Details of the Target

General Information of Target

Target ID LDTP16716
Target Name Putative peripheral benzodiazepine receptor-related protein (TSPO)
Gene Name TSPO
Synonyms
PBRS; Putative peripheral benzodiazepine receptor-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLKQGSFLWYLYLDKIYCLLSVRNVKALAEYFHILDVHGKNTLNDVLFYHFLHHVTDLK
KAQINIVFDMLDWNAVGEIDFEKFYMLVCMLLAHQNHLEGQFMYRHSRPVFDLLDLKGDL
RIGAKNFEMYRFLFNIQKQELKDLFRDFDITGDNRLNYQEFKLYTIIYTDKLQKRQKTEE
KEKGERKRSLYSKCHIK
Target Bioclass
Other
Uniprot ID
B1AH88
HGNC ID
HGNC:1158

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C19(1.88)  LDD3345  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-3
 Probe Info  		2.10  LDD0074  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C19(2.96)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C19(2.75)  LDD2660  [1]
 LDCM0024  KB05 NCI-H1650 C19(1.88)  LDD3345  [1]
 LDCM0016  Ranjitkar_cp1 A431 2.10  LDD0074  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.