Details of the Target

General Information of Target

Target ID LDTP14259
Target Name Testis-expressed protein 264 (TEX264)
Gene Name TEX264
Gene ID 51368
Synonyms
ZSIG11; Testis-expressed protein 264; Putative secreted protein Zsig11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL
VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP
EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP
DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL
WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP
PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS
TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR
I
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN.
Uniprot ID
Q9Y6I9
Ensemble ID
ENST00000341333.10
HGNC ID
HGNC:30247
ChEMBL ID
CHEMBL4295994

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.97  LDD0402  [1]
STPyne
 Probe Info  		K160(5.07); K163(8.73); K201(9.13)  LDD0277  [2]
ONAyne
 Probe Info  		K163(0.78)  LDD0275  [2]
BTD
 Probe Info  		C165(0.88)  LDD1700  [3]
DA-P3
 Probe Info  		9.16  LDD0179  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C68(1.33)  LDD0080  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C182(0.00); C68(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C68(0.00); C165(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		C94(0.00); C68(0.00); C92(0.00)  LDD0026  [9]
NAIA_4
 Probe Info  		C92(0.00); C94(0.00); C182(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C94(0.00); C68(0.00)  LDD0027  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C182(0.00); C68(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		15.45  LDD1752  [17]
C056
 Probe Info  		34.54  LDD1753  [17]
C095
 Probe Info  		13.83  LDD1786  [17]
C112
 Probe Info  		17.63  LDD1799  [17]
C129
 Probe Info  		6.92  LDD1811  [17]
C145
 Probe Info  		8.57  LDD1827  [17]
C147
 Probe Info  		8.46  LDD1829  [17]
C161
 Probe Info  		24.93  LDD1841  [17]
C165
 Probe Info  		17.75  LDD1845  [17]
C166
 Probe Info  		8.06  LDD1846  [17]
C169
 Probe Info  		35.02  LDD1849  [17]
C170
 Probe Info  		10.63  LDD1850  [17]
C183
 Probe Info  		5.74  LDD1861  [17]
C186
 Probe Info  		14.93  LDD1864  [17]
C187
 Probe Info  		30.27  LDD1865  [17]
C191
 Probe Info  		12.55  LDD1868  [17]
C193
 Probe Info  		5.39  LDD1869  [17]
C198
 Probe Info  		10.41  LDD1874  [17]
C199
 Probe Info  		6.82  LDD1875  [17]
C201
 Probe Info  		27.10  LDD1877  [17]
C246
 Probe Info  		14.72  LDD1919  [17]
C249
 Probe Info  		12.30  LDD1922  [17]
C287
 Probe Info  		9.58  LDD1957  [17]
C289
 Probe Info  		36.00  LDD1959  [17]
C293
 Probe Info  		79.34  LDD1963  [17]
C296
 Probe Info  		14.03  LDD1966  [17]
C310
 Probe Info  		7.78  LDD1977  [17]
C313
 Probe Info  		16.34  LDD1980  [17]
C322
 Probe Info  		8.51  LDD1988  [17]
C326
 Probe Info  		8.75  LDD1990  [17]
C347
 Probe Info  		6.92  LDD2008  [17]
C361
 Probe Info  		29.45  LDD2022  [17]
C362
 Probe Info  		47.84  LDD2023  [17]
C367
 Probe Info  		5.21  LDD2028  [17]
C388
 Probe Info  		65.80  LDD2047  [17]
C389
 Probe Info  		6.06  LDD2048  [17]
C390
 Probe Info  		48.50  LDD2049  [17]
C403
 Probe Info  		14.22  LDD2061  [17]
C429
 Probe Info  		21.41  LDD2084  [17]
C433
 Probe Info  		5.86  LDD2088  [17]
OEA-DA
 Probe Info  		5.78  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C68(0.73)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C165(0.96); C68(0.78)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C165(1.29); C68(1.00)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C165(1.23)  LDD2103  [3]
 LDCM0214  AC1 HEK-293T C182(0.97); C94(1.04); C165(1.31); C68(1.15)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C68(1.09)  LDD0532  [6]
 LDCM0216  AC100 PaTu 8988t C68(0.73)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C68(0.98)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C68(0.78)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C68(0.77)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C68(0.99)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C68(1.03)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C68(0.93)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C68(0.81)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C68(0.87)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C68(0.78)  LDD1104  [6]
 LDCM0226  AC11 HCT 116 C68(1.23)  LDD0543  [6]
 LDCM0227  AC110 PaTu 8988t C68(0.86)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C68(0.96)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C68(0.89)  LDD1108  [6]
 LDCM0230  AC113 HCT 116 C182(0.86)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C182(1.01)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C182(0.95)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C182(0.90)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C182(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C182(0.80)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C182(0.82)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C68(1.16)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C182(0.92)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C182(0.82)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C182(0.90)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C182(0.74)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C182(0.80)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C182(0.83)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C182(0.85)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C182(0.81)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C182(1.44); C68(0.89)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C182(1.11); C68(1.17)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C182(1.26); C68(0.87)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C182(1.34); C68(1.06)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C182(1.14); C68(1.09)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C182(1.21); C68(0.92)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C182(1.17); C68(0.98)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C182(1.16); C68(1.10)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C182(1.22); C68(0.99)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C182(1.28); C68(1.23)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C182(1.59); C68(1.05)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C182(1.42); C68(1.02)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C68(1.04)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C182(1.23); C68(0.99)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C182(1.25); C68(0.96)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C182(1.12); C68(1.18)  LDD0579  [6]
 LDCM0263  AC143 PaTu 8988t C94(0.70)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C94(0.88)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C94(0.95)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C94(0.89)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C94(1.08)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C94(0.74)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C94(0.65)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C68(1.05)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C94(0.95)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C94(0.78)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C94(0.85)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C94(0.85)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C94(0.98)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C94(0.88)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C94(0.91)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C94(1.28)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C182(0.95)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C182(1.09)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C182(1.04)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C182(1.02); C94(0.97); C165(1.32); C68(0.84)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C182(0.95)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C182(0.86)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C182(0.94)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C182(0.93)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C182(0.94)  LDD0601  [6]
 LDCM0285  AC25 PaTu 8988t C68(1.15)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C68(1.01)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C68(1.10)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C68(1.21)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C68(1.11)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C182(1.05); C94(1.03); C165(1.23); C68(0.95)  LDD1529  [19]
 LDCM0291  AC30 PaTu 8988t C68(1.18)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C68(1.15)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C68(1.13)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C68(1.04)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C68(1.03)  LDD1174  [6]
 LDCM0296  AC35 HCT 116 C182(0.77); C68(1.08)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C182(0.73); C68(1.01)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C68(0.96); C182(1.06)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C182(1.04); C68(1.07)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C182(0.83); C68(1.12)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C182(1.00); C94(0.97); C165(1.42); C68(1.03)  LDD1540  [19]
 LDCM0302  AC40 HCT 116 C68(1.03); C182(1.27)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C68(1.00); C182(1.34)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C182(0.86); C68(1.02)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C182(0.89); C68(1.18)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C68(1.01); C182(1.33)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C68(0.89); C182(0.94)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C68(0.84); C182(0.98)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C68(0.90); C182(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C68(0.84); C182(0.99)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C68(0.83); C182(0.86)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C182(1.10); C94(1.00); C165(1.18); C68(1.01)  LDD1551  [19]
 LDCM0313  AC50 HCT 116 C68(0.86); C182(1.02)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C68(0.86); C182(1.06)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C68(0.76); C182(1.06)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C68(0.82); C182(1.00)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C68(0.84); C182(1.13)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C68(0.98); C182(1.09)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C68(0.75); C182(1.20)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C68(1.08)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C68(0.98)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C68(0.88)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C68(1.07)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C68(0.89)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C68(0.98)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C68(0.93)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C68(0.91)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C68(0.94)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C68(0.92)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C68(0.91)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C68(0.92)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C68(0.99)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C68(1.06)  LDD0662  [6]
 LDCM0349  AC83 PaTu 8988t C68(1.09)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C68(0.85)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C68(1.01)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C68(1.07)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C68(0.95)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C68(1.09)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C68(1.18)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C68(0.94)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C68(1.15)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C68(1.17)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C68(1.29)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C68(1.11)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C68(0.84)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C68(0.37)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C68(0.95)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C68(0.80)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C68(0.85)  LDD1245  [6]
 LDCM0248  AKOS034007472 HCT 116 C68(1.05)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C68(1.10)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C68(1.04)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C68(1.00)  LDD2171  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C68(2.28)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C68(1.21)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C68(1.10)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C182(1.05); C94(0.94); C165(1.64); C68(1.09)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C68(1.04)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C68(1.11)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C68(1.25)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C68(1.18)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C182(1.09)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C182(1.13)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C182(1.19)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C182(1.16)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C182(0.93)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C68(1.16)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C182(0.93)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C182(1.10)  LDD0698  [6]
 LDCM0382  CL112 PaTu 8988t C68(1.17)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C68(1.12)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C68(1.21)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C68(1.20)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C68(1.37)  LDD1265  [6]
 LDCM0387  CL117 HCT 116 C182(0.89); C68(1.11)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C182(1.07); C68(1.12)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C68(0.96); C182(1.05)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C68(1.07)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C182(1.00); C68(1.07)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C68(0.80); C182(0.94)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C68(0.76); C182(0.89)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C182(0.78); C68(0.96)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C68(0.84); C182(1.08)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C68(0.97)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C68(0.91)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C68(0.91)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C68(1.10)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C68(0.99)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C68(1.22)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C68(1.29)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C94(0.58)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C94(0.65)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C94(0.80)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C94(0.53)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C68(1.14)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C94(0.51)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C94(0.62)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C94(0.88)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C94(0.63)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C94(0.50)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C94(0.64)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C94(0.48)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C94(0.62)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C94(0.58)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C94(0.70)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C68(1.07)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C94(0.60)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C68(1.01)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C68(0.94)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C68(1.18)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C68(0.96)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C68(1.00)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C68(0.70)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C68(1.04)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C68(1.10)  LDD1307  [6]
 LDCM0429  CL4 HCT 116 C68(1.17)  LDD0746  [6]
 LDCM0430  CL40 PaTu 8988t C68(1.00)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C68(0.94)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C68(1.02)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C68(1.12)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C68(0.95)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C68(0.98)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C68(1.08)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C68(1.07)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C68(1.08)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C68(1.14)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C68(0.94)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C68(1.10)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C68(1.19)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C68(1.04)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C68(0.90)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C68(1.04)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C68(1.17)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C68(0.99)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C68(1.00)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C68(0.96)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C68(1.07)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C68(1.04)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C68(1.08)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C182(2.06)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C182(2.20)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C182(1.69)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C182(2.44)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C182(2.09)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C182(2.26)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C182(1.69)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C182(1.17)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C182(2.45)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C68(1.14)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C182(2.83)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C182(1.68)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C182(2.35)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C182(1.67)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C182(1.68)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C68(0.94)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C68(0.99)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C68(0.99)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C68(1.00)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C68(0.91)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C68(0.97)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C68(1.12)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C68(1.14)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C68(1.07)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C68(0.86)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C68(0.90)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C68(1.10)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C68(1.15)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C68(1.13)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C68(0.97)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C68(1.02)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C68(1.07)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C182(1.11); C94(1.05); C165(0.78); C68(1.00)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C182(1.01); C94(1.06); C165(1.11); C68(1.08)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C182(1.15); C94(0.98); C165(0.84); C68(1.23)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C182(0.99); C94(0.93); C165(0.65); C68(1.05)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C182(1.12); C94(1.32); C165(1.12); C68(0.90)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C182(1.32); C94(1.26); C165(1.05); C68(1.30)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C182(1.12); C94(1.11); C165(1.34)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C182(1.08); C94(0.94); C165(1.29)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C182(1.04); C94(0.91); C165(1.18); C68(0.91)  LDD1697  [19]
 LDCM0027  Dopamine HEK-293T 9.16  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C182(0.98); C94(0.96); C165(1.31); C68(0.79)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C165(34.53); C182(1.78); C94(1.63); C68(1.04)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C165(2.07); C68(0.88); C92(1.61); C94(0.60)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C68(1.20); C92(0.44); C94(1.15)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C165(1.12); C92(0.19)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C68(1.46); C92(0.41); C94(1.27)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C165(1.12); C68(1.15); C94(0.24)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C68(0.72); C92(1.07); C94(0.55)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C68(1.66); C92(0.56)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C165(1.71); C68(1.02); C92(0.41); C94(0.91)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C165(0.67); C68(0.84); C92(0.19); C94(0.68)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C165(0.67); C68(0.95); C92(0.71); C94(1.00)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C165(1.75); C68(1.05); C92(0.64); C94(0.91)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C165(1.55); C68(1.18); C92(0.35); C94(1.59)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C165(1.59); C68(1.06); C92(0.55)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C68(0.97); C92(0.45); C94(0.71)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C182(1.85)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C165(1.86); C68(1.20); C94(1.31)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C68(1.43); C92(1.07); C94(0.55)  LDD2184  [20]
 LDCM0427  Fragment51 PaTu 8988t C68(0.87)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C68(1.26); C94(0.69)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C165(1.25); C68(1.06); C92(0.59); C94(1.35)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C68(1.98); C92(1.52); C94(0.32)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C68(1.76); C92(0.64); C94(1.04)  LDD2188  [20]
 LDCM0022  KB02 HCT 116 C68(1.33)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C68(1.32)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C68(0.91)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C165(1.14)  LDD2102  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C68(0.88)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C165(1.55)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C165(0.90)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C165(1.20); C68(1.01)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C165(0.91)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C165(1.18)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C165(0.84); C68(0.82)  LDD2099  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C165(0.90)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C165(1.24)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C165(0.89)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C165(0.72); C68(0.77)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C165(0.93); C68(1.02)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C165(1.73); C68(1.55)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C165(0.63)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C165(0.80); C68(0.98)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C165(0.92); C68(0.92)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C165(1.23); C68(1.06)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C165(1.03)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C165(1.11); C68(1.06)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C165(1.32); C68(0.73)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C165(0.82); C68(0.82)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C165(0.88)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C165(0.67); C68(0.67)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C165(1.47); C68(0.66)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C165(2.51); C68(1.93)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C165(0.78)  LDD2146  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C182(2.15)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C165(0.73); C68(0.54)  LDD2207  [21]
 LDCM0131  RA190 MM1.R C165(1.60); C68(1.50)  LDD0304  [22]
 LDCM0021  THZ1 HCT 116 C68(1.00)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Ceramide synthase 4 (CERS4) . Q9HA82
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ileal sodium/bile acid cotransporter (SLC10A2) Bile acid:sodium symporter (BASS) family Q12908
Gap junction beta-1 protein (GJB1) Connexin family P08034
Transmembrane 4 L6 family member 18 (TM4SF18) L6 tetraspanin family Q96CE8
LHFPL tetraspan subfamily member 4 protein (LHFPL4) LHFP family Q7Z7J7
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) MS4A family Q96HJ5
Tetraspanin-12 (TSPAN12) Tetraspanin (TM4SF) family O95859
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Transmembrane protein 79 (TMEM79) . Q9BSE2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Free fatty acid receptor 3 (FFAR3) G-protein coupled receptor 1 family O14843
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Adhesion G protein-coupled receptor G3 (ADGRG3) G-protein coupled receptor 2 family Q86Y34
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Claudin-2 (CLDN2) Claudin family P57739
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Small integral membrane protein 3 (SMIM3) . Q9BZL3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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