General Information of Experiment

Probe Name C117  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 11.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 9.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 6.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 6.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 5.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 5.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 4.9
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 13.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 8.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 8.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.8
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 6.6
 LDTP10885  Sortilin (SORT1) 5.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.5
 LDTP14140  Ceramide transfer protein (CERT1) 5.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.2
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 5.1
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 12.7
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 8.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587