Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C199  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04689  Adenosine kinase (ADK) 15.1
 LDTP05551  Quinone oxidoreductase (CRYZ) 13.7
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 12.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 9.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.6
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 8.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 7.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 6.8
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 6.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 6.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.4
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 6.1
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 5.9
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 5.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.8
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 5.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.5
 LDTP00988  Protein O-GlcNAcase (OGA) 5.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 5.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 5.0
Transporter and channel
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 22.2
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 14.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 9.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 9.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 9.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 8.2
 LDTP01804  ATP synthase subunit a (MT-ATP6) 8.2
 LDTP10985  Equilibrative nucleoside transporter 1 (SLC29A1) 7.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 7.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 7.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.7
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 6.6
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 6.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 6.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 5.4
 LDTP03546  Translocator protein (TSPO) 5.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 5.1
Other
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 10.2
 LDTP11076  Apolipoprotein L2 (APOL2) 10.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 7.7
 LDTP14259  Testis-expressed protein 264 (TEX264) 6.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 6.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587