Details of the Target

General Information of Target

Target ID LDTP01241
Target Name Bis(monoacylglycero)phosphate synthase CLN5 (CLN5)
Gene Name CLN5
Gene ID 1203
Synonyms
BMPS; Bis(monoacylglycero)phosphate synthase CLN5; BMP synthase CLN5; EC 2.3.1.-; Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5; Palmitoyl protein thioesterase CLN5; EC 3.1.2.22; S-depalmitoylase CLN5) [Cleaved into: Bis(monoacylglycero)phosphate synthase CLN5, secreted form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQEVDTAQGAEMRRGAGAARGRASWCWALALLWLAVVPGWSRVSGIPSRRHWPVPYKRF
DFRPKPDPYCQAKYTFCPTGSPIPVMEGDDDIEVFRLQAPVWEFKYGDLLGHLKIMHDAI
GFRSTLTGKNYTMEWYELFQLGNCTFPHLRPEMDAPFWCNQGAACFFEGIDDVHWKENGT
LVQVATISGNMFNQMAKWVKQDNETGIYYETWNVKASPEKGAETWFDSYDCSKFVLRTFN
KLAEFGAEFKNIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLGLAIKRFYYPFKPHLP
TKEFLLSLLQIFDAVIVHKQFYLFYNFEYWFLPMKFPFIKITYEEIPLPIRNKTLSGL
Target Bioclass
Enzyme
Family
CLN5 family
Subcellular location
Lysosome; Membrane
Function
[Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.; Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.
Uniprot ID
O75503
Ensemble ID
ENST00000377453.9
HGNC ID
HGNC:2076

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		30.18  LDD0318  [1]
TH211
 Probe Info  		Y106(5.96)  LDD0257  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
DBIA
 Probe Info  		C231(1.08)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
IPM
 Probe Info  		C231(0.00); C70(0.00)  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
MPP-AC
 Probe Info  		N.A.  LDD0428  [8]
TPP-AC
 Probe Info  		N.A.  LDD0427  [8]
HHS-482
 Probe Info  		Y106(1.20)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 147 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.69  LDD1714  [10]
C010
 Probe Info  		6.63  LDD1719  [10]
C011
 Probe Info  		6.73  LDD1720  [10]
C018
 Probe Info  		5.58  LDD1726  [10]
C022
 Probe Info  		13.09  LDD1728  [10]
C026
 Probe Info  		5.90  LDD1732  [10]
C036
 Probe Info  		9.92  LDD1736  [10]
C039
 Probe Info  		6.59  LDD1739  [10]
C040
 Probe Info  		12.73  LDD1740  [10]
C041
 Probe Info  		18.38  LDD1741  [10]
C045
 Probe Info  		11.96  LDD1744  [10]
C053
 Probe Info  		5.58  LDD1751  [10]
C063
 Probe Info  		24.59  LDD1760  [10]
C064
 Probe Info  		9.25  LDD1761  [10]
C067
 Probe Info  		5.58  LDD1763  [10]
C070
 Probe Info  		13.83  LDD1766  [10]
C071
 Probe Info  		9.45  LDD1767  [10]
C072
 Probe Info  		7.31  LDD1768  [10]
C073
 Probe Info  		7.16  LDD1769  [10]
C078
 Probe Info  		5.13  LDD1771  [10]
C079
 Probe Info  		5.28  LDD1772  [10]
C082
 Probe Info  		7.31  LDD1774  [10]
C085
 Probe Info  		9.58  LDD1777  [10]
C087
 Probe Info  		22.16  LDD1779  [10]
C091
 Probe Info  		11.96  LDD1782  [10]
C092
 Probe Info  		20.39  LDD1783  [10]
C099
 Probe Info  		7.01  LDD1788  [10]
C106
 Probe Info  		26.72  LDD1793  [10]
C107
 Probe Info  		17.27  LDD1794  [10]
C108
 Probe Info  		13.18  LDD1795  [10]
C112
 Probe Info  		34.54  LDD1799  [10]
C115
 Probe Info  		17.39  LDD1802  [10]
C117
 Probe Info  		9.32  LDD1804  [10]
C130
 Probe Info  		6.87  LDD1812  [10]
C134
 Probe Info  		27.67  LDD1816  [10]
C139
 Probe Info  		12.47  LDD1821  [10]
C140
 Probe Info  		13.45  LDD1822  [10]
C141
 Probe Info  		15.56  LDD1823  [10]
C143
 Probe Info  		14.72  LDD1825  [10]
C145
 Probe Info  		11.24  LDD1827  [10]
C147
 Probe Info  		12.38  LDD1829  [10]
C149
 Probe Info  		13.64  LDD1830  [10]
C153
 Probe Info  		15.14  LDD1834  [10]
C159
 Probe Info  		15.35  LDD1839  [10]
C160
 Probe Info  		13.36  LDD1840  [10]
C161
 Probe Info  		27.28  LDD1841  [10]
C164
 Probe Info  		7.21  LDD1844  [10]
C170
 Probe Info  		34.06  LDD1850  [10]
C171
 Probe Info  		9.92  LDD1851  [10]
C177
 Probe Info  		11.08  LDD1856  [10]
C183
 Probe Info  		11.96  LDD1861  [10]
C186
 Probe Info  		27.67  LDD1864  [10]
C187
 Probe Info  		33.13  LDD1865  [10]
C193
 Probe Info  		5.03  LDD1869  [10]
C194
 Probe Info  		11.31  LDD1870  [10]
C197
 Probe Info  		20.68  LDD1873  [10]
C198
 Probe Info  		16.00  LDD1874  [10]
C201
 Probe Info  		34.30  LDD1877  [10]
C205
 Probe Info  		7.78  LDD1880  [10]
C206
 Probe Info  		25.46  LDD1881  [10]
C208
 Probe Info  		13.64  LDD1883  [10]
C211
 Probe Info  		17.03  LDD1885  [10]
C213
 Probe Info  		17.88  LDD1887  [10]
C219
 Probe Info  		9.51  LDD1893  [10]
C220
 Probe Info  		17.03  LDD1894  [10]
C221
 Probe Info  		15.03  LDD1895  [10]
C223
 Probe Info  		14.93  LDD1897  [10]
C225
 Probe Info  		10.20  LDD1898  [10]
C226
 Probe Info  		6.54  LDD1899  [10]
C228
 Probe Info  		18.64  LDD1901  [10]
C229
 Probe Info  		7.78  LDD1902  [10]
C231
 Probe Info  		12.82  LDD1904  [10]
C232
 Probe Info  		33.82  LDD1905  [10]
C233
 Probe Info  		10.93  LDD1906  [10]
C237
 Probe Info  		8.40  LDD1910  [10]
C239
 Probe Info  		9.32  LDD1912  [10]
C240
 Probe Info  		8.75  LDD1913  [10]
C243
 Probe Info  		13.27  LDD1916  [10]
C246
 Probe Info  		13.27  LDD1919  [10]
C249
 Probe Info  		24.59  LDD1922  [10]
C260
 Probe Info  		5.54  LDD1932  [10]
C264
 Probe Info  		17.39  LDD1935  [10]
C265
 Probe Info  		20.82  LDD1936  [10]
C270
 Probe Info  		7.41  LDD1940  [10]
C273
 Probe Info  		5.39  LDD1943  [10]
C277
 Probe Info  		8.40  LDD1947  [10]
C280
 Probe Info  		12.64  LDD1950  [10]
C281
 Probe Info  		11.96  LDD1951  [10]
C282
 Probe Info  		15.89  LDD1952  [10]
C286
 Probe Info  		5.66  LDD1956  [10]
C287
 Probe Info  		13.93  LDD1957  [10]
C288
 Probe Info  		13.27  LDD1958  [10]
C293
 Probe Info  		23.43  LDD1963  [10]
C296
 Probe Info  		19.03  LDD1966  [10]
C299
 Probe Info  		7.78  LDD1968  [10]
C302
 Probe Info  		17.39  LDD1971  [10]
C305
 Probe Info  		22.01  LDD1974  [10]
C310
 Probe Info  		19.16  LDD1977  [10]
C314
 Probe Info  		21.86  LDD1981  [10]
C326
 Probe Info  		27.10  LDD1990  [10]
C334
 Probe Info  		7.11  LDD1997  [10]
C336
 Probe Info  		5.54  LDD1999  [10]
C338
 Probe Info  		12.04  LDD2001  [10]
C339
 Probe Info  		7.26  LDD2002  [10]
C342
 Probe Info  		6.02  LDD2004  [10]
C343
 Probe Info  		13.93  LDD2005  [10]
C346
 Probe Info  		29.86  LDD2007  [10]
C348
 Probe Info  		20.68  LDD2009  [10]
C349
 Probe Info  		14.52  LDD2010  [10]
C350
 Probe Info  		37.27  LDD2011  [10]
C353
 Probe Info  		16.80  LDD2014  [10]
C355
 Probe Info  		94.35  LDD2016  [10]
C356
 Probe Info  		20.82  LDD2017  [10]
C357
 Probe Info  		9.19  LDD2018  [10]
C360
 Probe Info  		8.40  LDD2021  [10]
C363
 Probe Info  		21.56  LDD2024  [10]
C369
 Probe Info  		6.06  LDD2030  [10]
C376
 Probe Info  		6.92  LDD2036  [10]
C378
 Probe Info  		7.26  LDD2037  [10]
C380
 Probe Info  		8.69  LDD2039  [10]
C382
 Probe Info  		10.34  LDD2041  [10]
C383
 Probe Info  		22.01  LDD2042  [10]
C386
 Probe Info  		12.21  LDD2045  [10]
C390
 Probe Info  		81.01  LDD2049  [10]
C393
 Probe Info  		7.16  LDD2052  [10]
C399
 Probe Info  		8.94  LDD2058  [10]
C403
 Probe Info  		17.15  LDD2061  [10]
C407
 Probe Info  		14.62  LDD2064  [10]
C408
 Probe Info  		11.08  LDD2065  [10]
C420
 Probe Info  		10.93  LDD2075  [10]
C425
 Probe Info  		26.35  LDD2080  [10]
C428
 Probe Info  		8.22  LDD2083  [10]
C429
 Probe Info  		30.70  LDD2084  [10]
C431
 Probe Info  		21.11  LDD2086  [10]
C433
 Probe Info  		8.46  LDD2088  [10]
FFF probe11
 Probe Info  		12.69  LDD0471  [11]
FFF probe12
 Probe Info  		20.00  LDD0473  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe15
 Probe Info  		6.31  LDD0478  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]
FFF probe4
 Probe Info  		20.00  LDD0466  [11]
FFF probe7
 Probe Info  		10.38  LDD0483  [11]
FFF probe9
 Probe Info  		20.00  LDD0470  [11]
JN0003
 Probe Info  		20.00  LDD0469  [11]
BD-F
 Probe Info  		P78(0.00); I83(0.00); S81(0.00); T79(0.00)  LDD0024  [12]
OEA-DA
 Probe Info  		20.00  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C231(0.97)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C231(0.93)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C231(1.20)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C231(1.33)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C231(1.12)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C231(1.26)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C231(1.16)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C231(1.13)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C231(1.43)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C231(1.30)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C231(1.28)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C231(1.11)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C231(0.95)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C231(1.27)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C231(1.24)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C231(1.21)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C231(1.12)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C231(1.18)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C231(1.44)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C231(1.41)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C231(1.25)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C231(1.24)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C231(1.28)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C231(1.04)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C231(1.31)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C231(1.18)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C231(1.24)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C231(1.03)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C231(1.03)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C231(1.23)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C231(1.30)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C231(1.33)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C231(1.22)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C231(0.73)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C231(0.97)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C231(0.71)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C231(0.79)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C231(1.04)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C231(1.10)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C231(1.03)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C231(0.98)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C231(0.92)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C231(0.91)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C231(0.98)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C231(0.82)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C231(1.06)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C231(0.98)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C231(0.92)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C231(0.90)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C231(1.35)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C231(1.14)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C231(1.02)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C231(1.23)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C231(1.34)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C231(1.16)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C231(1.02)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C231(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C231(0.97)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C231(1.17)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C231(1.35)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C231(1.12)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C231(1.10)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C231(1.01)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C231(0.94)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C231(0.96)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C231(1.36)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C231(1.30)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C231(1.16)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C231(1.30)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C231(1.29)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C231(0.82)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C231(0.89)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C231(1.53)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C231(1.33)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C231(1.19)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C231(1.31)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C231(1.35)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C231(1.32)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C231(1.10)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C231(1.79)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C231(1.42)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C231(1.52)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C231(1.33)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C231(1.64)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C231(0.83)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C231(0.81)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C231(0.78)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C231(1.34)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C231(1.08)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C231(1.02)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C231(0.95)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C231(0.80)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C231(1.08)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C231(1.21)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C231(0.73)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C231(0.82)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C231(0.84)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C231(0.92)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C231(0.88)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C231(0.76)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C231(1.18)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C231(0.76)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C231(0.73)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C231(0.79)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C231(0.79)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C231(0.75)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C231(0.72)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C231(0.78)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C231(1.08)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C231(1.19)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C231(1.20)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C231(0.95)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C231(1.22)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C231(1.18)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C231(1.31)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C231(1.23)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C231(1.51)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C231(1.34)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C231(1.33)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C231(1.29)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C231(1.02)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C231(1.09)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C231(1.08)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C231(1.11)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C231(1.06)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C231(1.06)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C231(1.34)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C231(1.39)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C231(1.43)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C231(1.18)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C231(1.19)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C231(1.05)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C231(1.05)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C231(0.96)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C231(1.07)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C231(1.01)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C231(1.59)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C231(0.81)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C231(0.81)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C231(0.82)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C231(0.95)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C231(1.01)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C231(0.90)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C231(0.95)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C231(1.06)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C231(0.91)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C231(0.87)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C231(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C231(0.93)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C231(1.09)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C231(0.87)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C231(0.93)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C231(1.27)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C231(1.32)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C231(1.00)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C231(1.05)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C231(0.94)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C231(1.02)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C231(1.03)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C231(0.99)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C231(0.82)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C231(0.71)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C231(0.89)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C231(0.81)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C231(2.11)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C231(1.84)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C231(1.29)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C231(1.97)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C231(0.93)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C231(0.97)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C231(1.15)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C231(1.32)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C231(1.04)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C231(1.57)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C231(1.15)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C231(1.31)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C231(1.50)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C231(0.93)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C231(0.94)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C231(0.87)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C231(1.04)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C231(1.00)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C231(0.84)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C231(0.90)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C231(0.72)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C231(0.69)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C231(0.98)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C231(1.06)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C231(1.05)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C231(1.22)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C231(1.18)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C231(1.19)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C231(1.01)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C231(1.27)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C231(1.18)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C231(1.17)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C231(1.11)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C231(1.00)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C231(1.32)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C231(1.19)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C231(1.22)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C231(1.36)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C231(1.22)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C231(1.08)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C231(1.27)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C231(1.28)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C231(1.44)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C231(1.36)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C231(1.07)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C231(1.24)  LDD1298  [4]
 LDCM0420  CL31 HCT 116 C231(1.00)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C231(1.03)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C231(0.81)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C231(1.19)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C231(0.79)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C231(0.74)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C231(0.67)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C231(0.65)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C231(1.38)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C231(0.65)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C231(0.92)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C231(0.70)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C231(0.94)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C231(0.81)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C231(0.94)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C231(0.89)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C231(0.87)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C231(0.88)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C231(0.89)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C231(1.08)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C231(0.88)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C231(0.86)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C231(0.86)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C231(0.78)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C231(0.76)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C231(0.89)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C231(0.91)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C231(0.84)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C231(0.78)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C231(0.88)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C231(1.05)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C231(0.86)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C231(0.74)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C231(0.79)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C231(0.68)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C231(0.88)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C231(0.72)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C231(0.90)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C231(0.68)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C231(0.76)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C231(0.91)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C231(1.12)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C231(0.80)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C231(0.90)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C231(1.20)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C231(0.82)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C231(0.90)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C231(1.15)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C231(1.44)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C231(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C231(1.08)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C231(0.72)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C231(1.25)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C231(1.21)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C231(1.37)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C231(1.15)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C231(1.15)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C231(1.16)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C231(1.19)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C231(1.10)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C231(1.14)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C231(1.18)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C231(1.14)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C231(1.18)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C231(1.30)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C231(1.05)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C231(0.91)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C231(0.90)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C231(1.01)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C231(1.12)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C231(1.13)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C231(1.03)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C231(1.15)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C70(0.83); C231(0.88)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C231(0.79)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C231(0.48)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C231(1.08)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C231(1.27)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C231(1.21)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]
 LDCM0131  RA190 MM1.R C231(1.31)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Battenin (CLN3) Battenin family Q13286

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.