Details of the Target

General Information of Target

Target ID LDTP03198
Target Name Ferrochelatase, mitochondrial (FECH)
Gene Name FECH
Gene ID 2235
Synonyms
Ferrochelatase, mitochondrial; EC 4.98.1.1; Heme synthase; Protoheme ferro-lyase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Target Type
Successful
Target Bioclass
Enzyme
Family
Ferrochelatase family
Subcellular location
Mitochondrion inner membrane
Function Catalyzes the ferrous insertion into protoporphyrin IX.
TTD ID
T42822
Uniprot ID
P22830
DrugMap ID
TTQ6VF4
Ensemble ID
ENST00000262093.11
HGNC ID
HGNC:3647
ChEMBL ID
CHEMBL3879831

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A185T DBIA    Probe Info 
DOTC24510 SNV: p.H341Q DBIA    Probe Info 
HEC1 SNV: p.R65M; p.H86Y DBIA    Probe Info 
MOLT4 SNV: p.A53V IA-alkyne    Probe Info 
NCIH1944 SNV: p.T338I DBIA    Probe Info 
RKO SNV: p.P275T DBIA    Probe Info 
WM793 Deletion: p.K37SfsTer36 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.32  LDD0215  [1]
TH211
 Probe Info  		Y123(20.00); Y276(14.97); Y159(8.84); Y209(8.28)  LDD0260  [2]
STPyne
 Probe Info  		K113(2.21); K118(8.32)  LDD0277  [3]
Probe 1
 Probe Info  		Y276(25.08)  LDD3495  [4]
P11
 Probe Info  		20.00  LDD0201  [5]
Alkylaryl probe 2
 Probe Info  		4.00  LDD0390  [6]
Dasatinib-CA-4PAP
 Probe Info  		15.00  LDD0270  [7]
DBIA
 Probe Info  		C202(2.05); C366(1.86); C300(2.14)  LDD3311  [8]
BTD
 Probe Info  		C360(1.09)  LDD2140  [9]
AHL-Pu-1
 Probe Info  		C360(5.52)  LDD0170  [10]
HPAP
 Probe Info  		3.22  LDD0062  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C196(0.00); C395(0.00); C294(0.00); C236(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C196(0.00); C395(0.00); C360(0.00); C294(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C196(0.00); C395(0.00); C360(0.00); C294(0.00)  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		C196(0.00); C323(0.00); C395(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		12.10  LDD0443  [20]
NAIA_5
 Probe Info  		C395(0.00); C360(0.00); C323(0.00); C236(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 82 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		6.92  LDD1712  [21]
C018
 Probe Info  		5.78  LDD1726  [21]
C024
 Probe Info  		17.51  LDD1730  [21]
C027
 Probe Info  		11.88  LDD1733  [21]
C056
 Probe Info  		72.00  LDD1753  [21]
C070
 Probe Info  		32.00  LDD1766  [21]
C072
 Probe Info  		7.84  LDD1768  [21]
C106
 Probe Info  		45.57  LDD1793  [21]
C134
 Probe Info  		20.68  LDD1816  [21]
C143
 Probe Info  		15.35  LDD1825  [21]
C145
 Probe Info  		12.30  LDD1827  [21]
C147
 Probe Info  		7.11  LDD1829  [21]
C158
 Probe Info  		19.56  LDD1838  [21]
C159
 Probe Info  		18.25  LDD1839  [21]
C161
 Probe Info  		11.47  LDD1841  [21]
C170
 Probe Info  		12.73  LDD1850  [21]
C177
 Probe Info  		9.13  LDD1856  [21]
C178
 Probe Info  		21.56  LDD1857  [21]
C187
 Probe Info  		18.00  LDD1865  [21]
C198
 Probe Info  		55.33  LDD1874  [21]
C199
 Probe Info  		12.82  LDD1875  [21]
C201
 Probe Info  		39.67  LDD1877  [21]
C205
 Probe Info  		37.53  LDD1880  [21]
C212
 Probe Info  		15.45  LDD1886  [21]
C216
 Probe Info  		17.39  LDD1890  [21]
C220
 Probe Info  		15.03  LDD1894  [21]
C225
 Probe Info  		6.77  LDD1898  [21]
C229
 Probe Info  		15.67  LDD1902  [21]
C234
 Probe Info  		5.58  LDD1907  [21]
C239
 Probe Info  		19.03  LDD1912  [21]
C244
 Probe Info  		27.67  LDD1917  [21]
C246
 Probe Info  		12.47  LDD1919  [21]
C249
 Probe Info  		23.26  LDD1922  [21]
C257
 Probe Info  		12.64  LDD1930  [21]
C264
 Probe Info  		39.12  LDD1935  [21]
C271
 Probe Info  		7.73  LDD1941  [21]
C272
 Probe Info  		11.88  LDD1942  [21]
C273
 Probe Info  		5.31  LDD1943  [21]
C282
 Probe Info  		27.28  LDD1952  [21]
C287
 Probe Info  		16.34  LDD1957  [21]
C296
 Probe Info  		15.56  LDD1966  [21]
C305
 Probe Info  		26.54  LDD1974  [21]
C314
 Probe Info  		34.78  LDD1981  [21]
C320
 Probe Info  		6.68  LDD1986  [21]
C326
 Probe Info  		28.44  LDD1990  [21]
C339
 Probe Info  		11.00  LDD2002  [21]
C346
 Probe Info  		20.97  LDD2007  [21]
C350
 Probe Info  		29.24  LDD2011  [21]
C354
 Probe Info  		8.57  LDD2015  [21]
C361
 Probe Info  		52.35  LDD2022  [21]
C362
 Probe Info  		39.67  LDD2023  [21]
C363
 Probe Info  		42.81  LDD2024  [21]
C364
 Probe Info  		37.27  LDD2025  [21]
C373
 Probe Info  		8.57  LDD2033  [21]
C378
 Probe Info  		15.03  LDD2037  [21]
C380
 Probe Info  		5.90  LDD2039  [21]
C388
 Probe Info  		58.49  LDD2047  [21]
C389
 Probe Info  		20.68  LDD2048  [21]
C390
 Probe Info  		75.58  LDD2049  [21]
C391
 Probe Info  		48.50  LDD2050  [21]
C396
 Probe Info  		8.17  LDD2055  [21]
C399
 Probe Info  		9.25  LDD2058  [21]
C403
 Probe Info  		13.74  LDD2061  [21]
C407
 Probe Info  		13.74  LDD2064  [21]
C408
 Probe Info  		11.31  LDD2065  [21]
C409
 Probe Info  		5.03  LDD2066  [21]
C413
 Probe Info  		38.59  LDD2069  [21]
C420
 Probe Info  		50.91  LDD2075  [21]
C426
 Probe Info  		14.52  LDD2081  [21]
C431
 Probe Info  		17.63  LDD2086  [21]
C433
 Probe Info  		22.47  LDD2088  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
FFF probe3
 Probe Info  		17.18  LDD0465  [22]
FFF probe4
 Probe Info  		20.00  LDD0466  [22]
FFF probe7
 Probe Info  		20.00  LDD0483  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
Dasatinib-CA-3PAP
 Probe Info  		4.91  LDD0365  [7]
Dasatinib-CA-8PAP
 Probe Info  		4.00  LDD0364  [7]
A-DA
 Probe Info  		4.83  LDD0142  [23]
AEA-DA
 Probe Info  		13.73  LDD0146  [23]
OEA-DA
 Probe Info  		20.00  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C360(5.52)  LDD0170  [10]
 LDCM0214  AC1 HEK-293T C294(0.94); C395(1.08); C236(0.96); C411(1.09)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C294(1.05); C395(0.98); C236(1.01); C196(1.05)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C294(1.19); C395(0.87); C236(1.10); C196(1.11)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C360(1.03); C294(1.07); C395(0.93); C236(1.03)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C294(1.03); C395(0.94); C236(0.98); C196(1.18)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C360(1.28); C294(1.03); C395(0.89); C236(1.09)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C294(0.99); C395(1.08); C236(1.01); C411(1.21)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C294(1.08); C395(1.00); C236(0.98); C196(1.04)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C294(0.81); C395(0.65); C236(0.67); C196(0.86)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C294(0.98); C395(1.11); C236(1.04); C196(1.17)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C360(1.10); C294(0.98); C395(0.97); C236(1.01)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C294(1.08); C395(1.14); C236(1.01); C196(1.13)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C294(1.03); C395(0.94); C236(1.02); C196(1.06)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C360(1.12); C294(1.07); C395(1.02); C236(1.02)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C294(1.10); C395(0.96); C236(1.01); C196(0.92)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C294(1.04); C395(1.11); C236(0.96); C411(1.22)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C294(1.04); C395(0.98); C236(1.02); C196(1.08)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C294(1.13); C395(0.98); C236(1.09); C196(1.00)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C360(1.30); C294(1.13); C395(1.10); C236(1.14)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C294(1.13); C395(1.08); C236(1.05); C196(1.05)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C294(1.16); C395(0.94); C236(1.06); C196(0.98)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C294(1.08); C395(0.92); C236(0.92); C196(1.12)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C360(1.14); C294(1.08); C395(1.00); C236(0.97)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C294(1.09); C395(1.02); C236(1.03); C196(0.99)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C294(0.93); C395(1.01); C236(0.91); C411(1.08)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C294(1.03); C395(1.00); C236(1.04); C196(1.04)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C294(1.12); C395(0.94); C236(1.01); C196(1.07)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C360(0.90); C294(1.04); C395(0.94); C236(0.99)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C294(1.12); C395(1.00); C236(0.97); C196(0.97)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C294(1.08); C395(0.91); C236(1.02); C196(1.27)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C360(1.20); C294(1.09); C395(0.95); C236(1.04)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C360(0.93); C294(1.02); C395(1.00); C236(0.99)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C294(1.20); C395(1.06); C236(1.29); C196(0.87)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C294(0.94); C395(1.00); C236(0.91); C411(1.00)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C294(0.98); C395(0.93); C236(0.89); C196(0.99)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C294(1.22); C395(0.98); C236(1.08); C196(1.08)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C360(0.96); C294(1.05); C395(0.94); C236(0.96)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C294(1.07); C395(1.00); C236(0.91); C196(0.86)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C294(0.98); C395(0.92); C236(1.01); C196(1.08)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C360(1.33); C294(1.09); C395(1.03); C236(1.07)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C294(1.06); C395(0.94); C236(0.97); C196(0.90)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C294(0.92); C395(0.99); C236(0.95); C411(1.06)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C294(1.08); C395(1.01); C236(0.99); C196(1.11)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C294(1.08); C395(1.03); C236(1.03); C196(1.22)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C294(1.28); C395(0.95); C236(1.01); C196(1.06)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C360(1.08); C294(1.05); C395(0.95); C236(1.03)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C294(1.07); C395(1.10); C236(0.95); C196(0.93)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C294(1.04); C395(0.94); C236(0.98); C196(1.09)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C360(1.17); C294(1.04); C395(0.95); C236(1.04)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C294(1.11); C395(0.99); C236(1.06); C196(1.01)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C294(0.90); C395(0.93); C236(0.90); C411(1.11)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C294(1.02); C395(0.95); C236(0.96); C196(1.09)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C294(1.23); C395(0.95); C236(1.07); C196(1.03)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C294(0.97); C395(0.90); C236(0.98); C196(1.03)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C360(1.31); C294(1.13); C395(1.04); C236(1.08)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C294(0.99); C395(1.00); C236(0.86); C196(1.13)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C294(0.99); C395(0.91); C236(0.95); C196(1.07)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C360(1.10); C294(1.08); C395(0.93); C236(0.99)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C294(1.07); C395(0.88); C236(0.96); C196(1.02)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C360(1.14); C294(1.01); C395(1.01); C236(1.04)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C294(1.04); C395(0.93); C236(1.02); C196(1.04)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C294(1.02); C395(1.02); C236(0.97); C196(1.05)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C294(0.93); C395(1.04); C236(0.88); C411(1.12)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C294(1.03); C395(0.98); C236(1.15); C196(0.91)  LDD1514  [25]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [5]
 LDCM0108  Chloroacetamide HeLa C294(0.00); H167(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C395(0.27)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C360(1.27); C294(1.10); C395(1.26); C236(1.46)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C294(0.86); C395(0.98); C236(1.32); C196(0.89)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C294(0.97); C395(0.99); C236(0.97); C196(0.89)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C360(0.95); C294(0.97); C395(0.96); C236(0.98)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C294(0.95); C395(0.93); C236(0.94); C196(1.00)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C294(1.05); C395(0.99); C236(1.06); C196(1.09)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C294(1.06); C395(0.96); C236(0.98); C196(0.95)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C360(1.00); C294(0.94); C395(1.00); C236(0.95)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C294(0.95); C395(0.96); C236(1.11); C196(0.93)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C294(1.03); C395(1.05); C236(1.07); C196(1.02)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C294(1.02); C395(1.04); C236(0.98); C196(0.92)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C360(0.90); C294(0.96); C395(0.98); C236(0.94)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C360(0.43); C294(0.93); C395(0.96); C236(2.08)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C294(0.93); C395(0.94); C236(0.86); C196(0.99)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C294(0.93); C395(0.94); C236(1.01); C196(0.89)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C294(1.01); C395(0.98); C236(0.91); C196(0.90)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C360(1.09); C294(1.03); C395(1.08); C236(1.06)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C294(0.95); C395(0.92); C236(0.97); C196(0.93)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C294(0.96); C395(1.01); C236(0.94); C196(0.95)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C294(1.11); C395(1.00); C236(0.93); C196(0.92)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C360(1.02); C294(1.09); C395(1.01); C236(1.06)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C294(0.95); C395(0.91); C236(0.95); C196(0.95)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C294(1.04); C395(0.98); C236(1.08); C196(1.13)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C294(0.90); C395(0.88); C236(1.89); C196(0.86)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C294(1.01); C395(0.98); C236(0.95); C196(0.92)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C360(0.99); C294(1.04); C395(0.96); C236(1.00)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C294(1.06); C395(1.07); C236(0.98); C196(1.07)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C294(1.03); C395(0.95); C236(0.98); C196(1.06)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C294(0.98); C395(0.86); C236(0.99); C196(0.88)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C360(1.04); C294(1.01); C395(0.99); C236(0.96)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C294(1.06); C395(0.98); C236(1.06); C196(1.24)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C294(1.03); C395(0.94); C236(1.00); C196(1.18)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C294(1.03); C395(0.93); C236(0.94); C196(0.93)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C360(0.99); C294(0.93); C395(0.93); C236(1.06)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C294(0.95); C395(0.98); C236(1.05); C196(1.08)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C294(1.10); C395(0.93); C236(1.25); C196(1.09)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C294(1.07); C395(0.98); C236(1.18); C196(0.90)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C294(0.90); C395(0.89); C236(1.13); C411(1.12)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C294(1.03); C395(0.97); C236(1.22); C196(1.11)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C294(1.53); C395(0.86); C236(1.38); C196(1.04)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C294(1.01); C395(0.96); C236(1.11); C196(1.18)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C360(1.06); C294(0.97); C395(0.86); C236(1.74)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C294(0.87); C395(0.89); C236(1.62); C196(0.86)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C294(0.98); C395(1.01); C236(1.81); C196(1.00)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C360(0.42); C294(1.01); C395(0.81); C236(2.14)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C294(0.97); C395(0.81); C236(1.84); C196(0.87)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C360(0.90); C294(1.00); C395(0.90); C236(1.03)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C294(1.03); C395(1.02); C236(1.03); C196(1.09)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C294(1.01); C395(1.02); C236(1.04); C196(1.00)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C294(1.04); C395(1.03); C236(1.17); C196(0.98)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C294(1.10); C395(1.07); C236(1.15); C411(1.10)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C294(1.02); C395(0.91); C236(1.18); C196(1.00)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C294(1.13); C395(0.95); C236(1.16); C196(1.04)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C294(1.50); C395(0.96); C236(1.37); C196(0.90)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C360(1.10); C294(1.07); C395(0.91); C236(1.34)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C294(1.20); C395(1.02); C236(1.98); C196(1.07)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C294(1.06); C395(1.02); C236(1.68); C196(0.91)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C360(0.38); C294(1.00); C395(0.91); C236(2.15)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C294(0.99); C395(0.95); C236(2.02); C196(0.84)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C360(1.05); C294(1.06); C395(0.99); C236(1.03)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C294(1.02); C395(1.03); C236(1.03); C196(0.95)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C294(1.04); C395(0.96); C236(1.20); C196(0.95)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C294(1.08); C395(1.01); C236(0.98); C196(0.94)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C294(0.98); C395(0.91); C236(0.93); C411(1.06)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C294(1.06); C395(0.93); C236(1.21); C196(1.24)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C294(1.71); C395(0.91); C236(1.48); C196(0.95)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C360(1.04); C294(1.06); C395(0.91); C236(1.42)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C294(1.03); C395(1.04); C236(1.57); C196(0.90)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C294(0.98); C395(0.87); C236(1.65); C196(0.98)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C360(0.44); C294(1.08); C395(0.95); C236(1.97)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C294(1.03); C395(0.90); C236(1.68); C196(0.98)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C360(1.04); C294(1.08); C395(1.05); C236(1.16)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C294(0.93); C395(0.90); C236(1.06); C411(1.11)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C294(1.04); C395(0.91); C236(0.99); C196(1.00)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C294(1.04); C395(1.04); C236(1.04); C196(0.96)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C294(0.93); C395(0.91); C236(0.98); C411(0.89)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C294(0.97); C395(0.84); C236(1.01); C196(0.94)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C294(1.33); C395(0.94); C236(1.42); C196(0.93)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C360(1.09); C294(0.98); C395(0.93); C236(1.49)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C294(1.12); C395(1.17); C236(1.69); C196(1.02)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C294(1.07); C395(0.96); C236(1.55); C196(0.97)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C360(0.53); C294(1.06); C395(0.89); C236(1.88)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C294(0.95); C395(0.87); C236(1.30); C196(1.20)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C294(1.08); C395(0.95); C236(2.04); C196(0.81)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C360(0.91); C294(1.10); C395(1.00); C236(1.03)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C294(1.03); C395(1.01); C236(1.05); C196(1.03)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C294(1.05); C395(0.96); C236(0.98); C196(0.99)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C294(1.03); C395(0.86); C236(1.07); C196(0.95)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C294(0.97); C395(0.97); C236(0.98); C411(1.27)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C294(1.00); C395(0.91); C236(1.02); C196(1.15)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C294(1.49); C395(0.86); C236(1.26); C196(0.89)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C360(1.11); C294(1.12); C395(0.86); C236(1.45)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C294(0.98); C395(0.78); C236(1.36); C196(0.94)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C294(1.64); C395(0.89); C236(1.26); C196(1.15)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C294(1.04); C395(0.91); C236(1.62); C196(1.03)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C360(0.56); C294(1.00); C395(0.89); C236(1.72)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C294(1.07); C395(0.89); C236(1.63); C196(0.79)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C360(0.96); C294(1.02); C395(1.00); C236(1.06)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C294(1.01); C395(1.06); C236(1.04); C196(1.07)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C294(1.02); C395(0.93); C236(1.06); C196(0.92)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C294(0.86); C395(0.92); C236(0.94); C411(1.04)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C294(1.07); C395(0.94); C236(1.14); C196(0.98)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C294(1.66); C395(0.98); C236(1.26); C196(1.10)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C360(1.00); C294(0.78); C395(0.73); C236(1.37)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C360(1.05); C294(1.10); C395(0.96); C236(1.38)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C294(1.04); C395(1.02); C236(1.30); C196(0.93)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C294(0.99); C395(0.92); C236(1.51); C196(1.01)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C360(0.64); C294(1.09); C395(0.94); C236(1.74)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C294(0.95); C395(0.85); C236(1.34); C196(0.82)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C360(0.96); C294(1.06); C395(0.98); C236(1.06)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C294(1.09); C395(1.01); C236(1.18); C196(1.11)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C294(1.02); C395(0.94); C236(0.93); C196(1.06)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C294(1.06); C395(0.96); C236(1.03); C196(0.90)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C294(1.00); C395(0.92); C236(0.97); C411(1.00)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C294(0.96); C395(1.12); C236(1.41); C196(0.90)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C294(1.02); C395(0.94); C236(1.08); C196(0.94)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C294(1.88); C395(0.92); C236(1.43); C196(0.92)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C360(1.04); C294(1.06); C395(0.85); C236(1.07)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C294(1.30); C395(1.06); C236(1.51); C196(0.95)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C294(0.90); C395(0.89); C236(1.19); C196(0.99)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C360(0.83); C294(0.86); C395(0.78); C236(1.17)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C294(0.92); C395(0.81); C236(1.22); C196(0.85)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C360(0.89); C294(0.96); C395(0.94); C236(0.91)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C294(0.97); C395(1.05); C236(0.94); C196(0.98)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C294(1.01); C395(0.88); C236(0.99); C196(0.97)  LDD1697  [25]
 LDCM0097  Dasatinib K562 15.00  LDD0270  [7]
 LDCM0495  E2913 HEK-293T C294(1.06); C395(1.02); C236(1.17); C196(0.98)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C395(1.72)  LDD1702  [9]
 LDCM0625  F8 Ramos C196(0.87)  LDD2187  [26]
 LDCM0082  FK866 A-549 4.83  LDD0142  [23]
 LDCM0572  Fragment10 Ramos C196(0.66)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C395(0.41)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C196(0.66)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C196(0.98)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C395(1.24)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C196(0.62)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C196(0.99)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C196(0.46)  LDD2196  [26]
 LDCM0586  Fragment28 Ramos C395(1.27)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C196(0.47)  LDD2199  [26]
 LDCM0590  Fragment32 Ramos C196(0.47)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C294(1.07); C395(1.02); C236(1.12); C196(1.02)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos C196(0.66)  LDD2203  [26]
 LDCM0427  Fragment51 HEK-293T C294(1.06); C395(0.98); C236(1.03); C196(0.92)  LDD1631  [25]
 LDCM0569  Fragment7 Ramos C196(0.84)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C196(0.46)  LDD2188  [26]
 LDCM0107  IAA HeLa H167(0.00); C294(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C294(0.95); C395(0.92); C236(0.96); C196(0.90)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C294(1.00); C395(0.90); C236(0.94); C196(1.11)  LDD1497  [25]
 LDCM0024  KB05 G361 C202(2.05); C366(1.86); C300(2.14)  LDD3311  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C360(1.09)  LDD2140  [9]
 LDCM0014  Panhematin HEK-293T 3.22  LDD0062  [11]
 LDCM0099  Phenelzine HEK-293T 4.00  LDD0390  [6]
 LDCM0131  RA190 MM1.R C196(1.12)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholic Acid Small molecular drug D0OR2L
Methyl Aminolevulinate Small molecular drug D0OL6O
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lead Acetate Small molecular drug D0S4VW
N-methylmesoporphyrin Small molecular drug D0X5ZA
N-methylmesoporphyrin Containing Copper Small molecular drug D00GJZ

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.