General Information of Experiment

Probe Name C036  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02223  Cathepsin B (CTSB) 10.4
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.9
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 8.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 7.5
 LDTP00316  Ribonuclease T2 (RNASET2) 5.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 5.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 5.4
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.2
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02071  Amyloid-beta precursor protein (APP) 8.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.5
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 5.9
 LDTP01969  Transferrin receptor protein 1 (TFRC) 5.5
 LDTP10885  Sortilin (SORT1) 5.2
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.2
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 6.5
 LDTP15623  Neuferricin (CYB5D2) 5.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587