Details of the Target

General Information of Target

Target ID LDTP03944
Target Name Tyrosine-protein kinase CSK (CSK)
Gene Name CSK
Gene ID 1445
Synonyms
Tyrosine-protein kinase CSK; EC 2.7.10.2; C-Src kinase; Protein-tyrosine kinase CYL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
Subcellular location
Cytoplasm
Function
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
TTD ID
T08741
Uniprot ID
P41240
DrugMap ID
TTX6F0Q
Ensemble ID
ENST00000220003.14
HGNC ID
HGNC:2444
ChEMBL ID
CHEMBL2634

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y64(17.19)  LDD0257  [3]
TH216
 Probe Info  		Y64(16.09)  LDD0259  [3]
STPyne
 Probe Info  		K196(2.38); K347(10.00); K393(10.00); K401(8.33)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y48(31.06); Y64(14.09); Y184(7.45); Y214(13.62)  LDD3495  [5]
Dasatinib-CA-4PAP
 Probe Info  		16.06  LDD0270  [6]
BTD
 Probe Info  		C223(0.28)  LDD2089  [7]
WP
 Probe Info  		2.49  LDD0192  [8]
DA-P3
 Probe Info  		4.67  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C31(2.33)  LDD0169  [10]
HHS-482
 Probe Info  		Y64(0.99)  LDD0285  [11]
HHS-475
 Probe Info  		Y18(0.84); Y64(0.89); Y97(0.89); Y184(0.90)  LDD0264  [12]
HHS-465
 Probe Info  		Y133(1.65); Y18(10.00); Y184(10.00); Y64(7.26)  LDD2237  [13]
DBIA
 Probe Info  		C31(1.14)  LDD0078  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		K337(0.00); K347(0.00); K351(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C299(0.00); C411(0.00); C422(0.00); C290(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C223(0.00); C299(0.00); C164(0.00); C411(0.00)  LDD0036  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		C299(0.00); C164(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C223(0.00); C299(0.00); C164(0.00); C411(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
KY-26
 Probe Info  		N.A.  LDD0301  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
IPM
 Probe Info  		C290(0.00); C31(0.00)  LDD0005  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
PPMS
 Probe Info  		N.A.  LDD0008  [20]
SF
 Probe Info  		K222(0.00); Y64(0.00)  LDD0028  [24]
TFBX
 Probe Info  		C290(0.00); C31(0.00)  LDD0148  [25]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
1c-yne
 Probe Info  		K203(0.00); K225(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		N.A.  LDD0217  [28]
W1
 Probe Info  		C411(0.00); C31(0.00)  LDD0236  [29]
AOyne
 Probe Info  		14.10  LDD0443  [30]
NAIA_5
 Probe Info  		C299(0.00); C290(0.00); C422(0.00); C31(0.00)  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.25  LDD0472  [32]
FFF probe13
 Probe Info  		13.03  LDD0475  [32]
FFF probe2
 Probe Info  		6.02  LDD0463  [32]
Dasatinib-CA-8PAP
 Probe Info  		8.83  LDD0364  [6]
DFG-out-3
 Probe Info  		2.00  LDD0074  [33]
DFG-out-4
 Probe Info  		8.80  LDD0075  [33]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [34]
DA-2
 Probe Info  		N.A.  LDD0070  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C290(0.44)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C290(0.63)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C290(1.07)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C31(2.72)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C31(2.33)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C290(1.03); C31(1.05); C422(1.02)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C119(0.43); C122(0.43); C290(1.09); C411(0.79)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C119(0.44); C122(0.44); C290(1.02); C31(0.90)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C119(0.42); C122(0.42); C290(1.08); C31(0.95)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C119(0.54); C122(0.54); C290(1.13); C31(1.09)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C119(0.23); C122(0.23); C290(1.26); C31(1.23)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C119(0.53); C122(0.53); C290(1.04); C31(1.22)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C119(0.31); C122(0.31); C290(1.17); C31(1.13)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C119(0.31); C122(0.31); C290(1.25); C31(1.15)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C119(0.36); C122(0.36); C290(1.25); C31(0.69)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C119(0.48); C122(0.43); C290(1.02); C31(0.75)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C119(0.62); C122(0.60); C290(0.84); C31(0.79)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C119(0.47); C122(0.47); C290(1.23); C411(0.73)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C119(0.47); C122(0.47); C290(1.11); C31(0.87)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C119(0.43); C122(0.43); C290(1.11); C31(0.89)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C119(0.33); C122(0.37); C290(1.27); C31(0.89)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C119(1.31); C122(1.31); C290(0.95); C31(0.99)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C119(1.18); C122(1.14); C290(1.13); C31(1.05)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C119(1.08); C122(1.08); C290(1.45); C31(1.25)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C119(1.10); C122(1.11); C290(1.62); C31(1.17)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C119(1.09); C122(1.12); C290(1.23); C31(1.12)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C119(1.26); C122(1.29); C290(1.23); C31(1.02)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C119(1.05); C122(0.98); C290(1.26); C31(1.24)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C119(0.77); C122(0.77); C290(1.09); C411(0.93)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C119(0.99); C122(0.94); C290(1.38); C31(1.40)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C119(1.48); C122(1.51); C290(1.24); C31(1.05)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C119(1.29); C122(1.27); C290(1.25); C31(0.89)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C119(1.84); C122(1.66); C290(1.17); C31(1.04)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C119(1.60); C122(1.64); C290(1.03); C31(0.93)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C119(1.27); C122(1.25); C290(1.19); C31(0.96)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C119(1.64); C122(1.65); C290(1.36); C31(1.13)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C119(1.45); C122(1.44); C290(1.38); C31(1.06)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C119(0.81); C122(0.81); C290(1.24); C411(1.08)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C119(1.12); C122(1.12); C290(0.94); C411(1.03)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C119(0.67); C122(0.67); C290(1.26); C411(0.91)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C119(1.13); C122(1.13); C290(1.07); C411(1.02)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C119(1.24); C122(1.24); C290(1.15); C411(1.02)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C119(0.88); C122(0.88); C290(1.21); C411(1.06)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C119(0.68); C122(0.68); C290(1.26); C411(0.91)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C119(0.69); C122(0.69); C290(1.31); C411(0.93)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C119(0.79); C122(0.79); C290(1.23); C411(0.88)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C119(0.89); C122(0.89); C290(1.32); C411(0.93)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C119(0.65); C122(0.65); C290(1.58); C411(0.86)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C119(0.77); C122(0.77); C290(1.40); C411(0.84)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C119(0.53); C122(0.53); C290(1.08); C411(0.70)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C119(0.65); C122(0.65); C290(1.58); C411(0.78)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C119(0.66); C122(0.66); C290(1.48); C411(0.81)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C119(1.07); C122(1.07); C290(1.31); C411(0.92)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C119(0.85); C122(0.81); C290(1.14); C31(1.17)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C122(0.49); C119(0.60); C290(1.25); C422(1.53)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C122(0.79); C119(0.91); C422(1.11); C290(1.15)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C122(0.67); C119(0.89); C290(1.27); C422(1.33)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C122(0.55); C119(0.67); C422(1.30); C31(1.40)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C122(0.62); C119(0.87); C422(1.55); C290(1.84)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C122(0.46); C119(0.47); C422(1.36); C290(1.44)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C119(0.52); C122(0.52); C411(0.80); C422(0.91)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C122(0.65); C119(0.72); C290(1.23); C422(1.30)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C122(0.77); C119(0.92); C290(1.13); C422(1.25)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C122(0.53); C119(0.64); C290(1.27); C422(1.55)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C122(0.48); C119(0.58); C422(1.61); C290(2.01)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C119(1.07); C122(0.77); C290(1.37); C31(1.44)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C119(1.02); C122(0.75); C290(1.31); C31(1.33)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C119(0.94); C122(0.86); C290(1.13); C31(1.28)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C119(1.55); C122(1.17); C290(1.07); C31(0.89)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C31(0.76); C411(0.94); C422(1.00); C290(1.02)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C31(0.62); C411(0.65); C290(0.73); C422(1.03)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C31(0.66); C411(0.75); C290(0.95); C422(1.07)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C422(0.90); C290(0.94); C31(0.96)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C422(0.76); C290(0.84); C411(0.87); C31(0.91)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C31(0.73); C290(0.75); C422(0.77); C411(0.92)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C31(0.79); C411(0.91); C422(0.91); C290(0.93)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C31(0.80); C411(0.88); C290(0.94); C422(0.97)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C31(0.70); C290(1.07); C422(1.12); C411(1.12)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C411(0.74); C422(0.96); C290(1.01); C31(1.08)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C411(0.76); C122(0.88); C422(0.96); C290(1.27)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C411(0.76); C122(0.82); C422(0.96); C290(1.21)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C411(0.85); C422(0.87); C290(1.21); C122(1.22)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C122(0.67); C411(0.76); C422(0.87); C290(1.03)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C31(0.94); C290(0.95); C422(0.98)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C411(0.68); C122(0.69); C422(0.73); C290(1.05)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C122(0.75); C422(0.90); C411(0.97); C290(1.06)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C122(0.69); C422(0.78); C411(0.83); C31(1.54)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C411(0.69); C422(0.78); C122(1.04); C290(1.34)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C411(0.63); C422(0.70); C122(0.93); C290(1.30)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C31(0.88); C290(1.03); C411(1.04); C422(1.05)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C31(0.88); C411(0.92); C422(0.94); C290(1.02)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C31(0.71); C411(0.94); C422(1.18); C290(1.30)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C31(0.86); C411(0.91); C422(1.03); C290(1.10)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C422(0.83); C411(0.95); C119(0.96); C122(0.96)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C290(0.86); C31(0.95); C422(1.01)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C119(0.86); C411(0.87); C122(0.87); C31(1.00)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C31(0.81); C411(0.90); C422(0.99); C119(1.07)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C411(0.83); C31(0.92); C422(0.99); C290(1.04)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C31(0.86); C411(0.86); C122(0.91); C119(0.96)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C411(0.89); C31(0.91); C422(1.05); C119(1.06)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C119(0.79); C411(0.85); C422(0.87); C31(0.90)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C122(0.85); C119(0.89); C31(0.93); C422(0.98)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C122(0.81); C119(0.84); C411(0.88); C31(0.98)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C122(0.75); C119(0.80); C411(0.81); C31(0.86)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C119(0.40); C122(0.42); C411(0.59); C422(0.97)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C290(0.95); C422(0.97); C31(1.03)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C119(0.44); C122(0.46); C411(0.67); C31(0.98)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C31(0.64); C422(1.07); C290(1.08); C411(1.25)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C122(0.82); C119(0.85); C31(0.85); C422(0.88)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C411(0.70); C119(0.73); C122(0.74); C31(1.02)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C122(0.63); C119(0.65); C411(0.76); C422(1.04)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C411(0.73); C119(0.73); C122(0.73); C31(1.11)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C119(0.48); C122(0.49); C411(0.59); C422(1.03)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C122(0.24); C119(0.25); C290(0.83); C31(0.85)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C119(0.17); C122(0.19); C290(0.75); C411(0.79)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C119(0.17); C122(0.19); C290(0.82); C411(0.94)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C119(0.49); C122(0.49); C422(0.84); C411(0.93)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C119(0.16); C122(0.17); C290(0.75); C422(0.90)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C122(0.20); C119(0.21); C422(0.85); C31(0.96)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C119(0.16); C122(0.17); C290(0.81); C31(0.83)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C119(0.18); C122(0.18); C422(0.69); C290(0.83)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C119(0.14); C122(0.15); C422(0.79); C290(0.86)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C119(0.18); C122(0.20); C411(0.89); C31(1.01)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C119(0.21); C122(0.23); C31(0.89); C411(0.99)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C119(0.09); C122(0.10); C290(0.61); C422(0.84)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C119(0.66); C122(0.69); C422(0.87); C31(1.02)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C119(0.67); C122(0.69); C31(0.96); C422(1.04)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C119(0.55); C122(0.55); C411(0.80); C422(0.98)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C119(0.55); C122(0.59); C422(0.86); C31(0.93)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C119(0.84); C122(0.89); C31(0.91); C422(1.01)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C119(0.67); C122(0.73); C422(0.88); C31(0.98)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C119(0.52); C122(0.55); C422(0.75); C31(1.09)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C119(0.59); C122(0.61); C31(1.06); C422(1.20)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C119(0.47); C122(0.50); C31(0.85); C422(0.91)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C119(0.64); C122(0.68); C422(0.84); C31(0.95)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C119(0.56); C122(0.60); C422(0.90); C31(0.97)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C119(0.79); C122(0.83); C422(0.91); C290(1.12)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C119(0.77); C122(0.82); C422(0.87); C31(0.91)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C119(0.59); C122(0.59); C422(1.00); C411(1.03)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C119(0.71); C422(0.75); C122(0.76); C31(1.08)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C422(0.87); C31(0.90); C119(0.98); C290(1.04)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C119(0.61); C122(0.65); C422(0.75); C31(0.94)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C119(0.37); C122(0.37); C411(0.45); C422(1.40)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C119(0.39); C122(0.39); C411(0.48); C290(1.34)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C411(0.46); C119(0.51); C122(0.51); C290(1.16)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C411(0.50); C119(0.57); C122(0.57); C31(1.20)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C411(0.48); C119(0.63); C122(0.63); C31(1.03)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C411(0.49); C119(0.58); C122(0.58); C290(1.09)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C411(0.51); C119(0.52); C122(0.52); C422(1.18)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C411(0.44); C31(0.84); C422(1.07); C290(1.07)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C411(0.61); C119(0.61); C122(0.61); C422(1.21)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C119(0.46); C122(0.46); C411(0.47); C290(1.25)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C411(0.54); C119(0.57); C122(0.57); C290(1.12)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C411(0.83); C119(0.95); C122(0.95); C290(0.97)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C411(0.45); C119(0.54); C122(0.54); C422(1.04)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C119(0.74); C122(0.74); C411(0.75); C290(1.08)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C411(0.41); C119(0.47); C122(0.47); C422(1.00)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C411(0.16); C119(0.18); C122(0.18); C422(0.71)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C119(0.46); C122(0.46); C411(0.63); C422(0.72)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C223(0.18)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C119(0.71); C122(0.71); C290(1.05); C411(1.24)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C119(0.53); C122(0.53); C411(0.78); C422(0.98)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C119(0.21); C122(0.21); C411(0.54); C422(0.88)  LDD0592  [14]
 LDCM0020  ARS-1620 HCC44 C31(1.14)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C223(0.33)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C290(20.00); C14(3.16); C422(1.62)  LDD2227  [31]
 LDCM0367  CL1 HCT 116 C411(0.90); C290(0.95); C422(0.96); C119(1.04)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C122(0.29); C119(0.45); C411(0.82); C290(0.94)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C422(0.92); C290(0.99); C31(1.02)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C119(0.43); C122(0.43); C411(0.85); C290(1.04)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C119(0.66); C122(0.66); C422(0.94); C290(1.16)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C119(0.76); C122(0.76); C411(1.01); C290(1.05)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C119(0.65); C122(0.65); C422(0.85); C290(0.95)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C31(0.77); C290(0.80); C411(0.87); C422(0.95)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C411(0.47); C290(0.66); C31(0.77); C422(1.14)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C411(0.61); C290(0.66); C31(0.76); C422(1.13)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C411(0.61); C31(0.78); C290(0.80); C422(1.12)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C411(0.73); C31(0.87); C422(1.02); C290(1.13)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C122(0.22); C119(0.48); C422(0.76); C31(0.83)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C411(0.53); C31(0.94); C422(1.14); C290(1.75)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C411(0.83); C31(1.11); C422(1.12); C290(1.27)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C122(0.81); C411(0.95); C422(0.96); C31(1.18)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C122(0.69); C422(0.76); C411(0.83); C290(1.15)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C122(0.72); C422(0.81); C31(0.94); C411(0.95)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C422(0.83); C411(0.86); C122(0.93); C31(1.31)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C411(0.82); C422(0.88); C122(0.93); C31(1.16)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C119(0.58); C122(0.58); C411(0.75); C422(0.75)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C422(0.82); C411(0.84); C119(0.94); C122(0.97)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C411(0.80); C422(0.83); C122(0.88); C119(0.89)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C122(0.21); C119(0.44); C31(0.96); C411(0.99)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C31(0.77); C411(0.90); C422(1.01); C119(1.06)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C411(0.74); C422(0.92); C31(0.98); C290(1.02)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C119(0.63); C122(0.65); C411(0.72); C422(0.90)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C119(0.66); C122(0.68); C422(0.83); C411(0.93)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C119(0.50); C122(0.51); C411(0.71); C422(0.94)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C422(0.70); C122(0.78); C119(0.84); C31(0.96)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C119(0.68); C122(0.71); C411(0.80); C290(1.00)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C119(0.46); C122(0.47); C411(0.93); C31(1.03)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C119(0.20); C122(0.21); C290(0.72); C422(0.77)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C122(0.25); C119(0.46); C31(0.87); C290(0.95)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C122(0.56); C119(0.68); C31(0.89); C411(0.93)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C122(0.36); C119(0.51); C31(0.70); C411(0.86)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C411(0.70); C119(0.74); C122(0.74); C290(1.12)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C422(0.56); C119(0.71); C122(0.71); C411(0.90)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C119(0.39); C122(0.39); C411(0.68); C422(0.75)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C119(0.49); C122(0.49); C411(0.87); C422(0.88)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C119(0.90); C122(0.94); C31(0.96); C422(0.97)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C119(0.31); C122(0.31); C422(0.74); C411(0.83)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C119(0.26); C122(0.26); C422(0.67); C411(0.76)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C119(0.23); C122(0.23); C411(0.75); C422(1.08)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C119(0.43); C122(0.43); C411(0.79); C422(0.84)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C119(0.26); C122(0.26); C411(0.69); C31(1.04)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C119(0.33); C122(0.33); C31(0.90); C411(0.63)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C119(0.44); C122(0.44); C31(1.13); C411(0.67)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C119(0.50); C122(0.50); C31(1.09); C411(0.81)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C119(0.40); C122(0.40); C31(1.13); C411(0.68)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C119(0.37); C122(0.37); C31(1.18); C411(0.74)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C119(0.70); C122(0.68); C290(0.87); C31(1.05)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C119(0.63); C122(0.63); C31(1.11); C411(0.75)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C119(0.76); C122(0.80); C290(0.90); C31(0.99)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C119(0.71); C122(0.76); C290(1.18); C31(0.80)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C119(0.63); C122(0.67); C290(1.04); C31(0.83)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C119(0.59); C122(0.62); C290(0.92); C31(0.83)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C119(0.52); C122(0.56); C290(1.11); C31(1.30)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C119(0.56); C122(0.59); C290(1.07); C31(1.10)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C119(0.53); C122(0.56); C290(1.02); C31(1.23)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C119(0.72); C122(0.75); C290(1.17); C31(1.04)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C119(0.68); C122(0.60); C290(0.95); C31(1.16)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C119(0.57); C122(0.61); C290(1.21); C31(0.99)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C119(0.65); C122(0.70); C290(1.06); C31(0.84)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C119(0.42); C122(0.45); C290(0.92); C31(1.07)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C119(0.59); C122(0.62); C290(0.95); C31(0.80)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C119(0.50); C122(0.54); C290(0.92); C31(0.81)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C119(0.66); C122(0.69); C290(1.03); C31(0.75)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C119(2.35); C122(2.35); C290(0.80); C31(0.61)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C119(2.07); C122(2.07); C290(0.89); C31(0.77)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C119(1.73); C122(1.73); C290(0.74); C31(0.56)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C119(1.38); C122(1.38); C290(0.91); C31(1.20)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C119(0.66); C122(0.46); C290(0.92); C31(0.81)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C119(1.80); C122(1.80); C290(1.16); C31(0.83)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C119(1.87); C122(1.87); C290(0.80); C31(0.75)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C119(1.78); C122(1.78); C290(0.91); C31(0.87)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C119(1.92); C122(1.92); C290(1.07); C31(0.64)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C119(2.14); C122(2.14); C290(0.84); C31(0.60)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C119(1.91); C122(1.91); C290(0.62); C31(0.83)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C119(1.31); C122(1.31); C290(0.85); C31(0.85)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C119(1.86); C122(1.86); C290(0.72); C31(0.60)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C119(2.17); C122(2.17); C290(0.71); C31(0.71)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C119(1.39); C122(1.39); C290(0.90); C31(0.87)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C119(0.51); C122(0.34); C290(0.99); C31(0.73)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C119(1.31); C122(1.31); C290(1.09); C31(0.95)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C119(0.70); C122(0.70); C290(1.15); C31(0.88)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C119(0.78); C122(0.78); C290(1.20); C31(0.73)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C119(0.55); C122(0.55); C290(1.44); C31(0.95)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C119(0.34); C122(0.34); C290(1.04); C31(0.82)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C119(0.67); C122(0.67); C290(1.04); C31(0.97)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C119(0.26); C122(0.26); C290(1.00); C31(0.82)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C119(0.33); C122(0.33); C290(0.88); C31(0.85)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C119(0.36); C122(0.36); C290(0.98); C31(1.66)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C119(0.56); C122(0.56); C290(1.29); C31(1.01)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C119(0.50); C122(0.29); C290(0.96); C31(0.74)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C119(0.40); C122(0.40); C290(1.03); C31(0.94)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C119(0.43); C122(0.43); C290(1.29); C31(0.91)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C119(0.78); C122(0.78); C290(1.12); C31(1.08)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C119(0.50); C122(0.50); C290(1.17); C31(1.15)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C119(0.43); C122(0.43); C290(1.06); C31(1.02)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C119(0.49); C122(0.58); C290(1.33); C31(1.23)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C119(0.49); C122(0.55); C290(1.26); C31(1.24)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C119(0.47); C122(0.51); C290(1.16); C31(0.93)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C119(0.29); C122(0.34); C290(1.48); C31(1.10)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C119(0.32); C122(0.19); C290(0.95); C31(0.88)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C119(0.48); C122(0.53); C290(1.23); C31(1.00)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C119(0.48); C122(0.57); C290(1.43); C31(0.87)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C119(0.19); C122(0.23); C290(1.56); C31(0.95)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C119(0.21); C122(0.27); C290(1.89); C31(1.02)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C119(0.16); C122(0.20); C290(2.26); C31(1.02)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C119(0.44); C122(0.42); C290(1.37); C31(1.19)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C119(0.79); C122(0.77); C290(1.02); C31(1.13)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C119(0.39); C122(0.54); C290(1.39); C31(1.34)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C119(0.24); C122(0.29); C290(1.29); C31(1.17)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C119(0.18); C122(0.22); C290(1.92); C31(0.97)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C119(0.48); C122(0.39); C290(1.17); C31(0.83)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C119(0.82); C122(1.05); C290(1.04); C31(0.98)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C290(1.04); C31(0.92); C422(0.92)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C290(0.95); C31(0.90); C422(0.89)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C290(0.83); C31(0.85); C422(0.86)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C290(0.89); C31(0.95); C422(0.96)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C290(1.09); C31(1.06); C422(0.93)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C290(0.98); C31(1.09); C422(0.95)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C290(1.03); C31(1.11); C422(0.88)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C290(1.07); C31(1.04); C422(1.06)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C290(1.02); C31(1.06); C422(1.02)  LDD0811  [14]
 LDCM0097  Dasatinib K562 16.06  LDD0270  [6]
 LDCM0017  DFG-out-2 A431 8.80  LDD0075  [33]
 LDCM0495  E2913 HEK-293T C422(0.91); C290(0.96); C411(1.00); C164(0.64)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C290(2.18); C31(1.00)  LDD1702  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.67  LDD0183  [9]
 LDCM0625  F8 Ramos C290(1.03); C31(0.82); C411(0.87); C422(2.09)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C290(1.81); C31(1.16); C411(0.56)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C290(0.02); C31(0.08); C411(0.29); C422(0.25)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C290(0.71); C31(0.67); C411(0.75)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C290(0.86); C31(0.95); C411(0.76)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C290(0.56); C31(0.51); C411(1.12); C422(0.70)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C290(1.23); C31(0.77); C411(0.50)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C290(0.81); C31(0.96); C411(0.90)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C290(0.96); C31(1.29); C411(0.96)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C290(0.89); C31(1.13); C411(0.78)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C290(0.90); C31(0.76); C411(0.63); C422(2.50)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C290(0.99); C31(0.93); C411(1.02)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C290(0.84); C31(0.79); C411(1.19)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C290(1.11); C31(0.78); C411(0.46)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C119(0.52); C122(0.52); C290(1.15); C31(0.90)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C290(0.95); C31(0.59); C411(0.81)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C290(1.15); C31(0.65); C411(0.62); C422(1.10)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C119(0.37); C122(0.39); C290(1.22); C31(1.24)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C290(1.02); C31(0.83); C411(0.72)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C290(1.09); C31(1.01); C411(0.90)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C290(1.80); C31(0.82); C411(0.80); C422(0.50)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C290(1.44); C31(0.71); C411(0.35)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y18(0.84); Y64(0.89); Y97(0.89); Y184(0.90)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y184(0.64); Y97(0.66); Y18(0.71); Y64(1.51)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y97(0.50); Y18(0.69); Y64(0.86); Y184(0.95)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y184(0.58); Y18(0.81); Y97(0.84); Y64(1.74)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y64(0.53); Y18(0.81); Y97(0.96); Y184(1.28)  LDD0268  [12]
 LDCM0015  HNE MDA-MB-231 C290(1.04)  LDD0346  [38]
 LDCM0123  JWB131 DM93 Y64(0.99)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y64(0.55)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y64(1.03)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y64(3.39)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y64(1.98)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y64(0.81)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y64(0.38)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y64(1.24)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C31(1.37)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C31(1.01)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C31(1.04)  LDD0082  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C290(0.51); C223(0.24)  LDD2121  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C223(0.28)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C290(1.52)  LDD2090  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C290(0.68); C223(0.58)  LDD2099  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C223(0.56)  LDD2109  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C290(0.85)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C290(1.02); C223(0.77)  LDD2125  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C290(0.98); C223(0.73)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C290(1.08); C223(1.05)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C290(1.12)  LDD2137  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C290(1.04)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C223(0.30)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C290(0.99); C31(0.07)  LDD2206  [39]
 LDCM0628  OTUB2-COV-1 HEK-293T C31(1.28); C290(0.54)  LDD2207  [39]
 LDCM0131  RA190 MM1.R C290(1.13); C411(1.12); C31(0.91)  LDD0304  [40]
 LDCM0016  Ranjitkar_cp1 A431 2.00  LDD0074  [33]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [34]
 LDCM0021  THZ1 HCT 116 C31(1.12)  LDD2173  [14]
 LDCM0112  W16 Hep-G2 C290(0.77)  LDD0239  [29]
 LDCM0085  WA NCI-H1975 2.49  LDD0192  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase CSK (CSK) Tyr protein kinase family P41240
Insulin-like growth factor 1 receptor (IGF1R) Tyr protein kinase family P08069
Receptor-type tyrosine-protein phosphatase C (PTPRC) Protein-tyrosine phosphatase family P08575
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Paxillin (PXN) Paxillin family P49023
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) . Q5T7N3
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) . Q9NWQ8
SLP adapter and CSK-interacting membrane protein (SCIMP) . Q6UWF3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dasatinib Small molecular drug DB01254
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ng-25 Small molecular drug D0X7IC
Staurosporine Small molecular drug DB02010
Tg-100801 Small molecular drug DB05075
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
936563-93-8 Small molecular drug D02DJP

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol. 2021 Oct;46:102130. doi: 10.1016/j.redox.2021.102130. Epub 2021 Sep 9.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
34 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
35 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
36 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
40 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.