Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C257  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 12.6
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 11.9
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) 8.5
 LDTP01769  Dihydrofolate reductase (DHFR) 7.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 5.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.4
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 7.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 6.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587