Details of the Target

General Information of Target

Target ID LDTP04454
Target Name Signal transducer and activator of transcription 5B (STAT5B)
Gene Name STAT5B
Gene ID 6777
Synonyms
Signal transducer and activator of transcription 5B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
WIPHAQS
Target Bioclass
Transcription factor
Family
Transcription factor STAT family
Subcellular location
Cytoplasm
Function
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Uniprot ID
P51692
Ensemble ID
ENST00000293328.8
HGNC ID
HGNC:11367
ChEMBL ID
CHEMBL5817

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K71(6.25)  LDD0277  [1]
HHS-475
 Probe Info  		Y699(0.86); Y668(1.05)  LDD0264  [2]
DBIA
 Probe Info  		C688(1.01)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
N1
 Probe Info  		N.A.  LDD0245  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C508(0.00); C688(0.00); C101(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C101(0.00); C508(0.00); C688(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C101(0.00); C508(0.00); C688(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
Acrolein
 Probe Info  		H141(0.00); C688(0.00)  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
HHS-465
 Probe Info  		Y699(0.00); Y114(0.00); K701(0.00)  LDD2240  [14]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.85  LDD0472  [15]
FFF probe13
 Probe Info  		10.46  LDD0476  [15]
FFF probe3
 Probe Info  		8.12  LDD0465  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]
Dasatinib-CA-8PAP
 Probe Info  		N.A.  LDD0364  [17]
DA-2
 Probe Info  		N.A.  LDD0073  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C688(0.75)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C508(0.92)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C508(1.08)  LDD0824  [3]
 LDCM0230  AC113 HEK-293T C508(0.94)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C508(0.97)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C508(0.97)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C508(1.03)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C508(1.20)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C508(1.27)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C508(1.03)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C508(1.05)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C508(0.88)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C508(0.87)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C508(1.13)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C508(1.27)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C508(0.87)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C508(0.89)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C508(1.15)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C508(1.28)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C508(1.00)  LDD0857  [3]
 LDCM0270  AC15 HEK-293T C508(0.95)  LDD0868  [3]
 LDCM0276  AC17 HEK-293T C688(0.95)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C688(0.89)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C688(0.95)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C688(1.05)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C688(0.99)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C688(0.83)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C688(0.91)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C688(1.03)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C688(0.88)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C688(1.11)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C688(1.32)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C688(1.35)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C688(1.01)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C688(1.26)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C688(1.01)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C688(1.26)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C688(1.16)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C688(1.18)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C688(1.26)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C688(1.09)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C279(1.22)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C279(0.90)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C279(0.72)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C279(0.97)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C279(1.33)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C688(0.82)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C279(1.11)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C279(1.15)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C279(0.84)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C279(1.23)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C279(0.95)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C279(0.89)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C688(1.15)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C688(1.09)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C688(1.19)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C688(1.06)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C688(0.83)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C688(1.20)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C688(1.33)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C688(1.20)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C688(1.07)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C688(1.29)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C688(1.16)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C688(1.17)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C688(1.00)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C688(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C688(1.04)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C508(0.81)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C688(0.82)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C688(1.25)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C688(1.14)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C688(1.15)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C688(1.11)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C688(1.34)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C688(1.01)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C688(1.08)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C508(1.20); C688(1.02)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C508(1.18); C688(0.93)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C508(0.74)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C508(1.10); C688(1.16)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C508(1.26); C688(1.16)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C508(0.99); C688(1.03)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C508(1.16); C688(1.03)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C508(1.04); C688(1.11)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C508(0.91); C688(0.99)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C508(0.94); C688(1.28)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C508(1.10); C688(1.06)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C508(1.22); C688(1.07)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C508(1.16); C688(0.99)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C508(0.97)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C508(1.09); C688(1.06)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C508(1.08); C688(0.96)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C508(1.27); C688(1.21)  LDD0946  [3]
 LDCM0248  AKOS034007472 HEK-293T C508(0.83)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C508(0.79)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C508(0.89)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C688(1.01)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa C688(0.00); H141(0.00); H25(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C688(3.64)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C688(1.05)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C688(0.95)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C688(0.95)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C508(1.10)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C508(1.05)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C508(0.98)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C508(0.99)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C688(0.94)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C688(0.95)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C688(0.85)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C688(1.01)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C688(0.91)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C688(1.05)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C688(0.90)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C688(0.79)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C688(1.10)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C688(1.07)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C688(1.43)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C688(1.16)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C688(1.31)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C279(0.92)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C279(0.86)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C279(0.69)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C688(1.04)  LDD0988  [3]
 LDCM0391  CL120 PaTu 8988t C279(0.73)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C688(1.22)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C688(1.20)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C688(1.23)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C688(1.03)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C688(1.04)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C688(1.11)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C688(0.95)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C688(1.02)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C688(0.85)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C688(0.95)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C688(0.97)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C508(0.88); C688(0.80)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C508(0.73); C688(0.80)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C508(0.91); C688(0.85)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C508(0.91); C688(1.05)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C688(1.12)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C508(0.83); C688(1.05)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C508(0.68); C688(1.12)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C508(0.68); C688(0.99)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C508(0.97); C688(0.94)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C508(0.87); C688(0.98)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C508(0.68); C688(0.84)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C508(0.82); C688(0.81)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C508(0.97); C688(0.98)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C508(0.86); C688(0.98)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C508(0.99); C688(0.90)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C688(1.05)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C508(0.68); C688(1.02)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C688(0.82)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C688(0.88)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C688(1.16)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C688(1.11)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C688(0.95)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C688(1.00)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C688(0.99)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C688(1.20)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C688(1.22)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C688(1.06)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C688(1.04)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C688(1.22)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C688(1.25)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C688(0.98)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C688(1.02)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C688(0.99)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C688(0.96)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C688(0.95)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C688(0.97)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C688(1.17)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C688(1.26)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C688(1.07)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C688(0.85)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C688(0.79)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C688(1.10)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C688(0.95)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C688(1.09)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C688(0.89)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C688(1.02)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C688(1.10)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C688(1.25)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C688(1.11)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C688(0.95)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C688(1.17)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C688(1.07)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C688(1.08)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C688(1.02)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C688(1.01)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C688(1.08)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C688(0.98)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C688(0.86)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C688(0.97)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C688(1.09)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C688(0.96)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C688(0.94)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C688(0.94)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C688(0.99)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C688(1.00)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C688(1.05)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C688(0.74)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C688(0.87)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C688(0.97)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C688(0.98)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C688(0.96)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C688(1.10)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C688(1.20)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C688(0.77)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C688(0.90)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C688(0.87)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C688(1.24)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C688(1.12)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C688(0.80)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C688(0.91)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C688(1.66)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C688(0.80)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C688(0.83)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C688(0.84)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C688(0.96)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C688(1.07)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C688(0.85)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C688(0.81)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C688(0.97)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C688(0.89)  LDD1092  [3]
 LDCM0097  Dasatinib K562 N.A.  LDD0364  [17]
 LDCM0495  E2913 HEK-293T C101(1.06); C688(0.88)  LDD1698  [19]
 LDCM0625  F8 Ramos C688(0.29); C101(1.11)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C688(1.61)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C688(0.23); C101(3.56)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C688(1.60)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C688(1.02)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C688(1.18)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C688(2.95)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C688(1.08)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C688(1.50)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C688(0.96)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C688(0.58); C101(0.36)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C688(1.11)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C688(0.91)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C688(1.81)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C688(1.02)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C688(0.95)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C101(1.26)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C688(0.93)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C688(1.03)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C688(1.16)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C688(0.13); C101(0.84)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C688(1.29)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y699(0.86); Y668(1.05)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y699(0.65); Y668(1.20)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y699(0.71); Y668(0.79)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y699(0.87); Y668(1.28)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y699(0.85); Y668(1.06)  LDD0268  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C101(0.93); C688(0.88)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C101(0.99); C688(0.98)  LDD1497  [19]
 LDCM0024  KB05 IGR37 C688(2.20)  LDD3314  [21]
 LDCM0109  NEM HeLa H141(0.00); H25(0.00); H111(0.00)  LDD0223  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH3 and cysteine-rich domain-containing protein (STAC) . Q99469
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 5B (STAT5B) Transcription factor STAT family P51692
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein bS6m (MRPS6) Bacterial ribosomal protein bS6 family P82932
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
N-myc-interactor (NMI) NMI family Q13287
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3) . Q96EY1
LIM domain transcription factor LMO4 (LMO4) . P61968
Placental protein 13-like (LGALS14) . Q8TCE9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dasatinib Small molecular drug DB01254

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
18 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840