Details of the Target

General Information of Target

Target ID LDTP09810
Target Name Protein NDRG1 (NDRG1)
Gene Name NDRG1
Gene ID 10397
Synonyms
CAP43; DRG1; RTP; Protein NDRG1; Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALH
QRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATHLHDTVKRNLDSATS
PQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKHS
LGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNL
MPDLNLNEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKT
EFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTSGQPRADNPS
PNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATP
APAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGP
YLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALM
AYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAV
SVASSHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQ
QFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMP
MGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAH
IPRQTNVGQNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQ
HQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVG
SLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQA
YPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ
Target Bioclass
Enzyme
Family
NDRG family
Subcellular location
Cytoplasm, cytosol
Function
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
Uniprot ID
Q92597
Ensemble ID
ENST00000323851.13
HGNC ID
HGNC:7679
ChEMBL ID
CHEMBL4295916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A177S DBIA    Probe Info 
SISO SNV: p.V309M DBIA    Probe Info 
SNGM Deletion: p.A370PfsTer107 DBIA    Probe Info 
SUPT1 SNV: p.Q35K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		20.00  LDD0122  [1]
C-Sul
 Probe Info  		11.87  LDD0066  [2]
TH211
 Probe Info  		Y307(17.10)  LDD0257  [3]
STPyne
 Probe Info  		K280(2.39); K388(0.81)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C289(1.21)  LDD2099  [7]
HHS-465
 Probe Info  		Y231(10.00); Y307(8.06)  LDD2237  [8]
DBIA
 Probe Info  		C289(1.46)  LDD0080  [9]
5E-2FA
 Probe Info  		H209(0.00); H225(0.00); H371(0.00); H365(0.00)  LDD2235  [10]
m-APA
 Probe Info  		H247(0.00); H209(0.00); H225(0.00); H365(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C289(0.00); C168(0.00)  LDD0037  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		H365(0.00); C289(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [18]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [19]
Photoindomethacin
 Probe Info  		N.A.  LDD0155  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C168(2.23)  LDD0371  [21]
 LDCM0214  AC1 HCT 116 C253(0.52); C272(0.52); C289(1.05)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C253(0.96); C272(0.96); C289(1.16)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C289(0.80)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C289(0.82)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C289(0.85)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C289(0.86)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C289(0.85)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C289(0.85)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C289(0.88)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C289(0.85)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C289(0.86)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C289(1.04)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C253(0.83); C272(0.83); C289(1.05)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C289(0.94)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C289(0.80)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C289(0.85)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C289(1.07)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C289(0.97)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C289(0.88)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C289(0.89)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C289(1.01)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C289(1.07)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C289(0.97)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C253(1.04); C272(1.04); C289(1.28)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C289(0.76)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C289(1.06)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C289(1.02)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C289(0.89)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C289(1.05)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C289(1.03)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C289(1.10)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C289(1.02)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C289(0.95)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C289(0.97)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C289(0.82)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C289(0.80)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C289(0.78)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C289(0.79)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C289(0.78)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C289(0.80)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C289(0.84)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C289(0.88)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C289(0.84)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C289(0.75)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C253(0.65); C272(0.65); C289(1.05)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C289(0.84)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C289(0.78)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C289(0.73)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C289(0.80)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C289(1.03)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C289(1.01)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C289(0.68)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C289(1.08)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C289(0.58)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C289(0.60)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C253(0.92); C272(0.92); C289(1.11)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C289(0.86)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C289(0.95)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C289(0.76)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C289(0.47)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C289(0.72)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C289(0.71)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C289(0.78)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C289(0.66)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C289(0.98)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C289(1.02)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C289(1.04)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C253(0.77); C272(0.77); C289(0.92)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C289(0.90)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C289(0.98)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C289(1.00)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C289(1.13)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C289(1.10)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C289(1.10)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C289(0.99)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C289(1.01)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C289(1.03)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C289(0.94)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C253(0.69); C272(0.69); C289(0.96)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C289(0.99)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C289(0.91)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C289(0.96)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C289(1.00)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C289(1.04)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C253(1.10); C272(1.10); C289(1.11)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C253(0.90); C272(0.90); C289(0.93)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C289(1.04); C253(1.27); C272(1.27)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C253(0.96); C272(0.96); C289(0.97)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C253(0.90); C272(0.90); C289(1.14)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C253(0.75); C272(0.75); C289(1.05)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C253(0.75); C272(0.75); C289(0.99)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C289(0.83); C253(0.94); C272(0.94)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C253(0.95); C272(0.95); C289(1.00)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C289(0.90); C253(2.12); C272(2.12)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C289(1.02); C253(1.32); C272(1.32)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C289(0.98); C253(1.02); C272(1.02)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C289(0.69)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C289(0.78)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C289(0.60)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C289(0.76)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C253(0.66); C272(0.66); C289(1.00)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C289(0.73)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C289(0.85)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C289(0.93)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C289(0.77)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C289(0.78)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C289(0.83)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C289(0.75)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C289(0.80); C253(0.88); C272(0.88)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C289(0.83); C253(1.03); C272(1.03)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C289(0.79); C253(0.96); C272(0.96)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C289(0.94); C253(0.96); C272(0.96)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C289(0.70); C253(1.01); C272(1.01)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C289(0.74); C253(0.92); C272(0.92)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C289(0.77); C253(1.02); C272(1.02)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C289(0.76); C253(1.21); C272(1.21)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C289(0.80); C253(1.32); C272(1.32)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C289(0.74); C253(0.90); C272(0.90)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C289(0.71); C253(0.92); C272(0.92)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C289(0.64); C253(0.98); C272(0.98)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C253(0.90); C272(0.90); C289(1.14)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C253(1.08); C272(1.08); C289(1.14)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C253(0.81); C272(0.81); C289(1.02)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C253(0.81); C272(0.81); C289(1.06)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C253(0.98); C272(0.98); C289(1.17)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C253(0.87); C272(0.87); C289(1.12)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C253(0.86); C272(0.86); C289(0.96)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C253(1.00); C272(1.00); C289(1.04)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C253(0.94); C272(0.94); C289(1.07)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C289(1.00); C253(1.21); C272(1.21)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C289(0.97); C253(1.04); C272(1.04)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C289(0.97); C253(1.16); C272(1.16)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C253(0.97); C272(0.97); C289(1.14)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C289(1.00); C253(1.07); C272(1.07)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C289(1.01); C253(1.22); C272(1.22)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C289(1.04); C253(1.19); C272(1.19)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C289(0.94); C253(1.01); C272(1.01)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C289(0.93); C253(1.07); C272(1.07)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C253(0.85); C272(0.85); C289(1.01)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C253(0.96); C272(0.96); C289(0.96)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C289(0.86); C253(1.46); C272(1.46)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C253(0.86); C272(0.86); C289(1.09)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C289(1.12); C253(1.27); C272(1.27)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C289(0.95); C253(1.46); C272(1.46)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C289(0.99); C253(3.27); C272(3.27)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C289(1.00); C253(1.10); C272(1.10)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C289(0.98); C253(1.29); C272(1.29)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C253(0.99); C272(0.99); C289(1.01)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C253(0.92); C272(0.92); C289(1.20)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C253(0.79); C272(0.79); C289(0.97)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C253(0.99); C272(0.99); C289(1.04)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C289(0.85); C253(1.01); C272(1.01)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C289(0.84)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C289(0.82)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C253(0.73); C272(0.73); C289(1.18)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C289(0.96); C253(1.16); C272(1.16)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C253(0.62); C272(0.62); C289(1.04)  LDD0592  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C289(0.89); C253(1.01); C272(1.01)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C253(0.49); C272(0.49); C289(0.82)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C253(0.60); C272(0.60); C289(0.96)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C289(1.01); C253(1.14); C272(1.14)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C253(0.77); C272(0.77); C289(0.91)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C253(0.95); C272(0.95); C289(1.13)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C253(0.98); C272(0.98); C289(1.02)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C289(1.05)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C289(1.27)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C289(1.03)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C289(1.21)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C289(0.92)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C253(0.47); C272(0.47); C289(0.95)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C289(1.07)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C289(0.85)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C289(0.99)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C289(0.92)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C289(0.94)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C289(0.98)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C289(1.03)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C253(0.82); C272(0.82); C289(1.01)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C289(0.83); C253(0.91); C272(0.91)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C289(0.87); C253(1.12); C272(1.12)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C253(0.73); C272(0.73); C289(0.97)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C289(0.89); C253(1.28); C272(1.28)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C289(0.72)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C289(0.69)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C289(0.71)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C289(0.76)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C289(0.82); C253(0.84); C272(0.84)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C289(0.73); C253(0.78); C272(0.78)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C289(0.76); C253(0.77); C272(0.77)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C289(0.79); C253(0.94); C272(0.94)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C253(0.42); C272(0.42); C289(0.95)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C289(0.89); C253(0.89); C272(0.89)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C253(0.51); C272(0.51); C289(0.94)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C289(0.79)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C289(0.95)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C289(0.83)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C289(1.00)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C253(0.74); C272(0.74); C289(0.89)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C289(0.82)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C289(0.84)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C289(0.83)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C289(0.84)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C289(0.83)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C289(0.77)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C289(0.75)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C289(0.82)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C289(0.74)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C289(0.71)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C253(0.82); C272(0.82); C289(1.05)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C289(0.79)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C253(0.88); C272(0.88); C289(0.81)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C253(0.70); C272(0.70); C289(0.61)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C253(0.88); C272(0.88); C289(0.53)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C253(0.67); C272(0.67); C289(0.67)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C253(0.58); C272(0.58); C289(0.67)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C253(1.07); C272(1.07); C289(0.72)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C253(0.72); C272(0.72); C289(0.75)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C253(0.76); C272(0.76); C289(0.73)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C253(0.86); C272(0.86); C289(0.89)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C253(1.21); C272(1.21); C289(0.73)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C253(0.92); C272(0.92); C289(0.68)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C253(0.37); C272(0.37); C289(0.74)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C253(0.52); C272(0.52); C289(0.65)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C253(0.77); C272(0.77); C289(0.70)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C253(0.64); C272(0.64); C289(0.68)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C289(1.27)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C289(1.17)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C289(1.25)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C289(1.21)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C253(0.68); C272(0.68); C289(1.02)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C289(1.27)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C289(1.29)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C289(1.27)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C289(1.09)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C289(1.08)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C289(1.09)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C289(1.17)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C289(1.10)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C289(1.31)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C289(1.20)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C253(0.46); C272(0.46); C289(0.88)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C289(1.18)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C289(0.76)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C289(0.90)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C289(0.67)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C289(0.65)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C289(0.67)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C289(0.88)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C289(0.84)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C289(1.05)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C289(0.78)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C253(0.60); C272(0.60); C289(0.96)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C289(0.61)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C289(0.76)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C289(0.83)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C289(0.76)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C289(0.75)  LDD0784  [9]
 LDCM0469  CL76 PaTu 8988t C253(0.83); C272(0.83)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C253(0.82); C272(0.82)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C253(0.75); C272(0.75)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C253(1.01); C272(1.01)  LDD1351  [9]
 LDCM0473  CL8 HCT 116 C253(0.55); C272(0.55); C289(0.99)  LDD0790  [9]
 LDCM0474  CL80 PaTu 8988t C253(0.69); C272(0.69)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C253(0.73); C272(0.73)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C253(0.73); C272(0.73)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C253(0.64); C272(0.64)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C253(0.86); C272(0.86)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C253(1.04); C272(1.04)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C253(0.76); C272(0.76)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C253(0.64); C272(0.64)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C253(0.63); C272(0.63)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C253(1.04); C272(1.04)  LDD1362  [9]
 LDCM0484  CL9 HCT 116 C253(0.65); C272(0.65); C289(0.83)  LDD0801  [9]
 LDCM0485  CL90 PaTu 8988t C253(0.77); C272(0.77)  LDD1364  [9]
 LDCM0486  CL91 HCT 116 C253(0.82); C272(0.82); C289(0.98)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C253(0.82); C272(0.82); C289(0.94)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C253(0.74); C272(0.74); C289(1.12)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C253(0.49); C272(0.49); C289(0.94)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C253(0.62); C272(0.62); C289(0.88)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C253(0.71); C272(0.71); C289(0.88)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C253(0.53); C272(0.53); C289(0.91)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C253(0.64); C272(0.64); C289(0.88)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C253(0.68); C272(0.68); C289(0.94)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C289(1.04); C168(0.97)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C289(0.99)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C289(1.10)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C253(0.47); C272(0.47); C289(0.87)  LDD0744  [9]
 LDCM0107  IAA HeLa C289(0.00); H209(0.00)  LDD0221  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C289(1.46)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C289(1.50)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C289(0.77)  LDD0082  [9]
 LDCM0109  NEM HeLa H365(0.00); H209(0.00)  LDD0223  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C289(1.21)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C289(0.98)  LDD2107  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C289(0.98)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C289(1.02)  LDD2140  [7]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase isoenzyme 6 (AK6) Adenylate kinase family Q9Y3D8
5' exonuclease Apollo (DCLRE1B) DNA repair metallo-beta-lactamase (DRMBL) family Q9H816
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
L-lactate dehydrogenase A-like 6B (LDHAL6B) LDH family Q9BYZ2
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) MsrB Met sulfoxide reductase family Q9Y3D2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calnexin (CANX) Calreticulin family P27824
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein D4-like 6 (FOXD4L6) . Q3SYB3
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Mediator of RNA polymerase II transcription subunit 28 (MED28) Mediator complex subunit 28 family Q9H204
Histone deacetylase complex subunit SAP30 (SAP30) SAP30 family O75446
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
RING1 and YY1-binding protein (RYBP) . Q8N488
Tetratricopeptide repeat protein 33 (TTC33) . Q6PID6
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
20 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
21 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402