Details of the Target

General Information of Target

Target ID	LDTP06333
Target Name	Serum paraoxonase/arylesterase 2 (PON2)
Gene Name	PON2
Gene ID	5445
Synonyms	Serum paraoxonase/arylesterase 2; PON 2; EC 3.1.1.2; EC 3.1.1.81; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
Target Bioclass	Enzyme
Family	Paraoxonase family
Subcellular location	Membrane
Function	Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Uniprot ID	Q15165
Ensemble ID	ENST00000222572.8
HGNC ID	HGNC:9205
ChEMBL ID	CHEMBL4295823

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 14 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
FBPP2 Probe Info	22.21	LDD0318	[2]
FBP2 Probe Info	2.40	LDD0323	[2]
m-APA Probe Info	9.41	LDD0403	[3]
DBIA Probe Info	C42(3.56); C283(3.18)	LDD3312	[4]
BTD Probe Info	C42(0.99)	LDD2093	[5]
D5yne Probe Info	7.53	LDD0055	[6]
5E-2FA Probe Info	N.A.	LDD2235	[7]
IA-alkyne Probe Info	C42(0.00); C283(0.00)	LDD0162	[8]
IPM Probe Info	N.A.	LDD0025	[9]
TFBX Probe Info	N.A.	LDD0148	[9]
Phosphinate-6 Probe Info	N.A.	LDD0018	[10]
Acrolein Probe Info	H43(0.00); C42(0.00)	LDD0217	[11]
Methacrolein Probe Info	N.A.	LDD0218	[11]
NAIA_5 Probe Info	N.A.	LDD2223	[12]

PAL-AfBPP Probe

Click To Hide/Show 155 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C001 Probe Info	27.28	LDD1711	[13]
C004 Probe Info	7.62	LDD1714	[13]
C007 Probe Info	15.45	LDD1716	[13]
C009 Probe Info	9.06	LDD1718	[13]
C010 Probe Info	11.47	LDD1719	[13]
C011 Probe Info	11.96	LDD1720	[13]
C017 Probe Info	7.06	LDD1725	[13]
C022 Probe Info	28.84	LDD1728	[13]
C028 Probe Info	8.57	LDD1734	[13]
C040 Probe Info	9.85	LDD1740	[13]
C041 Probe Info	23.26	LDD1741	[13]
C044 Probe Info	6.63	LDD1743	[13]
C055 Probe Info	26.91	LDD1752	[13]
C056 Probe Info	50.56	LDD1753	[13]
C058 Probe Info	4.99	LDD1755	[13]
C063 Probe Info	37.79	LDD1760	[13]
C070 Probe Info	17.88	LDD1766	[13]
C071 Probe Info	17.51	LDD1767	[13]
C072 Probe Info	14.62	LDD1768	[13]
C082 Probe Info	5.54	LDD1774	[13]
C087 Probe Info	21.41	LDD1779	[13]
C091 Probe Info	14.12	LDD1782	[13]
C092 Probe Info	40.22	LDD1783	[13]
C094 Probe Info	74.54	LDD1785	[13]
C102 Probe Info	6.19	LDD1790	[13]
C105 Probe Info	7.21	LDD1792	[13]
C106 Probe Info	16.56	LDD1793	[13]
C107 Probe Info	8.82	LDD1794	[13]
C108 Probe Info	15.45	LDD1795	[13]
C112 Probe Info	33.13	LDD1799	[13]
C129 Probe Info	13.93	LDD1811	[13]
C130 Probe Info	17.51	LDD1812	[13]
C131 Probe Info	6.28	LDD1813	[13]
C134 Probe Info	22.78	LDD1816	[13]
C135 Probe Info	21.11	LDD1817	[13]
C139 Probe Info	31.56	LDD1821	[13]
C141 Probe Info	14.93	LDD1823	[13]
C143 Probe Info	20.68	LDD1825	[13]
C145 Probe Info	8.06	LDD1827	[13]
C147 Probe Info	10.13	LDD1829	[13]
C153 Probe Info	28.44	LDD1834	[13]
C159 Probe Info	44.94	LDD1839	[13]
C160 Probe Info	6.87	LDD1840	[13]
C161 Probe Info	37.79	LDD1841	[13]
C163 Probe Info	6.54	LDD1843	[13]
C166 Probe Info	12.04	LDD1846	[13]
C169 Probe Info	28.05	LDD1849	[13]
C173 Probe Info	10.06	LDD1853	[13]
C177 Probe Info	9.99	LDD1856	[13]
C178 Probe Info	42.22	LDD1857	[13]
C183 Probe Info	10.13	LDD1861	[13]
C187 Probe Info	17.15	LDD1865	[13]
C193 Probe Info	5.35	LDD1869	[13]
C198 Probe Info	44.63	LDD1874	[13]
C199 Probe Info	5.78	LDD1875	[13]
C201 Probe Info	27.47	LDD1877	[13]
C205 Probe Info	5.35	LDD1880	[13]
C206 Probe Info	99.73	LDD1881	[13]
C210 Probe Info	99.73	LDD1884	[13]
C212 Probe Info	9.58	LDD1886	[13]
C214 Probe Info	11.00	LDD1888	[13]
C217 Probe Info	15.78	LDD1891	[13]
C220 Probe Info	12.13	LDD1894	[13]
C222 Probe Info	10.93	LDD1896	[13]
C225 Probe Info	11.79	LDD1898	[13]
C226 Probe Info	11.88	LDD1899	[13]
C228 Probe Info	22.63	LDD1901	[13]
C231 Probe Info	41.07	LDD1904	[13]
C232 Probe Info	34.06	LDD1905	[13]
C234 Probe Info	17.88	LDD1907	[13]
C236 Probe Info	8.00	LDD1909	[13]
C238 Probe Info	14.83	LDD1911	[13]
C240 Probe Info	30.27	LDD1913	[13]
C243 Probe Info	21.86	LDD1916	[13]
C249 Probe Info	14.03	LDD1922	[13]
C251 Probe Info	57.28	LDD1924	[13]
C252 Probe Info	53.45	LDD1925	[13]
C255 Probe Info	20.82	LDD1928	[13]
C257 Probe Info	5.35	LDD1930	[13]
C264 Probe Info	58.89	LDD1935	[13]
C266 Probe Info	17.15	LDD1937	[13]
C269 Probe Info	9.00	LDD1939	[13]
C270 Probe Info	7.52	LDD1940	[13]
C272 Probe Info	7.21	LDD1942	[13]
C273 Probe Info	10.34	LDD1943	[13]
C274 Probe Info	5.35	LDD1944	[13]
C275 Probe Info	10.06	LDD1945	[13]
C280 Probe Info	12.91	LDD1950	[13]
C284 Probe Info	27.67	LDD1954	[13]
C285 Probe Info	39.67	LDD1955	[13]
C287 Probe Info	14.22	LDD1957	[13]
C289 Probe Info	63.56	LDD1959	[13]
C290 Probe Info	5.17	LDD1960	[13]
C293 Probe Info	38.05	LDD1963	[13]
C296 Probe Info	26.91	LDD1966	[13]
C299 Probe Info	7.21	LDD1968	[13]
C301 Probe Info	9.00	LDD1970	[13]
C305 Probe Info	28.05	LDD1974	[13]
C307 Probe Info	5.21	LDD1975	[13]
C322 Probe Info	6.28	LDD1988	[13]
C326 Probe Info	34.54	LDD1990	[13]
C327 Probe Info	9.51	LDD1991	[13]
C328 Probe Info	5.17	LDD1992	[13]
C329 Probe Info	9.06	LDD1993	[13]
C333 Probe Info	9.45	LDD1996	[13]
C338 Probe Info	93.05	LDD2001	[13]
C339 Probe Info	26.54	LDD2002	[13]
C343 Probe Info	14.03	LDD2005	[13]
C344 Probe Info	14.12	LDD2006	[13]
C346 Probe Info	14.93	LDD2007	[13]
C347 Probe Info	23.92	LDD2008	[13]
C348 Probe Info	27.67	LDD2009	[13]
C349 Probe Info	11.24	LDD2010	[13]
C350 Probe Info	33.36	LDD2011	[13]
C351 Probe Info	27.10	LDD2012	[13]
C353 Probe Info	7.62	LDD2014	[13]
C354 Probe Info	8.46	LDD2015	[13]
C355 Probe Info	30.70	LDD2016	[13]
C356 Probe Info	9.13	LDD2017	[13]
C357 Probe Info	6.96	LDD2018	[13]
C361 Probe Info	19.84	LDD2022	[13]
C362 Probe Info	64.00	LDD2023	[13]
C363 Probe Info	51.63	LDD2024	[13]
C364 Probe Info	20.25	LDD2025	[13]
C366 Probe Info	11.79	LDD2027	[13]
C367 Probe Info	6.23	LDD2028	[13]
C376 Probe Info	7.52	LDD2036	[13]
C378 Probe Info	8.94	LDD2037	[13]
C380 Probe Info	5.74	LDD2039	[13]
C386 Probe Info	11.63	LDD2045	[13]
C388 Probe Info	73.01	LDD2047	[13]
C389 Probe Info	5.21	LDD2048	[13]
C390 Probe Info	58.49	LDD2049	[13]
C391 Probe Info	34.54	LDD2050	[13]
C392 Probe Info	23.26	LDD2051	[13]
C396 Probe Info	28.64	LDD2055	[13]
C399 Probe Info	21.41	LDD2058	[13]
C405 Probe Info	6.23	LDD2063	[13]
C407 Probe Info	12.38	LDD2064	[13]
C413 Probe Info	14.83	LDD2069	[13]
C419 Probe Info	13.00	LDD2074	[13]
C420 Probe Info	17.51	LDD2075	[13]
C426 Probe Info	26.35	LDD2081	[13]
C427 Probe Info	7.52	LDD2082	[13]
C429 Probe Info	15.89	LDD2084	[13]
C433 Probe Info	10.13	LDD2088	[13]
FFF probe15 Probe Info	20.00	LDD0478	[14]
FFF probe2 Probe Info	12.15	LDD0463	[14]
FFF probe3 Probe Info	20.00	LDD0464	[14]
FFF probe7 Probe Info	20.00	LDD0483	[14]
STS-1 Probe Info	N.A.	LDD0136	[15]
STS-2 Probe Info	N.A.	LDD0138	[15]
A-DA Probe Info	4.27	LDD0142	[16]
AEA-DA Probe Info	2.92	LDD0146	[16]
OEA-DA Probe Info	20.00	LDD0046	[17]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C42(0.71)	LDD2117	[5]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C42(1.14)	LDD2152	[5]
LDCM0226	AC11	HEK-293T	C42(1.03)	LDD1509	[18]
LDCM0237	AC12	HEK-293T	C283(1.08); C42(1.07)	LDD1510	[18]
LDCM0259	AC14	HEK-293T	C283(1.00); C42(0.96)	LDD1512	[18]
LDCM0270	AC15	HEK-293T	C42(1.02)	LDD1513	[18]
LDCM0278	AC19	HEK-293T	C42(1.39)	LDD1517	[18]
LDCM0280	AC20	HEK-293T	C283(1.07); C42(1.02)	LDD1519	[18]
LDCM0281	AC21	HEK-293T	C283(0.92)	LDD1520	[18]
LDCM0282	AC22	HEK-293T	C283(1.10); C42(0.86)	LDD1521	[18]
LDCM0283	AC23	HEK-293T	C42(1.05)	LDD1522	[18]
LDCM0284	AC24	HEK-293T	C42(1.05)	LDD1523	[18]
LDCM0287	AC27	HEK-293T	C42(0.99)	LDD1526	[18]
LDCM0288	AC28	HEK-293T	C283(1.18); C42(1.00)	LDD1527	[18]
LDCM0289	AC29	HEK-293T	C283(1.02)	LDD1528	[18]
LDCM0290	AC3	HEK-293T	C42(1.06)	LDD1529	[18]
LDCM0291	AC30	HEK-293T	C283(0.93); C42(1.04)	LDD1530	[18]
LDCM0292	AC31	HEK-293T	C42(1.02)	LDD1531	[18]
LDCM0293	AC32	HEK-293T	C42(0.98)	LDD1532	[18]
LDCM0296	AC35	HEK-293T	C42(1.15)	LDD1535	[18]
LDCM0297	AC36	HEK-293T	C283(1.31); C42(1.04)	LDD1536	[18]
LDCM0298	AC37	HEK-293T	C283(1.28)	LDD1537	[18]
LDCM0299	AC38	HEK-293T	C283(1.21); C42(0.98)	LDD1538	[18]
LDCM0300	AC39	HEK-293T	C42(1.07)	LDD1539	[18]
LDCM0301	AC4	HEK-293T	C283(0.98); C42(1.10)	LDD1540	[18]
LDCM0302	AC40	HEK-293T	C42(1.06)	LDD1541	[18]
LDCM0305	AC43	HEK-293T	C42(1.02)	LDD1544	[18]
LDCM0306	AC44	HEK-293T	C283(1.23); C42(1.02)	LDD1545	[18]
LDCM0307	AC45	HEK-293T	C283(1.30)	LDD1546	[18]
LDCM0308	AC46	HEK-293T	C283(0.88); C42(1.12)	LDD1547	[18]
LDCM0309	AC47	HEK-293T	C42(0.99)	LDD1548	[18]
LDCM0310	AC48	HEK-293T	C42(0.99)	LDD1549	[18]
LDCM0312	AC5	HEK-293T	C283(0.96)	LDD1551	[18]
LDCM0314	AC51	HEK-293T	C42(1.05)	LDD1553	[18]
LDCM0315	AC52	HEK-293T	C283(1.05); C42(1.01)	LDD1554	[18]
LDCM0316	AC53	HEK-293T	C283(0.98)	LDD1555	[18]
LDCM0317	AC54	HEK-293T	C283(1.31); C42(0.96)	LDD1556	[18]
LDCM0318	AC55	HEK-293T	C42(1.02)	LDD1557	[18]
LDCM0319	AC56	HEK-293T	C42(0.88)	LDD1558	[18]
LDCM0322	AC59	HEK-293T	C42(1.04)	LDD1561	[18]
LDCM0323	AC6	HEK-293T	C283(0.87); C42(0.94)	LDD1562	[18]
LDCM0324	AC60	HEK-293T	C283(1.02); C42(1.05)	LDD1563	[18]
LDCM0325	AC61	HEK-293T	C283(0.94)	LDD1564	[18]
LDCM0326	AC62	HEK-293T	C283(0.70); C42(0.99)	LDD1565	[18]
LDCM0327	AC63	HEK-293T	C42(1.08)	LDD1566	[18]
LDCM0328	AC64	HEK-293T	C42(0.97)	LDD1567	[18]
LDCM0334	AC7	HEK-293T	C42(1.03)	LDD1568	[18]
LDCM0345	AC8	HEK-293T	C42(0.96)	LDD1569	[18]
LDCM0248	AKOS034007472	HEK-293T	C283(1.14)	LDD1511	[18]
LDCM0275	AKOS034007705	HEK-293T	C42(0.95)	LDD1514	[18]
LDCM0156	Aniline	NCI-H1299	9.41	LDD0403	[3]
LDCM0020	ARS-1620	HCC44	C42(0.92)	LDD2171	[19]
LDCM0083	Avasimibe	A-549	2.47	LDD0143	[16]
LDCM0108	Chloroacetamide	HeLa	C42(0.00); H43(0.00)	LDD0222	[11]
LDCM0367	CL1	HEK-293T	C283(1.06); C42(1.12)	LDD1571	[18]
LDCM0368	CL10	HEK-293T	C283(1.19); C42(1.45)	LDD1572	[18]
LDCM0369	CL100	HEK-293T	C42(1.00)	LDD1573	[18]
LDCM0370	CL101	HEK-293T	C283(1.08); C42(1.03)	LDD1574	[18]
LDCM0372	CL103	HEK-293T	C283(1.00); C42(1.02)	LDD1576	[18]
LDCM0373	CL104	HEK-293T	C42(1.01)	LDD1577	[18]
LDCM0374	CL105	HEK-293T	C283(0.91); C42(1.10)	LDD1578	[18]
LDCM0376	CL107	HEK-293T	C283(0.91); C42(1.07)	LDD1580	[18]
LDCM0377	CL108	HEK-293T	C42(1.02)	LDD1581	[18]
LDCM0378	CL109	HEK-293T	C283(1.00); C42(1.14)	LDD1582	[18]
LDCM0379	CL11	HEK-293T	C42(1.13)	LDD1583	[18]
LDCM0381	CL111	HEK-293T	C283(0.87); C42(1.11)	LDD1585	[18]
LDCM0382	CL112	HEK-293T	C42(1.13)	LDD1586	[18]
LDCM0383	CL113	HEK-293T	C283(0.98); C42(1.10)	LDD1587	[18]
LDCM0385	CL115	HEK-293T	C283(1.02); C42(1.14)	LDD1589	[18]
LDCM0386	CL116	HEK-293T	C42(1.03)	LDD1590	[18]
LDCM0387	CL117	HEK-293T	C283(1.07); C42(1.05)	LDD1591	[18]
LDCM0389	CL119	HEK-293T	C283(0.99); C42(1.10)	LDD1593	[18]
LDCM0390	CL12	HEK-293T	C42(1.01)	LDD1594	[18]
LDCM0391	CL120	HEK-293T	C42(0.94)	LDD1595	[18]
LDCM0392	CL121	HEK-293T	C283(0.89); C42(1.01)	LDD1596	[18]
LDCM0394	CL123	HEK-293T	C283(1.00); C42(1.04)	LDD1598	[18]
LDCM0395	CL124	HEK-293T	C42(1.10)	LDD1599	[18]
LDCM0396	CL125	HEK-293T	C283(1.01); C42(1.05)	LDD1600	[18]
LDCM0398	CL127	HEK-293T	C283(1.01); C42(1.06)	LDD1602	[18]
LDCM0399	CL128	HEK-293T	C42(1.08)	LDD1603	[18]
LDCM0400	CL13	HEK-293T	C283(0.91); C42(0.98)	LDD1604	[18]
LDCM0402	CL15	HEK-293T	C283(0.94); C42(1.24)	LDD1606	[18]
LDCM0403	CL16	HEK-293T	C42(1.08)	LDD1607	[18]
LDCM0406	CL19	HEK-293T	C42(1.08)	LDD1610	[18]
LDCM0408	CL20	HEK-293T	C283(1.06); C42(1.01)	LDD1612	[18]
LDCM0409	CL21	HEK-293T	C283(1.05)	LDD1613	[18]
LDCM0410	CL22	HEK-293T	C283(1.00); C42(0.91)	LDD1614	[18]
LDCM0411	CL23	HEK-293T	C42(0.96)	LDD1615	[18]
LDCM0412	CL24	HEK-293T	C42(1.06)	LDD1616	[18]
LDCM0413	CL25	HEK-293T	C283(0.94); C42(1.08)	LDD1617	[18]
LDCM0415	CL27	HEK-293T	C283(1.01); C42(1.17)	LDD1619	[18]
LDCM0416	CL28	HEK-293T	C42(0.99)	LDD1620	[18]
LDCM0418	CL3	HEK-293T	C283(0.94); C42(1.03)	LDD1622	[18]
LDCM0420	CL31	HEK-293T	C42(1.07)	LDD1624	[18]
LDCM0421	CL32	HEK-293T	C283(1.02); C42(1.01)	LDD1625	[18]
LDCM0422	CL33	HEK-293T	C283(0.96)	LDD1626	[18]
LDCM0423	CL34	HEK-293T	C283(1.15); C42(0.95)	LDD1627	[18]
LDCM0424	CL35	HEK-293T	C42(0.97)	LDD1628	[18]
LDCM0425	CL36	HEK-293T	C42(0.85)	LDD1629	[18]
LDCM0426	CL37	HEK-293T	C283(1.02); C42(0.98)	LDD1630	[18]
LDCM0428	CL39	HEK-293T	C283(0.88); C42(1.19)	LDD1632	[18]
LDCM0429	CL4	HEK-293T	C42(1.03)	LDD1633	[18]
LDCM0430	CL40	HEK-293T	C42(0.96)	LDD1634	[18]
LDCM0433	CL43	HEK-293T	C42(1.08)	LDD1637	[18]
LDCM0434	CL44	HEK-293T	C283(1.09); C42(0.91)	LDD1638	[18]
LDCM0435	CL45	HEK-293T	C283(0.92)	LDD1639	[18]
LDCM0436	CL46	HEK-293T	C283(0.88); C42(0.94)	LDD1640	[18]
LDCM0437	CL47	HEK-293T	C42(1.02)	LDD1641	[18]
LDCM0438	CL48	HEK-293T	C42(0.87)	LDD1642	[18]
LDCM0439	CL49	HEK-293T	C283(0.95); C42(0.95)	LDD1643	[18]
LDCM0443	CL52	HEK-293T	C42(1.00)	LDD1646	[18]
LDCM0446	CL55	HEK-293T	C42(1.07)	LDD1649	[18]
LDCM0447	CL56	HEK-293T	C283(1.01); C42(0.98)	LDD1650	[18]
LDCM0448	CL57	HEK-293T	C283(1.22)	LDD1651	[18]
LDCM0449	CL58	HEK-293T	C283(0.84); C42(1.05)	LDD1652	[18]
LDCM0450	CL59	HEK-293T	C42(1.02)	LDD1653	[18]
LDCM0452	CL60	HEK-293T	C42(1.15)	LDD1655	[18]
LDCM0453	CL61	HEK-293T	C283(0.95); C42(0.94)	LDD1656	[18]
LDCM0455	CL63	HEK-293T	C283(0.81); C42(1.00)	LDD1658	[18]
LDCM0456	CL64	HEK-293T	C42(1.10)	LDD1659	[18]
LDCM0459	CL67	HEK-293T	C42(1.00)	LDD1662	[18]
LDCM0460	CL68	HEK-293T	C283(0.93); C42(1.00)	LDD1663	[18]
LDCM0461	CL69	HEK-293T	C283(1.30)	LDD1664	[18]
LDCM0462	CL7	HEK-293T	C42(1.16)	LDD1665	[18]
LDCM0463	CL70	HEK-293T	C283(1.53); C42(1.02)	LDD1666	[18]
LDCM0464	CL71	HEK-293T	C42(1.10)	LDD1667	[18]
LDCM0465	CL72	HEK-293T	C42(0.89)	LDD1668	[18]
LDCM0466	CL73	HEK-293T	C283(1.11); C42(1.16)	LDD1669	[18]
LDCM0469	CL76	HEK-293T	C42(0.96)	LDD1672	[18]
LDCM0472	CL79	HEK-293T	C42(1.05)	LDD1675	[18]
LDCM0473	CL8	HEK-293T	C283(1.02); C42(1.78)	LDD1676	[18]
LDCM0474	CL80	HEK-293T	C283(0.96); C42(0.95)	LDD1677	[18]
LDCM0475	CL81	HEK-293T	C283(0.96)	LDD1678	[18]
LDCM0476	CL82	HEK-293T	C283(0.97); C42(0.86)	LDD1679	[18]
LDCM0477	CL83	HEK-293T	C42(1.12)	LDD1680	[18]
LDCM0478	CL84	HEK-293T	C42(0.86)	LDD1681	[18]
LDCM0479	CL85	HEK-293T	C283(0.98); C42(1.11)	LDD1682	[18]
LDCM0481	CL87	HEK-293T	C283(1.03); C42(1.09)	LDD1684	[18]
LDCM0482	CL88	HEK-293T	C42(1.01)	LDD1685	[18]
LDCM0484	CL9	HEK-293T	C283(1.45)	LDD1687	[18]
LDCM0486	CL91	HEK-293T	C42(0.98)	LDD1689	[18]
LDCM0487	CL92	HEK-293T	C283(1.19); C42(1.04)	LDD1690	[18]
LDCM0488	CL93	HEK-293T	C283(1.05)	LDD1691	[18]
LDCM0489	CL94	HEK-293T	C283(0.94); C42(1.07)	LDD1692	[18]
LDCM0490	CL95	HEK-293T	C42(1.75)	LDD1693	[18]
LDCM0491	CL96	HEK-293T	C42(1.02)	LDD1694	[18]
LDCM0492	CL97	HEK-293T	C283(1.10); C42(1.12)	LDD1695	[18]
LDCM0494	CL99	HEK-293T	C283(0.88); C42(0.99)	LDD1697	[18]
LDCM0191	Compound 21	HEK-293T	4.73	LDD0508	[14]
LDCM0190	Compound 34	HEK-293T	8.47	LDD0510	[14]
LDCM0192	Compound 35	HEK-293T	4.41	LDD0509	[14]
LDCM0193	Compound 36	HEK-293T	19.05	LDD0511	[14]
LDCM0095	DC-LC3IN-D5	HeLa	7.53	LDD0055	[6]
LDCM0495	E2913	HEK-293T	C283(1.15); C42(1.11)	LDD1698	[18]
LDCM0082	FK866	A-549	4.27	LDD0142	[16]
LDCM0468	Fragment33	HEK-293T	C283(0.99); C42(1.06)	LDD1671	[18]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[11]
LDCM0022	KB02	HEK-293T	C42(1.02)	LDD1492	[18]
LDCM0023	KB03	HEK-293T	C42(1.00)	LDD1497	[18]
LDCM0024	KB05	HMCB	C42(3.56); C283(3.18)	LDD3312	[4]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[11]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C42(0.99)	LDD2093	[5]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C42(1.08)	LDD2099	[5]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C42(1.23)	LDD2111	[5]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C42(1.00)	LDD2119	[5]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C42(0.68)	LDD2127	[5]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C42(1.14)	LDD2129	[5]
LDCM0084	Ro 48-8071	A-549	3.55	LDD0145	[16]
LDCM0021	THZ1	HCT 116	C42(0.92)	LDD2173	[19]

References

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2	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
3	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
5	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
6	Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5. Mass spectrometry data entry: PXD026874
7	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
8	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
10	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
11	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
13	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
14	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
17	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
18	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
19	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.

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Prof. Feng Zhu

Prof. Feng Ni