Details of the Target

General Information of Target

Target ID LDTP01804
Target Name ATP synthase subunit a (MT-ATP6)
Gene Name MT-ATP6
Gene ID 4508
Synonyms
ATP6; ATPASE6; MTATP6; ATP synthase subunit a; F-ATPase protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMTM
HNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVIMGFRSK
IKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLA
MSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT
Target Bioclass
Transporter and channel
Family
ATPase A chain family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Uniprot ID
P00846
Ensemble ID
ENST00000361899.2
HGNC ID
HGNC:7414

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y36(6.57)  LDD0260  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
TPP-AC
 Probe Info  		N.A.  LDD0427  [3]
PAL-AfBPP Probe
Click To Hide/Show 109 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		73.01  LDD1752  [4]
C056
 Probe Info  		64.89  LDD1753  [4]
C059
 Probe Info  		7.21  LDD1756  [4]
C063
 Probe Info  		42.22  LDD1760  [4]
C064
 Probe Info  		11.08  LDD1761  [4]
C065
 Probe Info  		14.72  LDD1762  [4]
C082
 Probe Info  		8.94  LDD1774  [4]
C083
 Probe Info  		7.94  LDD1775  [4]
C085
 Probe Info  		9.78  LDD1777  [4]
C086
 Probe Info  		6.50  LDD1778  [4]
C087
 Probe Info  		11.24  LDD1779  [4]
C091
 Probe Info  		21.56  LDD1782  [4]
C092
 Probe Info  		39.67  LDD1783  [4]
C094
 Probe Info  		57.28  LDD1785  [4]
C106
 Probe Info  		73.01  LDD1793  [4]
C107
 Probe Info  		16.56  LDD1794  [4]
C108
 Probe Info  		45.89  LDD1795  [4]
C153
 Probe Info  		37.01  LDD1834  [4]
C177
 Probe Info  		55.72  LDD1856  [4]
C178
 Probe Info  		41.07  LDD1857  [4]
C194
 Probe Info  		19.03  LDD1870  [4]
C196
 Probe Info  		99.73  LDD1872  [4]
C198
 Probe Info  		58.89  LDD1874  [4]
C199
 Probe Info  		8.17  LDD1875  [4]
C210
 Probe Info  		77.17  LDD1884  [4]
C213
 Probe Info  		17.15  LDD1887  [4]
C216
 Probe Info  		19.97  LDD1890  [4]
C217
 Probe Info  		33.36  LDD1891  [4]
C218
 Probe Info  		78.25  LDD1892  [4]
C219
 Probe Info  		12.55  LDD1893  [4]
C220
 Probe Info  		51.98  LDD1894  [4]
C222
 Probe Info  		6.68  LDD1896  [4]
C225
 Probe Info  		24.42  LDD1898  [4]
C226
 Probe Info  		28.84  LDD1899  [4]
C228
 Probe Info  		99.73  LDD1901  [4]
C229
 Probe Info  		23.59  LDD1902  [4]
C231
 Probe Info  		38.59  LDD1904  [4]
C232
 Probe Info  		99.73  LDD1905  [4]
C233
 Probe Info  		33.36  LDD1906  [4]
C234
 Probe Info  		31.12  LDD1907  [4]
C235
 Probe Info  		81.01  LDD1908  [4]
C238
 Probe Info  		31.12  LDD1911  [4]
C240
 Probe Info  		22.16  LDD1913  [4]
C243
 Probe Info  		36.50  LDD1916  [4]
C244
 Probe Info  		33.59  LDD1917  [4]
C246
 Probe Info  		55.72  LDD1919  [4]
C252
 Probe Info  		52.35  LDD1925  [4]
C258
 Probe Info  		11.55  LDD1931  [4]
C260
 Probe Info  		15.14  LDD1932  [4]
C264
 Probe Info  		34.78  LDD1935  [4]
C265
 Probe Info  		27.28  LDD1936  [4]
C269
 Probe Info  		11.71  LDD1939  [4]
C280
 Probe Info  		17.63  LDD1950  [4]
C282
 Probe Info  		27.86  LDD1952  [4]
C284
 Probe Info  		55.72  LDD1954  [4]
C285
 Probe Info  		28.05  LDD1955  [4]
C287
 Probe Info  		30.27  LDD1957  [4]
C288
 Probe Info  		21.41  LDD1958  [4]
C289
 Probe Info  		43.11  LDD1959  [4]
C290
 Probe Info  		21.26  LDD1960  [4]
C293
 Probe Info  		66.72  LDD1963  [4]
C296
 Probe Info  		39.40  LDD1966  [4]
C297
 Probe Info  		16.22  LDD1967  [4]
C299
 Probe Info  		6.92  LDD1968  [4]
C301
 Probe Info  		5.90  LDD1970  [4]
C305
 Probe Info  		45.57  LDD1974  [4]
C313
 Probe Info  		21.41  LDD1980  [4]
C314
 Probe Info  		50.56  LDD1981  [4]
C317
 Probe Info  		10.27  LDD1983  [4]
C322
 Probe Info  		57.28  LDD1988  [4]
C326
 Probe Info  		21.11  LDD1990  [4]
C342
 Probe Info  		9.06  LDD2004  [4]
C343
 Probe Info  		15.56  LDD2005  [4]
C346
 Probe Info  		15.24  LDD2007  [4]
C348
 Probe Info  		51.27  LDD2009  [4]
C349
 Probe Info  		71.01  LDD2010  [4]
C350
 Probe Info  		99.73  LDD2011  [4]
C351
 Probe Info  		7.73  LDD2012  [4]
C353
 Probe Info  		11.47  LDD2014  [4]
C354
 Probe Info  		58.08  LDD2015  [4]
C355
 Probe Info  		30.48  LDD2016  [4]
C356
 Probe Info  		32.67  LDD2017  [4]
C357
 Probe Info  		23.43  LDD2018  [4]
C361
 Probe Info  		46.21  LDD2022  [4]
C362
 Probe Info  		99.73  LDD2023  [4]
C363
 Probe Info  		95.67  LDD2024  [4]
C364
 Probe Info  		99.73  LDD2025  [4]
C366
 Probe Info  		99.73  LDD2027  [4]
C367
 Probe Info  		44.63  LDD2028  [4]
C376
 Probe Info  		23.10  LDD2036  [4]
C378
 Probe Info  		8.63  LDD2037  [4]
C380
 Probe Info  		16.11  LDD2039  [4]
C382
 Probe Info  		28.44  LDD2041  [4]
C383
 Probe Info  		14.62  LDD2042  [4]
C386
 Probe Info  		8.34  LDD2045  [4]
C388
 Probe Info  		99.73  LDD2047  [4]
C390
 Probe Info  		82.14  LDD2049  [4]
C391
 Probe Info  		53.08  LDD2050  [4]
C393
 Probe Info  		4.99  LDD2052  [4]
C396
 Probe Info  		12.82  LDD2055  [4]
C399
 Probe Info  		29.24  LDD2058  [4]
C403
 Probe Info  		48.84  LDD2061  [4]
C429
 Probe Info  		36.00  LDD2084  [4]
C430
 Probe Info  		6.87  LDD2085  [4]
C431
 Probe Info  		76.11  LDD2086  [4]
C433
 Probe Info  		19.56  LDD2088  [4]
STS-1
 Probe Info  		N.A.  LDD0136  [5]
STS-2
 Probe Info  		N.A.  LDD0138  [5]
LD-F
 Probe Info  		T146(0.00); I147(0.00); M140(0.00); P139(0.00)  LDD0015  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Estradiol Small molecular drug DB00783
Estradiol Acetate Small molecular drug DB13952
Estradiol Cypionate Small molecular drug DB13954
Estradiol Valerate Small molecular drug DB13956
Estradiol Benzoate . DB13953
Estradiol Dienanthate . DB13955

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
6 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652