Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DFG-out-3  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Ranjitkar_cp1  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Skin
Disease Model Skin squamous cell carcinoma [ICD-11:2C31]
Model Name Human skin squamous cell carcinoma cell lysate (A431)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03992  Tyrosine-protein kinase FRK (FRK) 100.0
 LDTP04631  Ephrin type-B receptor 4 (EPHB4) 35.0
 LDTP03445  Mitogen-activated protein kinase 1 (MAPK1) 19.0
 LDTP03474  Ephrin type-A receptor 2 (EPHA2) 15.0
 LDTP03477  Ephrin type-B receptor 2 (EPHB2) 15.0
 LDTP02638  Proto-oncogene tyrosine-protein kinase Src (SRC) 14.0
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 10.5
 LDTP03008  Spermidine synthase (SRM) 9.9
 LDTP05996  Protein-tyrosine kinase 6 (PTK6) 7.7
 LDTP13056  Leucine--tRNA ligase, cytoplasmic (LARS1) 4.3
 LDTP12148  UDP-glucuronosyltransferase 1A10 (UGT1A10) 4.0
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 3.9
 LDTP04319  Glycogen synthase kinase-3 beta (GSK3B) 3.6
 LDTP06100  Protein-tyrosine kinase 2-beta (PTK2B) 2.7
 LDTP01420  Serine/threonine-protein kinase 10 (STK10) 2.7
 LDTP05453  Focal adhesion kinase 1 (PTK2) 2.5
 LDTP04584  Mitogen-activated protein kinase 10 (MAPK10) 2.5
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 2.4
 LDTP02149  Cyclin-dependent kinase 1 (CDK1) 2.1
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 2.0
 LDTP07975  Serine/threonine-protein kinase TAO1 (TAOK1) 2.0
 LDTP03944  Tyrosine-protein kinase CSK (CSK) 2.0
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12533  Ubiquilin-4 (UBQLN4) 2.1
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13110  Coatomer subunit gamma-2 (COPG2) 7.9
 LDTP11212  Tubulin-specific chaperone D (TBCD) 4.9
 LDTP03557  Leukocyte elastase inhibitor (SERPINB1) 2.5
 LDTP16716  Putative peripheral benzodiazepine receptor-related protein (TSPO) 2.1

References

1 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.