General Information of Experiment

Probe Name Photoindomethacin  Probe Info 
Probe concentration 250 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
Experiment Method
SIM-PAL
In Vivo Experiment Model Model Type Living cell
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cells (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05069  Actin, alpha cardiac muscle 1 (ACTC1) A99
 LDTP04876  Actin, cytoplasmic 1 (ACTB) H101
 LDTP04876  Actin, cytoplasmic 1 (ACTB) D154
 LDTP04876  Actin, cytoplasmic 1 (ACTB) T106
 LDTP04876  Actin, cytoplasmic 1 (ACTB) L105
 LDTP04876  Actin, cytoplasmic 1 (ACTB) L293
 LDTP04876  Actin, cytoplasmic 1 (ACTB) D292
 LDTP04876  Actin, cytoplasmic 1 (ACTB) I317
 LDTP09918  DNA repair endonuclease XPF (ERCC4) Q322
 LDTP12233  Helicase MOV-10 (MOV10) H544
 LDTP09396  Minor histocompatibility antigen H13 (HM13) E68
 LDTP09396  Minor histocompatibility antigen H13 (HM13) I70
 LDTP09810  Protein NDRG1 (NDRG1) T279
 LDTP01420  Serine/threonine-protein kinase 10 (STK10) R28
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) E71
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) V68
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) K370
Other
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP02734  Endoplasmin (HSP90B1) I105
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) E208
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) I211
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) A53
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) E62
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19) A61
 LDTP08450  Histone H2A type 2-B (H2AC21) L64
 LDTP08450  Histone H2A type 2-B (H2AC21) T60
 LDTP08450  Histone H2A type 2-B (H2AC21) I63
 LDTP08450  Histone H2A type 2-B (H2AC21) E62
 LDTP08450  Histone H2A type 2-B (H2AC21) L59
 LDTP08450  Histone H2A type 2-B (H2AC21) A61
 LDTP01054  Histone H2B type 1-K (H2BC12) I62
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E54
 LDTP10924  Prohibitin-2 (PHB2) V144
 LDTP10924  Prohibitin-2 (PHB2) A146
 LDTP02205  Tubulin beta chain (TUBB) E288
 LDTP02205  Tubulin beta chain (TUBB) V286
 LDTP02205  Tubulin beta chain (TUBB) K297
 LDTP02205  Tubulin beta chain (TUBB) D295
 LDTP11233  Tubulin beta-6 chain (TUBB6) G93

References

1 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094