Details of the Target

General Information of Target

Target ID LDTP05235
Target Name Transcription factor A, mitochondrial (TFAM)
Gene Name TFAM
Gene ID 7019
Synonyms
TCF6; TCF6L2; Transcription factor A, mitochondrial; mtTFA; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRF
SKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQ
LTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQE
KLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRK
YGAEEC
Target Bioclass
Transcription factor
Subcellular location
Mitochondrion
Function
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Uniprot ID
Q00059
Ensemble ID
ENST00000373895.7
HGNC ID
HGNC:11741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.I133T DBIA    Probe Info 
HT115 SNV: p.F35C; p.R169I .
MEWO SNV: p.T23I; p.I98T .
SUDHL6 SNV: p.L149Ter; p.T150A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.60  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K118(6.74); K52(6.25); K95(5.88)  LDD0277  [3]
AZ-9
 Probe Info  		E130(10.00)  LDD2209  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
BTD
 Probe Info  		C49(1.03)  LDD1700  [5]
DBIA
 Probe Info  		C246(1.17)  LDD0078  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
Alkyne tyramide
 Probe Info  		Y200(0.00); Y103(0.00); Y162(0.00)  LDD0003  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		N.A.  LDD0147  [11]
NHS
 Probe Info  		K118(0.00); K174(0.00)  LDD0010  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1c-yne
 Probe Info  		K216(0.00); K118(0.00)  LDD0228  [14]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
Acrolein
 Probe Info  		C49(0.00); C246(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		H212(0.00); C49(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		14.50  LDD0443  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [18]
TPP-AC
 Probe Info  		N.A.  LDD0427  [18]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		13.74  LDD1713  [19]
C220
 Probe Info  		14.72  LDD1894  [19]
C355
 Probe Info  		22.32  LDD2016  [19]
C397
 Probe Info  		11.63  LDD2056  [19]
FFF probe13
 Probe Info  		10.86  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe3
 Probe Info  		5.13  LDD0464  [20]
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C49(0.70)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C49(2.45); C246(0.93)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C49(0.63)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C49(0.94)  LDD2152  [5]
 LDCM0214  AC1 HCT 116 C246(1.28)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C246(0.65)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C246(0.89)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C246(1.09)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C246(1.04)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C246(1.29)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C246(1.07)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C246(1.13)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C246(1.15)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C246(1.10)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C246(1.17)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C246(1.07)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C246(0.72)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C246(1.21)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C246(1.24)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C246(1.20)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C246(1.10)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C246(0.98)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C246(0.97)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C246(1.07)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C246(1.11)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C246(0.91)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C246(1.03)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C246(0.60)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C246(0.97)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C246(1.13)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C246(0.89)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C246(1.30)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C246(0.98)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C246(0.95)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C246(0.90)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C246(0.90)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C246(0.66)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C246(0.76)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C246(0.79)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C246(0.95)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C246(0.82)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C246(0.91)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C246(1.13)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C246(0.70)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C246(1.21)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C246(0.75)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C246(1.00)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C246(1.09)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C246(0.68)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C246(1.32)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C246(1.20)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C246(0.85)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C246(1.39)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C246(1.20)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C246(1.32)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C246(1.52)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C246(1.22)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C246(1.95)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C246(1.73)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C246(0.76)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C246(1.11)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C246(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C246(1.09)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C246(1.88)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C246(1.30)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C246(1.61)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C246(1.30)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C246(1.28)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C246(0.89)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C246(0.78)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C246(0.89)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C246(1.18)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C246(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C246(0.86)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C246(0.87)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C246(0.80)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C246(0.92)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C246(1.02)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C246(1.03)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C246(1.07)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C246(1.49)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C246(1.38)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C246(1.11)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C246(1.76)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C246(1.05)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C246(1.28)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C246(1.38)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C246(1.64)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C246(1.02)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C246(1.01)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C246(1.06)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C246(0.99)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C246(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C246(0.94)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C246(1.06)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C246(1.28)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C246(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C246(1.19)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C246(1.28)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C246(1.46)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C246(1.32)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C246(1.19)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C246(1.19)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C246(1.15)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C246(0.95)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C246(1.16)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C246(1.19)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C246(1.14)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C246(1.23)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C246(1.14)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C246(1.35)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C246(1.28)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C246(0.73)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C246(0.84)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C246(0.80)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C246(1.00)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C246(1.07)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C246(0.80)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C246(0.94)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C246(0.80)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C246(0.70)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C246(0.74)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C246(0.64)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C246(0.91)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C246(1.04)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C246(1.03)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C246(0.82)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C246(1.33)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C246(0.96)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C246(1.08)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C246(0.99)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C246(0.92)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C246(1.21)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C246(0.87)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C246(1.20)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C246(1.02)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C246(1.11)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C246(0.82)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C246(0.89)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C246(0.96)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C246(0.99)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C246(1.46)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C246(1.24)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C246(1.32)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C246(1.29)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C246(1.02)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C246(1.03)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C246(1.29)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C246(1.11)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C246(1.24)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C246(1.33)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C246(1.55)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C246(1.52)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C246(1.07)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C246(1.43)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C246(1.56)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C246(1.24)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C246(1.15)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C246(0.74)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C246(0.71)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C246(0.69)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.25  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C246(1.17)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C49(0.00); C246(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C246(1.06)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C246(1.00)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C246(0.79)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C246(0.71)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C246(0.61)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C246(0.67)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C246(0.70)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C246(1.04)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C246(0.67)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C246(0.85)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C246(0.87)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C246(0.99)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C246(0.90)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C246(0.83)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C246(0.81)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C246(0.94)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C246(1.27)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C246(1.66)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C246(1.36)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C246(1.32)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C246(1.14)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C246(0.94)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C246(0.90)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C246(1.02)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C246(1.06)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C246(1.09)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C246(1.17)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C246(1.34)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C246(1.02)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C246(1.02)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C246(1.00)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C246(1.56)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C246(0.80)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C246(0.87)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C246(0.87)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C246(0.73)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C246(1.49)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C246(1.05)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C246(0.99)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C246(0.87)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C246(1.05)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C246(0.99)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C246(0.83)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C246(1.42)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C246(1.10)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C246(1.25)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C246(0.86)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C246(1.07)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C246(0.90)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C246(1.02)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C246(1.11)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C246(0.90)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C246(1.03)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C246(0.79)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C246(0.82)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C246(0.94)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C246(1.03)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C246(1.08)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C246(0.98)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C246(0.97)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C246(0.79)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C246(0.89)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C246(0.72)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C246(0.98)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C246(0.81)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C246(0.82)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C246(0.78)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C246(0.79)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C246(1.14)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C246(1.20)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C246(1.25)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C246(0.78)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C246(0.90)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C246(0.92)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C246(0.74)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C246(1.05)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C246(1.16)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C246(0.88)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C246(0.89)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C246(1.01)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C246(0.91)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C246(0.89)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C246(0.86)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C246(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C246(0.85)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C22(1.02); C246(0.89); C25(0.87)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C22(1.20); C246(0.80); C25(1.15)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C22(1.11); C246(0.86); C25(0.93)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C22(1.82); C246(0.80); C25(2.60)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C22(1.19); C246(1.00); C25(1.09)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C22(1.34); C246(0.82); C25(1.42)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C22(1.06); C246(0.83); C25(0.95)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C22(1.21); C246(0.86); C25(1.36)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C22(1.85); C246(0.92); C25(2.60)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C246(0.96)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C22(1.20); C246(0.89); C25(1.17)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C22(1.30); C246(0.92); C25(1.44)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C22(1.08); C246(1.08); C25(1.09)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C22(1.80); C246(0.81); C25(2.42)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C22(1.05); C246(0.85); C25(1.02)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C22(1.05); C246(1.19)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C22(1.07); C246(1.01)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C22(0.80); C246(0.99)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C22(0.98); C246(1.11)  LDD1070  [6]
 LDCM0473  CL8 HCT 116 C246(1.09)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C22(0.86); C246(1.15)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C22(0.95); C246(1.15)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C22(1.28); C246(1.16)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C22(1.28); C246(1.30)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C22(0.97); C246(1.19)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C22(0.90); C246(1.08)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C22(0.75); C246(1.07)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C22(0.95); C246(1.15)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C22(1.10); C246(1.51)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C22(1.02); C246(1.26)  LDD1081  [6]
 LDCM0484  CL9 HCT 116 C246(1.09)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C22(1.16); C246(1.16)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C246(1.18)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C246(1.43)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C246(0.99)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C246(0.66)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C246(0.99)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C246(1.17)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C246(1.61)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C246(1.33)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C246(1.30)  LDD0811  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C49(0.96)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C22(1.55); C246(0.97); C25(1.95)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C246(1.22)  LDD0744  [6]
 LDCM0107  IAA HeLa C49(0.00); H212(0.00)  LDD0221  [15]
 LDCM0022  KB02 697 C246(0.91)  LDD2245  [22]
 LDCM0023  KB03 MDA-MB-231 C49(1.49)  LDD1701  [5]
 LDCM0024  KB05 HMCB C246(1.01)  LDD3312  [22]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C49(1.14); C246(0.87)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0227  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C49(1.91); C246(0.97)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C49(1.15); C246(1.01)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C49(1.70); C246(1.66)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C49(1.07)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C49(1.43); C246(0.56)  LDD2098  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C246(0.46)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C49(2.02)  LDD2101  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C49(0.87); C246(0.71)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C49(1.12)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C49(0.69); C246(0.53)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C49(0.53)  LDD2109  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C49(0.93)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C49(1.16)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C49(0.96)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C49(1.96)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C49(0.84)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C49(0.99)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C49(0.72)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C49(0.66)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C49(0.66)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C49(0.74)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C49(1.01)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C49(0.98)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C49(0.60)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C49(0.97)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C49(0.73)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C49(0.65)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C49(1.03)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C49(0.57)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C246(0.47)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C49(1.02)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C49(2.28)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C49(0.76)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C49(2.80)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C49(0.52)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C49(0.90)  LDD2149  [5]
 LDCM0021  THZ1 HCT 116 C246(1.15)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dimethyladenosine transferase 1, mitochondrial (TFB1M) rRNA adenine N(6)-methyltransferase family Q8WVM0
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Statherin (STATH) Histatin/statherin family P02808
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Tetraspanin-1 (TSPAN1) Tetraspanin (TM4SF) family O60635
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840