Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name PARPYnD  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name Olaparib  Competitor Info 
Competitor Concentration 5 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-468)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13240  Poly [ADP-ribose] polymerase 2 (PARP2) 3.0
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) 2.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 1.9
 LDTP04183  Lanosterol synthase (LSS) 1.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 1.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 1.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03798  Monocarboxylate transporter 8 (SLC16A2) 2.3

References

1 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.