Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Dasatinib-CA-8PAP  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Dasatinib  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03989  Tyrosine-protein kinase Tec (TEC) 23.0
 LDTP03944  Tyrosine-protein kinase CSK (CSK) 8.8
 LDTP02824  Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) 8.0
 LDTP14075  AFG3-like protein 2 (AFG3L2) 6.0
 LDTP06547  Mitogen-activated protein kinase 14 (MAPK14) 5.0
 LDTP04689  Adenosine kinase (ADK) 4.8
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 4.2
 LDTP04552  Biliverdin reductase A (BLVRA) 4.0
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 4.0
 LDTP00400  Torsin-1B (TOR1B) 4.0
 LDTP01283  U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) 4.0
 LDTP02560  Breakpoint cluster region protein (BCR) .
 LDTP00497  Cyclin-G-associated kinase (GAK) .
 LDTP04631  Ephrin type-B receptor 4 (EPHB4) .
 LDTP05554  Epithelial discoidin domain-containing receptor 1 (DDR1) .
 LDTP06547  Mitogen-activated protein kinase 14 (MAPK14) .
 LDTP02638  Proto-oncogene tyrosine-protein kinase Src (SRC) .
 LDTP00751  Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) .
 LDTP01784  Tyrosine-protein kinase ABL1 (ABL1) .
 LDTP05478  Tyrosine-protein kinase BTK (BTK) .
 LDTP02139  Tyrosine-protein kinase Fyn (FYN) .
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01204  Large neutral amino acids transporter small subunit 3 (SLC43A1) 8.5
 LDTP16201  B-cell receptor-associated protein 29 (BCAP29) 8.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04454  Signal transducer and activator of transcription 5B (STAT5B) .
Other
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 16.5
 LDTP01931  Keratin, type II cytoskeletal 6A (KRT6A) 5.0
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) 5.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.0
 LDTP02030  Keratin, type II cytoskeletal 6B (KRT6B) 4.9
 LDTP11774  Oxysterol-binding protein-related protein 2 (OSBPL2) 4.6
 LDTP10282  DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3) 4.5
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6) 4.3
 LDTP05424  Keratin, type I cytoskeletal 17 (KRT17) .
 LDTP08043  Keratin, type I cytoskeletal 27 (KRT27) .
 LDTP08138  Keratin, type II cytoskeletal 1b (KRT77) .

References

1 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.