Details of the Target

General Information of Target

Target ID LDTP00400
Target Name Torsin-1B (TOR1B)
Gene Name TOR1B
Gene ID 27348
Synonyms
DQ1; Torsin-1B; Torsin ATPase-1B; EC 3.6.4.-; Torsin family 1 member B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRAGWLRGAAALALLLAARVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREE
RPLNASALKLDLEEKLFGQHLATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQ
IVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMD
KLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQL
KDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAID
EDIVTRVAEEMTFFPRDEKIYSDKGCKTVQSRLDFH
Target Bioclass
Enzyme
Family
ClpA/ClpB family, Torsin subfamily
Subcellular location
Endoplasmic reticulum lumen
Function
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.
Uniprot ID
O14657
Ensemble ID
ENST00000259339.7
HGNC ID
HGNC:11995

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.29  LDD0318  [1]
BTD
 Probe Info  		C57(0.57)  LDD2141  [2]
IPM
 Probe Info  		C57(2.14)  LDD1702  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
ATP probe
 Probe Info  		N.A.  LDD0035  [4]
DBIA
 Probe Info  		C56(4.38)  LDD2236  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		18.00  LDD1753  [8]
C091
 Probe Info  		12.64  LDD1782  [8]
C092
 Probe Info  		23.92  LDD1783  [8]
C094
 Probe Info  		24.59  LDD1785  [8]
C112
 Probe Info  		21.26  LDD1799  [8]
C210
 Probe Info  		59.30  LDD1884  [8]
C218
 Probe Info  		14.93  LDD1892  [8]
C220
 Probe Info  		12.38  LDD1894  [8]
C228
 Probe Info  		17.15  LDD1901  [8]
C231
 Probe Info  		12.04  LDD1904  [8]
C235
 Probe Info  		17.75  LDD1908  [8]
C278
 Probe Info  		72.50  LDD1948  [8]
C282
 Probe Info  		18.13  LDD1952  [8]
C289
 Probe Info  		41.93  LDD1959  [8]
C293
 Probe Info  		17.75  LDD1963  [8]
C310
 Probe Info  		7.89  LDD1977  [8]
C362
 Probe Info  		42.81  LDD2023  [8]
C388
 Probe Info  		95.01  LDD2047  [8]
C390
 Probe Info  		23.10  LDD2049  [8]
C403
 Probe Info  		19.29  LDD2061  [8]
C407
 Probe Info  		11.16  LDD2064  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
Dasatinib-CA-8PAP
 Probe Info  		4.00  LDD0364  [10]
OEA-DA
 Probe Info  		11.25  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0097  Dasatinib K562 4.00  LDD0364  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C57(2.14)  LDD1702  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C57(0.57)  LDD2141  [2]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
5 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570