Details of the Target

General Information of Target

Target ID	LDTP13282
Target Name	Prenylcysteine oxidase 1 (PCYOX1)
Gene Name	PCYOX1
Gene ID	51449
Synonyms	KIAA0908; PCL1; Prenylcysteine oxidase 1; EC 1.8.3.5; Prenylcysteine lyase
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAGSPLLWGPRAGGVGLLVLLLLGLFRPPPALCARPVKEPRGLSAASPPLAETGAPRRFR RSVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRVWGAPRNSD PALGLDDDPDAPAAQLARALLRARLDPAALAAQLVPAPVPAAALRPRPPVYDDGPAGPDA EEAGDETPDVDPELLRYLLGRILAGSADSEGVAAPRRLRRAADHDVGSELPPEGVLGALL RVKRLETPAPQVPARRLLPP
Target Bioclass	Enzyme
Family	Prenylcysteine oxidase family
Subcellular location	Lysosome
Function	Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.
Uniprot ID	Q9UHG3
Ensemble ID	ENST00000433351.7
HGNC ID	HGNC:20588

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
ABC1	SNV: p.E67K	DBIA Probe Info
HCC44	SNV: p.V4F	DBIA Probe Info
HCT116	SNV: p.L17M	.
HGC27	SNV: p.Q204K	DBIA Probe Info
OVKATE	SNV: p.R197Ter	DBIA Probe Info
SNU478	Substitution: p.A28F	DBIA Probe Info
SUPT1	SNV: p.A478T	DBIA Probe Info

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 33 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
ILS-2 Probe Info	2.44	LDD0416	[2]
FBPP2 Probe Info	2.05	LDD0318	[3]
TG42 Probe Info	4.23	LDD0326	[4]
C-Sul Probe Info	3.75	LDD0066	[5]
YN-1 Probe Info	100.00	LDD0444	[6]
YN-4 Probe Info	100.00	LDD0445	[6]
STPyne Probe Info	K415(6.94); K62(10.00)	LDD0277	[7]
IPM Probe Info	N.A.	LDD0241	[8]
Probe 1 Probe Info	Y174(9.64); Y285(95.37); Y403(19.11)	LDD3495	[9]
Alkylaryl probe 3 Probe Info	7.69	LDD0283	[10]
BTD Probe Info	C258(1.01)	LDD2093	[11]
Curcusone 37 Probe Info	2.19	LDD0188	[12]
HPAP Probe Info	3.00	LDD0063	[13]
Alkyne-RA190 Probe Info	3.43	LDD0299	[14]
DBIA Probe Info	C242(0.92)	LDD0547	[15]
5E-2FA Probe Info	N.A.	LDD2235	[16]
ATP probe Probe Info	N.A.	LDD0199	[17]
m-APA Probe Info	N.A.	LDD2231	[16]
4-Iodoacetamidophenylacetylene Probe Info	C445(0.00); C462(0.00); C258(0.00)	LDD0038	[18]
IA-alkyne Probe Info	C462(0.00); C445(0.00); C258(0.00)	LDD0036	[18]
Lodoacetamide azide Probe Info	C445(0.00); C258(0.00); C462(0.00)	LDD0037	[18]
WYneN Probe Info	N.A.	LDD0021	[19]
WYneO Probe Info	N.A.	LDD0022	[19]
NHS Probe Info	K415(0.00); K205(0.00)	LDD0010	[19]
Acrolein Probe Info	N.A.	LDD0217	[20]
Crotonaldehyde Probe Info	N.A.	LDD0219	[20]
Methacrolein Probe Info	N.A.	LDD0218	[20]
W1 Probe Info	W155(0.00); H153(0.00)	LDD0236	[8]
AOyne Probe Info	10.60	LDD0443	[21]
MPP-AC Probe Info	N.A.	LDD0428	[22]
NAIA_5 Probe Info	N.A.	LDD2223	[23]
TER-AC Probe Info	N.A.	LDD0426	[22]
TPP-AC Probe Info	N.A.	LDD0427	[22]

PAL-AfBPP Probe

Click To Hide/Show 216 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
PARPYnD Probe Info	4.72	LDD0374	[24]
ILS-1 PP Probe Info	2.25	LDD0417	[2]
C001 Probe Info	9.38	LDD1711	[25]
C004 Probe Info	11.08	LDD1714	[25]
C008 Probe Info	5.21	LDD1717	[25]
C010 Probe Info	7.41	LDD1719	[25]
C011 Probe Info	9.51	LDD1720	[25]
C017 Probe Info	8.11	LDD1725	[25]
C018 Probe Info	5.28	LDD1726	[25]
C022 Probe Info	15.67	LDD1728	[25]
C025 Probe Info	5.62	LDD1731	[25]
C026 Probe Info	8.17	LDD1732	[25]
C039 Probe Info	7.21	LDD1739	[25]
C040 Probe Info	45.57	LDD1740	[25]
C041 Probe Info	16.34	LDD1741	[25]
C044 Probe Info	7.94	LDD1743	[25]
C049 Probe Info	8.22	LDD1747	[25]
C051 Probe Info	5.74	LDD1749	[25]
C052 Probe Info	5.13	LDD1750	[25]
C053 Probe Info	6.50	LDD1751	[25]
C055 Probe Info	17.39	LDD1752	[25]
C056 Probe Info	45.25	LDD1753	[25]
C060 Probe Info	15.24	LDD1757	[25]
C063 Probe Info	21.86	LDD1760	[25]
C064 Probe Info	8.94	LDD1761	[25]
C067 Probe Info	9.51	LDD1763	[25]
C070 Probe Info	19.84	LDD1766	[25]
C072 Probe Info	13.83	LDD1768	[25]
C082 Probe Info	31.78	LDD1774	[25]
C085 Probe Info	12.91	LDD1777	[25]
C087 Probe Info	13.64	LDD1779	[25]
C088 Probe Info	7.78	LDD1780	[25]
C091 Probe Info	40.79	LDD1782	[25]
C092 Probe Info	57.28	LDD1783	[25]
C094 Probe Info	59.30	LDD1785	[25]
C095 Probe Info	10.41	LDD1786	[25]
C100 Probe Info	13.45	LDD1789	[25]
C102 Probe Info	5.94	LDD1790	[25]
C106 Probe Info	38.59	LDD1793	[25]
C107 Probe Info	15.78	LDD1794	[25]
C108 Probe Info	16.34	LDD1795	[25]
C112 Probe Info	49.52	LDD1799	[25]
C117 Probe Info	5.21	LDD1804	[25]
C130 Probe Info	18.38	LDD1812	[25]
C134 Probe Info	43.41	LDD1816	[25]
C135 Probe Info	12.47	LDD1817	[25]
C136 Probe Info	9.25	LDD1818	[25]
C140 Probe Info	21.41	LDD1822	[25]
C141 Probe Info	48.50	LDD1823	[25]
C143 Probe Info	21.86	LDD1825	[25]
C145 Probe Info	24.08	LDD1827	[25]
C147 Probe Info	17.03	LDD1829	[25]
C153 Probe Info	64.89	LDD1834	[25]
C156 Probe Info	7.94	LDD1836	[25]
C158 Probe Info	10.06	LDD1838	[25]
C159 Probe Info	32.67	LDD1839	[25]
C160 Probe Info	55.33	LDD1840	[25]
C161 Probe Info	31.34	LDD1841	[25]
C163 Probe Info	29.45	LDD1843	[25]
C166 Probe Info	7.94	LDD1846	[25]
C169 Probe Info	61.82	LDD1849	[25]
C170 Probe Info	11.55	LDD1850	[25]
C173 Probe Info	6.87	LDD1853	[25]
C177 Probe Info	8.88	LDD1856	[25]
C178 Probe Info	25.81	LDD1857	[25]
C183 Probe Info	6.45	LDD1861	[25]
C185 Probe Info	6.32	LDD1863	[25]
C186 Probe Info	21.56	LDD1864	[25]
C187 Probe Info	33.13	LDD1865	[25]
C191 Probe Info	20.53	LDD1868	[25]
C193 Probe Info	13.18	LDD1869	[25]
C194 Probe Info	20.25	LDD1870	[25]
C195 Probe Info	13.27	LDD1871	[25]
C196 Probe Info	17.27	LDD1872	[25]
C197 Probe Info	8.75	LDD1873	[25]
C198 Probe Info	36.00	LDD1874	[25]
C199 Probe Info	9.25	LDD1875	[25]
C201 Probe Info	86.22	LDD1877	[25]
C204 Probe Info	16.56	LDD1879	[25]
C206 Probe Info	37.53	LDD1881	[25]
C210 Probe Info	70.03	LDD1884	[25]
C211 Probe Info	14.62	LDD1885	[25]
C213 Probe Info	21.11	LDD1887	[25]
C214 Probe Info	21.86	LDD1888	[25]
C215 Probe Info	13.00	LDD1889	[25]
C216 Probe Info	7.01	LDD1890	[25]
C218 Probe Info	37.53	LDD1892	[25]
C219 Probe Info	18.90	LDD1893	[25]
C220 Probe Info	36.76	LDD1894	[25]
C222 Probe Info	8.69	LDD1896	[25]
C225 Probe Info	12.30	LDD1898	[25]
C226 Probe Info	10.20	LDD1899	[25]
C228 Probe Info	41.93	LDD1901	[25]
C231 Probe Info	28.64	LDD1904	[25]
C232 Probe Info	49.18	LDD1905	[25]
C233 Probe Info	17.39	LDD1906	[25]
C234 Probe Info	16.80	LDD1907	[25]
C235 Probe Info	20.53	LDD1908	[25]
C238 Probe Info	33.82	LDD1911	[25]
C240 Probe Info	11.08	LDD1913	[25]
C242 Probe Info	21.86	LDD1915	[25]
C243 Probe Info	17.51	LDD1916	[25]
C244 Probe Info	36.25	LDD1917	[25]
C246 Probe Info	31.12	LDD1919	[25]
C249 Probe Info	19.43	LDD1922	[25]
C251 Probe Info	28.25	LDD1924	[25]
C252 Probe Info	16.45	LDD1925	[25]
C258 Probe Info	5.17	LDD1931	[25]
C260 Probe Info	6.59	LDD1932	[25]
C264 Probe Info	28.25	LDD1935	[25]
C265 Probe Info	34.30	LDD1936	[25]
C266 Probe Info	11.39	LDD1937	[25]
C269 Probe Info	5.98	LDD1939	[25]
C270 Probe Info	7.41	LDD1940	[25]
C271 Probe Info	8.28	LDD1941	[25]
C272 Probe Info	6.96	LDD1942	[25]
C273 Probe Info	7.16	LDD1943	[25]
C277 Probe Info	28.05	LDD1947	[25]
C282 Probe Info	48.50	LDD1952	[25]
C284 Probe Info	33.82	LDD1954	[25]
C285 Probe Info	21.26	LDD1955	[25]
C286 Probe Info	6.32	LDD1956	[25]
C287 Probe Info	14.22	LDD1957	[25]
C288 Probe Info	11.55	LDD1958	[25]
C289 Probe Info	37.27	LDD1959	[25]
C290 Probe Info	19.56	LDD1960	[25]
C292 Probe Info	5.31	LDD1962	[25]
C293 Probe Info	27.47	LDD1963	[25]
C296 Probe Info	21.26	LDD1966	[25]
C297 Probe Info	11.88	LDD1967	[25]
C299 Probe Info	21.86	LDD1968	[25]
C301 Probe Info	7.36	LDD1970	[25]
C303 Probe Info	7.26	LDD1972	[25]
C305 Probe Info	18.64	LDD1974	[25]
C307 Probe Info	7.73	LDD1975	[25]
C310 Probe Info	11.88	LDD1977	[25]
C313 Probe Info	17.03	LDD1980	[25]
C314 Probe Info	22.78	LDD1981	[25]
C317 Probe Info	8.17	LDD1983	[25]
C322 Probe Info	16.11	LDD1988	[25]
C326 Probe Info	13.93	LDD1990	[25]
C327 Probe Info	9.25	LDD1991	[25]
C333 Probe Info	12.55	LDD1996	[25]
C338 Probe Info	25.46	LDD2001	[25]
C339 Probe Info	7.84	LDD2002	[25]
C343 Probe Info	24.42	LDD2005	[25]
C346 Probe Info	10.93	LDD2007	[25]
C348 Probe Info	29.65	LDD2009	[25]
C349 Probe Info	41.93	LDD2010	[25]
C350 Probe Info	60.97	LDD2011	[25]
C351 Probe Info	7.01	LDD2012	[25]
C353 Probe Info	14.93	LDD2014	[25]
C354 Probe Info	25.11	LDD2015	[25]
C355 Probe Info	69.55	LDD2016	[25]
C356 Probe Info	24.42	LDD2017	[25]
C357 Probe Info	11.08	LDD2018	[25]
C360 Probe Info	6.63	LDD2021	[25]
C361 Probe Info	42.81	LDD2022	[25]
C362 Probe Info	50.21	LDD2023	[25]
C363 Probe Info	19.97	LDD2024	[25]
C364 Probe Info	18.51	LDD2025	[25]
C366 Probe Info	6.77	LDD2027	[25]
C367 Probe Info	5.06	LDD2028	[25]
C373 Probe Info	9.38	LDD2033	[25]
C376 Probe Info	13.83	LDD2036	[25]
C378 Probe Info	12.55	LDD2037	[25]
C379 Probe Info	10.56	LDD2038	[25]
C380 Probe Info	5.90	LDD2039	[25]
C382 Probe Info	20.97	LDD2041	[25]
C383 Probe Info	22.16	LDD2042	[25]
C385 Probe Info	20.68	LDD2044	[25]
C386 Probe Info	41.36	LDD2045	[25]
C387 Probe Info	11.96	LDD2046	[25]
C388 Probe Info	78.25	LDD2047	[25]
C389 Probe Info	11.16	LDD2048	[25]
C390 Probe Info	99.73	LDD2049	[25]
C391 Probe Info	37.79	LDD2050	[25]
C393 Probe Info	13.64	LDD2052	[25]
C396 Probe Info	8.75	LDD2055	[25]
C399 Probe Info	23.75	LDD2058	[25]
C403 Probe Info	35.02	LDD2061	[25]
C405 Probe Info	5.31	LDD2063	[25]
C407 Probe Info	23.92	LDD2064	[25]
C408 Probe Info	6.59	LDD2065	[25]
C409 Probe Info	11.47	LDD2066	[25]
C413 Probe Info	38.05	LDD2069	[25]
C414 Probe Info	5.24	LDD2070	[25]
C416 Probe Info	8.88	LDD2071	[25]
C419 Probe Info	23.43	LDD2074	[25]
C420 Probe Info	28.84	LDD2075	[25]
C422 Probe Info	17.15	LDD2077	[25]
C423 Probe Info	13.64	LDD2078	[25]
C424 Probe Info	21.56	LDD2079	[25]
C426 Probe Info	85.63	LDD2081	[25]
C428 Probe Info	5.24	LDD2083	[25]
C429 Probe Info	35.26	LDD2084	[25]
C430 Probe Info	10.27	LDD2085	[25]
C431 Probe Info	68.59	LDD2086	[25]
C432 Probe Info	5.10	LDD2087	[25]
C433 Probe Info	13.36	LDD2088	[25]
FFF probe11 Probe Info	20.00	LDD0471	[26]
FFF probe12 Probe Info	13.35	LDD0473	[26]
FFF probe13 Probe Info	20.00	LDD0475	[26]
FFF probe14 Probe Info	20.00	LDD0477	[26]
FFF probe15 Probe Info	20.00	LDD0478	[26]
FFF probe2 Probe Info	20.00	LDD0463	[26]
FFF probe3 Probe Info	20.00	LDD0464	[26]
FFF probe4 Probe Info	17.03	LDD0466	[26]
FFF probe6 Probe Info	20.00	LDD0467	[26]
FFF probe7 Probe Info	20.00	LDD0483	[26]
FFF probe9 Probe Info	20.00	LDD0470	[26]
JN0003 Probe Info	20.00	LDD0469	[26]
STS-2 Probe Info	N.A.	LDD0138	[27]
A-DA Probe Info	2.58	LDD0142	[28]
BD-F Probe Info	I231(0.00); S241(0.00)	LDD0024	[29]
OEA-DA Probe Info	17.98	LDD0046	[30]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C258(1.44)	LDD2152	[11]
LDCM0214	AC1	HEK-293T	C445(1.04); C242(1.00); C258(0.99)	LDD1507	[31]
LDCM0215	AC10	HEK-293T	C445(0.89); C242(1.03)	LDD1508	[31]
LDCM0216	AC100	HEK-293T	C242(0.85)	LDD0814	[15]
LDCM0217	AC101	HEK-293T	C242(0.79)	LDD0815	[15]
LDCM0218	AC102	HEK-293T	C242(0.73)	LDD0816	[15]
LDCM0219	AC103	HEK-293T	C242(0.77)	LDD0817	[15]
LDCM0220	AC104	HEK-293T	C242(0.93)	LDD0818	[15]
LDCM0221	AC105	HEK-293T	C242(0.78)	LDD0819	[15]
LDCM0222	AC106	HEK-293T	C242(0.96)	LDD0820	[15]
LDCM0223	AC107	HEK-293T	C242(0.83)	LDD0821	[15]
LDCM0224	AC108	HEK-293T	C242(1.17)	LDD0822	[15]
LDCM0225	AC109	HEK-293T	C242(1.04)	LDD0823	[15]
LDCM0226	AC11	HEK-293T	C445(0.87); C242(0.90); C258(1.02)	LDD1509	[31]
LDCM0227	AC110	HEK-293T	C242(0.81)	LDD0825	[15]
LDCM0228	AC111	HEK-293T	C242(0.81)	LDD0826	[15]
LDCM0229	AC112	HEK-293T	C242(0.96)	LDD0827	[15]
LDCM0230	AC113	HCT 116	C242(0.92)	LDD0547	[15]
LDCM0231	AC114	HCT 116	C242(1.03)	LDD0548	[15]
LDCM0232	AC115	HCT 116	C242(1.20)	LDD0549	[15]
LDCM0233	AC116	HCT 116	C242(1.06)	LDD0550	[15]
LDCM0234	AC117	HCT 116	C242(1.21)	LDD0551	[15]
LDCM0235	AC118	HCT 116	C242(1.14)	LDD0552	[15]
LDCM0236	AC119	HCT 116	C242(0.95)	LDD0553	[15]
LDCM0237	AC12	HEK-293T	C445(0.84); C242(1.04); C258(1.05)	LDD1510	[31]
LDCM0238	AC120	HCT 116	C242(1.08)	LDD0555	[15]
LDCM0239	AC121	HCT 116	C242(0.98)	LDD0556	[15]
LDCM0240	AC122	HCT 116	C242(1.22)	LDD0557	[15]
LDCM0241	AC123	HCT 116	C242(0.91)	LDD0558	[15]
LDCM0242	AC124	HCT 116	C242(1.15)	LDD0559	[15]
LDCM0243	AC125	HCT 116	C242(0.97)	LDD0560	[15]
LDCM0244	AC126	HCT 116	C242(0.96)	LDD0561	[15]
LDCM0245	AC127	HCT 116	C242(1.10)	LDD0562	[15]
LDCM0246	AC128	HCT 116	C242(1.20)	LDD0563	[15]
LDCM0247	AC129	HCT 116	C242(0.88)	LDD0564	[15]
LDCM0249	AC130	HCT 116	C242(0.99)	LDD0566	[15]
LDCM0250	AC131	HCT 116	C242(0.91)	LDD0567	[15]
LDCM0251	AC132	HCT 116	C242(0.78)	LDD0568	[15]
LDCM0252	AC133	HCT 116	C242(0.94)	LDD0569	[15]
LDCM0253	AC134	HCT 116	C242(1.02)	LDD0570	[15]
LDCM0254	AC135	HCT 116	C242(0.86)	LDD0571	[15]
LDCM0255	AC136	HCT 116	C242(1.10)	LDD0572	[15]
LDCM0256	AC137	HCT 116	C242(0.80)	LDD0573	[15]
LDCM0257	AC138	HCT 116	C242(1.12)	LDD0574	[15]
LDCM0258	AC139	HCT 116	C242(0.82)	LDD0575	[15]
LDCM0259	AC14	HEK-293T	C445(1.09); C242(0.98); C258(1.06)	LDD1512	[31]
LDCM0260	AC140	HCT 116	C242(1.06)	LDD0577	[15]
LDCM0261	AC141	HCT 116	C242(1.12)	LDD0578	[15]
LDCM0262	AC142	HCT 116	C242(0.87)	LDD0579	[15]
LDCM0263	AC143	HEK-293T	C242(1.16)	LDD0861	[15]
LDCM0264	AC144	HEK-293T	C242(1.01)	LDD0862	[15]
LDCM0265	AC145	HEK-293T	C242(0.84)	LDD0863	[15]
LDCM0266	AC146	HEK-293T	C242(0.92)	LDD0864	[15]
LDCM0267	AC147	HEK-293T	C242(0.93)	LDD0865	[15]
LDCM0268	AC148	HEK-293T	C242(0.99)	LDD0866	[15]
LDCM0269	AC149	HEK-293T	C242(1.03)	LDD0867	[15]
LDCM0270	AC15	HEK-293T	C445(1.14); C242(1.09)	LDD1513	[31]
LDCM0271	AC150	HEK-293T	C242(0.99)	LDD0869	[15]
LDCM0272	AC151	HEK-293T	C242(0.92)	LDD0870	[15]
LDCM0273	AC152	HEK-293T	C242(1.05)	LDD0871	[15]
LDCM0274	AC153	HEK-293T	C242(0.93)	LDD0872	[15]
LDCM0621	AC154	HEK-293T	C242(1.15)	LDD2162	[15]
LDCM0622	AC155	HEK-293T	C242(0.96)	LDD2163	[15]
LDCM0623	AC156	HEK-293T	C242(1.11)	LDD2164	[15]
LDCM0624	AC157	HEK-293T	C242(0.90)	LDD2165	[15]
LDCM0276	AC17	HEK-293T	C445(0.93); C242(0.98); C258(1.04)	LDD1515	[31]
LDCM0277	AC18	HEK-293T	C445(0.91); C242(0.98)	LDD1516	[31]
LDCM0278	AC19	HEK-293T	C445(0.86); C242(0.76); C258(0.97)	LDD1517	[31]
LDCM0279	AC2	HEK-293T	C445(0.93); C242(1.04)	LDD1518	[31]
LDCM0280	AC20	HEK-293T	C445(1.03); C242(1.09); C258(0.99)	LDD1519	[31]
LDCM0281	AC21	HEK-293T	C445(1.11); C242(0.98); C258(1.19)	LDD1520	[31]
LDCM0282	AC22	HEK-293T	C445(1.06); C242(0.97); C258(1.04)	LDD1521	[31]
LDCM0283	AC23	HEK-293T	C445(1.09); C242(1.03)	LDD1522	[31]
LDCM0284	AC24	HEK-293T	C445(1.05); C242(1.02); C258(1.02)	LDD1523	[31]
LDCM0285	AC25	HCT 116	C242(1.50)	LDD0602	[15]
LDCM0286	AC26	HCT 116	C242(1.37)	LDD0603	[15]
LDCM0287	AC27	HCT 116	C242(1.78)	LDD0604	[15]
LDCM0288	AC28	HCT 116	C242(1.50)	LDD0605	[15]
LDCM0289	AC29	HCT 116	C242(1.71)	LDD0606	[15]
LDCM0290	AC3	HEK-293T	C445(0.88); C242(1.06); C258(1.11)	LDD1529	[31]
LDCM0291	AC30	HCT 116	C242(1.51)	LDD0608	[15]
LDCM0292	AC31	HCT 116	C242(1.14)	LDD0609	[15]
LDCM0293	AC32	HCT 116	C242(2.05)	LDD0610	[15]
LDCM0294	AC33	HCT 116	C242(1.96)	LDD0611	[15]
LDCM0295	AC34	HCT 116	C242(2.26)	LDD0612	[15]
LDCM0296	AC35	HEK-293T	C445(0.92); C242(0.96); C258(1.08)	LDD1535	[31]
LDCM0297	AC36	HEK-293T	C445(0.92); C242(1.06); C258(1.01)	LDD1536	[31]
LDCM0298	AC37	HEK-293T	C445(0.92); C242(1.10); C258(1.09)	LDD1537	[31]
LDCM0299	AC38	HEK-293T	C445(1.15); C242(1.13); C258(1.12)	LDD1538	[31]
LDCM0300	AC39	HEK-293T	C445(0.89); C242(0.98)	LDD1539	[31]
LDCM0301	AC4	HEK-293T	C445(1.01); C242(0.90); C258(0.84)	LDD1540	[31]
LDCM0302	AC40	HEK-293T	C445(1.07); C242(1.00); C258(1.02)	LDD1541	[31]
LDCM0303	AC41	HEK-293T	C445(0.96); C242(0.90); C258(0.91)	LDD1542	[31]
LDCM0304	AC42	HEK-293T	C445(0.99); C242(0.89)	LDD1543	[31]
LDCM0305	AC43	HEK-293T	C445(0.98); C242(1.72); C258(1.27)	LDD1544	[31]
LDCM0306	AC44	HEK-293T	C445(0.85); C242(1.16); C258(1.08)	LDD1545	[31]
LDCM0307	AC45	HEK-293T	C445(0.97); C242(1.07); C258(1.12)	LDD1546	[31]
LDCM0308	AC46	HCT 116	C258(0.94)	LDD0625	[15]
LDCM0309	AC47	HCT 116	C258(1.00)	LDD0626	[15]
LDCM0310	AC48	HCT 116	C258(1.10)	LDD0627	[15]
LDCM0311	AC49	HCT 116	C258(0.56)	LDD0628	[15]
LDCM0312	AC5	HEK-293T	C445(1.01); C242(1.22); C258(0.96)	LDD1551	[31]
LDCM0313	AC50	HCT 116	C258(0.67)	LDD0630	[15]
LDCM0314	AC51	HCT 116	C258(0.94)	LDD0631	[15]
LDCM0315	AC52	HCT 116	C258(0.92)	LDD0632	[15]
LDCM0316	AC53	HCT 116	C258(0.78)	LDD0633	[15]
LDCM0317	AC54	HCT 116	C258(0.78)	LDD0634	[15]
LDCM0318	AC55	HCT 116	C258(0.60)	LDD0635	[15]
LDCM0319	AC56	HCT 116	C258(0.36)	LDD0636	[15]
LDCM0320	AC57	PaTu 8988t	C242(1.31)	LDD1199	[15]
LDCM0321	AC58	PaTu 8988t	C242(1.15)	LDD1200	[15]
LDCM0322	AC59	PaTu 8988t	C242(1.14)	LDD1201	[15]
LDCM0323	AC6	HEK-293T	C445(1.11); C242(0.95); C258(0.98)	LDD1562	[31]
LDCM0324	AC60	PaTu 8988t	C242(1.18)	LDD1203	[15]
LDCM0325	AC61	PaTu 8988t	C242(1.02)	LDD1204	[15]
LDCM0326	AC62	PaTu 8988t	C242(1.32)	LDD1205	[15]
LDCM0327	AC63	PaTu 8988t	C242(1.41)	LDD1206	[15]
LDCM0328	AC64	PaTu 8988t	C242(1.24)	LDD1207	[15]
LDCM0329	AC65	PaTu 8988t	C242(1.15)	LDD1208	[15]
LDCM0330	AC66	PaTu 8988t	C242(1.19)	LDD1209	[15]
LDCM0331	AC67	PaTu 8988t	C242(1.03)	LDD1210	[15]
LDCM0332	AC68	HCT 116	C258(0.93); C242(1.89)	LDD0649	[15]
LDCM0333	AC69	HCT 116	C258(1.12); C242(1.47)	LDD0650	[15]
LDCM0334	AC7	HEK-293T	C445(1.03); C242(1.00)	LDD1568	[31]
LDCM0335	AC70	HCT 116	C258(0.95); C242(1.44)	LDD0652	[15]
LDCM0336	AC71	HCT 116	C242(1.04); C258(1.25)	LDD0653	[15]
LDCM0337	AC72	HCT 116	C258(1.09); C242(1.63)	LDD0654	[15]
LDCM0338	AC73	HCT 116	C258(0.73); C242(1.85)	LDD0655	[15]
LDCM0339	AC74	HCT 116	C258(0.77); C242(1.65)	LDD0656	[15]
LDCM0340	AC75	HCT 116	C258(0.48); C242(2.00)	LDD0657	[15]
LDCM0341	AC76	HCT 116	C258(1.02); C242(1.76)	LDD0658	[15]
LDCM0342	AC77	HCT 116	C258(0.95); C242(1.26)	LDD0659	[15]
LDCM0343	AC78	HCT 116	C258(1.21); C242(1.59)	LDD0660	[15]
LDCM0344	AC79	HCT 116	C258(1.19); C242(1.23)	LDD0661	[15]
LDCM0345	AC8	HEK-293T	C445(1.04); C242(0.94); C258(1.10)	LDD1569	[31]
LDCM0346	AC80	HCT 116	C258(1.23); C242(2.05)	LDD0663	[15]
LDCM0347	AC81	HCT 116	C242(0.76); C258(1.08)	LDD0664	[15]
LDCM0348	AC82	HCT 116	C258(0.33); C242(2.89)	LDD0665	[15]
LDCM0349	AC83	HCT 116	C258(0.66)	LDD0666	[15]
LDCM0350	AC84	HCT 116	C258(0.79)	LDD0667	[15]
LDCM0351	AC85	HCT 116	C258(1.10)	LDD0668	[15]
LDCM0352	AC86	HCT 116	C258(1.11)	LDD0669	[15]
LDCM0353	AC87	HCT 116	C258(0.99)	LDD0670	[15]
LDCM0354	AC88	HCT 116	C258(0.86)	LDD0671	[15]
LDCM0355	AC89	HCT 116	C258(0.78)	LDD0672	[15]
LDCM0357	AC90	HCT 116	C258(0.79)	LDD0674	[15]
LDCM0358	AC91	HCT 116	C258(0.66)	LDD0675	[15]
LDCM0359	AC92	HCT 116	C258(0.72)	LDD0676	[15]
LDCM0360	AC93	HCT 116	C258(0.80)	LDD0677	[15]
LDCM0361	AC94	HCT 116	C258(0.98)	LDD0678	[15]
LDCM0362	AC95	HCT 116	C258(0.98)	LDD0679	[15]
LDCM0363	AC96	HCT 116	C258(0.87)	LDD0680	[15]
LDCM0364	AC97	HCT 116	C258(0.83)	LDD0681	[15]
LDCM0365	AC98	HEK-293T	C242(0.97)	LDD0963	[15]
LDCM0366	AC99	HEK-293T	C242(1.12)	LDD0964	[15]
LDCM0520	AKOS000195272	MDA-MB-231	C258(0.81)	LDD2113	[11]
LDCM0248	AKOS034007472	HEK-293T	C445(1.03); C242(1.01); C258(1.05)	LDD1511	[31]
LDCM0356	AKOS034007680	HEK-293T	C445(0.95); C242(0.98); C258(0.99)	LDD1570	[31]
LDCM0275	AKOS034007705	HEK-293T	C445(1.03); C242(0.99); C258(0.99)	LDD1514	[31]
LDCM0147	AZ0108	MDA-MB-468	2.03	LDD0376	[24]
LDCM0108	Chloroacetamide	HeLa	C258(0.00); H153(0.00)	LDD0222	[20]
LDCM0367	CL1	HCT 116	C258(1.05)	LDD0684	[15]
LDCM0368	CL10	HCT 116	C258(0.89)	LDD0685	[15]
LDCM0369	CL100	HEK-293T	C445(0.98); C242(0.89); C258(0.94)	LDD1573	[31]
LDCM0370	CL101	HEK-293T	C445(0.71); C242(1.00); C258(1.00)	LDD1574	[31]
LDCM0371	CL102	HEK-293T	C445(0.93); C242(0.97)	LDD1575	[31]
LDCM0372	CL103	HEK-293T	C445(0.90); C242(1.03)	LDD1576	[31]
LDCM0373	CL104	HEK-293T	C445(0.93); C242(1.00); C258(1.00)	LDD1577	[31]
LDCM0374	CL105	HEK-293T	C445(0.80); C242(0.92); C258(1.05)	LDD1578	[31]
LDCM0375	CL106	HEK-293T	C445(0.97); C242(0.97)	LDD1579	[31]
LDCM0376	CL107	HEK-293T	C445(1.00); C242(1.02)	LDD1580	[31]
LDCM0377	CL108	HEK-293T	C445(0.95); C242(0.99); C258(0.92)	LDD1581	[31]
LDCM0378	CL109	HEK-293T	C445(1.00); C242(0.96); C258(1.01)	LDD1582	[31]
LDCM0379	CL11	HCT 116	C258(0.69)	LDD0696	[15]
LDCM0380	CL110	HEK-293T	C445(1.06); C242(1.88)	LDD1584	[31]
LDCM0381	CL111	HEK-293T	C445(1.01); C242(1.16)	LDD1585	[31]
LDCM0382	CL112	HCT 116	C242(1.54)	LDD0699	[15]
LDCM0383	CL113	HCT 116	C242(1.61)	LDD0700	[15]
LDCM0384	CL114	HCT 116	C242(1.72)	LDD0701	[15]
LDCM0385	CL115	HCT 116	C242(1.61)	LDD0702	[15]
LDCM0386	CL116	HCT 116	C242(1.37)	LDD0703	[15]
LDCM0387	CL117	HEK-293T	C445(0.88); C242(0.95); C258(0.97)	LDD1591	[31]
LDCM0388	CL118	HEK-293T	C445(1.00); C242(0.94)	LDD1592	[31]
LDCM0389	CL119	HEK-293T	C445(1.07); C242(0.95)	LDD1593	[31]
LDCM0390	CL12	HCT 116	C258(0.69)	LDD0707	[15]
LDCM0391	CL120	HEK-293T	C445(1.03); C242(1.00); C258(0.91)	LDD1595	[31]
LDCM0392	CL121	HCT 116	C258(0.80)	LDD0709	[15]
LDCM0393	CL122	HCT 116	C258(1.14)	LDD0710	[15]
LDCM0394	CL123	HCT 116	C258(0.78)	LDD0711	[15]
LDCM0395	CL124	HCT 116	C258(0.76)	LDD0712	[15]
LDCM0396	CL125	PaTu 8988t	C242(1.08)	LDD1275	[15]
LDCM0397	CL126	PaTu 8988t	C242(1.33)	LDD1276	[15]
LDCM0398	CL127	PaTu 8988t	C242(1.06)	LDD1277	[15]
LDCM0399	CL128	PaTu 8988t	C242(1.04)	LDD1278	[15]
LDCM0400	CL13	HCT 116	C258(0.94)	LDD0717	[15]
LDCM0401	CL14	HCT 116	C258(1.04)	LDD0718	[15]
LDCM0402	CL15	HCT 116	C258(0.49)	LDD0719	[15]
LDCM0403	CL16	HEK-293T	C445(0.90); C242(0.94); C258(0.95)	LDD1607	[31]
LDCM0404	CL17	HEK-293T	C445(0.91); C242(1.08); C258(0.95)	LDD1608	[31]
LDCM0405	CL18	HEK-293T	C445(0.86); C242(0.97)	LDD1609	[31]
LDCM0406	CL19	HEK-293T	C445(0.95); C242(1.14); C258(1.12)	LDD1610	[31]
LDCM0407	CL2	HCT 116	C258(1.00)	LDD0724	[15]
LDCM0408	CL20	HEK-293T	C445(0.91); C242(0.99); C258(1.13)	LDD1612	[31]
LDCM0409	CL21	HEK-293T	C445(1.14); C242(1.05); C258(1.03)	LDD1613	[31]
LDCM0410	CL22	HEK-293T	C445(1.28); C242(1.15); C258(1.13)	LDD1614	[31]
LDCM0411	CL23	HEK-293T	C445(1.17); C242(1.15)	LDD1615	[31]
LDCM0412	CL24	HEK-293T	C445(1.19); C242(0.94); C258(1.05)	LDD1616	[31]
LDCM0413	CL25	HEK-293T	C445(0.70); C242(1.13); C258(1.05)	LDD1617	[31]
LDCM0414	CL26	HEK-293T	C445(0.98); C242(0.96)	LDD1618	[31]
LDCM0415	CL27	HEK-293T	C445(1.11); C242(0.97)	LDD1619	[31]
LDCM0416	CL28	HEK-293T	C445(1.01); C242(1.02); C258(1.12)	LDD1620	[31]
LDCM0417	CL29	HEK-293T	C445(1.00); C242(0.94); C258(1.04)	LDD1621	[31]
LDCM0418	CL3	HCT 116	C258(1.04)	LDD0735	[15]
LDCM0419	CL30	HEK-293T	C445(1.00); C242(1.03)	LDD1623	[31]
LDCM0420	CL31	HEK-293T	C242(1.05)	LDD1018	[15]
LDCM0421	CL32	HEK-293T	C242(1.02)	LDD1019	[15]
LDCM0422	CL33	HEK-293T	C242(1.08)	LDD1020	[15]
LDCM0423	CL34	HEK-293T	C242(1.10)	LDD1021	[15]
LDCM0424	CL35	HEK-293T	C242(1.04)	LDD1022	[15]
LDCM0425	CL36	HEK-293T	C242(0.86)	LDD1023	[15]
LDCM0426	CL37	HEK-293T	C242(1.18)	LDD1024	[15]
LDCM0428	CL39	HEK-293T	C242(0.95)	LDD1026	[15]
LDCM0429	CL4	HCT 116	C258(1.12)	LDD0746	[15]
LDCM0430	CL40	HEK-293T	C242(1.00)	LDD1028	[15]
LDCM0431	CL41	HEK-293T	C242(0.89)	LDD1029	[15]
LDCM0432	CL42	HEK-293T	C242(0.88)	LDD1030	[15]
LDCM0433	CL43	HEK-293T	C242(0.97)	LDD1031	[15]
LDCM0434	CL44	HEK-293T	C242(1.07)	LDD1032	[15]
LDCM0435	CL45	HEK-293T	C242(0.96)	LDD1033	[15]
LDCM0436	CL46	HCT 116	C242(0.97)	LDD0753	[15]
LDCM0437	CL47	HCT 116	C242(0.77)	LDD0754	[15]
LDCM0438	CL48	HCT 116	C242(0.96)	LDD0755	[15]
LDCM0439	CL49	HCT 116	C242(1.11)	LDD0756	[15]
LDCM0440	CL5	HCT 116	C258(0.99)	LDD0757	[15]
LDCM0441	CL50	HCT 116	C242(1.02)	LDD0758	[15]
LDCM0442	CL51	HCT 116	C242(1.09)	LDD0759	[15]
LDCM0443	CL52	HCT 116	C242(0.99)	LDD0760	[15]
LDCM0444	CL53	HCT 116	C242(1.32)	LDD0761	[15]
LDCM0445	CL54	HCT 116	C242(0.98)	LDD0762	[15]
LDCM0446	CL55	HCT 116	C242(0.92)	LDD0763	[15]
LDCM0447	CL56	HCT 116	C242(1.16)	LDD0764	[15]
LDCM0448	CL57	HCT 116	C242(0.86)	LDD0765	[15]
LDCM0449	CL58	HCT 116	C242(0.82)	LDD0766	[15]
LDCM0450	CL59	HCT 116	C242(1.12)	LDD0767	[15]
LDCM0451	CL6	HCT 116	C258(1.08)	LDD0768	[15]
LDCM0452	CL60	HCT 116	C242(0.86)	LDD0769	[15]
LDCM0453	CL61	PaTu 8988t	C242(0.72)	LDD1332	[15]
LDCM0454	CL62	PaTu 8988t	C242(0.75)	LDD1333	[15]
LDCM0455	CL63	PaTu 8988t	C242(0.86)	LDD1334	[15]
LDCM0456	CL64	PaTu 8988t	C242(0.79)	LDD1335	[15]
LDCM0457	CL65	PaTu 8988t	C242(0.49)	LDD1336	[15]
LDCM0458	CL66	PaTu 8988t	C242(1.19)	LDD1337	[15]
LDCM0459	CL67	PaTu 8988t	C242(1.03)	LDD1338	[15]
LDCM0460	CL68	PaTu 8988t	C242(1.03)	LDD1339	[15]
LDCM0461	CL69	PaTu 8988t	C242(1.16)	LDD1340	[15]
LDCM0462	CL7	HCT 116	C258(0.97)	LDD0779	[15]
LDCM0463	CL70	PaTu 8988t	C242(1.32)	LDD1342	[15]
LDCM0464	CL71	PaTu 8988t	C242(0.64)	LDD1343	[15]
LDCM0465	CL72	PaTu 8988t	C242(0.59)	LDD1344	[15]
LDCM0466	CL73	PaTu 8988t	C242(1.99)	LDD1345	[15]
LDCM0467	CL74	PaTu 8988t	C242(0.56)	LDD1346	[15]
LDCM0469	CL76	PaTu 8988t	C242(1.23)	LDD1348	[15]
LDCM0470	CL77	PaTu 8988t	C242(1.20)	LDD1349	[15]
LDCM0471	CL78	PaTu 8988t	C242(1.15)	LDD1350	[15]
LDCM0472	CL79	PaTu 8988t	C242(1.00)	LDD1351	[15]
LDCM0473	CL8	HCT 116	C258(0.66)	LDD0790	[15]
LDCM0474	CL80	PaTu 8988t	C242(1.09)	LDD1353	[15]
LDCM0475	CL81	PaTu 8988t	C242(1.17)	LDD1354	[15]
LDCM0476	CL82	PaTu 8988t	C242(1.18)	LDD1355	[15]
LDCM0477	CL83	PaTu 8988t	C242(1.47)	LDD1356	[15]
LDCM0478	CL84	PaTu 8988t	C242(1.53)	LDD1357	[15]
LDCM0479	CL85	PaTu 8988t	C242(0.99)	LDD1358	[15]
LDCM0480	CL86	PaTu 8988t	C242(1.14)	LDD1359	[15]
LDCM0481	CL87	PaTu 8988t	C242(1.45)	LDD1360	[15]
LDCM0482	CL88	PaTu 8988t	C242(1.34)	LDD1361	[15]
LDCM0483	CL89	PaTu 8988t	C242(1.44)	LDD1362	[15]
LDCM0484	CL9	HCT 116	C258(0.90)	LDD0801	[15]
LDCM0485	CL90	PaTu 8988t	C242(1.34)	LDD1364	[15]
LDCM0486	CL91	HEK-293T	C445(0.94); C242(1.03); C258(1.15)	LDD1689	[31]
LDCM0487	CL92	HEK-293T	C445(0.82); C242(0.94); C258(1.27)	LDD1690	[31]
LDCM0488	CL93	HEK-293T	C445(1.35); C242(1.18); C258(1.31)	LDD1691	[31]
LDCM0489	CL94	HEK-293T	C445(1.22); C242(1.04); C258(1.21)	LDD1692	[31]
LDCM0490	CL95	HEK-293T	C445(1.08); C242(1.09)	LDD1693	[31]
LDCM0491	CL96	HEK-293T	C445(1.09); C242(0.95); C258(1.06)	LDD1694	[31]
LDCM0492	CL97	HEK-293T	C445(0.85); C242(0.96); C258(1.05)	LDD1695	[31]
LDCM0493	CL98	HEK-293T	C445(0.97); C242(0.94)	LDD1696	[31]
LDCM0494	CL99	HEK-293T	C445(0.96); C242(0.95)	LDD1697	[31]
LDCM0033	Curcusone1d	MCF-7	2.19	LDD0188	[12]
LDCM0495	E2913	HEK-293T	C445(0.97); C242(0.97)	LDD1698	[31]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C445(8.25); C258(3.96)	LDD1702	[11]
LDCM0082	FK866	A-549	2.58	LDD0142	[28]
LDCM0468	Fragment33	PaTu 8988t	C242(0.79)	LDD1347	[15]
LDCM0427	Fragment51	HEK-293T	C242(1.16)	LDD1025	[15]
LDCM0107	IAA	HeLa	C258(0.00); H153(0.00)	LDD0221	[20]
LDCM0022	KB02	HEK-293T	C445(0.83); C242(1.12); C258(1.09)	LDD1492	[31]
LDCM0023	KB03	HEK-293T	C445(0.83); C242(1.04); C258(1.00)	LDD1497	[31]
LDCM0024	KB05	G361	C445(2.01)	LDD3311	[32]
LDCM0109	NEM	HeLa	H172(0.00); C258(0.00)	LDD0223	[20]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C258(1.01)	LDD2093	[11]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C258(0.91)	LDD2097	[11]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C258(0.99)	LDD2099	[11]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C258(1.05)	LDD2111	[11]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C258(0.57)	LDD2115	[11]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C258(0.69)	LDD2125	[11]
LDCM0533	Nucleophilic fragment 29b	MDA-MB-231	C258(0.10)	LDD2126	[11]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C258(0.73)	LDD2127	[11]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C258(1.12)	LDD2129	[11]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C258(0.56)	LDD2133	[11]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C258(0.84)	LDD2134	[11]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C258(1.31)	LDD2135	[11]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C258(0.84)	LDD2137	[11]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C258(0.62)	LDD2141	[11]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C258(0.18)	LDD2145	[11]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C258(0.82)	LDD2146	[11]
LDCM0148	Olaparib	MDA-MB-468	1.88	LDD0377	[24]
LDCM0014	Panhematin	K562	3.00	LDD0063	[13]
LDCM0099	Phenelzine	MDA-MB-231	7.69	LDD0283	[10]
LDCM0131	RA190	MM1.R	3.43	LDD0299	[14]
LDCM0084	Ro 48-8071	A-549	2.46	LDD0144	[28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Homeobox protein Hox-A1 (HOXA1)				Antp homeobox family	P49639

References

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2	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
3	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
4	Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d. Mass spectrometry data entry: PXD010277
5	Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
8	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10	Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
11	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
12	Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
13	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
14	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
15	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
17	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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19	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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24	Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
25	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
26	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
29	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
30	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
31	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
32	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni