Details of the Target

General Information of Target

Target ID LDTP08450
Target Name Histone H2A type 2-B (H2AC21)
Gene Name H2AC21
Gene ID 317772
Synonyms
HIST2H2AB; Histone H2A type 2-B; H2A-clustered histone 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TESHKPGKNK
Target Bioclass
Other
Family
Histone H2A family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q8IUE6
Ensemble ID
ENST00000331128.6
HGNC ID
HGNC:20508

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K120(9.22); K125(8.92)  LDD0277  [1]
AZ-9
 Probe Info  		E92(1.09)  LDD2208  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
m-APA
 Probe Info  		N.A.  LDD2234  [4]
SF
 Probe Info  		K37(0.00); Y40(0.00); K10(0.00)  LDD0028  [5]
1c-yne
 Probe Info  		K119(0.00); K96(0.00)  LDD0228  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Photocelecoxib
 Probe Info  		A54(0.00); V55(0.00); L56(0.00); E57(0.00)  LDD0019  [7]
Photoindomethacin
 Probe Info  		L64(0.00); T60(0.00); I63(0.00); E62(0.00)  LDD0155  [7]
Photonaproxen
 Probe Info  		L56(0.00); I63(0.00); E62(0.00); L59(0.00)  LDD0157  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H1.1 (H1-1) Histone H1/H5 family Q02539

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094