Details of the Target

General Information of Target

Target ID LDTP05551
Target Name Quinone oxidoreductase (CRYZ)
Gene Name CRYZ
Gene ID 1429
Synonyms
Quinone oxidoreductase; EC 1.6.5.5; NADPH:quinone reductase; Zeta-crystallin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS
RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK
LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA
GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG
GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG
SQYPLEKVAEAHENIIHGSGATGKMILLL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
Subcellular location
Cytoplasm
Function
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
TTD ID
T83284
Uniprot ID
Q08257
DrugMap ID
TTP6UO8
Ensemble ID
ENST00000340866.10
HGNC ID
HGNC:2419
ChEMBL ID
CHEMBL6118

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.S143G DBIA    Probe Info 
HCT15 SNV: p.K276N DBIA    Probe Info 
HT115 SNV: p.L327F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.33  LDD0215  [1]
TH211
 Probe Info  		Y53(14.03)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K62(20.00)  LDD2217  [4]
m-APA
 Probe Info  		11.61  LDD0403  [5]
BTD
 Probe Info  		C145(1.49)  LDD1700  [6]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [7]
AHL-Pu-1
 Probe Info  		C45(2.12)  LDD0171  [8]
DBIA
 Probe Info  		C145(0.94)  LDD0531  [9]
W1
 Probe Info  		C45(3.47)  LDD0237  [10]
5E-2FA
 Probe Info  		H317(0.00); H312(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K324(0.00); K34(0.00); K41(0.00); K23(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C166(0.00); C145(0.00); C45(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C166(0.00); C145(0.00); C45(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C145(0.00); C45(0.00); C166(0.00)  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		K175(0.00); K62(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C45(0.00); H317(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
NAIA_5
 Probe Info  		C166(0.00); C145(0.00); C45(0.00)  LDD2223  [19]
HHS-475
 Probe Info  		Y106(0.53)  LDD2238  [20]
HHS-482
 Probe Info  		Y53(0.74)  LDD2239  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C199
 Probe Info  		13.74  LDD1875  [21]
STS-1
 Probe Info  		N.A.  LDD0136  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C45(1.37)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C145(0.77); C166(0.79)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C145(1.52)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C145(0.45)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C145(0.44)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C45(2.12)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C145(0.94)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C145(1.07)  LDD0532  [9]
 LDCM0216  AC100 PaTu 8988t C145(1.02)  LDD1095  [9]
 LDCM0217  AC101 PaTu 8988t C145(1.21)  LDD1096  [9]
 LDCM0218  AC102 PaTu 8988t C145(1.18)  LDD1097  [9]
 LDCM0219  AC103 PaTu 8988t C145(1.10)  LDD1098  [9]
 LDCM0220  AC104 PaTu 8988t C145(1.07)  LDD1099  [9]
 LDCM0221  AC105 PaTu 8988t C145(1.06)  LDD1100  [9]
 LDCM0222  AC106 PaTu 8988t C145(1.13)  LDD1101  [9]
 LDCM0223  AC107 PaTu 8988t C145(1.02)  LDD1102  [9]
 LDCM0224  AC108 PaTu 8988t C145(1.04)  LDD1103  [9]
 LDCM0225  AC109 PaTu 8988t C145(1.08)  LDD1104  [9]
 LDCM0226  AC11 HCT 116 C145(0.97)  LDD0543  [9]
 LDCM0227  AC110 PaTu 8988t C145(1.09)  LDD1106  [9]
 LDCM0228  AC111 PaTu 8988t C145(1.17)  LDD1107  [9]
 LDCM0229  AC112 PaTu 8988t C145(0.95)  LDD1108  [9]
 LDCM0230  AC113 HCT 116 C145(1.08)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C145(1.14)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C145(1.22)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C145(1.25)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C145(1.15)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C145(1.12)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C145(1.17)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C145(0.92)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C145(1.20)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C145(1.10)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C145(1.17)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C145(1.08)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C145(1.10)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C145(1.09)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C145(1.16)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C145(1.16)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C145(1.21)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C145(0.86)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C145(1.10)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C145(0.85)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C145(1.07)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C145(1.11)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C145(1.25)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C145(1.25)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C145(1.16)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C145(1.12)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C145(1.11)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C145(1.00)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C145(1.05)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C145(1.17)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C145(1.05)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C145(0.93)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C145(0.99)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C145(1.04)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C145(1.04)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C145(1.08)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C145(1.03)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C145(1.17)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C145(1.02)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C145(1.02)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C145(0.99)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C145(0.99)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C145(1.06)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C145(1.34)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C145(1.02)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C145(0.99)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C145(0.96)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C145(0.82)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C145(1.01)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C145(1.11)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C145(1.05)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C145(1.03)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C145(0.95)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C145(0.98)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C145(0.88)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C145(0.79)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C145(1.04)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C145(1.05)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C145(1.08)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C145(1.15)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C145(1.04)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C145(1.06)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C145(0.99)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C145(1.15)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C145(1.05)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C145(1.19)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C145(1.03)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C145(1.08)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C145(0.73)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C145(0.89)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C145(0.71)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C145(0.90)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C145(0.81)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C145(0.99)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C145(0.73)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C145(0.64)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C145(0.69)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C145(0.73)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C145(0.57)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C145(0.52)  LDD0624  [9]
 LDCM0308  AC46 PaTu 8988t C145(1.00)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C145(1.09)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C145(1.11)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C145(1.17)  LDD1190  [9]
 LDCM0312  AC5 HCT 116 C145(1.06)  LDD0629  [9]
 LDCM0313  AC50 PaTu 8988t C145(1.10)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C145(0.63)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C145(1.15)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C145(1.08)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C145(1.48)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C145(1.01)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C145(1.01)  LDD1198  [9]
 LDCM0320  AC57 HCT 116 C145(1.08)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C145(1.05)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C145(1.24)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C145(1.07)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C145(1.11)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C145(1.09)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C145(1.01)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C145(1.10)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C145(1.19)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C145(1.11)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C145(1.08)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C145(1.15)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C145(1.03)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C145(0.91)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C145(1.09)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C145(0.98)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C145(0.88)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C145(0.92)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C145(0.99)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C145(0.93)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C145(1.09)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C145(0.90)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C145(0.88)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C145(0.91)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C145(0.97)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C145(1.07)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C145(0.88)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C145(0.82)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C145(0.80)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C145(1.17)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C145(1.25)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C145(1.21)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C145(1.35)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C145(1.05)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C145(1.18)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C145(1.27)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C145(1.10)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C145(0.94)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C145(0.99)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C145(1.07)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C145(0.98)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C145(0.93)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C145(0.88)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C145(1.06)  LDD0681  [9]
 LDCM0365  AC98 PaTu 8988t C145(1.14)  LDD1244  [9]
 LDCM0366  AC99 PaTu 8988t C145(1.09)  LDD1245  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C45(1.46)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C145(1.00)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C145(1.08)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C145(1.15)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [5]
 LDCM0020  ARS-1620 HCC44 C145(1.05)  LDD2171  [9]
 LDCM0498  BS-3668 MDA-MB-231 C145(0.40)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa H317(0.00); C145(0.00); H36(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C145(0.81)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C145(0.99)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C145(0.99)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C145(1.06)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C145(1.06)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C145(0.94)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C145(0.97)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C145(1.13)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C145(1.22)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C145(1.13)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C145(1.40)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C145(1.07)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C145(1.05)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C145(1.02)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C145(0.96)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C145(1.02)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C145(1.00)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C145(0.94)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C145(1.01)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C145(1.05)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C145(0.83)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C145(0.71)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C145(0.72)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C145(1.23)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C145(0.76)  LDD0708  [9]
 LDCM0392  CL121 PaTu 8988t C145(1.09)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C145(0.95)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C145(1.36)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C145(1.25)  LDD1274  [9]
 LDCM0396  CL125 HCT 116 C145(1.02)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C145(1.08)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C145(1.03)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C145(1.13)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C145(1.01)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C145(0.94)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C145(0.96)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C145(1.11)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C145(1.09)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C145(1.24)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C145(1.19)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C145(0.86)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C145(1.12)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C145(1.24)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C145(1.46)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C145(1.15)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C145(1.24)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C145(1.29)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C145(1.10)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C145(1.15)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C145(1.20)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C145(1.26)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C145(0.90)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C145(1.06)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C145(1.02)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C145(1.12)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C145(0.88)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C145(1.06)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C145(1.15)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C145(0.96)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C145(1.10)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C145(1.07)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C145(0.91)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C145(0.99)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C145(1.01)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C145(1.22)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C145(1.06)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C145(1.02)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C145(1.11)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C145(0.99)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C145(0.98)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C145(0.96)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C145(0.97)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C145(0.85)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C145(0.91)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C145(1.03)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C145(0.81)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C145(0.72)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C145(0.65)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C145(0.72)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C145(0.70)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C145(0.82)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C145(0.63)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C145(0.74)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C145(0.93)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C145(0.78)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C145(0.99)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C145(1.10)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C145(1.16)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C145(1.10)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C145(1.08)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C145(1.31)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C145(1.17)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C145(1.05)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C145(1.00)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C145(1.13)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C145(1.02)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C145(1.04)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C145(0.97)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C145(1.09)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C145(1.00)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C145(1.06)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C145(0.87)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C145(1.09)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C145(1.04)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C145(0.98)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C145(1.03)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C145(1.00)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C145(1.10)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C145(1.11)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C145(1.20)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C145(1.09)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C145(1.07)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C145(1.11)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C145(1.09)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C145(1.14)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C145(0.99)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C145(0.94)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C145(1.10)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C145(0.96)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C145(0.84)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C145(0.99)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C145(1.04)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C145(0.99)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C145(1.08)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C145(1.02)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C145(1.02)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C145(0.92); C45(1.01)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C45(1.47); C145(1.28)  LDD1702  [6]
 LDCM0625  F8 Ramos C45(1.59); C145(0.73); C166(1.12)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C45(0.64); C145(1.53)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C45(2.56); C145(0.15)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C45(0.75); C145(1.62)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C45(1.33); C145(1.65)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C45(0.94); C145(1.22); C166(0.80)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C45(0.58)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C45(1.11); C145(1.63)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C45(0.80); C145(0.98)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C45(1.45); C145(1.15)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C45(0.57); C145(0.76)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C45(0.90); C145(1.22)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C45(1.24); C145(1.42)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C45(0.65); C145(1.44)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C145(0.93)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C45(1.47); C145(1.26)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C45(1.02); C145(0.64); C166(0.90)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C145(1.17)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C45(1.23); C145(1.87)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C45(1.29); C145(1.44)  LDD2205  [25]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [7]
 LDCM0569  Fragment7 Ramos C45(0.75); C145(0.64); C166(0.78)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C45(0.60); C145(1.11)  LDD2188  [25]
 LDCM0107  IAA HeLa H317(0.00); C45(0.00); H36(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C45(1.03); C145(1.04)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C45(0.95); C145(1.02)  LDD1497  [24]
 LDCM0024  KB05 G361 C145(1.01); C45(1.21)  LDD3311  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C166(1.00)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C145(0.55)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C145(0.53)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C166(1.00)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C166(1.15)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C145(1.56); C45(1.06)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C166(0.24)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C145(0.89)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C145(0.29); C166(1.04)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C145(1.55)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C145(1.00)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C145(0.90)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C145(1.51); C45(1.07)  LDD2111  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C166(1.01)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C166(0.45)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C145(2.35); C45(1.56); C166(1.87)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C166(0.56)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C145(1.32); C45(0.95)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C166(0.60)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C145(0.94)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C145(0.85)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C145(1.38)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C45(0.80)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C145(1.22)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C145(1.12); C45(1.40); C166(1.19)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C145(1.06); C45(1.14)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C145(1.49)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C145(1.03)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C45(0.81)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C145(2.26); C166(2.74)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C166(0.43)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C145(1.39); C45(0.91)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C145(0.38)  LDD2150  [6]
 LDCM0021  THZ1 HCT 116 C145(1.05)  LDD2173  [9]
 LDCM0110  W12 Hep-G2 C45(3.47)  LDD0237  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Quinone oxidoreductase (CRYZ) Zinc-containing alcohol dehydrogenase family Q08257

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cannabidiol Small molecular drug DB09061
Dicoumarol Small molecular drug DB00266
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nabiximols Small molecular drug DB14011
Medical Cannabis . DB14009
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840