenoxy]-2-methylpropanoic Acid . DB08077
4-carboxycinnamic Acid . D06EEJ
Discontinued
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
An-10 Small molecular drug D0Q5QE
Diaspirin Crosslinked Hemoglobin . D0ZL9B
Hemoximer . D0G6EO
Hrc-101 . D09ZFF
Hrc-102 . D00XQK
Hrc-201 . D09ZCH
Hrc-302 . D0S3WK
Rhb1.1 . D00HNK
Vx-366 . D0AL3O

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094