Details of the Target

General Information of Target

Target ID LDTP01420
Target Name Serine/threonine-protein kinase 10 (STK10)
Gene Name STK10
Gene ID 6793
Synonyms
LOK; Serine/threonine-protein kinase 10; EC 2.7.11.1; Lymphocyte-oriented kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA
LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA
IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL
NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN
KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE
SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDA
RIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGP
SKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV
SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ
EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM
KKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRRE
ICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKE
REQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKI
KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK
ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFF
PYSSADAS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Cell membrane
Function
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Uniprot ID
O94804
Ensemble ID
ENST00000176763.10
HGNC ID
HGNC:11388
ChEMBL ID
CHEMBL3981

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.63  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
STPyne
 Probe Info  		K17(6.98); K181(6.25); K251(0.25); K605(6.10)  LDD0277  [3]
ONAyne
 Probe Info  		K955(10.00)  LDD0275  [3]
BTD
 Probe Info  		C722(0.94)  LDD2096  [4]
AHL-Pu-1
 Probe Info  		C888(2.95)  LDD0170  [5]
DBIA
 Probe Info  		C487(1.10); C491(1.10)  LDD0078  [6]
ATP probe
 Probe Info  		K65(0.00); K159(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C888(0.00); C138(0.00); C947(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C888(0.00); C947(0.00); C138(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C138(0.00); C947(0.00)  LDD0037  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
ENE
 Probe Info  		C947(0.00); C888(0.00)  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		C888(0.00); C947(0.00)  LDD0007  [11]
YN-1
 Probe Info  		N.A.  LDD0447  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		10.80  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-3
 Probe Info  		2.70  LDD0074  [16]
DFG-out-4
 Probe Info  		11.00  LDD0075  [16]
Photoindomethacin
 Probe Info  		N.A.  LDD0155  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C888(2.95)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C947(2.33); C888(3.85)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C138(1.06)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C138(0.95); C88(0.86)  LDD1508  [18]
 LDCM0216  AC100 HCT 116 C487(0.84); C491(0.84)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C487(0.84); C491(0.84)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C487(1.00); C491(1.00)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C487(1.19); C491(1.19)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C487(1.01); C491(1.01)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C487(1.18); C491(1.18)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C487(1.08); C491(1.08)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C487(1.07); C491(0.98)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C487(1.13); C491(0.91)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C487(0.89); C491(0.96)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C138(1.16); C88(0.89)  LDD1509  [18]
 LDCM0227  AC110 HCT 116 C487(0.85); C491(0.95)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C487(0.92); C491(0.94)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C487(1.10); C491(0.94)  LDD0546  [6]
 LDCM0237  AC12 HEK-293T C138(0.95)  LDD1510  [18]
 LDCM0246  AC128 HCT 116 C487(1.17); C491(1.17)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C487(0.91); C491(0.91)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C487(1.19); C491(1.19)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C487(1.22); C491(1.22)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C487(0.73); C491(0.73)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C487(1.12); C491(1.12)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C487(0.93); C491(0.93)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C487(1.13); C491(1.13)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C487(0.97); C491(0.97)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C487(0.89); C491(0.89)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C487(0.84); C491(0.84)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C487(1.03); C491(1.03)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C138(1.09); C947(1.43); C88(1.04)  LDD1512  [18]
 LDCM0260  AC140 HCT 116 C487(0.90); C491(0.90)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C487(1.02); C491(1.02)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C487(0.70); C491(0.70)  LDD0579  [6]
 LDCM0270  AC15 HEK-293T C138(1.02); C88(1.01)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C138(0.82)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C138(1.11); C88(0.94)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C138(1.02); C88(1.03)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C138(1.07); C88(1.17)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C138(0.89)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C728(0.96); C138(0.95); C947(0.93); C88(1.32)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C138(1.02); C947(1.03); C88(0.95)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C138(1.05); C88(1.00)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C138(1.00); C88(1.03)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C138(0.92)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C138(1.12); C88(0.83)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C138(0.98); C88(0.91)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C138(0.87)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C728(1.01); C138(1.01); C947(1.02); C88(1.09)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C138(1.05); C88(0.99)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C138(0.99); C947(1.05); C88(0.90)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C138(1.03); C88(1.07)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C138(0.99); C88(0.81)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C138(1.08)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C138(0.94); C88(0.86)  LDD1534  [18]
 LDCM0296  AC35 HCT 116 C487(1.04); C491(1.04)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C487(1.10); C491(1.10)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C487(0.88); C491(0.88)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C487(1.11); C491(1.11)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C487(0.87); C491(0.87)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C138(0.85)  LDD1540  [18]
 LDCM0302  AC40 HCT 116 C487(1.03); C491(1.03)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C487(0.94); C491(0.94)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C487(1.10); C491(1.10)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C487(0.91); C491(0.91)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C487(0.75); C491(0.75)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C487(0.73); C491(0.73)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C138(1.03); C947(0.82); C88(1.02)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C138(1.07); C88(0.93)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C138(1.00); C88(1.03)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C138(0.84)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C728(1.02); C138(1.22); C947(0.89); C88(0.94)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C138(1.07); C88(1.22)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C138(1.28); C88(0.80)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C138(1.09)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C728(1.04); C138(1.11); C947(0.96); C88(0.99)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C138(1.22); C947(1.06); C88(0.94)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C138(0.94); C88(1.14)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C138(1.14); C88(0.93)  LDD1558  [18]
 LDCM0320  AC57 HCT 116 C487(0.67); C491(0.67)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C487(1.02); C491(1.02)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C487(0.78); C491(0.78)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C138(0.98); C947(0.90); C88(0.99)  LDD1562  [18]
 LDCM0324  AC60 HCT 116 C487(0.78); C491(0.78)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C487(0.72); C491(0.72)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C487(0.69); C491(0.69)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C487(0.65); C491(0.65)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C487(0.78); C491(0.78)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C487(0.54); C491(0.54)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C487(0.51); C491(0.51)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C487(0.53); C491(0.53)  LDD0648  [6]
 LDCM0334  AC7 HEK-293T C138(1.03); C88(0.78)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C138(0.85); C88(0.80)  LDD1569  [18]
 LDCM0349  AC83 HCT 116 C487(1.89); C491(1.89)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C487(1.82); C491(1.82)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C487(1.36); C491(1.36)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C487(1.50); C491(1.50)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C487(1.27); C491(1.27)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C487(1.67); C491(1.67)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C487(1.70); C491(1.70)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C487(1.14); C491(1.14)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C487(2.05); C491(2.05)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C487(1.94); C491(1.94)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C487(1.56); C491(1.56)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C487(1.39); C491(1.39)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C487(1.35); C491(1.35)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C487(2.04); C491(2.04)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C487(1.82); C491(1.82)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C487(1.39); C491(1.39)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C487(0.72); C491(0.72)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C722(0.86)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C728(1.05); C138(1.05); C947(0.93); C88(1.01)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C138(0.98)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C138(1.13); C88(1.10)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.93  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C487(1.10); C491(1.10)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C947(2.16); C888(1.06); C888(0.93)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C728(1.12); C138(0.94); C947(0.97); C88(1.16)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C138(1.71); C947(0.99); C88(1.63)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C138(0.93); C88(0.88)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C728(1.02); C138(0.98); C947(1.09); C88(1.11)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C138(0.98); C88(0.94)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C728(1.02); C947(0.96); C88(0.78)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C138(0.74); C88(0.92)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C728(1.06); C138(1.02); C947(1.12); C88(1.03)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C138(0.87); C88(0.77)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C728(0.94); C947(0.91); C88(0.80)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C138(0.68); C88(0.84)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C728(0.96); C138(0.96); C947(1.01); C88(1.19)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C138(1.20); C88(1.29)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C138(0.89); C88(1.33)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C728(0.98); C947(1.03); C88(0.82)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C138(0.92); C88(0.84)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C728(1.00); C138(0.98); C947(1.12); C88(1.05)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C138(1.10); C88(0.96)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C728(1.13); C947(1.04); C88(0.96)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C138(0.63); C88(0.84)  LDD1590  [18]
 LDCM0387  CL117 HCT 116 C487(0.89); C491(0.89)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C487(0.92); C491(0.92)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C487(0.82); C491(0.82)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C138(1.18); C88(1.33)  LDD1594  [18]
 LDCM0391  CL120 HCT 116 C487(1.00); C491(1.00)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C728(0.95); C138(0.98); C947(1.13); C88(1.03)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C138(1.24); C88(0.97)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C728(0.94); C947(0.94); C88(0.92)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C138(0.82); C88(1.22)  LDD1599  [18]
 LDCM0396  CL125 HCT 116 C487(0.85); C491(0.85)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C487(0.75); C491(0.75)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C487(0.83); C491(0.83)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C487(1.07); C491(1.07)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C728(1.00); C138(1.01); C947(1.04); C88(1.09)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C138(1.17); C88(1.05)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C728(0.97); C947(0.96); C88(0.86)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C138(0.84); C88(1.07)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C138(1.01)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C138(1.01); C88(0.96)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C138(1.39); C88(1.19)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C138(1.20); C88(0.90)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C138(0.90)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C728(0.91); C138(1.13); C947(0.88); C88(1.27)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C138(1.10); C947(1.18); C88(1.20)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C138(1.08); C88(1.02)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C138(1.09); C88(1.10)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C728(0.98); C138(0.93); C947(0.94); C88(1.23)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C138(1.04); C88(0.84)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C728(0.96); C947(0.99); C88(0.74)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C138(1.05); C88(0.91)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C138(0.90)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C728(1.02); C947(0.94); C88(1.14)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C138(0.95); C88(0.83)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C138(1.08); C88(1.11)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C138(0.85)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C728(0.81); C138(1.17); C947(0.82); C88(1.48)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C138(1.23); C947(0.97); C88(1.21)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C138(1.11); C88(0.97)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C138(1.07); C88(1.14)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C728(1.17); C138(1.07); C947(0.99); C88(1.16)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C728(1.02); C947(0.93); C88(0.84)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C138(0.67); C88(1.05)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C138(1.10); C88(0.90)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C138(1.07)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C138(1.03); C88(1.09)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C138(1.01); C88(0.90)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C138(0.99)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C728(0.86); C138(1.08); C947(0.99); C88(1.33)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C138(1.15); C947(0.91); C88(1.04)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C138(1.07); C88(1.01)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C138(1.07); C88(1.28)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C728(1.12); C138(0.99); C947(1.04); C88(1.35)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C138(1.05)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C138(1.25); C88(1.18)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C138(0.90); C88(1.05)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C138(1.10)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C138(0.92); C88(1.19)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C138(1.42); C88(1.12)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C138(0.99)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C728(0.95); C138(1.04); C947(0.96); C88(1.66)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C138(1.25); C947(0.94); C88(1.40)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C138(1.12); C88(0.89)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C138(1.31); C88(1.64)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C138(1.07); C88(1.09)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C728(1.11); C138(0.92); C947(1.09); C88(1.10)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C138(1.24); C88(0.92)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C728(1.18); C947(1.08); C88(0.90)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C138(0.84); C88(0.99)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C138(1.04)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C138(0.95); C88(1.15)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C138(1.62); C88(0.76)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C138(0.94)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C728(0.96); C138(1.09); C947(0.81); C88(1.39)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C138(1.07); C88(1.12)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C138(1.63); C947(1.04); C88(1.23)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C138(0.96); C88(1.50)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C138(1.10); C88(0.97)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C728(1.03); C138(0.98); C947(1.04); C88(1.23)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C138(0.88); C88(0.98)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C138(0.86); C88(0.93)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C138(0.90)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C138(1.08); C88(0.89)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C138(1.00); C88(1.08)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C138(1.35)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C138(1.10)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C728(1.05); C138(1.08); C947(0.98); C88(1.22)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C138(0.93); C947(1.20); C88(1.17)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C138(1.15); C88(1.05)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C138(1.22); C88(1.10)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C728(1.61); C138(1.02); C947(1.08); C88(1.20)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C138(1.06); C88(1.23)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C728(1.18); C947(0.95); C88(0.84)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C138(1.05); C88(0.91)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C138(1.17)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C728(1.03); C138(1.06); C947(0.88); C88(1.03)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C138(1.33); C88(0.41)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C138(1.30); C88(0.92)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C138(0.89)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C728(0.95); C138(1.11); C947(0.95); C88(1.54)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C138(1.65); C947(1.10); C88(1.08)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C138(1.19); C88(1.51)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C138(0.98); C88(1.32)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C728(0.90); C138(0.96); C947(0.96); C88(1.22)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C138(1.34); C88(1.00)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C728(1.00); C947(1.06); C88(0.85)  LDD1697  [18]
 LDCM0634  CY-0357 Hep-G2 C947(2.85); C888(0.52)  LDD2228  [10]
 LDCM0017  DFG-out-2 A431 11.00  LDD0075  [16]
 LDCM0495  E2913 HEK-293T C728(1.10); C947(1.02); C88(0.88)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C947(1.24)  LDD1702  [4]
 LDCM0625  F8 Ramos C947(0.64)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C947(0.45)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C947(0.39)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C947(0.63)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C947(0.50)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C947(0.23)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C947(1.23)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C947(0.44)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C947(0.89)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C947(0.46)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C947(0.86)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C947(0.43)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C947(0.81)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C728(1.08); C947(1.00); C88(0.95)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C947(0.56)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C947(0.66)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C138(1.02); C88(0.83)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C947(0.67)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C947(0.47)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C947(0.43)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C947(0.41)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C487(2.89); C491(2.89)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C487(1.34); C491(1.34)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C487(2.90); C491(2.90)  LDD0082  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C722(0.81)  LDD2121  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C722(0.94)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C722(0.85)  LDD2098  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C722(1.08)  LDD2118  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C138(2.32)  LDD2136  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C947(0.07)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C947(1.43)  LDD0304  [21]
 LDCM0016  Ranjitkar_cp1 A431 2.70  LDD0074  [16]
 LDCM0021  THZ1 HCT 116 C487(1.32); C491(1.32)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase 10 (STK10) STE Ser/Thr protein kinase family O94804

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
17 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.