Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C058  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01769  Dihydrofolate reductase (DHFR) 9.6
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 8.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.7
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.2
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.0
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03952  Reduced folate transporter (SLC19A1) 5.4
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 4.9
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587