Details of the Target

General Information of Target

Target ID LDTP12533
Target Name Ubiquilin-4 (UBQLN4)
Gene Name UBQLN4
Gene ID 56893
Synonyms
C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPS
TTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPM
PPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGR
GERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRS
PSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSEN
YYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESS
SESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI
FEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELY
DWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIA
NMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPA
QLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTV
ELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHP
SHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPS
RINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDR
FMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLN
YPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTL
GHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYA
ITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWND
PKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQA
EMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK
Target Bioclass
Transporter and channel
Subcellular location
Nucleus
Function
Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.
Uniprot ID
Q9NRR5
Ensemble ID
ENST00000368309.4
HGNC ID
HGNC:1237

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.T123I .
CCK81 SNV: p.S336Ter .
HCT15 SNV: p.Q395H .
JURKAT SNV: p.Q206Ter; p.L251F .
MOLT4 SNV: p.R216C .
NCIH446 SNV: p.R284L .
SNU1 Deletion: p.S100PfsTer72 .
SW1116 SNV: p.S135R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.14  LDD0402  [1]
TH211
 Probe Info  		Y279(9.19)  LDD0260  [2]
TH214
 Probe Info  		Y279(11.72)  LDD0258  [2]
TH216
 Probe Info  		Y286(20.00); Y279(15.22)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		E260(10.00)  LDD2208  [4]
Probe 1
 Probe Info  		Y279(19.34); Y286(19.62)  LDD3495  [5]
BTD
 Probe Info  		C29(0.99)  LDD2091  [6]
DA-P3
 Probe Info  		5.78  LDD0180  [7]
AHL-Pu-1
 Probe Info  		C29(2.88)  LDD0169  [8]
HHS-482
 Probe Info  		Y279(0.84)  LDD0285  [9]
HHS-475
 Probe Info  		Y286(0.43); Y279(0.93)  LDD0264  [10]
HHS-465
 Probe Info  		Y279(9.16); Y286(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C29(0.96)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_5
 Probe Info  		N.A.  LDD2224  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C235
 Probe Info  		22.47  LDD1908  [20]
FFF probe11
 Probe Info  		18.62  LDD0471  [21]
FFF probe12
 Probe Info  		12.22  LDD0473  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
DFG-out-3
 Probe Info  		2.10  LDD0074  [22]
Kambe_3
 Probe Info  		2.00  LDD0130  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C29(1.12)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C29(0.96)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C29(0.66)  LDD2103  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C29(2.88)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C29(1.06)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C29(0.87)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C29(1.01)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C29(1.02)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C29(0.93)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C29(1.21)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C29(0.99)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C29(1.13)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C29(1.14)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C29(0.97)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C29(1.06)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C29(0.88)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C29(1.02)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C29(0.96)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C29(0.94)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C29(1.06)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C29(1.02)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C29(1.30)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C29(1.22)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C29(1.31)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C29(1.15)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C29(1.15)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C29(1.17)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C29(0.85)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C29(1.04)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C29(1.16)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C29(1.19)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C29(1.04)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C29(1.08)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C29(1.27)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C29(1.29)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C29(1.50)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C29(0.82)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C29(1.02)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C29(1.03)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C29(1.04)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C29(1.13)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C29(1.07)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C29(1.17)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C29(0.96)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C29(1.10)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C29(1.09)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C29(1.22)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C29(1.23)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C29(0.86)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C29(1.33)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C29(1.32)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C29(1.00)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C29(1.20)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C29(1.43)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C29(1.26)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C29(1.57)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C29(1.46)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C29(2.00)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C29(1.70)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C29(0.91)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C29(1.04)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C29(1.15)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C29(1.41)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C29(2.06)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C29(1.43)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C29(1.39)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C29(1.04)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C29(1.00)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C29(1.20)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C29(1.26)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C29(1.24)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C29(1.24)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C29(0.99)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C29(1.08)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C29(1.15)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C29(1.17)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C29(1.13)  LDD0601  [12]
 LDCM0285  AC25 HEK-293T C29(0.92)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C29(0.91)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C29(0.94)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C29(0.79)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C29(0.83)  LDD0887  [12]
 LDCM0290  AC3 HCT 116 C29(1.02)  LDD0607  [12]
 LDCM0291  AC30 HEK-293T C29(0.85)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C29(0.87)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C29(0.90)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C29(0.93)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C29(0.94)  LDD0893  [12]
 LDCM0296  AC35 HCT 116 C29(1.01)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C29(1.06)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C29(0.87)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C29(1.09)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C29(1.09)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C29(1.23)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C29(1.21)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C29(1.17)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C29(1.09)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C29(1.08)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C29(1.06)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C29(1.31)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C29(1.21)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C29(1.07)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C29(1.12)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C29(1.15)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C29(1.25)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C29(1.14)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C29(1.02)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C29(1.02)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C29(1.03)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C29(0.97)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C29(0.95)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C29(1.05)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C29(1.56)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C29(1.65)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C29(1.83)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C29(1.08)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C29(1.60)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C29(1.41)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C29(1.66)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C29(1.58)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C29(1.69)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C29(1.64)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C29(1.63)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C29(1.81)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C29(0.99)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C29(1.05)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C29(0.96)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C29(1.27)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C29(1.06)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C29(1.09)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C29(1.37)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C29(1.37)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C29(1.50)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C29(1.23)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C29(1.24)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C29(0.96)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C29(1.10)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C29(1.02)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C29(1.03)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C29(1.12)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C29(1.68)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C29(1.59)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C29(1.43)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C29(1.48)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C29(1.36)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C29(1.02)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C29(1.23)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C29(1.12)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C29(0.93)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C29(1.27)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C29(1.11)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C29(0.92)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C29(0.80)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C29(0.89)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C29(0.94)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C29(1.33)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C29(1.30)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C29(1.02)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C29(0.81)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C29(1.02)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C29(1.19)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 13.56  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C29(0.96)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C29(0.99)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C29(0.89)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C29(0.98)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C29(1.26)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C29(1.21)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C29(1.03)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C29(0.94)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C29(1.06)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C29(1.04)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C29(1.08)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C29(0.99)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C29(1.14)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C29(1.14)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C29(1.20)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C29(1.36)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C29(1.20)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C29(1.28)  LDD0698  [12]
 LDCM0382  CL112 HEK-293T C29(1.04)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C29(0.84)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C29(0.87)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C29(1.00)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C29(0.85)  LDD0984  [12]
 LDCM0387  CL117 HCT 116 C29(1.49)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C29(0.98)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C29(1.13)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C29(1.23)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C29(1.05)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C29(1.01)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C29(0.95)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C29(0.96)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C29(1.05)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C29(1.23)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C29(1.24)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C29(1.23)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C29(1.56)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C29(1.16)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C29(0.89)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C29(1.34)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C29(1.26)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C29(1.44)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C29(1.41)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C29(1.06)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C29(1.11)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C29(1.39)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C29(1.61)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C29(2.07)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C29(1.20)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C29(1.38)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C29(1.30)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C29(1.18)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C29(1.32)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C29(1.27)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C29(1.58)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C29(0.93)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C29(1.14)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C29(1.21)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C29(1.13)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C29(1.08)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C29(0.93)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C29(1.07)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C29(1.01)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C29(1.00)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C29(0.97)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C29(1.39)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C29(1.21)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C29(0.97)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C29(1.05)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C29(1.01)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C29(0.93)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C29(0.96)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C29(0.90)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C29(0.89)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C29(0.86)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C29(0.85)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C29(1.06)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C29(0.97)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C29(1.01)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C29(0.97)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C29(1.03)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C29(0.91)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C29(0.88)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C29(1.10)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C29(0.96)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C29(0.86)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C29(0.97)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C29(1.16)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C29(1.01)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C29(1.06)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C29(1.09)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C29(1.03)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C29(1.10)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C29(0.96)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C29(1.29)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C29(1.15)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C29(1.14)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C29(1.07)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C29(1.25)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C29(0.92)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C29(1.10)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C29(1.01)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C29(1.10)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C29(1.23)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C29(1.12)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C29(1.11)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C29(1.32)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C29(1.56)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C29(1.16)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C29(1.09)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C29(1.27)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C29(1.52)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C29(1.55)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C29(1.90)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C29(1.29)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C29(1.19)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C29(1.44)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C29(1.45)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C29(1.70)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C29(1.37)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C29(1.49)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C29(1.30)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C29(1.32)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C29(1.08)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C29(1.69)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C29(1.59)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C29(1.19)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C29(1.19)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C29(1.43)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C29(1.23)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C29(0.80)  LDD2228  [16]
 LDCM0028  Dobutamine HEK-293T 5.78  LDD0180  [7]
 LDCM0495  E2913 HEK-293T C29(1.63)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C29(1.34)  LDD1702  [6]
 LDCM0625  F8 Ramos C29(1.78)  LDD2187  [25]
 LDCM0573  Fragment11 Ramos C29(0.13)  LDD2190  [25]
 LDCM0576  Fragment14 Ramos C29(0.93)  LDD2193  [25]
 LDCM0468  Fragment33 HCT 116 C29(1.08)  LDD0785  [12]
 LDCM0566  Fragment4 Ramos C29(0.75)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C29(1.12)  LDD0744  [12]
 LDCM0569  Fragment7 Ramos C29(1.66)  LDD2186  [25]
 LDCM0116  HHS-0101 DM93 Y286(0.43); Y279(0.93)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y279(0.85)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y279(0.84)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y279(0.94)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y279(1.09); Y286(4.94)  LDD0268  [10]
 LDCM0123  JWB131 DM93 Y279(0.84)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y279(0.65)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y279(1.10)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y279(2.42)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y279(2.04)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y279(1.02)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y279(0.54)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y279(0.94)  LDD0292  [9]
 LDCM0074  Kambe_cp66 PC-3 2.00  LDD0130  [23]
 LDCM0022  KB02 HCT 116 C29(3.44)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C29(1.29)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C29(1.42)  LDD0082  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C29(1.03)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C29(0.88)  LDD2104  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C29(0.97)  LDD2107  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C29(0.94)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C29(0.39)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C29(1.92)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C29(1.43)  LDD2119  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C29(0.97)  LDD2123  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C29(0.72)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C29(0.62)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C29(0.86)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C29(0.88)  LDD2137  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C29(0.87)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C29(1.30)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C29(1.64)  LDD2144  [6]
 LDCM0029  Quercetin HEK-293T 9.46  LDD0181  [7]
 LDCM0131  RA190 MM1.R C29(1.21)  LDD0304  [26]
 LDCM0016  Ranjitkar_cp1 A431 2.10  LDD0074  [22]
 LDCM0021  THZ1 HCT 116 C29(1.17)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) FKBP-type PPIase family P26885
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-4 (UBQLN4) . Q9NRR5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor RHIT (ZNF205) Krueppel C2H2-type zinc-finger protein family O95201
Protein AF-17 (MLLT6) . P55198
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Ataxin-1 (ATXN1) ATXN1 family P54253
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
23 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.