Details of the Target

General Information of Target

Target ID LDTP02640
Target Name X-ray repair cross-complementing protein 6 (XRCC6)
Gene Name XRCC6
Gene ID 2547
Synonyms
G22P1; X-ray repair cross-complementing protein 6; EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD
Target Bioclass
Enzyme
Family
Ku70 family
Subcellular location
Nucleus
Function
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Uniprot ID
P12956
Ensemble ID
ENST00000359308.8
HGNC ID
HGNC:4055
ChEMBL ID
CHEMBL4106136

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.S96L DBIA    Probe Info 
HEC1B SNV: p.K94N .
HT115 SNV: p.R325C DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.F216L DBIA    Probe Info 
JURKAT SNV: p.R403H; p.R470L Compound 10    Probe Info 
MEWO Substitution: p.S520F .
MFE319 SNV: p.M1? DBIA    Probe Info 
RL952 SNV: p.R115Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.05  LDD0215  [2]
CHEMBL5175495
 Probe Info  		8.24  LDD0196  [3]
CY4
 Probe Info  		6.86  LDD0244  [4]
N1
 Probe Info  		7.89  LDD0242  [4]
TH211
 Probe Info  		Y530(15.86); Y559(13.95); Y409(12.16); Y88(8.91)  LDD0260  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K114(7.69); K129(2.27); K189(6.09); K317(10.00)  LDD0277  [7]
AZ-9
 Probe Info  		D120(10.00); E479(10.00)  LDD2209  [8]
ONAyne
 Probe Info  		K189(0.00); K468(0.00); K463(0.00)  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K516(0.71); K238(0.96); K299(1.09); K297(1.09)  LDD3494  [9]
Probe 1
 Probe Info  		Y30(17.27); Y322(45.61); Y530(46.68); Y534(66.67)  LDD3495  [10]
SAHA-CA-4PAP
 Probe Info  		4.50  LDD0360  [11]
BTD
 Probe Info  		C398(0.91)  LDD1700  [12]
HHS-475
 Probe Info  		Y103(0.74); Y409(1.07)  LDD0264  [13]
HHS-465
 Probe Info  		Y559(10.00)  LDD2237  [14]
DBIA
 Probe Info  		C398(1.67)  LDD0531  [15]
AMP probe
 Probe Info  		K570(0.00); K582(0.00)  LDD0200  [16]
ATP probe
 Probe Info  		K570(0.00); K582(0.00); K357(0.00); K358(0.00)  LDD0199  [16]
m-APA
 Probe Info  		N.A.  LDD2231  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C66(0.00); C398(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C66(0.00); C398(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K358(0.00); K351(0.00)  LDD0035  [21]
IPM
 Probe Info  		C389(0.00); C398(0.00)  LDD0025  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
TFBX
 Probe Info  		N.A.  LDD0027  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
NHS
 Probe Info  		K539(0.00); K123(0.00); K317(0.00); K556(0.00)  LDD0010  [24]
SF
 Probe Info  		Y103(0.00); K287(0.00); K189(0.00); K468(0.00)  LDD0028  [25]
1c-yne
 Probe Info  		K351(0.00); K510(0.00); K526(0.00); K516(0.00)  LDD0228  [26]
1d-yne
 Probe Info  		K424(0.00); K317(0.00)  LDD0357  [26]
Acrolein
 Probe Info  		H232(0.00); H486(0.00); H204(0.00); H176(0.00)  LDD0217  [27]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [27]
Crotonaldehyde
 Probe Info  		H486(0.00); H232(0.00); C398(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		H486(0.00); C398(0.00)  LDD0218  [27]
W1
 Probe Info  		K351(0.00); D476(0.00); E467(0.00); E479(0.00)  LDD0236  [28]
NAIA_5
 Probe Info  		N.A.  LDD2223  [29]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.36  LDD1740  [30]
C106
 Probe Info  		17.15  LDD1793  [30]
C176
 Probe Info  		7.89  LDD1855  [30]
C177
 Probe Info  		11.88  LDD1856  [30]
C186
 Probe Info  		15.35  LDD1864  [30]
C194
 Probe Info  		10.48  LDD1870  [30]
C220
 Probe Info  		11.55  LDD1894  [30]
C289
 Probe Info  		26.35  LDD1959  [30]
C305
 Probe Info  		17.39  LDD1974  [30]
C326
 Probe Info  		8.28  LDD1990  [30]
C361
 Probe Info  		18.51  LDD2022  [30]
C389
 Probe Info  		9.19  LDD2048  [30]
C407
 Probe Info  		20.39  LDD2064  [30]
C420
 Probe Info  		15.56  LDD2075  [30]
FFF probe13
 Probe Info  		14.89  LDD0475  [31]
FFF probe2
 Probe Info  		10.05  LDD0463  [31]
FFF probe3
 Probe Info  		10.08  LDD0464  [31]
FFF probe4
 Probe Info  		12.45  LDD0466  [31]
JN0003
 Probe Info  		20.00  LDD0469  [31]
STS-1
 Probe Info  		N.A.  LDD0136  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
Diazir
 Probe Info  		E491(0.00); E479(0.00); Y103(0.00)  LDD0011  [24]
BD-F
 Probe Info  		E499(0.00); L497(0.00); M498(0.00); D496(0.00)  LDD0024  [34]
LD-F
 Probe Info  		A494(0.00); D13(0.00); D496(0.00); N23(0.00)  LDD0015  [34]
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [35]
Photonaproxen
 Probe Info  		M498(0.00); L490(0.00)  LDD0157  [35]
DA-2
 Probe Info  		N.A.  LDD0072  [36]
OEA-DA
 Probe Info  		8.69  LDD0046  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C398(0.49)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C398(1.17)  LDD2112  [12]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C398(0.83)  LDD2130  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C398(0.98)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C398(0.71)  LDD2152  [12]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C398(0.94)  LDD2103  [12]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C398(0.41)  LDD2132  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C398(2.85)  LDD0372  [38]
 LDCM0214  AC1 HCT 116 C398(1.67)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C398(1.17)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C398(1.17)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C398(1.10)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C398(1.08)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C398(1.27)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C398(1.00)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C398(1.27)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C398(1.02)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C398(1.14)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C398(0.85)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C398(1.09)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C398(0.62)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C398(1.11)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C398(1.12)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C398(0.57)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C398(1.13)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C398(1.09)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C398(0.90)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C398(1.03)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C398(1.02)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C398(1.17)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C398(1.02)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C398(1.01)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C398(1.07)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C398(1.37)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C398(1.15)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C398(1.34)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C398(1.45)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C398(1.27)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C398(1.25)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C398(1.29)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C398(2.03)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C398(1.65)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C398(1.57)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C398(1.27)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C398(1.02)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C398(1.24)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C398(0.87)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C398(0.98)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C398(0.95)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C398(0.94)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C398(0.68)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C398(0.65)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C398(0.90)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C398(0.64)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C398(0.66)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C398(0.89)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C398(1.06)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C398(1.18)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C398(1.11)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C398(0.99)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C398(1.23)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C398(1.01)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C398(0.74)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C398(1.15)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C398(0.92)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C398(0.86)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C398(0.98)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C398(0.80)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C398(1.04)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C398(0.94)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C398(0.95)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C398(0.90)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C398(1.61)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C398(1.08)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C398(1.65)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C398(1.12)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C398(1.71)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C398(1.12)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C398(1.37)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C398(1.54)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C398(1.57)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C398(0.92)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C398(0.70)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C398(0.78)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C398(0.77)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C398(0.52)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C398(1.55)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C398(0.59)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C398(0.87)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C398(0.54)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C398(0.68)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C398(0.72)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C398(1.30)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C398(0.83)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C398(1.23)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C398(0.73)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C398(1.00)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C398(1.93)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C398(0.89)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C398(0.78)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C398(0.75)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C398(0.64)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C398(1.39)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C398(1.36)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C398(0.83)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C398(0.78)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C398(0.76)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C398(0.75)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C398(2.07)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C398(0.81)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C398(0.75)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C398(0.81)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C398(0.84)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C398(0.86)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C398(1.05)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C398(0.81)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C398(1.14)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C398(0.96)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C398(1.05)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C398(1.13)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C398(1.05)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C398(1.01)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C398(1.12)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C398(1.60)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C398(1.65)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C398(0.84)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C398(0.96)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C398(0.87)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C398(0.99)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C398(1.08)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C398(0.67)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C398(0.94)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C398(1.24)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C398(0.98)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C398(0.85)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C398(1.24)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C398(0.90)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C398(1.32)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C398(0.90)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C398(0.95)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C398(0.91)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C398(0.84)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C398(1.19)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C398(1.19)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C398(1.05)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C398(0.97)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C398(0.78)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C398(0.94)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C398(0.94)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C398(0.95)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C398(0.95)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C398(0.97)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C398(1.08)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C398(1.27)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C398(1.11)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C398(0.97)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C398(1.59)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C398(1.15)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C398(1.23)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C398(0.82)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C398(0.96)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C398(1.11)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C398(0.48)  LDD2138  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C398(1.03)  LDD2113  [12]
 LDCM0248  AKOS034007472 HCT 116 C398(0.91)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C398(0.75)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C398(1.11)  LDD0592  [15]
 LDCM0498  BS-3668 MDA-MB-231 C398(0.67)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa H486(0.00); H204(0.00); H232(0.00); C398(0.00)  LDD0222  [27]
 LDCM0367  CL1 HCT 116 C398(0.88)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C398(1.06)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C398(1.50)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C398(1.04)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C398(0.92)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C398(1.08)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C398(0.99)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C398(1.13)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C398(1.45)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C398(0.88)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C398(1.39)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C398(1.20)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C398(1.29)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C398(1.41)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C398(0.89)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C398(0.84)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C398(0.54)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C398(0.46)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C398(0.49)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C398(0.65)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C398(0.86)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C398(0.80)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C398(0.73)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C398(1.14)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C398(0.68)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C398(0.69)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C398(0.82)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C398(0.96)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C398(0.88)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C398(0.78)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C398(0.81)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C398(0.90)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C398(1.03)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C398(1.17)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C398(1.22)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C398(1.19)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C398(0.70)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C398(1.07)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C398(0.96)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C398(0.99)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C398(1.13)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C398(0.78)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C398(1.14)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C398(1.05)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C398(0.86)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C398(0.90)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C398(1.10)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C398(0.87)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C398(1.03)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C398(0.80)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C398(0.89)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C398(1.39)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C398(1.10)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C398(0.94)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C398(0.79)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C398(0.74)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C398(0.73)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C398(0.81)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C398(0.95)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C398(0.95)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C398(0.96)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C398(0.99)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C398(0.81)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C398(0.81)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C398(1.13)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C398(0.81)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C398(1.19)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C398(0.86)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C398(0.91)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C398(1.03)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C398(1.09)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C398(1.10)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C398(1.31)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C398(1.11)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C398(0.99)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C398(0.83)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C398(1.10)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C398(1.00)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C398(1.18)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C398(1.10)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C398(1.07)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C398(1.08)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C398(1.33)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C398(0.98)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C398(0.90)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C398(1.01)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C398(0.97)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C398(1.02)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C398(1.16)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C398(1.18)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C398(1.06)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C398(1.21)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C398(1.24)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C398(0.76)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C398(1.14)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C398(0.90)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C398(0.94)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C398(0.92)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C398(0.96)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C398(0.98)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C398(1.21)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C398(1.11)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C398(1.07)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C398(1.19)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C398(1.15)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C398(1.34)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C398(1.40)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C398(1.75)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C398(1.49)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C398(1.24)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C398(1.11)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C398(1.31)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C398(1.87)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C398(1.62)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C398(1.35)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C398(0.92)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C398(1.27)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C398(1.12)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C398(1.19)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C398(1.67)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C398(1.54)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C398(1.24)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C398(1.18)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C398(0.97)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C398(1.24)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C398(1.41)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C398(0.92); C66(1.09)  LDD1698  [39]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C398(2.59)  LDD1702  [12]
 LDCM0468  Fragment33 HCT 116 C398(1.25)  LDD0785  [15]
 LDCM0427  Fragment51 HCT 116 C398(1.03)  LDD0744  [15]
 LDCM0116  HHS-0101 DM93 Y103(0.74); Y409(1.07)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y103(0.90); Y409(1.08)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y103(0.67); Y409(0.79)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y409(0.68); Y103(0.84)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y409(0.67); Y103(0.89)  LDD0268  [13]
 LDCM0107  IAA HeLa H486(0.00); H232(0.00); H204(0.00); H176(0.00)  LDD0221  [27]
 LDCM0022  KB02 HEK-293T C398(0.99)  LDD1492  [39]
 LDCM0023  KB03 HEK-293T C398(1.00)  LDD1497  [39]
 LDCM0024  KB05 COLO792 C398(3.50)  LDD3310  [40]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C398(1.00)  LDD2102  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C398(0.51)  LDD2121  [12]
 LDCM0109  NEM HeLa H486(0.00); H232(0.00); H204(0.00); H176(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C398(0.83)  LDD2089  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C398(0.61)  LDD2092  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C398(1.44)  LDD2094  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C398(0.72)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C398(1.03)  LDD2098  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C398(0.54)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C398(1.95)  LDD2101  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C398(1.24)  LDD2107  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C398(0.98)  LDD2109  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C398(0.63)  LDD2115  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C398(0.18)  LDD2118  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C398(0.87)  LDD2120  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C398(0.11)  LDD2122  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C398(0.08)  LDD2124  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C398(1.17)  LDD2127  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C398(1.36)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C398(0.68)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C398(0.37)  LDD2134  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C398(1.41)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C398(1.12)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C398(0.91)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C398(0.92)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C398(0.45)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C398(0.83)  LDD2143  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C398(2.06)  LDD2147  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C398(0.37)  LDD2148  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C398(0.52)  LDD2150  [12]
 LDCM0096  SAHA K562 4.50  LDD0360  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase D (PPID) Cyclophilin-type PPIase family Q08752
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN) Helicase family Q14191
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Protein NDRG1 (NDRG1) NDRG family Q92597
DNA-dependent protein kinase catalytic subunit (PRKDC) PI3/PI4-kinase family P78527
Protein phosphatase 1G (PPM1G) PP2C family O15355
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis regulator BAX (BAX) Bcl-2 family Q07812
Huntingtin (HTT) Huntingtin family P42858
Cellular tumor antigen p53 (TP53) P53 family P04637
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Transcription factor 7-like 2 (TCF7L2) TCF/LEF family Q9NQB0
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) . O75398
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coilin (COIL) Coilin family P38432
Translationally-controlled tumor protein (TPT1) TCTP family P13693
DNA repair protein XRCC4 (XRCC4) XRCC4-XLF family Q13426
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) . Q96P48
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
35 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
36 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
37 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
38 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
39 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
40 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840