Details of the Target

General Information of Target

Target ID LDTP08364
Target Name Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2)
Gene Name ANKLE2
Gene ID 23141
Synonyms
KIAA0692; LEM4; Ankyrin repeat and LEM domain-containing protein 2; LEM domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPAS
GEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSF
YHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAF
STREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANS
YKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFAC
KFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPL
LRAEETSSPVIGELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWK
TPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLE
EYLTQQEIGKKAQQETGEREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNAARN
NSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPR
GEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSRINAVERDLLEPSPA
DQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLA
ALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDLSGPHSYSPGRN
SVAGSNPAKPGLGSPGRYSPVHGSQLRRMARLAELAAL
Target Bioclass
Other
Family
ANKLE2 family
Subcellular location
Endoplasmic reticulum membrane
Function
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Uniprot ID
Q86XL3
Ensemble ID
ENST00000357997.10
HGNC ID
HGNC:29101

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.T64I DBIA    Probe Info 
A498 SNV: p.W30L DBIA    Probe Info 
CCK81 Deletion: p.F827LfsTer52 DBIA    Probe Info 
COLO320 SNV: p.S622P DBIA    Probe Info 
DOTC24510 SNV: p.M646I DBIA    Probe Info 
DU145 SNV: p.E82Ter; p.A780V DBIA    Probe Info 
HCC1806 SNV: p.R822T DBIA    Probe Info 
IGR1 SNV: p.S622F DBIA    Probe Info 
LS123 SNV: p.S622P DBIA    Probe Info 
U2OS SNV: p.R397C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		2.05  LDD0324  [2]
DA-P2
 Probe Info  		22.73  LDD0348  [3]
HRP
 Probe Info  		17.08  LDD0347  [3]
STPyne
 Probe Info  		K104(2.04); K105(5.52); K222(7.69); K90(7.69)  LDD0277  [4]
Probe 1
 Probe Info  		Y217(34.00)  LDD3495  [5]
AHL-Pu-1
 Probe Info  		C203(2.65); C844(2.19); C254(2.84)  LDD0169  [6]
DBIA
 Probe Info  		C254(1.10); C176(1.05); C350(0.96); C203(0.94)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C674(0.00); C367(0.00); C254(0.00); C454(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C91(0.00); C367(0.00); C454(0.00); C350(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C91(0.00); C367(0.00); C254(0.00); C350(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C254(0.00); C674(0.00); C844(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
DA-P3
 Probe Info  		N.A.  LDD0178  [3]
Compound 10
 Probe Info  		C254(0.00); C454(0.00); C674(0.00); C91(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C254(0.00); C674(0.00)  LDD2213  [12]
IPM
 Probe Info  		C91(0.00); C286(0.00); C254(0.00)  LDD0005  [11]
SF
 Probe Info  		N.A.  LDD0028  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		C91(0.00); C702(0.00); C350(0.00); C623(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		14.90  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 159 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.16  LDD1714  [18]
C017
 Probe Info  		16.00  LDD1725  [18]
C022
 Probe Info  		6.73  LDD1728  [18]
C026
 Probe Info  		5.70  LDD1732  [18]
C027
 Probe Info  		5.78  LDD1733  [18]
C040
 Probe Info  		9.71  LDD1740  [18]
C041
 Probe Info  		8.28  LDD1741  [18]
C055
 Probe Info  		22.47  LDD1752  [18]
C056
 Probe Info  		21.56  LDD1753  [18]
C059
 Probe Info  		5.13  LDD1756  [18]
C063
 Probe Info  		12.47  LDD1760  [18]
C064
 Probe Info  		6.73  LDD1761  [18]
C070
 Probe Info  		12.38  LDD1766  [18]
C072
 Probe Info  		8.88  LDD1768  [18]
C082
 Probe Info  		7.46  LDD1774  [18]
C085
 Probe Info  		5.21  LDD1777  [18]
C091
 Probe Info  		18.51  LDD1782  [18]
C092
 Probe Info  		18.51  LDD1783  [18]
C094
 Probe Info  		23.10  LDD1785  [18]
C107
 Probe Info  		8.75  LDD1794  [18]
C108
 Probe Info  		10.93  LDD1795  [18]
C129
 Probe Info  		7.41  LDD1811  [18]
C130
 Probe Info  		8.82  LDD1812  [18]
C131
 Probe Info  		5.17  LDD1813  [18]
C134
 Probe Info  		21.41  LDD1816  [18]
C135
 Probe Info  		20.82  LDD1817  [18]
C139
 Probe Info  		13.55  LDD1821  [18]
C140
 Probe Info  		11.08  LDD1822  [18]
C141
 Probe Info  		21.11  LDD1823  [18]
C143
 Probe Info  		24.93  LDD1825  [18]
C145
 Probe Info  		8.82  LDD1827  [18]
C147
 Probe Info  		9.65  LDD1829  [18]
C153
 Probe Info  		27.28  LDD1834  [18]
C159
 Probe Info  		10.93  LDD1839  [18]
C160
 Probe Info  		9.65  LDD1840  [18]
C161
 Probe Info  		13.18  LDD1841  [18]
C163
 Probe Info  		13.64  LDD1843  [18]
C165
 Probe Info  		25.99  LDD1845  [18]
C166
 Probe Info  		13.45  LDD1846  [18]
C169
 Probe Info  		25.11  LDD1849  [18]
C170
 Probe Info  		7.62  LDD1850  [18]
C177
 Probe Info  		12.55  LDD1856  [18]
C178
 Probe Info  		31.12  LDD1857  [18]
C183
 Probe Info  		4.99  LDD1861  [18]
C186
 Probe Info  		11.00  LDD1864  [18]
C187
 Probe Info  		39.40  LDD1865  [18]
C191
 Probe Info  		20.82  LDD1868  [18]
C193
 Probe Info  		10.34  LDD1869  [18]
C194
 Probe Info  		12.55  LDD1870  [18]
C196
 Probe Info  		17.27  LDD1872  [18]
C197
 Probe Info  		6.77  LDD1873  [18]
C198
 Probe Info  		18.38  LDD1874  [18]
C199
 Probe Info  		5.50  LDD1875  [18]
C206
 Probe Info  		19.97  LDD1881  [18]
C211
 Probe Info  		12.64  LDD1885  [18]
C213
 Probe Info  		15.45  LDD1887  [18]
C214
 Probe Info  		6.15  LDD1888  [18]
C216
 Probe Info  		5.13  LDD1890  [18]
C218
 Probe Info  		17.15  LDD1892  [18]
C219
 Probe Info  		8.28  LDD1893  [18]
C220
 Probe Info  		15.24  LDD1894  [18]
C222
 Probe Info  		4.99  LDD1896  [18]
C225
 Probe Info  		6.77  LDD1898  [18]
C226
 Probe Info  		7.26  LDD1899  [18]
C228
 Probe Info  		15.03  LDD1901  [18]
C229
 Probe Info  		10.34  LDD1902  [18]
C231
 Probe Info  		15.67  LDD1904  [18]
C232
 Probe Info  		33.82  LDD1905  [18]
C233
 Probe Info  		13.09  LDD1906  [18]
C234
 Probe Info  		18.13  LDD1907  [18]
C235
 Probe Info  		25.28  LDD1908  [18]
C238
 Probe Info  		17.39  LDD1911  [18]
C240
 Probe Info  		10.13  LDD1913  [18]
C243
 Probe Info  		10.56  LDD1916  [18]
C252
 Probe Info  		17.39  LDD1925  [18]
C264
 Probe Info  		16.56  LDD1935  [18]
C265
 Probe Info  		13.93  LDD1936  [18]
C266
 Probe Info  		9.19  LDD1937  [18]
C269
 Probe Info  		7.84  LDD1939  [18]
C270
 Probe Info  		10.56  LDD1940  [18]
C271
 Probe Info  		5.70  LDD1941  [18]
C272
 Probe Info  		6.73  LDD1942  [18]
C273
 Probe Info  		12.13  LDD1943  [18]
C277
 Probe Info  		19.16  LDD1947  [18]
C280
 Probe Info  		12.21  LDD1950  [18]
C282
 Probe Info  		27.28  LDD1952  [18]
C284
 Probe Info  		32.22  LDD1954  [18]
C285
 Probe Info  		22.47  LDD1955  [18]
C286
 Probe Info  		7.26  LDD1956  [18]
C287
 Probe Info  		16.34  LDD1957  [18]
C288
 Probe Info  		10.56  LDD1958  [18]
C290
 Probe Info  		7.31  LDD1960  [18]
C293
 Probe Info  		17.27  LDD1963  [18]
C296
 Probe Info  		14.12  LDD1966  [18]
C297
 Probe Info  		6.50  LDD1967  [18]
C299
 Probe Info  		17.88  LDD1968  [18]
C304
 Probe Info  		5.50  LDD1973  [18]
C305
 Probe Info  		14.52  LDD1974  [18]
C307
 Probe Info  		9.38  LDD1975  [18]
C310
 Probe Info  		11.71  LDD1977  [18]
C313
 Probe Info  		15.14  LDD1980  [18]
C314
 Probe Info  		15.78  LDD1981  [18]
C317
 Probe Info  		8.00  LDD1983  [18]
C320
 Probe Info  		5.46  LDD1986  [18]
C322
 Probe Info  		7.94  LDD1988  [18]
C326
 Probe Info  		14.52  LDD1990  [18]
C327
 Probe Info  		5.21  LDD1991  [18]
C338
 Probe Info  		17.27  LDD2001  [18]
C339
 Probe Info  		15.14  LDD2002  [18]
C343
 Probe Info  		17.75  LDD2005  [18]
C346
 Probe Info  		10.48  LDD2007  [18]
C347
 Probe Info  		5.94  LDD2008  [18]
C348
 Probe Info  		21.26  LDD2009  [18]
C349
 Probe Info  		15.14  LDD2010  [18]
C350
 Probe Info  		24.59  LDD2011  [18]
C353
 Probe Info  		6.63  LDD2014  [18]
C354
 Probe Info  		10.20  LDD2015  [18]
C355
 Probe Info  		26.54  LDD2016  [18]
C356
 Probe Info  		10.63  LDD2017  [18]
C357
 Probe Info  		6.54  LDD2018  [18]
C361
 Probe Info  		18.51  LDD2022  [18]
C363
 Probe Info  		16.45  LDD2024  [18]
C364
 Probe Info  		15.89  LDD2025  [18]
C366
 Probe Info  		9.65  LDD2027  [18]
C367
 Probe Info  		5.17  LDD2028  [18]
C373
 Probe Info  		20.53  LDD2033  [18]
C376
 Probe Info  		14.32  LDD2036  [18]
C378
 Probe Info  		9.78  LDD2037  [18]
C382
 Probe Info  		15.67  LDD2041  [18]
C383
 Probe Info  		23.92  LDD2042  [18]
C386
 Probe Info  		10.63  LDD2045  [18]
C387
 Probe Info  		5.10  LDD2046  [18]
C388
 Probe Info  		36.00  LDD2047  [18]
C390
 Probe Info  		27.28  LDD2049  [18]
C391
 Probe Info  		18.64  LDD2050  [18]
C399
 Probe Info  		11.88  LDD2058  [18]
C403
 Probe Info  		15.03  LDD2061  [18]
C407
 Probe Info  		12.21  LDD2064  [18]
C409
 Probe Info  		7.57  LDD2066  [18]
C413
 Probe Info  		17.51  LDD2069  [18]
C416
 Probe Info  		5.54  LDD2071  [18]
C419
 Probe Info  		13.45  LDD2074  [18]
C420
 Probe Info  		16.68  LDD2075  [18]
C424
 Probe Info  		19.03  LDD2079  [18]
C426
 Probe Info  		40.79  LDD2081  [18]
C429
 Probe Info  		18.38  LDD2084  [18]
C430
 Probe Info  		5.03  LDD2085  [18]
C431
 Probe Info  		23.92  LDD2086  [18]
C433
 Probe Info  		6.15  LDD2088  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe15
 Probe Info  		13.10  LDD0478  [19]
FFF probe2
 Probe Info  		17.82  LDD0463  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
FFF probe9
 Probe Info  		20.00  LDD0485  [19]
JN0003
 Probe Info  		20.00  LDD0484  [19]
A-DA
 Probe Info  		3.05  LDD0145  [20]
OEA-DA
 Probe Info  		20.00  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C254(2.99)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C203(2.65); C844(2.19); C254(2.84)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C203(1.00); C254(0.87); C350(1.05); C420(1.07)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C203(0.95); C254(0.98); C350(1.30); C454(0.97)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C203(0.84); C254(0.87); C350(1.12); C454(0.76)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C203(0.91); C254(0.97); C350(1.01); C454(0.79)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C203(0.97); C254(0.97); C350(1.00); C454(0.77)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C203(0.99); C254(0.88); C350(1.24); C454(0.74)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C203(0.97); C254(0.99); C350(1.09); C454(0.79)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C203(1.07); C254(0.92); C350(1.13); C454(0.76)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C203(0.95); C254(0.96); C350(1.18); C454(0.76)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C203(1.10); C254(0.85); C350(1.37); C454(0.81)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C203(1.01); C254(1.00); C350(1.30); C454(0.74)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C203(1.11); C254(1.04); C350(1.02); C454(1.12)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C203(0.97); C254(1.33); C350(1.30); C454(0.96)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C203(1.18); C254(1.01); C350(1.07); C454(0.80)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C203(1.10); C254(1.00); C350(0.93); C454(0.92)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C203(1.27); C254(1.20); C350(1.25); C454(0.71)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C203(1.20); C254(1.11); C350(0.85); C420(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C203(1.00); C254(1.01); C350(0.88); C420(1.09)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C203(1.06); C254(0.91); C350(1.18); C420(0.87)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C203(1.13); C254(0.97); C350(1.14); C420(1.08)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C203(1.16); C254(1.04); C350(1.19); C420(0.94)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C203(0.98); C254(1.06); C350(0.90); C420(0.98)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C203(1.23); C254(1.10); C350(1.06); C420(1.61)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C203(0.91); C254(1.02); C350(1.24); C454(0.99)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C203(1.42); C254(1.04); C350(1.13); C420(1.43)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C203(1.23); C254(0.92); C350(1.08); C420(0.92)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C203(1.17); C254(1.02); C350(0.87); C420(1.23)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C203(1.14); C254(1.01); C350(1.24); C420(0.92)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C203(1.16); C254(1.03); C350(1.00); C420(1.20)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C203(1.10); C254(0.98); C350(0.91); C420(1.37)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C203(1.19); C254(0.93); C350(1.24); C420(1.12)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C203(1.27); C254(0.90); C350(0.97); C420(1.02)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C203(0.87); C254(0.81); C350(0.95); C454(1.06)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C203(1.02); C254(0.90); C350(1.05); C454(1.07)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C203(0.67); C254(0.85); C350(1.24); C454(1.07)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C203(0.81); C254(0.79); C350(0.94); C454(1.05)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C203(1.03); C254(1.05); C350(1.29); C454(1.17)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C203(0.92); C254(0.89); C350(1.26); C454(1.11)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C203(0.66); C254(1.01); C350(1.13); C454(1.03)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C203(0.99); C254(0.79); C350(1.08); C454(1.12)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C203(0.95); C254(1.12); C350(1.18); C454(1.12)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C203(0.84); C254(0.91); C350(1.21); C454(0.98)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C203(0.87); C254(0.84); C350(1.32); C454(1.08)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C203(1.20); C254(0.96); C350(1.46); C454(1.11)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C203(0.99); C254(1.13); C350(1.22); C454(1.19)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C203(1.04); C254(0.88); C350(1.86); C454(1.07)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C203(0.80); C254(1.08); C350(1.43); C454(1.09)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C203(0.81); C254(0.88); C350(1.45); C454(1.23)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C203(1.03); C254(1.10); C350(0.86); C91(1.08)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C350(0.77); C203(0.90); C254(1.06); C91(1.25)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C350(0.81); C254(1.04); C203(1.05); C91(1.08)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C350(0.93); C203(1.03); C91(1.18); C254(1.18)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C350(0.91); C254(1.01); C203(1.02); C91(1.35)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C203(1.12); C254(1.13); C350(1.28); C91(1.49)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C350(0.92); C203(0.99); C254(1.14); C91(1.16)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C454(1.00); C203(1.01); C91(1.04); C350(1.22)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C350(0.83); C203(1.03); C91(1.04); C254(1.04)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C350(0.92); C91(1.01); C254(1.07); C203(1.16)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C203(1.05); C350(1.07); C91(1.13); C254(1.14)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C350(1.06); C203(1.17); C254(1.39); C91(1.45)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C203(1.09); C254(1.19); C350(0.79); C91(1.13)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C203(1.22); C254(1.19); C350(0.90); C91(1.10)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C203(1.00); C254(1.09); C350(0.84); C91(1.06)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C203(1.14); C254(1.12); C350(0.78); C91(1.19)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C91(0.75); C454(0.82); C350(0.89); C420(0.93)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C91(0.66); C454(0.69); C203(0.94); C420(0.96)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C454(0.69); C91(0.79); C203(0.97); C420(0.99)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C454(0.79); C254(0.90); C350(0.94); C203(0.96)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C454(0.67); C91(0.74); C420(0.91); C350(1.00)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C91(0.73); C454(0.87); C420(0.95); C203(1.06)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C91(0.75); C454(0.93); C420(1.06); C350(1.12)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C91(0.68); C454(0.84); C203(0.96); C420(1.01)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C91(0.64); C454(0.69); C350(0.89); C420(0.94)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C91(0.82); C420(0.90); C454(0.90); C203(1.00)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C454(0.78); C420(0.82); C203(0.98); C350(1.00)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C454(0.64); C420(0.93); C203(1.12); C350(1.15)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C454(0.77); C420(0.98); C203(1.10); C350(1.13)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C454(0.65); C420(0.75); C350(0.95); C203(1.16)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C254(0.85); C203(0.98); C350(1.02); C454(1.06)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C454(0.68); C420(0.88); C350(1.05); C203(1.18)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C454(0.85); C420(0.93); C350(0.94); C203(0.95)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C420(0.77); C454(0.78); C203(0.92); C254(0.99)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C454(0.67); C420(0.78); C91(1.00); C203(1.19)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C454(0.82); C420(0.93); C91(0.95); C350(1.26)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C91(0.72); C203(0.94); C350(0.99); C420(1.01)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C350(0.72); C454(0.94); C91(0.95); C420(1.16)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C350(0.90); C91(1.01); C420(1.08); C454(1.09)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C91(0.89); C454(0.90); C350(1.05); C420(1.19)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C91(0.82); C350(0.89); C454(0.97); C203(1.09)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C454(0.84); C203(0.92); C254(0.93); C420(0.96)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C91(0.83); C454(0.89); C350(1.02); C420(1.14)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C454(0.93); C420(0.94); C91(0.97); C350(1.21)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C91(0.85); C454(0.94); C420(1.14); C350(1.29)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C454(0.85); C91(0.95); C420(1.01); C350(1.12)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C91(0.87); C420(0.88); C350(0.93); C454(1.14)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C91(0.91); C350(0.98); C420(1.09); C454(1.38)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C350(0.98); C454(1.01); C203(1.11); C91(1.22)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C350(0.95); C454(0.97); C203(1.07); C91(1.19)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C350(0.99); C203(1.20); C454(1.25); C91(1.29)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C454(1.01); C350(1.08); C91(1.14); C203(1.20)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C203(0.82); C254(0.87); C454(0.92); C420(1.00)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C454(0.97); C350(1.06); C203(1.15); C91(1.44)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C350(1.02); C91(1.15); C203(1.18); C454(1.19)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C454(0.91); C91(1.10); C203(1.19); C350(1.35)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C454(0.94); C91(1.12); C203(1.20); C350(1.23)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C350(0.85); C454(1.00); C91(1.14); C203(1.30)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C454(1.04); C203(1.28); C350(1.29); C91(1.36)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C454(1.27); C350(1.29); C203(1.48); C91(1.59)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C454(0.87); C420(0.87); C203(0.88); C350(1.03)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C454(0.68); C420(0.84); C203(0.89); C254(0.99)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C454(0.70); C420(0.78); C203(0.83); C254(1.15)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C454(0.83); C203(0.93); C254(1.05); C350(1.24)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C454(0.72); C420(0.78); C203(0.92); C254(1.15)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C420(0.79); C254(0.86); C203(0.90); C454(0.91)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C454(0.66); C420(0.82); C203(0.84); C254(1.00)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C420(0.74); C454(0.80); C203(0.84); C350(1.18)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C420(0.72); C454(0.75); C203(0.90); C254(1.29)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C420(0.78); C454(0.78); C203(0.83); C254(1.09)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C454(0.70); C203(0.83); C420(0.85); C254(1.05)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C454(0.70); C420(0.70); C203(0.80); C254(1.23)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C454(0.75); C254(0.94); C350(0.96); C203(1.01)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C254(0.90); C454(0.91); C350(0.94); C420(0.96)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C203(0.93); C454(0.97); C254(1.08); C91(1.15)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C454(0.74); C420(0.81); C254(0.85); C91(0.96)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C254(0.81); C454(0.93); C350(0.95); C203(1.04)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C454(0.79); C420(0.84); C203(0.94); C350(1.01)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C420(0.91); C454(0.91); C350(1.06); C203(1.19)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C254(1.00); C454(1.00); C420(1.01); C203(1.02)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C420(0.73); C350(1.01); C254(1.04); C454(1.22)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C454(0.91); C420(0.96); C350(0.98); C254(1.01)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C454(0.80); C420(0.83); C350(0.98); C203(0.98)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C420(0.90); C454(0.98); C254(1.04); C350(1.07)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C454(0.63); C420(0.84); C254(1.00); C350(1.11)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C91(0.90); C203(0.94); C454(0.95); C254(1.19)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C454(0.61); C203(1.05); C350(1.10); C254(1.13)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C254(0.77); C91(0.82); C420(0.82); C203(1.06)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C420(0.89); C254(0.94); C350(1.00); C203(1.06)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C454(0.86); C420(1.00); C203(1.15); C91(1.27)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C454(0.87); C91(0.95); C420(0.97); C203(1.07)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C454(0.90); C254(1.02); C91(1.04); C203(1.05)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C454(0.72); C420(0.87); C203(0.93); C254(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C254(0.92); C454(0.96); C420(0.99); C203(1.01)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C454(0.86); C254(0.97); C420(0.98); C203(1.02)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C454(0.84); C420(0.99); C203(1.01); C254(1.06)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C454(0.82); C254(0.96); C203(1.00); C420(1.03)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C420(0.91); C454(0.99); C91(1.26); C254(1.27)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C420(0.95); C454(0.99); C254(1.04); C203(1.15)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C91(0.90); C454(0.97); C420(0.97); C203(1.01)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C91(0.76); C420(1.03); C454(1.03); C203(1.08)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C254(0.97); C420(0.97); C91(1.04); C454(1.06)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C454(0.96); C91(1.03); C420(1.07); C203(1.11)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C454(0.80); C91(1.06); C203(1.07); C420(1.09)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C454(0.78); C203(1.02); C254(1.02); C91(1.24)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C91(0.74); C254(0.94); C203(0.96); C454(0.98)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C203(1.00); C254(1.01); C350(1.09); C454(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C203(1.01); C91(1.10); C254(1.10); C454(1.13)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C454(0.81); C203(0.98); C254(1.18); C91(1.43)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C254(1.10); C176(1.05); C350(0.96); C203(0.94)  LDD0078  [7]
 LDCM0102  BDHI 8 Jurkat C91(13.97)  LDD0204  [22]
 LDCM0087  Capsaicin HEK-293T 67.82  LDD0185  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C702(1.31); C674(0.34); C286(0.30)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C91(0.95); C350(0.96); C454(1.03); C203(1.28)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C454(1.06); C350(1.14); C203(1.30); C91(1.30)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C454(0.85); C254(0.96); C91(1.00); C203(1.04)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C454(0.87); C350(0.88); C203(0.95); C91(1.30)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C454(0.88); C203(0.92); C350(0.99); C91(1.17)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C203(0.91); C454(0.94); C91(1.04); C254(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C454(1.04); C203(1.04); C254(1.06); C91(1.19)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C91(0.72); C454(0.76); C350(0.99); C203(1.01)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C91(0.68); C454(0.71); C203(0.98); C420(1.00)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C454(0.63); C91(0.87); C203(0.94); C420(1.06)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C454(0.67); C91(0.86); C420(0.88); C203(1.03)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C454(0.75); C91(0.79); C420(0.97); C203(1.09)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C350(0.93); C454(1.13); C91(1.23); C203(1.37)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C454(0.63); C91(0.78); C203(0.90); C420(0.97)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C91(0.70); C454(0.71); C420(0.84); C203(0.95)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C420(0.87); C203(0.92); C454(0.95); C254(1.03)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C454(0.57); C420(0.79); C203(1.05); C254(1.12)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C420(0.80); C454(0.82); C203(1.03); C350(1.18)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C454(0.75); C420(0.97); C91(0.98); C203(1.14)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C454(0.80); C420(0.83); C350(0.87); C91(0.99)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C454(0.83); C91(1.01); C420(1.19); C350(1.46)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C91(0.87); C203(0.95); C454(1.03); C350(1.10)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C91(0.83); C454(0.86); C203(0.96); C420(1.04)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C454(0.97); C350(1.07); C203(1.22); C91(1.49)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C454(0.87); C91(0.87); C350(0.94); C420(1.07)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C454(0.76); C350(0.77); C91(1.17); C203(1.33)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C350(0.93); C454(1.19); C91(1.20); C203(1.32)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C454(0.92); C91(1.13); C203(1.18); C350(1.19)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C454(0.99); C350(1.06); C203(1.21); C91(1.23)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C420(0.81); C454(0.83); C203(0.84); C350(0.94)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C454(0.72); C420(0.79); C203(0.85); C350(0.99)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C454(0.76); C203(0.76); C420(0.82); C350(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C454(0.80); C203(0.81); C420(0.86); C254(0.87)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C454(0.92); C350(0.95); C91(1.13); C203(1.19)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C454(0.88); C350(0.90); C91(1.12); C203(1.26)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C350(0.88); C454(0.96); C203(1.27); C91(1.27)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C350(0.93); C454(1.00); C203(1.05); C91(1.13)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C350(0.85); C203(0.89); C454(0.92); C91(0.97)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C91(0.85); C350(0.98); C254(0.98); C203(1.12)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C254(0.87); C91(0.95); C203(0.99); C454(1.04)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C350(0.91); C91(1.02); C454(1.04); C203(1.33)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C254(0.88); C203(0.92); C350(0.92); C91(0.97)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C91(0.91); C203(0.92); C454(0.94); C350(0.99)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C91(0.92); C254(0.96); C454(0.99); C203(1.20)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C254(0.96); C350(0.96); C454(1.03); C91(1.03)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C254(0.85); C454(0.95); C203(0.99); C350(1.17)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C203(0.90); C254(0.98); C350(1.16); C454(0.91)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C203(0.95); C254(0.98); C350(1.01); C454(0.88)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C203(1.01); C254(0.90); C350(1.02); C454(0.85)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C203(0.96); C254(1.23); C350(1.02); C454(0.91)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C203(0.95); C254(0.84); C350(1.10); C454(0.97)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C203(1.29); C350(0.93); C454(0.86); C91(0.98)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C203(1.12); C254(0.92); C350(0.87); C454(1.10)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C203(0.92); C254(1.21); C350(1.24); C454(0.85)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C203(1.17); C254(1.04); C350(1.21); C454(0.77)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C203(0.98); C254(1.14); C350(0.97); C454(0.74)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C203(1.14); C254(1.03); C350(1.35); C454(0.78)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C203(1.24); C254(1.13); C350(1.63); C454(0.83)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C203(1.12); C254(1.37); C350(1.22); C454(0.85)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C203(1.32); C254(1.37); C350(1.37); C454(1.09)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C203(1.14); C254(1.14); C350(1.25); C454(0.77)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C203(1.15); C350(0.92); C454(1.06); C91(0.91)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C203(1.18); C254(1.80); C350(1.13); C454(0.72)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C203(1.38); C254(1.01); C350(1.15); C454(0.83)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C203(1.17); C254(1.35); C350(1.60); C454(0.70)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C203(1.26); C254(1.18); C350(1.44); C454(0.80)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C203(1.07); C254(1.22); C350(1.26); C454(1.03)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C203(1.58); C254(1.31); C350(1.49); C454(0.80)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C203(1.02); C254(1.25); C350(0.92); C420(0.90)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C203(0.84); C254(1.02); C350(1.03); C420(1.02)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C203(1.03); C254(0.93); C350(1.05); C420(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C203(0.86); C254(1.01); C350(1.06); C420(0.99)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C203(1.34); C350(0.95); C454(1.01); C91(1.18)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C203(0.98); C254(1.05); C350(0.80); C420(0.93)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C203(0.94); C254(1.13); C350(0.91); C420(0.95)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C203(0.98); C254(1.27); C350(1.25); C420(0.87)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C203(1.06); C254(1.19); C350(0.88); C420(1.22)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C203(1.03); C254(1.15); C350(0.96); C420(0.92)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C203(1.07); C254(1.09); C350(0.83); C420(1.11)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C203(1.11); C254(0.94); C350(0.98); C420(1.10)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C203(1.04); C254(1.13); C350(0.99); C420(1.10)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C203(1.21); C254(1.21); C350(1.11); C420(1.09)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C203(1.05); C254(1.08); C350(1.10); C420(1.07)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C203(1.42); C350(0.88); C454(1.02); C91(1.01)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C203(0.89); C254(1.20); C350(1.13); C420(1.03)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C203(0.97); C350(1.01); C454(1.18); C91(0.77)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C203(0.85); C350(1.08); C454(1.17); C91(1.05)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C203(0.89); C350(1.16); C454(0.96); C91(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C203(0.98); C350(1.22); C454(0.99); C91(1.02)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C203(0.97); C350(1.04); C454(1.17); C91(0.88)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C203(0.83); C350(1.37); C454(1.07); C91(1.09)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C203(1.25); C350(1.44); C454(0.96); C91(0.92)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C203(1.07); C350(1.17); C454(1.18); C91(1.24)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C203(1.06); C350(0.97); C454(1.36); C91(1.05)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C203(1.20); C350(0.97); C454(1.11); C91(1.19)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C203(0.91); C350(1.03); C454(1.07); C91(0.80)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C203(0.82); C350(1.20); C454(1.05); C91(0.75)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C203(1.23); C350(0.99); C454(1.50); C91(0.96)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C203(1.11); C350(1.10); C454(1.09); C91(1.07)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C203(1.08); C350(1.11); C454(1.11); C91(1.23)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C203(0.99); C254(1.12); C350(1.66); C454(0.99)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C203(1.08); C254(1.05); C350(0.97); C454(0.64)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C203(0.98); C254(1.09); C350(1.11); C454(0.67)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C203(0.94); C254(0.84); C350(1.40); C454(0.74)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C203(1.26); C350(1.08); C454(0.73); C91(1.20)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C203(1.19); C254(0.93); C350(1.15); C454(1.03)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C203(0.85); C254(1.02); C350(1.25); C454(0.79)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C203(0.97); C254(0.92); C350(1.64); C454(0.76)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C203(0.94); C254(0.87); C350(1.23); C454(1.29)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C203(1.01); C254(0.98); C350(1.73); C454(0.81)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C203(0.94); C254(0.95); C350(1.47); C454(0.87)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C203(0.88); C254(0.85); C350(1.18); C454(0.76)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C203(0.84); C254(1.06); C350(1.13); C454(0.75)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C203(0.90); C254(0.90); C350(1.49); C454(0.80)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C203(1.13); C254(0.97); C350(1.92); C454(0.96)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C203(1.22); C350(1.11); C454(0.84); C91(1.12)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C203(0.91); C254(1.20); C350(0.91); C454(0.87)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C203(1.02); C254(1.05); C350(0.92); C420(0.95)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C203(1.10); C254(1.22); C350(0.87); C420(1.07)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C203(1.09); C254(0.99); C350(0.97); C420(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C203(0.94); C254(1.21); C350(0.93); C420(1.25)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C203(0.86); C254(1.35); C350(0.95); C420(1.03)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C203(0.97); C254(0.99); C350(1.14); C420(1.04)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C203(0.95); C254(1.04); C350(1.07); C420(1.06)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C203(0.89); C254(1.03); C350(1.06); C420(0.96)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C203(0.89); C254(1.02); C350(0.92); C420(0.97)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C254(0.33)  LDD2228  [9]
 LDCM0028  Dobutamine HEK-293T 4.82  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C702(0.71); C91(1.11); C454(1.09); C420(1.08)  LDD1698  [23]
 LDCM0625  F8 Ramos C350(1.10); C91(1.54)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C350(1.25); C91(0.94)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C350(4.71)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C350(1.15)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C350(1.54)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C350(1.08)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C350(0.96)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C350(1.40)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C350(1.29)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C350(2.23)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C350(0.83); C91(0.37)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C350(1.26)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C350(1.82)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C350(1.86)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C203(0.95); C350(1.04); C454(1.13); C91(0.97)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C350(1.02); C91(1.74)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C350(1.01); C91(0.94)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C203(1.27); C254(1.88); C350(1.61); C454(0.91)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C350(1.55)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C350(1.45); C91(2.06)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C350(1.10)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C350(1.22); C91(2.04)  LDD2188  [24]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C286(1.92); C254(4.01); C176(2.11); C203(1.65)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C286(1.87); C254(2.48); C176(1.32); C203(2.05)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C286(3.04); C254(3.02); C176(1.73); C203(1.48)  LDD0082  [7]
 LDCM0030  Luteolin HEK-293T 11.05  LDD0182  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0029  Quercetin HEK-293T 14.02  LDD0181  [3]
 LDCM0084  Ro 48-8071 A-549 3.05  LDD0145  [20]
 LDCM0021  THZ1 HCT 116 C350(1.57); C91(1.25); C254(1.11); C203(0.96)  LDD2173  [7]

References

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Mass spectrometry data entry: PXD018580
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578