Details of the Target

General Information of Target

Target ID LDTP05947
Target Name Cullin-2 (CUL2)
Gene Name CUL2
Gene ID 8453
Synonyms
Cullin-2; CUL-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
CIEVLIDKQYIERSQASADEYSYVA
Target Bioclass
Enzyme
Family
Cullin family
Subcellular location
Nucleus
Function
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase.
TTD ID
T01531
Uniprot ID
Q13617
DrugMap ID
TTCU5EN
Ensemble ID
ENST00000374748.5
HGNC ID
HGNC:2552

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R686C DBIA    Probe Info 
LS180 Deletion: p.K441NfsTer3 DBIA    Probe Info 
MCC13 Substitution: p.E208Ter DBIA    Probe Info 
NCIH1793 SNV: p.I704T DBIA    Probe Info 
WM2664 Insertion: p.H68QfsTer7 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.23  LDD0402  [1]
A-EBA
 Probe Info  		2.84  LDD0215  [2]
TH211
 Probe Info  		Y107(7.56)  LDD0260  [3]
STPyne
 Probe Info  		K114(10.00); K149(10.00); K393(6.93); K433(8.06)  LDD0277  [4]
Probe 1
 Probe Info  		Y58(66.07); Y90(21.06); Y107(19.51); Y378(34.20)  LDD3495  [5]
BTD
 Probe Info  		C266(2.27)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C103(2.00)  LDD0169  [7]
DBIA
 Probe Info  		C721(4.96)  LDD0205  [8]
HHS-475
 Probe Info  		Y107(0.76); Y730(0.97); Y378(1.23)  LDD0264  [9]
IPM
 Probe Info  		C266(10.14); C395(0.63)  LDD1701  [6]
HHS-465
 Probe Info  		Y730(10.00)  LDD2237  [10]
ATP probe
 Probe Info  		K652(0.00); K659(0.00); K393(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C721(0.00); C46(0.00); C103(0.00); C560(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C721(0.00); C465(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C721(0.00); C46(0.00); C103(0.00); C395(0.00)  LDD0037  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
SF
 Probe Info  		Y378(0.00); Y107(0.00)  LDD0028  [15]
TFBX
 Probe Info  		C103(0.00); C395(0.00)  LDD0148  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
Acrolein
 Probe Info  		C266(0.00); C46(0.00); C465(0.00); C103(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		7.50  LDD0443  [20]
NAIA_5
 Probe Info  		C721(0.00); C250(0.00); C465(0.00); C282(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C266(0.56)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C721(0.61)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C266(0.57)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C266(1.19); C721(1.75); C250(1.04); C395(1.83)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C266(1.42); C721(1.88); C250(1.43)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C266(1.01)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C266(0.51)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C266(0.67)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C103(2.00)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C266(0.92); C103(1.05); C46(0.99); C395(0.88)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C266(0.93); C103(0.98); C46(1.17); C395(1.05)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C266(1.05); C103(0.92); C46(1.19); C395(1.05)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C266(1.01); C103(1.06); C46(1.06); C395(1.06)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C266(1.02); C103(1.00); C46(0.98); C395(0.96)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C266(0.98); C103(0.99); C46(0.92); C395(1.02)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C266(0.93); C103(1.01); C46(0.98); C395(0.93)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C266(1.02); C103(0.97); C46(1.08); C395(0.94)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C266(0.93); C103(0.83); C46(0.91); C395(0.99)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C266(1.03); C103(0.98); C46(1.22); C395(1.06)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C266(1.00); C103(1.03); C46(0.87); C395(0.95)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C266(1.04); C103(1.03); C46(1.04); C395(1.17)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C266(0.99); C103(0.98); C46(0.85); C395(1.01)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C266(1.03); C103(0.99); C46(0.96); C395(1.03)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C266(0.93); C103(0.96); C46(1.14); C395(0.89)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C266(0.92); C103(1.03); C46(1.05); C395(0.88)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C266(1.04); C103(1.00); C46(1.28); C395(0.99)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C266(0.97); C103(0.94); C46(1.01); C395(1.02)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C266(0.99); C103(1.07); C46(0.83); C395(1.10)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C266(1.05); C103(1.01); C46(1.09); C395(1.17)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C266(1.00); C103(1.01); C46(1.03); C395(1.01)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C266(0.98); C103(0.92); C46(0.98); C395(1.03)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C266(0.93); C103(0.98); C46(0.98); C395(1.04)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C266(1.02); C103(1.00); C46(0.95); C395(0.97)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C266(0.87); C103(1.04); C46(1.05); C395(0.88)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C266(1.04); C103(0.95); C46(1.24); C395(0.95)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C266(0.92); C103(0.98); C46(1.20); C395(1.03)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C266(0.97); C103(1.02); C46(0.99); C395(1.07)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C266(1.04); C103(0.97); C46(1.08); C395(1.15)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C266(1.07); C103(1.00); C46(1.00); C395(1.09)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C266(1.02); C103(0.99); C46(0.98); C395(1.00)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C266(1.01); C103(1.03); C46(0.87); C395(1.01)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C266(1.01); C103(1.09); C46(0.93); C395(0.86)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C266(0.92); C103(1.07); C46(1.09); C395(0.87)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C266(0.92); C103(1.10); C46(1.28); C395(0.94)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C266(0.91); C103(1.00); C46(0.97); C395(1.00)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C266(0.91); C103(0.99); C46(0.96); C395(1.08)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C266(0.93); C103(1.02); C46(1.04); C395(1.00)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C266(1.02); C103(1.01); C46(1.13); C395(0.95)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C266(1.00); C103(1.02); C46(0.93); C395(1.07)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C266(0.96); C103(0.96); C46(1.09); C395(1.03)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C266(0.93); C103(1.02); C46(1.01); C395(0.91)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C266(0.95); C103(0.97); C46(0.95); C395(1.02)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C266(1.02); C103(0.96); C46(1.18); C395(1.02)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C266(0.89); C103(0.95); C46(0.95); C395(1.05)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C266(1.01); C103(1.00); C46(0.93); C395(0.99)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C266(1.00); C103(1.00); C46(0.98); C395(1.02)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C266(1.03); C103(0.97); C46(1.21); C395(0.97)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C266(1.04); C103(0.93); C46(0.93); C395(1.02)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C266(1.04); C103(1.02); C46(1.08); C395(0.80)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C266(0.91); C103(1.00); C46(0.97); C395(0.80)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C266(1.05); C103(0.97); C46(1.31); C395(0.93)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C266(1.05); C103(1.00); C46(1.11); C395(1.05)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C266(1.00); C103(0.98); C46(1.12); C395(1.03)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C266(0.94); C103(1.03); C46(0.92); C395(0.98)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C266(1.11); C103(1.01); C46(1.02); C395(1.01)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C266(1.04); C103(0.96); C46(1.13); C395(1.00)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C266(0.95); C103(0.96); C46(0.99); C395(1.06)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C266(1.02); C103(1.02); C46(1.08); C395(0.93)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C266(0.95); C103(0.97); C46(0.93); C395(1.00)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C266(0.99); C103(1.06); C46(1.08); C395(1.04)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C266(0.50)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C266(0.80); C395(1.07)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C266(1.00); C103(1.06); C46(1.03); C395(1.09)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C266(0.94); C103(1.02); C46(1.01); C395(0.99)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C266(1.00); C103(0.98); C46(1.00); C395(0.99)  LDD1514  [23]
 LDCM0103  BDHI 10 Jurkat C721(4.96)  LDD0205  [8]
 LDCM0498  BS-3668 MDA-MB-231 C266(0.55); C250(0.59)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C103(0.00); C266(0.00); C721(0.00); C46(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C103(20.00); C266(20.00); C385(1.52)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C266(1.42); C465(1.13); C103(1.00); C46(0.97)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C266(1.01); C103(1.02); C46(0.79); C395(0.97)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C266(0.86); C465(1.08); C103(0.99); C46(0.89)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C266(0.94); C465(1.01); C103(1.00); C46(1.00)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C266(0.95); C103(1.02); C46(0.93); C395(0.96)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C266(0.99); C103(1.02); C46(0.96); C395(1.06)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C266(1.10); C465(1.21); C103(1.01); C46(0.96)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C266(0.95); C465(0.93); C103(0.92); C46(0.83)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C266(1.00); C103(1.02); C46(0.80); C395(0.89)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C266(0.95); C103(0.95); C46(1.14); C395(1.05)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C266(1.01); C465(1.12); C103(0.96); C46(0.99)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C266(0.94); C465(1.08); C103(1.00); C46(0.92)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C266(1.18); C103(0.99); C46(0.97); C395(0.94)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C266(0.89); C103(1.07); C46(0.79); C395(0.80)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C266(0.93); C103(0.96); C46(0.89); C395(0.99)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C266(1.08); C465(1.01); C103(0.96); C46(1.04)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C266(1.02); C465(1.06); C103(0.97); C46(1.27)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C266(0.87); C103(1.00); C46(0.87); C395(0.86)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C266(1.08); C103(0.94); C46(1.00); C395(1.06)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C266(0.98); C465(1.05); C103(1.01); C46(0.83)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C266(1.00); C465(1.36); C103(0.99); C46(1.02)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C266(1.01); C103(1.03); C46(0.91); C395(0.90)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C266(1.14); C103(0.97); C46(0.95); C395(1.11)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C266(1.16); C103(0.98); C46(1.02); C395(0.97)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C266(1.02); C465(1.14); C103(0.92); C46(1.08)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C266(0.96); C465(1.16); C103(0.95); C46(1.12)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C266(0.97); C103(0.99); C46(1.07); C395(1.00)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C266(0.87); C103(0.98); C46(0.92); C395(1.05)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C266(0.99); C465(1.08); C103(1.01); C46(0.84)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C266(1.18); C465(1.16); C103(0.93); C46(1.22)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C266(1.06); C103(0.97); C46(1.01); C395(0.79)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C266(1.20); C103(1.02); C46(0.96); C395(1.01)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C266(0.96); C465(1.15); C103(0.99); C46(1.05)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C266(1.43); C465(0.96); C103(0.90); C46(1.07)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C266(1.05); C103(0.99); C46(1.05); C395(0.95)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C266(1.01); C103(1.10); C46(0.90); C395(1.01)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C266(1.15); C465(1.27); C103(1.05); C46(1.07)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C266(0.86); C103(1.13); C46(0.81); C395(0.82)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C266(1.27); C103(0.97); C46(1.15); C395(1.00)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C266(1.53); C103(0.98); C46(1.06); C395(1.07)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C266(1.06); C103(0.97); C46(1.18); C395(0.95)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C266(1.92); C103(1.07); C46(0.92); C395(0.89)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C266(1.22); C103(1.21); C46(0.81); C395(1.11)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C266(1.37); C103(1.03); C46(1.15); C395(0.98)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C266(1.27); C103(1.10); C46(1.11); C395(0.97)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C266(1.24); C103(1.12); C46(1.05); C395(0.93)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C266(0.95); C465(1.22); C103(1.02); C46(0.98)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C266(1.10); C103(0.99); C46(1.02); C395(0.91)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C266(1.17); C103(0.98); C46(1.05); C395(1.07)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C266(1.14); C465(1.06); C103(0.97); C46(0.86)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C266(1.08); C103(1.04); C46(1.10); C395(0.96)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C266(1.25); C103(1.01); C46(1.06); C395(1.02)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C266(1.26); C103(1.00); C46(1.30); C395(1.15)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C266(1.67); C103(0.95); C46(0.99); C395(1.00)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C266(2.15); C103(1.06); C46(0.85); C395(1.01)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C266(1.28); C103(1.21); C46(0.83); C395(1.10)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C266(1.10); C103(1.03); C46(1.14); C395(1.04)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C266(1.31); C103(1.20); C46(0.97); C395(1.10)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C266(1.22); C103(1.14); C46(1.04); C395(0.96)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C266(1.11); C465(1.69); C103(0.99); C46(1.15)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C266(1.05); C103(1.04); C46(1.01); C395(1.00)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C266(1.05); C465(1.20); C103(1.01); C46(0.90)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C266(1.14); C465(1.09); C103(1.06); C46(1.13)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C266(0.99); C103(0.94); C46(0.91); C395(0.93)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C266(1.15); C103(1.10); C46(1.22); C395(1.05)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C266(1.64); C103(1.05); C46(1.08); C395(1.05)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C266(1.89); C103(1.08); C46(0.92); C395(1.04)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C266(1.24); C103(1.16); C46(0.83); C395(0.90)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C266(1.07); C103(1.04); C46(1.34); C395(0.99)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C266(1.33); C103(1.18); C46(1.00); C395(1.01)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C266(1.13); C103(1.18); C46(0.94); C395(0.93)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C266(1.13); C465(1.43); C103(0.94); C46(1.13)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C266(1.03); C103(1.09); C46(1.03); C395(0.90)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C266(1.01); C103(0.95); C46(0.89); C395(0.97)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C266(1.03); C465(1.18); C103(1.14); C46(0.92)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C266(0.92); C103(1.06); C46(1.04); C395(0.88)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C266(1.02); C103(0.97); C46(1.20); C395(0.91)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C266(1.56); C103(1.00); C46(1.00); C395(1.02)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C266(1.80); C103(1.13); C46(0.97); C395(1.01)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C266(1.47); C103(1.08); C46(0.77); C395(0.96)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C266(1.08); C103(1.05); C46(1.12); C395(0.98)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C266(1.29); C103(1.11); C46(0.94); C395(1.01)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C266(1.06); C103(0.98); C46(1.08); C395(0.93)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C266(1.22); C103(1.05); C46(0.88); C395(0.90)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C266(1.26); C465(1.13); C103(1.00); C46(1.11)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C266(0.97); C103(0.99); C46(1.10); C395(0.96)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C266(1.07); C103(1.09); C46(1.03); C395(1.20)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C266(1.00); C465(1.00); C103(0.98); C46(0.89)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C266(1.00); C103(1.10); C46(1.07); C395(0.96)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C266(1.04); C103(1.00); C46(1.30); C395(1.00)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C266(1.26); C103(0.96); C46(0.99); C395(1.02)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C266(1.80); C103(1.05); C46(0.99); C395(1.07)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C266(1.63); C103(1.15); C46(0.96); C395(1.14)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C266(1.40); C103(1.07); C46(1.22); C395(1.02)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C266(1.15); C103(1.11); C46(1.08); C395(1.02)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C266(1.20); C103(1.07); C46(0.97); C395(1.02)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C266(1.19); C103(1.11); C46(1.09); C395(0.87)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C266(1.06); C465(1.12); C103(0.99); C46(1.03)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C266(1.05); C103(0.99); C46(0.80); C395(1.02)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C266(1.00); C465(1.08); C103(1.00); C46(0.86)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C266(0.88); C103(1.09); C46(0.96); C395(0.85)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C266(1.24); C103(0.98); C46(1.46); C395(0.96)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C266(1.26); C103(0.92); C46(1.17); C395(1.02)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C266(1.31); C103(1.37); C46(0.94); C395(0.84)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C266(1.58); C103(1.04); C46(0.90); C395(1.06)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C266(1.18); C103(1.10); C46(1.08); C395(1.02)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C266(1.27); C103(1.02); C46(1.26); C395(1.06)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C266(1.28); C103(1.02); C46(0.94); C395(1.06)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C266(1.01); C103(1.16); C46(0.94); C395(0.93)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C266(1.24); C465(1.17); C103(0.95); C46(1.07)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C266(1.05); C103(1.00); C46(1.03); C395(0.85)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C266(1.30); C103(0.95); C46(0.92); C395(1.01)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C266(1.21); C465(1.17); C103(1.02); C46(1.14)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C266(1.04); C103(1.05); C46(1.00); C395(0.88)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C266(1.58); C103(1.18); C46(0.96); C395(1.10)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C266(0.87); C103(0.94); C46(1.04); C395(0.91)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C266(1.46); C103(0.90); C46(0.91); C395(1.07)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C266(1.35); C103(1.05); C46(0.93); C395(1.04)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C266(1.18); C103(1.15); C46(0.82); C395(1.08)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C266(1.06); C103(1.06); C46(1.14); C395(1.02)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C266(0.91); C103(1.09); C46(0.81); C395(0.85)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C266(1.09); C103(1.09); C46(1.10); C395(0.77)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C266(0.97); C465(1.17); C103(0.95); C46(0.81)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C266(0.95); C103(0.99); C46(0.86); C395(0.88)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C266(1.26); C103(1.00); C46(0.88); C395(0.96)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C266(1.07); C103(0.97); C46(1.02); C395(1.05)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C465(2.02); C266(1.96)  LDD1702  [6]
 LDCM0625  F8 Ramos C266(0.89); C103(1.00)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C266(0.39); C103(1.37); C385(0.51)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C266(20.00); C103(0.10); C385(0.35)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C266(0.31); C103(1.38); C385(0.23)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C266(1.24); C103(0.91); C385(0.23)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C266(0.38); C103(1.00)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C266(0.43); C103(3.46); C385(0.31)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C266(0.41); C103(0.90); C385(0.85)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C266(0.39); C103(1.11); C385(0.25)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C266(1.05); C103(0.93); C385(0.23)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C266(1.71); C103(1.14); C385(0.70)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C266(1.15); C103(1.20); C385(0.30)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C266(0.31); C103(0.97); C385(0.63)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C266(0.51); C103(0.84); C385(0.52)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C266(1.35); C103(0.96); C46(1.09); C395(1.02)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C266(0.77); C103(1.12); C385(0.45)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C266(0.47); C103(1.25)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C266(1.00); C103(0.94); C46(1.05); C395(1.06)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C266(2.30); C103(0.98)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C266(1.68); C103(0.96)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C266(0.35); C103(1.36); C385(0.40)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C266(0.27); C103(4.41)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y107(0.76); Y730(0.97); Y378(1.23)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y378(0.73); Y107(0.84); Y730(0.97)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y730(0.75); Y378(0.89); Y107(0.91)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y378(0.70); Y107(1.02); Y730(1.07)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y107(0.75); Y378(0.95); Y730(1.68)  LDD0268  [9]
 LDCM0107  IAA HeLa C46(0.00); C266(0.00); H182(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C266(1.02); C282(0.99); C103(0.98); C232(1.14)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C266(1.02); C282(0.99); C103(1.07); C232(1.10)  LDD1497  [23]
 LDCM0024  KB05 G361 C740(1.48); C285(2.04)  LDD3311  [25]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C266(1.09)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C266(0.66); C232(1.05)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C266(0.62)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C266(1.02)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C250(0.72)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C266(0.92); C721(1.19); C250(0.76)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C266(1.31); C721(0.98); C250(1.06)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C266(0.06); C721(0.25); C250(0.18)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C266(0.94)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C250(0.62)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C266(1.07); C721(2.01); C250(0.98); C395(1.05)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C266(0.69); C395(0.84)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C266(0.98); C250(1.20)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C266(0.49)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C266(1.56)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C266(1.15); C250(1.18); C232(1.05); C465(1.03)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C266(0.68)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C266(0.80); C721(0.71); C250(0.71); C232(1.11)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C266(1.00); C721(1.27); C250(0.96)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C266(0.78)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C266(0.47); C250(0.47)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C266(0.35); C721(0.42); C250(0.33)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C721(0.58); C250(0.44); C395(0.18)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C721(2.05); C250(1.56)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C721(0.33); C250(0.23); C395(0.11)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C266(0.88); C721(1.17); C250(0.74); C465(0.95)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C721(0.31); C250(0.20)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C266(0.95); C721(0.97); C250(0.66); C232(1.14)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C266(0.13); C721(0.30); C250(0.20)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C266(1.09); C721(1.84); C250(1.35)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C266(0.55)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C266(0.97); C721(1.21)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C250(0.40)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C266(0.43); C250(0.63); C395(0.95)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C266(1.29); C721(1.49); C250(0.92)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C266(1.98); C721(1.93); C250(1.58); C395(1.45)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C266(0.97); C721(1.16); C250(0.76); C465(0.95)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C266(2.27)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C266(0.74); C721(0.92); C465(0.79); C395(0.98)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C266(0.62)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C266(0.78); C721(0.39)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C266(2.20); C721(1.98); C250(1.72)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C266(0.86); C721(0.77); C250(0.61)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C266(1.51)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C266(0.60); C465(0.43)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C266(0.34); C721(0.30); C250(0.20)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C266(0.48); C250(0.44); C465(0.63)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C721(0.36); C250(0.20)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C266(1.41)  LDD2153  [6]
 LDCM0131  RA190 MM1.R C103(2.06)  LDD0304  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-associated NEDD8-dissociated protein 1 (CAND1) CAND family Q86VP6
E3 ubiquitin-protein ligase RBX1 (RBX1) RING-box family P62877
von Hippel-Lindau disease tumor suppressor (VHL) VHL family P40337
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat-containing protein 14 (LRRC14) PRAME family Q15048
Elongin-C (ELOC) SKP1 family Q15369
Protein zyg-11 homolog B (ZYG11B) Zyg-11 family Q9C0D3
COMM domain-containing protein 1 (COMMD1) . Q8N668
Kelch domain-containing protein 3 (KLHDC3) . Q9BQ90
UBX domain-containing protein 7 (UBXN7) . O94888

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.