Details of the Target

General Information of Target

Target ID LDTP04684
Target Name Nucleosome assembly protein 1-like 1 (NAP1L1)
Gene Name NAP1L1
Gene ID 4673
Synonyms
NRP; Nucleosome assembly protein 1-like 1; NAP-1-related protein; hNRP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADIDNKEQSELDQDLDDVEEVEEEETGEETKLKARQLTVQMMQNPQILAALQERLDGLV
ETPTGYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEI
INAIYEPTEEECEWKPDEEDEISEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDL
LSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNEYFTNEVLTKTYRMRSEPD
DSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNF
FAPPEVPESGDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEE
ADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
Target Bioclass
Other
Family
Nucleosome assembly protein (NAP) family
Subcellular location
Nucleus
Function
Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair. Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter.; (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression.; (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA.
Uniprot ID
P55209
Ensemble ID
ENST00000393263.7
HGNC ID
HGNC:7637

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 SNV: p.S242Y .
IGROV1 Deletion: p.G265EfsTer6 DBIA    Probe Info 
IM95 SNV: p.R36C DBIA    Probe Info 
PF382 SNV: p.R331C DBIA    Probe Info 
SNGM Insertion: p.D158GfsTer2 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.04  LDD0214  [2]
m-APA
 Probe Info  		8.93  LDD0402  [3]
P2
 Probe Info  		2.46  LDD0449  [4]
P3
 Probe Info  		1.54  LDD0450  [4]
P8
 Probe Info  		10.00  LDD0451  [4]
FBPP2
 Probe Info  		6.74  LDD0318  [5]
TH211
 Probe Info  		Y96(16.09)  LDD0257  [6]
TH214
 Probe Info  		Y96(14.78); Y106(10.94)  LDD0258  [6]
TH216
 Probe Info  		Y106(16.75); Y66(16.63); Y110(11.49)  LDD0259  [6]
ONAyne
 Probe Info  		K194(5.57); K271(0.51); K82(0.62)  LDD0274  [7]
AZ-9
 Probe Info  		E68(0.93); E61(1.05)  LDD2208  [8]
Probe 1
 Probe Info  		Y66(6.72); Y96(49.81)  LDD3495  [9]
BTD
 Probe Info  		C388(0.84)  LDD1700  [10]
AHL-Pu-1
 Probe Info  		C388(2.81)  LDD0168  [11]
HHS-482
 Probe Info  		Y106(0.62); Y66(2.37); Y96(1.03)  LDD0285  [12]
HHS-475
 Probe Info  		Y66(0.76); Y96(1.82)  LDD0264  [13]
HHS-465
 Probe Info  		Y106(4.71); Y110(4.97); Y96(6.81)  LDD2237  [14]
DBIA
 Probe Info  		C388(0.93); C88(0.88)  LDD0078  [15]
ATP probe
 Probe Info  		K271(0.00); K194(0.00); K197(0.00); K87(0.00)  LDD0199  [16]
N1
 Probe Info  		N.A.  LDD0245  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C88(0.00); C132(0.00); C388(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C132(0.00); C255(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C88(0.00); C132(0.00); C388(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		N.A.  LDD0035  [21]
NAIA_4
 Probe Info  		N.A.  LDD2226  [22]
TFBX
 Probe Info  		N.A.  LDD0027  [23]
WYneO
 Probe Info  		N.A.  LDD0022  [24]
Compound 10
 Probe Info  		N.A.  LDD2216  [25]
ENE
 Probe Info  		N.A.  LDD0006  [24]
IPM
 Probe Info  		N.A.  LDD0147  [23]
NHS
 Probe Info  		N.A.  LDD0010  [24]
NPM
 Probe Info  		N.A.  LDD0016  [24]
SF
 Probe Info  		Y96(0.00); Y66(0.00); K271(0.00)  LDD0028  [26]
STPyne
 Probe Info  		N.A.  LDD0009  [24]
VSF
 Probe Info  		C88(0.00); C388(0.00)  LDD0007  [24]
Ox-W18
 Probe Info  		W134(0.00); W171(0.00); W262(0.00)  LDD2175  [27]
Acrolein
 Probe Info  		H188(0.00); C132(0.00)  LDD0217  [28]
AOyne
 Probe Info  		4.80  LDD0443  [29]
NAIA_5
 Probe Info  		C88(0.00); C132(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 68 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.92  LDD1714  [30]
C040
 Probe Info  		7.31  LDD1740  [30]
C041
 Probe Info  		8.69  LDD1741  [30]
C053
 Probe Info  		10.41  LDD1751  [30]
C087
 Probe Info  		8.82  LDD1779  [30]
C106
 Probe Info  		21.26  LDD1793  [30]
C134
 Probe Info  		28.44  LDD1816  [30]
C147
 Probe Info  		9.32  LDD1829  [30]
C153
 Probe Info  		15.35  LDD1834  [30]
C159
 Probe Info  		8.40  LDD1839  [30]
C160
 Probe Info  		9.19  LDD1840  [30]
C161
 Probe Info  		10.48  LDD1841  [30]
C170
 Probe Info  		7.41  LDD1850  [30]
C173
 Probe Info  		6.11  LDD1853  [30]
C178
 Probe Info  		17.75  LDD1857  [30]
C186
 Probe Info  		7.78  LDD1864  [30]
C194
 Probe Info  		9.45  LDD1870  [30]
C210
 Probe Info  		40.50  LDD1884  [30]
C213
 Probe Info  		16.56  LDD1887  [30]
C218
 Probe Info  		15.45  LDD1892  [30]
C219
 Probe Info  		5.31  LDD1893  [30]
C220
 Probe Info  		17.63  LDD1894  [30]
C225
 Probe Info  		4.99  LDD1898  [30]
C228
 Probe Info  		22.32  LDD1901  [30]
C229
 Probe Info  		7.62  LDD1902  [30]
C231
 Probe Info  		14.52  LDD1904  [30]
C232
 Probe Info  		33.13  LDD1905  [30]
C233
 Probe Info  		16.68  LDD1906  [30]
C246
 Probe Info  		16.68  LDD1919  [30]
C265
 Probe Info  		14.32  LDD1936  [30]
C269
 Probe Info  		8.17  LDD1939  [30]
C277
 Probe Info  		11.39  LDD1947  [30]
C284
 Probe Info  		24.25  LDD1954  [30]
C310
 Probe Info  		20.97  LDD1977  [30]
C322
 Probe Info  		5.82  LDD1988  [30]
C343
 Probe Info  		16.11  LDD2005  [30]
C347
 Probe Info  		5.54  LDD2008  [30]
C348
 Probe Info  		10.34  LDD2009  [30]
C350
 Probe Info  		29.04  LDD2011  [30]
C354
 Probe Info  		9.00  LDD2015  [30]
C356
 Probe Info  		7.94  LDD2017  [30]
C361
 Probe Info  		17.15  LDD2022  [30]
C376
 Probe Info  		7.94  LDD2036  [30]
C380
 Probe Info  		5.06  LDD2039  [30]
C382
 Probe Info  		17.27  LDD2041  [30]
C386
 Probe Info  		19.84  LDD2045  [30]
C388
 Probe Info  		51.98  LDD2047  [30]
C391
 Probe Info  		28.84  LDD2050  [30]
C403
 Probe Info  		16.91  LDD2061  [30]
C413
 Probe Info  		20.82  LDD2069  [30]
C420
 Probe Info  		15.89  LDD2075  [30]
FFF probe11
 Probe Info  		9.12  LDD0471  [31]
FFF probe12
 Probe Info  		20.00  LDD0473  [31]
FFF probe13
 Probe Info  		20.00  LDD0475  [31]
FFF probe14
 Probe Info  		16.82  LDD0477  [31]
FFF probe15
 Probe Info  		7.28  LDD0478  [31]
FFF probe2
 Probe Info  		10.23  LDD0463  [31]
FFF probe3
 Probe Info  		17.68  LDD0464  [31]
FFF probe4
 Probe Info  		13.35  LDD0466  [31]
FFF probe6
 Probe Info  		5.28  LDD0468  [31]
FFF probe7
 Probe Info  		12.81  LDD0483  [31]
FFF probe9
 Probe Info  		20.00  LDD0470  [31]
JN0003
 Probe Info  		16.01  LDD0469  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [33]
DA-2
 Probe Info  		N.A.  LDD0070  [34]
OEA-DA
 Probe Info  		6.66  LDD0046  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C388(0.87); C88(0.30)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C388(0.99); C88(0.63)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C388(0.90); C88(0.73)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C88(1.13)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C388(1.04); C88(1.28)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C388(1.02)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C388(0.76)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C388(0.63); C88(0.41)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C388(0.60); C88(0.96)  LDD2131  [10]
 LDCM0025  4SU-RNA HEK-293T C388(2.81)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C388(3.14)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C255(0.69); C258(0.64); C388(1.01); C88(1.42)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C255(0.59); C258(0.59); C388(1.37); C88(1.15)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C255(0.47); C258(0.47); C388(1.05); C88(1.09)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C255(0.50); C258(0.50); C388(1.26); C88(1.08)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C255(0.46); C258(0.46); C388(1.18); C88(1.09)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C255(0.32); C258(0.32); C388(1.25); C88(1.03)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C255(0.33); C258(0.33); C388(0.95); C88(1.11)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C255(0.35); C258(0.35); C388(1.03); C88(0.96)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C255(0.38); C258(0.38); C388(1.26); C88(1.10)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C255(0.30); C258(0.34); C388(1.09); C88(1.04)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C255(0.53); C258(0.52); C388(0.95); C88(1.10)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C255(0.52); C258(0.46); C388(0.97); C88(1.13)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C255(0.50); C258(0.50); C388(1.32); C88(1.24)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C255(0.48); C258(0.44); C388(1.30); C88(1.08)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C255(0.48); C258(0.46); C388(1.12); C88(1.05)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C255(0.36); C258(0.33); C388(1.36); C88(1.11)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C255(0.81); C258(0.81); C388(0.72); C88(1.08)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C255(0.58); C258(0.58); C388(1.21); C88(0.98)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C255(0.54); C258(0.54); C388(1.17); C88(0.96)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C255(0.53); C258(0.53); C388(1.27); C88(0.91)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C255(0.63); C258(0.63); C388(1.04); C88(0.91)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C255(0.81); C258(0.81); C388(0.79); C88(1.07)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C255(0.68); C258(0.68); C388(1.32); C88(0.89)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C255(0.68); C258(0.68); C388(1.11); C88(1.24)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C255(0.57); C258(0.57); C388(0.96); C88(0.93)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C255(0.85); C258(0.85); C388(1.03); C88(1.03)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C255(0.96); C258(0.96); C388(1.31); C88(1.03)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C255(0.88); C258(0.88); C388(1.03); C88(1.10)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C255(0.80); C258(0.80); C388(1.08); C88(1.02)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C255(0.75); C258(0.75); C388(0.98); C88(1.06)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C255(0.58); C258(0.58); C388(1.02); C88(1.10)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C255(0.57); C258(0.57); C388(1.12); C88(1.08)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C255(0.96); C258(0.96); C88(1.16)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C255(1.25); C258(1.25); C88(1.46)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C255(0.89); C258(0.89); C88(1.24)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C255(1.31); C258(1.31); C88(1.40)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C255(1.10); C258(1.10); C88(1.25)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C255(1.02); C258(1.02); C88(1.34)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C255(0.86); C258(0.86); C88(1.17)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C255(0.91); C258(0.91); C88(1.19)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C255(0.98); C258(0.98); C88(1.22)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C255(1.06); C258(1.06); C88(1.13)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C255(0.87); C258(0.87); C88(1.18)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C255(0.90); C258(0.90); C88(0.97)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C255(0.70); C258(0.70); C388(1.14); C88(1.07)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C255(0.80); C258(0.80); C88(1.04)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C255(0.82); C258(0.82); C88(1.02)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C255(1.38); C258(1.38); C88(1.34)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C255(0.83); C258(0.83); C88(0.94); C388(1.05)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C255(0.51); C258(0.51); C88(0.69); C388(0.88)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C255(0.72); C258(0.72); C88(0.83); C388(0.98)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C255(0.61); C258(0.61); C88(0.70); C388(1.10)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C255(0.53); C258(0.53); C88(0.73); C388(1.07)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C255(0.34); C258(0.34); C88(0.58); C388(1.27)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C255(0.48); C258(0.48); C88(0.72); C388(1.18)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C255(0.52); C258(0.52); C88(0.97); C388(1.22)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C255(0.66); C258(0.66); C388(0.86); C88(0.87)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C255(0.74); C258(0.74); C88(0.79); C388(0.97)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C255(0.46); C258(0.46); C88(0.65); C388(1.15)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C255(0.32); C258(0.32); C88(0.51); C388(1.63)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C255(0.56); C258(0.56); C388(1.07); C88(0.76)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C255(0.55); C258(0.55); C388(0.95); C88(0.75)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C255(0.87); C258(0.87); C388(0.92); C88(0.84)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C255(0.88); C258(0.88); C388(0.84); C88(0.78)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C255(0.74); C258(0.75); C388(1.09); C88(1.19)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C255(0.45); C258(0.47); C88(1.12); C388(1.13)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C255(0.72); C258(0.73); C88(1.16); C388(1.18)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C255(0.83); C258(0.86); C388(1.06); C88(1.21)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C258(0.78); C255(0.78); C88(0.91); C388(1.25)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C258(0.71); C255(0.74); C388(1.20); C88(1.20)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C258(0.85); C255(0.86); C88(1.26); C388(1.28)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C258(0.74); C255(0.76); C388(1.08); C88(1.17)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C255(0.88); C258(0.94); C88(1.25); C388(1.55)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C88(1.00); C255(1.11); C258(1.11); C388(1.15)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C88(0.79); C255(0.85); C258(0.85); C388(1.31)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C88(0.72); C255(1.00); C258(1.00); C388(1.27)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C88(0.77); C255(0.92); C258(0.92); C388(1.05)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C88(0.50); C388(1.12); C255(1.16); C258(1.16)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C258(0.79); C255(0.88); C388(1.03); C88(1.37)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C88(0.53); C255(0.88); C258(0.88); C388(1.38)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C88(0.70); C255(0.92); C258(0.92); C388(1.47)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C88(0.58); C255(0.79); C258(0.79); C388(1.60)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C255(0.96); C258(0.96); C88(0.97); C388(1.38)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C255(0.72); C258(0.72); C88(0.88); C388(1.34)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C388(0.82); C88(1.11); C255(1.34); C258(1.34)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C388(0.82); C88(0.90); C255(1.23); C258(1.23)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C388(0.89); C88(1.11); C255(1.25); C258(1.25)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C88(0.84); C388(0.96); C255(1.43); C258(1.43)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C88(0.99); C388(1.11); C255(1.13); C258(1.13)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C258(0.64); C255(0.69); C388(1.23); C88(1.55)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C88(0.92); C255(1.00); C258(1.00); C388(1.38)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C88(0.83); C388(0.90); C255(1.25); C258(1.25)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C88(0.86); C388(0.95); C255(0.99); C258(0.99)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C88(0.72); C255(0.98); C258(0.98); C388(1.15)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C255(1.03); C258(1.03); C88(1.11); C388(1.19)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C255(0.90); C258(0.90); C88(1.03); C388(1.28)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C88(0.73); C255(1.07); C258(1.07); C388(1.18)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C88(0.91); C255(0.94); C258(0.94); C388(1.03)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C88(0.84); C255(1.05); C258(1.05); C388(1.12)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C88(0.73); C255(0.84); C258(0.84); C388(1.37)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C258(0.72); C255(0.84); C388(1.21); C88(1.51)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C88(0.73); C255(0.82); C258(0.82); C388(1.33)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C88(0.80); C388(1.05); C255(1.40); C258(1.40)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C88(0.76); C388(0.92); C255(1.16); C258(1.16)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C388(0.88); C88(1.01); C255(1.13); C258(1.13)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C88(0.92); C255(1.07); C258(1.07); C388(1.22)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C255(1.01); C258(1.01); C88(1.14); C388(1.35)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C88(0.84); C255(0.91); C258(0.91); C388(2.14)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C255(0.49); C258(0.65); C388(1.14); C88(1.36)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C255(0.45); C258(0.58); C88(1.13); C388(1.21)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C255(0.44); C258(0.67); C388(1.24); C88(1.27)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C255(0.54); C258(0.54); C88(0.84); C388(1.31)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C255(0.42); C258(0.67); C388(1.09); C88(1.15)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C255(0.43); C258(0.58); C388(1.12); C88(1.42)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C255(0.42); C258(0.69); C388(0.98); C88(1.14)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C255(0.43); C258(0.70); C388(1.06); C88(1.38)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C255(0.42); C258(0.67); C388(1.12); C88(1.69)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C255(0.44); C258(0.69); C388(1.18); C88(1.20)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C255(0.45); C258(0.62); C388(1.15); C88(1.19)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C255(0.20); C258(0.46); C88(1.08); C388(1.12)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C255(0.83); C258(0.83); C388(0.86); C88(1.03)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C255(0.78); C258(0.78); C388(0.97); C88(1.04)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C255(0.58); C258(0.58); C88(1.02); C388(1.14)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C255(0.68); C258(0.68); C388(1.09); C88(1.16)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C388(0.86); C255(0.93); C258(0.93); C88(1.14)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C255(0.83); C258(0.83); C388(0.94); C88(1.11)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C255(0.64); C258(0.64); C88(1.10); C388(1.38)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C255(0.70); C258(0.70); C388(1.11); C88(1.19)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C255(0.67); C258(0.67); C88(0.94); C388(1.09)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C255(0.76); C258(0.76); C388(0.96); C88(1.34)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C255(0.76); C258(0.76); C388(0.89); C88(1.04)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C255(0.75); C258(0.75); C388(0.83); C88(1.05)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C255(0.95); C258(0.95); C88(1.00); C388(1.18)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C255(0.60); C258(0.60); C88(0.88); C388(1.28)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C255(0.83); C258(0.83); C388(1.06); C88(1.18)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C255(1.00); C258(1.00); C388(1.10); C88(1.24)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C255(0.61); C258(0.61); C88(1.15); C388(1.16)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C255(0.40); C258(0.40); C88(0.61)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C255(0.50); C258(0.50); C88(0.62)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C255(0.60); C258(0.60); C88(0.67)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C255(0.60); C258(0.60); C88(0.75)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C255(0.75); C258(0.75); C88(1.07)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C255(0.59); C258(0.59); C88(0.91)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C255(0.52); C258(0.52); C88(0.67)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C88(1.10); C255(1.15); C258(1.15)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C255(0.58); C258(0.58); C88(0.62)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C255(0.52); C258(0.52); C88(0.67)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C255(0.58); C258(0.58); C88(0.79)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C88(0.70); C255(0.84); C258(0.84)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C255(0.68); C258(0.68); C88(0.89)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C88(0.67); C255(0.77); C258(0.77)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C255(0.45); C258(0.45); C88(0.63)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C255(0.10); C258(0.10); C88(1.04); C388(1.20)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C255(0.56); C258(0.56); C88(1.05); C388(1.05)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C388(0.81); C88(0.97)  LDD2138  [10]
 LDCM0248  AKOS034007472 HCT 116 C255(0.73); C258(0.73); C388(1.18); C88(1.24)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C255(0.70); C258(0.70); C388(1.06); C88(1.19)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C255(0.44); C258(0.44); C88(0.78); C388(1.62)  LDD0592  [15]
 LDCM0020  ARS-1620 HCC44 C388(0.93); C88(0.88)  LDD0078  [15]
 LDCM0498  BS-3668 MDA-MB-231 C388(0.49); C88(1.16)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa H188(0.00); C132(0.00); C88(0.00)  LDD0222  [28]
 LDCM0367  CL1 HCT 116 C88(0.93); C255(1.22); C258(1.22)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C255(0.55); C258(0.55); C88(1.11)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C258(0.65); C255(0.67); C388(1.06); C88(1.33)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C255(0.61); C258(0.61); C88(1.00); C388(1.25)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C255(0.72); C258(0.72); C388(1.16); C88(1.20)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C255(0.82); C258(0.82); C88(1.09); C388(1.21)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C255(0.88); C258(0.88); C88(1.06); C388(1.18)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C255(0.59); C258(0.62); C388(1.03); C88(1.08)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C255(0.33); C258(0.37); C388(0.73); C88(1.37)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C255(0.50); C258(0.55); C388(0.77); C88(1.15)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C255(0.42); C258(0.48); C388(1.09); C88(1.20)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C255(0.63); C258(0.64); C88(1.13); C388(1.26)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C255(0.62); C258(0.62); C88(1.17)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C255(0.52); C258(0.57); C88(1.35); C388(1.39)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C255(0.62); C258(0.64); C88(1.13); C388(1.48)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C88(0.78); C388(1.09); C255(1.22); C258(1.22)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C88(0.55); C255(1.00); C258(1.00); C388(1.33)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C88(0.48); C255(1.01); C258(1.01); C388(1.17)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C88(0.67); C255(0.93); C258(0.93); C388(1.35)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C88(0.92); C255(1.04); C258(1.04); C388(1.21)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C255(0.69); C258(0.69); C88(0.90); C388(1.55)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C88(0.92); C255(1.03); C258(1.03); C388(1.14)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C88(0.91); C255(1.10); C258(1.10); C388(1.23)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C255(0.59); C258(0.59); C88(1.12)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C88(0.83); C388(1.05); C255(1.40); C258(1.40)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C88(0.89); C388(1.27); C255(1.32); C258(1.32)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C88(0.83); C255(0.92); C258(0.92); C388(1.13)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C88(0.83); C255(0.84); C258(0.84); C388(1.58)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C88(0.79); C255(0.80); C258(0.80); C388(1.44)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C255(1.00); C88(1.04); C258(1.07); C388(1.32)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C255(0.93); C258(1.02); C88(1.10); C388(1.47)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C255(0.75); C258(0.90); C88(1.00); C388(1.04)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C255(0.57); C258(0.79); C88(1.10); C388(1.10)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C255(0.58); C258(0.58); C88(1.26)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C255(0.82); C258(0.82); C88(1.16)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C255(0.65); C258(0.65); C88(1.27)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C255(0.77); C258(0.82); C88(1.12); C388(1.14)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C388(0.60); C255(0.76); C88(0.77); C258(0.79)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C258(0.59); C255(0.61); C88(1.09); C388(1.33)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C255(0.62); C258(0.67); C88(1.05); C388(1.34)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C88(0.97); C255(1.12); C258(1.12)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C88(0.64); C258(0.66); C255(0.66); C388(1.37)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C255(0.52); C258(0.53); C88(0.77); C388(2.53)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C258(0.43); C255(0.43); C88(0.75); C388(2.35)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C255(0.66); C258(0.68); C88(0.82); C388(1.07)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C255(0.56); C258(0.59); C88(0.92); C388(1.63)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C255(0.59); C258(0.61); C388(1.69); C88(1.07)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C255(0.66); C258(0.70); C388(1.20); C88(0.97)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C255(0.77); C258(0.79); C388(1.22); C88(0.92)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C255(0.58); C258(0.60); C388(1.56); C88(0.90)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C255(0.59); C258(0.60); C388(1.33); C88(0.61)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C255(0.94); C258(0.94); C88(1.17)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C255(0.74); C258(0.78); C388(1.10); C88(0.92)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C255(0.79); C258(0.79); C388(1.06); C88(0.92)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C255(0.59); C258(0.59); C388(1.12); C88(0.83)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C255(0.53); C258(0.53); C388(1.74); C88(0.84)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C255(0.51); C258(0.51); C388(1.45); C88(0.73)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C255(0.52); C258(0.52); C388(1.16); C88(0.82)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C255(0.61); C258(0.61); C388(1.37); C88(0.89)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C255(0.57); C258(0.57); C388(1.43); C88(0.93)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C255(0.52); C258(0.52); C388(1.81); C88(0.98)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C255(1.00); C258(1.00); C88(0.84)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C255(0.55); C258(0.55); C388(1.27); C88(0.92)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C255(0.63); C258(0.63); C388(1.13); C88(0.85)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C255(0.35); C258(0.35); C388(1.30); C88(0.87)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C255(0.43); C258(0.43); C388(1.30); C88(0.84)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C255(0.47); C258(0.47); C388(1.50); C88(0.93)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C255(0.42); C258(0.42); C388(1.48); C88(0.88)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C255(1.45); C258(1.45); C388(0.85); C88(0.75)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C255(1.34); C258(1.34); C388(0.79); C88(0.68)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C255(1.53); C258(1.53); C388(0.86); C88(1.01)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C255(1.19); C258(1.19); C388(0.99); C88(1.18)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C255(0.86); C258(0.86); C88(1.30)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C255(1.37); C258(1.37); C388(0.90); C88(1.19)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C255(1.45); C258(1.45); C388(1.22); C88(1.02)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C255(1.47); C258(1.47); C388(0.98); C88(0.98)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C255(1.43); C258(1.43); C388(0.80); C88(0.84)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C255(1.39); C258(1.39); C388(0.99); C88(0.91)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C255(1.46); C258(1.46); C388(0.74); C88(1.08)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C255(1.15); C258(1.15); C388(1.00); C88(1.01)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C255(1.38); C258(1.38); C388(1.35); C88(0.81)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C255(1.48); C258(1.48); C388(0.95); C88(1.06)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C255(1.17); C258(1.17); C388(0.91); C88(1.22)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C255(0.64); C258(0.64); C88(1.03)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C255(1.10); C258(1.10); C388(1.10); C88(1.05)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C255(0.88); C258(0.85); C388(0.85); C88(1.30)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C255(0.88); C258(0.86); C388(0.98); C88(0.82)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C255(0.87); C258(0.78); C388(1.23); C88(0.90)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C255(0.81); C258(0.72); C388(1.02); C88(1.27)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C255(0.85); C258(0.74); C388(1.90); C88(1.25)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C255(0.67); C258(0.60); C388(1.44); C88(1.14)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C255(0.70); C258(0.62); C388(2.15); C88(1.12)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C255(0.78); C258(0.70); C388(1.59); C88(1.54)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C255(0.89); C258(0.83); C388(1.85); C88(0.96)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C255(0.69); C258(0.69); C88(1.29)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C255(0.74); C258(0.68); C388(1.63); C88(1.22)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C255(0.80); C258(0.70); C388(1.24); C88(1.17)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C255(1.01); C258(0.95); C388(1.41); C88(1.33)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C255(0.81); C258(0.72); C388(1.87); C88(1.42)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C255(0.78); C258(0.70); C388(1.53); C88(1.05)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C255(0.74); C258(0.74); C388(1.34); C88(1.26)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C255(0.75); C258(0.75); C388(1.11); C88(1.38)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C255(0.78); C258(0.78); C388(1.41); C88(1.29)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C255(0.58); C258(0.58); C388(1.54); C88(1.31)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C255(0.56); C258(0.56); C88(1.00)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C255(0.75); C258(0.75); C388(1.20); C88(1.49)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C255(0.70); C258(0.70); C388(1.40); C88(1.60)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C255(0.49); C258(0.49); C388(2.00); C88(1.65)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C255(0.47); C258(0.47); C388(1.70); C88(1.05)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C255(0.36); C258(0.36); C388(2.00); C88(1.12)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C255(0.59); C258(0.59); C388(1.68); C88(1.09)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C255(0.73); C258(0.73); C388(1.43); C88(1.23)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C255(0.63); C258(0.63); C388(1.60); C88(1.38)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C255(0.49); C258(0.49); C388(2.00); C88(1.43)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C255(0.32); C258(0.32); C388(2.20); C88(1.59)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C255(0.87); C258(0.87); C88(0.99)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C255(0.88); C258(0.88); C388(1.34); C88(1.08)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C255(0.89); C258(0.81); C388(1.15); C88(0.98)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C255(0.84); C258(0.77); C388(0.96); C88(1.05)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C255(0.91); C258(0.87); C388(1.15); C88(1.47)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C255(0.77); C258(0.76); C388(1.10); C88(1.28)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C255(0.80); C258(0.75); C388(1.00); C88(1.15)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C255(0.78); C258(0.69); C388(1.18); C88(1.11)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C255(0.76); C258(0.66); C388(1.21); C88(1.03)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C255(0.80); C258(0.63); C388(1.23); C88(1.12)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C255(0.76); C258(0.66); C388(1.05); C88(1.34)  LDD0811  [15]
 LDCM0185  Compound 17 HEK-293T 3.72  LDD0512  [31]
 LDCM0191  Compound 21 HEK-293T 8.54  LDD0508  [31]
 LDCM0190  Compound 34 HEK-293T 8.58  LDD0510  [31]
 LDCM0192  Compound 35 HEK-293T 6.25  LDD0509  [31]
 LDCM0193  Compound 36 HEK-293T 7.22  LDD0511  [31]
 LDCM0495  E2913 HEK-293T C88(0.80); C132(1.07); C255(1.55)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C388(2.31)  LDD1702  [10]
 LDCM0625  F8 Ramos C88(0.87)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C88(1.35)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C88(0.19)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C88(1.00)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C88(1.25)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C88(0.68)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C88(1.06)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C88(1.09)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C88(1.47)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C88(1.19)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C88(0.83)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C88(1.90)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C88(1.46)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C88(0.82)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C255(0.73); C258(0.70); C388(1.69); C88(1.72)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C88(1.73)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C88(0.81)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C255(0.49); C258(0.49); C388(1.95); C88(0.87)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C88(2.15)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C88(2.47)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C88(0.55)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C88(0.85)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y66(0.76); Y96(1.82)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y66(0.75); Y96(2.62)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y66(0.62); Y96(2.40)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y66(0.74); Y96(1.75)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y66(0.70); Y96(2.02)  LDD0268  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y106(0.62); Y66(2.37); Y96(1.03)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y106(0.51); Y66(1.60); Y96(0.47)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y106(0.35); Y66(1.58); Y96(1.26)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y106(0.77); Y66(2.14); Y96(2.76)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y106(1.25); Y66(5.68); Y96(1.86)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y106(0.48); Y66(1.96); Y96(0.97)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y106(0.41); Y66(1.34); Y96(0.47)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y106(0.20); Y66(1.94); Y96(0.83)  LDD0292  [12]
 LDCM0022  KB02 HCT 116 C255(6.05); C258(1.52)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C255(4.51); C258(1.55)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C255(5.22); C258(1.52)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C388(0.93)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C388(0.51); C88(1.50)  LDD2121  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C388(0.57); C88(1.54)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C388(0.95)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C388(0.72)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C388(0.93); C88(1.47)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C388(1.34)  LDD2094  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C388(1.27)  LDD2096  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C388(0.62)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C388(0.68); C88(1.40)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C388(0.94); C88(0.42)  LDD2100  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C388(0.98); C88(0.43)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C388(1.36)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C388(0.83); C88(0.34)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C388(0.88); C88(0.97)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C388(0.87); C88(0.44)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C388(0.78); C88(0.95)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C388(1.74); C88(0.41)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C388(0.88)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C388(0.88); C88(0.40)  LDD2114  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C388(1.38)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C388(1.46)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C388(2.93)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C388(0.83)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C388(1.34)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C388(0.69); C88(1.01)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C388(1.46)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C388(0.86); C88(1.02)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C388(1.29)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C388(0.92); C88(1.16)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C388(0.81)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C388(0.65)  LDD2129  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C388(0.53)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C388(0.97); C88(1.65)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C388(0.98); C88(0.94)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C388(0.84)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C388(0.71); C88(0.95)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C388(0.75); C88(0.78)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C388(1.09)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C388(3.97)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C388(7.63); C88(1.02)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C388(0.83)  LDD2146  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C388(1.85)  LDD2149  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C388(0.39); C88(0.83)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C388(1.91)  LDD2151  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C388(1.15)  LDD2153  [10]
 LDCM0131  RA190 MM1.R C255(1.31); C258(1.31); C132(0.97)  LDD0304  [39]
 LDCM0021  THZ1 HCT 116 C88(0.98)  LDD2173  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Tyrosine-protein kinase JAK3 (JAK3) Tyr protein kinase family P52333
CREB-binding protein (CREBBP) . Q92793
Histone acetyltransferase p300 (EP300) . Q09472
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 2 group F member 6 (NR2F6) Nuclear hormone receptor family P10588
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Nucleosome assembly protein 1-like 2 (NAP1L2) Nucleosome assembly protein (NAP) family Q9ULW6
Nucleosome assembly protein 1-like 4 (NAP1L4) Nucleosome assembly protein (NAP) family Q99733
Inactive polyglycylase TTLL10 (TTLL10) . Q6ZVT0
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
5 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
36 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.