Details of the Target

General Information of Target

Target ID LDTP10182
Target Name TLC domain-containing protein 1 (TLCD1)
Gene Name TLCD1
Gene ID 116238
Synonyms
TLC domain-containing protein 1; Calfacilitin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST
QSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL
QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS
FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG
TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD
SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA
ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR
RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC
ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE
GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP
GAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA
TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD
DSFS
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function
Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis.
Uniprot ID
Q96CP7
Ensemble ID
ENST00000292090.8
HGNC ID
HGNC:25177

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 SNV: p.F150S .
NCIH358 Substitution: p.R109G .
OVK18 SNV: p.G137R .
SNU1196 SNV: p.R154C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C231(0.92)  LDD0531  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
PAL-AfBPP Probe
Click To Hide/Show 64 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C049
 Probe Info  		4.96  LDD1747  [4]
C053
 Probe Info  		5.03  LDD1751  [4]
C055
 Probe Info  		16.68  LDD1752  [4]
C056
 Probe Info  		18.64  LDD1753  [4]
C058
 Probe Info  		8.75  LDD1755  [4]
C067
 Probe Info  		32.67  LDD1763  [4]
C070
 Probe Info  		14.32  LDD1766  [4]
C072
 Probe Info  		8.57  LDD1768  [4]
C085
 Probe Info  		9.32  LDD1777  [4]
C100
 Probe Info  		11.00  LDD1789  [4]
C106
 Probe Info  		44.63  LDD1793  [4]
C107
 Probe Info  		31.12  LDD1794  [4]
C108
 Probe Info  		14.93  LDD1795  [4]
C112
 Probe Info  		23.26  LDD1799  [4]
C129
 Probe Info  		5.35  LDD1811  [4]
C141
 Probe Info  		11.63  LDD1823  [4]
C143
 Probe Info  		99.73  LDD1825  [4]
C147
 Probe Info  		9.00  LDD1829  [4]
C153
 Probe Info  		26.17  LDD1834  [4]
C160
 Probe Info  		54.19  LDD1840  [4]
C161
 Probe Info  		20.68  LDD1841  [4]
C169
 Probe Info  		32.00  LDD1849  [4]
C173
 Probe Info  		8.88  LDD1853  [4]
C177
 Probe Info  		10.20  LDD1856  [4]
C179
 Probe Info  		12.73  LDD1858  [4]
C186
 Probe Info  		30.48  LDD1864  [4]
C187
 Probe Info  		35.26  LDD1865  [4]
C199
 Probe Info  		5.54  LDD1875  [4]
C201
 Probe Info  		32.90  LDD1877  [4]
C204
 Probe Info  		9.78  LDD1879  [4]
C206
 Probe Info  		22.47  LDD1881  [4]
C211
 Probe Info  		10.20  LDD1885  [4]
C220
 Probe Info  		60.13  LDD1894  [4]
C222
 Probe Info  		5.31  LDD1896  [4]
C225
 Probe Info  		7.62  LDD1898  [4]
C226
 Probe Info  		5.66  LDD1899  [4]
C228
 Probe Info  		27.67  LDD1901  [4]
C246
 Probe Info  		15.78  LDD1919  [4]
C256
 Probe Info  		8.34  LDD1929  [4]
C264
 Probe Info  		19.29  LDD1935  [4]
C265
 Probe Info  		15.89  LDD1936  [4]
C270
 Probe Info  		6.06  LDD1940  [4]
C273
 Probe Info  		13.18  LDD1943  [4]
C274
 Probe Info  		14.03  LDD1944  [4]
C275
 Probe Info  		5.86  LDD1945  [4]
C277
 Probe Info  		86.22  LDD1947  [4]
C286
 Probe Info  		7.26  LDD1956  [4]
C288
 Probe Info  		12.82  LDD1958  [4]
C290
 Probe Info  		5.31  LDD1960  [4]
C293
 Probe Info  		20.39  LDD1963  [4]
C305
 Probe Info  		13.55  LDD1974  [4]
C371
 Probe Info  		13.64  LDD2032  [4]
C373
 Probe Info  		6.92  LDD2033  [4]
C376
 Probe Info  		12.38  LDD2036  [4]
C379
 Probe Info  		15.56  LDD2038  [4]
C386
 Probe Info  		9.32  LDD2045  [4]
C387
 Probe Info  		11.39  LDD2046  [4]
C388
 Probe Info  		79.34  LDD2047  [4]
C389
 Probe Info  		10.41  LDD2048  [4]
C393
 Probe Info  		12.73  LDD2052  [4]
C399
 Probe Info  		17.88  LDD2058  [4]
C403
 Probe Info  		19.97  LDD2061  [4]
C414
 Probe Info  		9.58  LDD2070  [4]
A-DA
 Probe Info  		11.70  LDD0145  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C231(0.92)  LDD0531  [1]
 LDCM0230  AC113 HCT 116 C231(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C231(1.04)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C231(1.12)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C231(1.15)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C231(1.04)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C231(0.97)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C231(1.09)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C231(0.98)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C231(0.87)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C231(0.92)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C231(0.87)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C231(0.94)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C231(0.96)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C231(0.98)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C231(0.97)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C231(1.15)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C231(0.86)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C231(1.15)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C231(0.70)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C231(1.00)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C231(1.01)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C231(1.03)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C231(1.24)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C231(1.00)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C231(0.95)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C231(1.19)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C231(1.07)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C231(1.08)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C231(1.16)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C231(1.00)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C231(0.93)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C231(1.17)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C231(1.10)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C231(0.96)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C231(1.11)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C231(1.40)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C231(1.31)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C231(1.20)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C231(1.04)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C231(1.05)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C231(1.20)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C231(1.47)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C231(1.14)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C231(1.03)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C231(0.94)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C231(0.87)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C231(1.04)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C231(1.12)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C231(1.22)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C231(1.07)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C231(1.00)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C231(1.16)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C231(1.05)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C231(1.07)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C231(1.01)  LDD0601  [1]
 LDCM0289  AC29 HEK-293T C231(1.02)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C231(1.02)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C231(1.04)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C231(1.11)  LDD1532  [6]
 LDCM0298  AC37 HEK-293T C231(1.03)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C231(1.02)  LDD1538  [6]
 LDCM0301  AC4 HCT 116 C231(1.02)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C231(1.02)  LDD1541  [6]
 LDCM0307  AC45 HEK-293T C231(1.04)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C231(1.00)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C231(1.08)  LDD1549  [6]
 LDCM0312  AC5 HCT 116 C231(1.13)  LDD0629  [1]
 LDCM0316  AC53 HEK-293T C231(0.95)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C231(1.01)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C231(1.14)  LDD1558  [6]
 LDCM0320  AC57 HCT 116 C231(1.11)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C231(1.08)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C231(1.18)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C231(0.96)  LDD1562  [6]
 LDCM0324  AC60 HCT 116 C231(1.27)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C231(1.07)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C231(1.26)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C231(1.28)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C231(1.38)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C231(1.07)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C231(1.03)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C231(1.19)  LDD0648  [1]
 LDCM0345  AC8 HEK-293T C231(1.00)  LDD1569  [6]
 LDCM0349  AC83 HCT 116 C231(1.32)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C231(1.46)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C231(1.21)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C231(1.12)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C231(0.95)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C231(1.00)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C231(1.14)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C231(0.90)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C231(1.66)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C231(1.39)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C231(0.98)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C231(1.15)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C231(0.98)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C231(1.06)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C231(1.23)  LDD0681  [1]
 LDCM0248  AKOS034007472 HEK-293T C231(1.00)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C231(1.03)  LDD1514  [6]
 LDCM0368  CL10 HEK-293T C231(4.24)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C231(0.83)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C231(0.92)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C231(1.19)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C231(1.17)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C231(1.20)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C231(1.33)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C231(1.00)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C231(1.30)  LDD0698  [1]
 LDCM0390  CL12 HEK-293T C231(1.59)  LDD1594  [6]
 LDCM0396  CL125 HCT 116 C231(1.19)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C231(1.22)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C231(1.11)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C231(1.20)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C231(0.98)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C231(2.02)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C231(1.11)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C231(0.99)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C231(1.21)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C231(2.49)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C231(1.35)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C231(0.99)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C231(1.16)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C231(1.77)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C231(1.09)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C231(1.09)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C231(1.21)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C231(1.19)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C231(1.10)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C231(0.94)  LDD0737  [1]
 LDCM0422  CL33 HEK-293T C231(2.80)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C231(1.56)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C231(1.34)  LDD1629  [6]
 LDCM0435  CL45 HEK-293T C231(1.67)  LDD1639  [6]
 LDCM0436  CL46 HCT 116 C231(1.01)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C231(0.96)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C231(1.11)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C231(1.14)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C231(0.98)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C231(1.28)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C231(1.18)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C231(1.16)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C231(2.09)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C231(0.87)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C231(0.83)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C231(2.04)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C231(0.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C231(0.97)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C231(1.05)  LDD0769  [1]
 LDCM0461  CL69 HEK-293T C231(1.48)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C231(1.22)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C231(1.41)  LDD1668  [6]
 LDCM0469  CL76 HCT 116 C231(0.86)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C231(1.00)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C231(0.90)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C231(0.88)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C231(0.95)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C231(1.01)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C231(1.04)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C231(1.86)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C231(1.20)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C231(0.89)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C231(0.80)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C231(0.85)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C231(0.72)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C231(0.89)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C231(1.30)  LDD1687  [6]
 LDCM0485  CL90 HCT 116 C231(1.82)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C231(1.05)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C231(1.05)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C231(0.91)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C231(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C231(1.20)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C231(1.08)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C231(1.20)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C231(1.02)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C231(0.92)  LDD0811  [1]
 LDCM0022  KB02 BRX29 C231(2.51)  LDD2270  [7]
 LDCM0023  KB03 BRX29 C231(2.71)  LDD2687  [7]
 LDCM0024  KB05 UACC257 C231(2.59)  LDD3325  [7]
 LDCM0084  Ro 48-8071 A-549 11.70  LDD0145  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 5 (CD40) . P25942
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840