Details of the Target

General Information of Target

Target ID LDTP10885
Target Name Sortilin (SORT1)
Gene Name SORT1
Gene ID 6272
Synonyms
Sortilin; 100 kDa NT receptor; Glycoprotein 95; Gp95; Neurotensin receptor 3; NT3; NTR3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTM
EQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGST
WSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVS
WSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASW
RYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACD
TLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKET
VQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
VPS10-related sortilin family, SORT1 subfamily
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
TTD ID
T63233
Uniprot ID
Q99523
DrugMap ID
TTRX9AV
Ensemble ID
ENST00000256637.8
HGNC ID
HGNC:11186
ChEMBL ID
CHEMBL3091

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDQP1 SNV: p.S12W DBIA    Probe Info 
HEC1 SNV: p.G17C DBIA    Probe Info 
HEC1B SNV: p.G17C; p.L239M; p.V474I .
HT115 SNV: p.R731Ter DBIA    Probe Info 
LN229 SNV: p.L27M DBIA    Probe Info 
MCC26 Substitution: p.W586_G587delinsTer DBIA    Probe Info 
MEC1 Insertion: p.L23_L24dup .
MEWO SNV: p.G247R DBIA    Probe Info 
MOLT4 Substitution: p.Q34R IA-alkyne    Probe Info 
NCIH1155 SNV: p.Q225Ter DBIA    Probe Info 
SNGM SNV: p.T551I DBIA    Probe Info 
SW1271 SNV: p.P478T DBIA    Probe Info 
YSCCC SNV: p.E732K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		5.43  LDD0196  [1]
BTD
 Probe Info  		C651(1.70)  LDD1700  [2]
FBPP2
 Probe Info  		2.43  LDD0054  [3]
IPM
 Probe Info  		C723(0.34)  LDD1701  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C702(6.15)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C723(0.00); C688(0.00); C556(0.00); C702(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C723(0.00); C740(0.00); C688(0.00); C556(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C723(0.00); C740(0.00); C688(0.00); C556(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
NAIA_5
 Probe Info  		C740(0.00); C702(0.00); C723(0.00); C448(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.17  LDD1711  [10]
C036
 Probe Info  		5.24  LDD1736  [10]
C045
 Probe Info  		5.62  LDD1744  [10]
C115
 Probe Info  		5.90  LDD1802  [10]
C117
 Probe Info  		5.70  LDD1804  [10]
C149
 Probe Info  		8.82  LDD1830  [10]
C164
 Probe Info  		6.96  LDD1844  [10]
C170
 Probe Info  		14.52  LDD1850  [10]
C186
 Probe Info  		8.06  LDD1864  [10]
C197
 Probe Info  		7.36  LDD1873  [10]
C237
 Probe Info  		9.78  LDD1910  [10]
C281
 Probe Info  		14.72  LDD1951  [10]
C302
 Probe Info  		15.03  LDD1971  [10]
C310
 Probe Info  		22.01  LDD1977  [10]
C313
 Probe Info  		12.13  LDD1980  [10]
C343
 Probe Info  		11.88  LDD2005  [10]
C346
 Probe Info  		17.63  LDD2007  [10]
C349
 Probe Info  		8.75  LDD2010  [10]
C350
 Probe Info  		22.63  LDD2011  [10]
C353
 Probe Info  		6.06  LDD2014  [10]
C425
 Probe Info  		13.00  LDD2080  [10]
FFF probe12
 Probe Info  		20.00  LDD0473  [11]
FFF probe13
 Probe Info  		8.47  LDD0476  [11]
FFF probe3
 Probe Info  		20.00  LDD0465  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C448(1.05); C651(1.04); C702(0.99); C556(1.84)  LDD1507  [12]
 LDCM0215  AC10 HCT 116 C702(0.96)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C651(1.01); C702(0.89); C723(1.15)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C651(1.08); C702(0.79); C723(0.97)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C651(0.88); C702(0.82); C723(1.10)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C651(1.03); C702(0.84); C723(1.27)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C651(1.18); C702(0.91); C723(1.13)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C651(0.67); C702(0.75); C723(0.98)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C651(0.75); C702(0.67); C723(0.84)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C651(0.99); C702(0.71); C723(1.23)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C651(0.77); C702(0.78); C723(0.98)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C651(0.80); C702(0.81); C723(1.09)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C702(0.95)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C651(1.29); C702(0.84); C723(1.61)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C651(1.82); C702(0.91); C723(1.78)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C651(1.46); C702(0.77); C723(1.78)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C702(1.04)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C702(1.13)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C702(0.89)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C702(0.92)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C702(1.54)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C702(1.16)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C702(1.17)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C702(1.10)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C702(2.00)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C702(1.34)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C702(1.17)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C702(1.35)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C702(1.33)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C702(1.31)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C702(1.29)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C702(1.35)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C651(0.99)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C651(1.07)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C651(1.05)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C651(1.08)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C651(1.18)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C651(1.22)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C651(0.87)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C651(1.24)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C651(1.66)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C651(1.45)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C651(1.64)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C651(1.60)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C702(1.04)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C651(1.28)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C651(1.57)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C651(1.31)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C702(1.12); C723(1.21)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C702(1.06); C723(1.29)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C702(1.33); C723(1.34)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C702(1.15); C723(1.30)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C702(1.40); C723(1.45)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C702(1.36); C723(1.38)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C702(0.95); C723(1.08)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C702(1.11)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C702(1.17); C723(1.28)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C702(1.34); C723(1.09)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C702(0.84); C723(1.16)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C702(0.82); C723(1.29)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C702(0.92); C723(1.13)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C702(0.90); C723(1.15)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C702(1.22); C723(1.34)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C702(0.83); C723(1.83)  LDD2165  [5]
 LDCM0276  AC17 PaTu 8988t C702(1.86)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C702(1.49)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C702(1.51)  LDD1157  [5]
 LDCM0279  AC2 HEK-293T C448(1.10); C723(1.12); C702(0.96); C556(1.57)  LDD1518  [12]
 LDCM0280  AC20 PaTu 8988t C702(1.59)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C702(1.97)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C702(1.87)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C702(1.60)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C702(1.42)  LDD1163  [5]
 LDCM0285  AC25 HCT 116 C702(0.91)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C702(0.89)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C702(0.93)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C702(0.95)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C702(0.98)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C723(1.02); C556(1.00); C688(1.09); C740(1.04)  LDD1529  [12]
 LDCM0291  AC30 HCT 116 C702(1.09)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C702(0.95)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C702(0.97)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C702(0.93)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C702(1.02)  LDD0612  [5]
 LDCM0296  AC35 PaTu 8988t C86(1.48)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C86(1.54)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C86(1.49)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C86(2.00)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C86(1.67)  LDD1179  [5]
 LDCM0301  AC4 HEK-293T C651(1.00); C723(0.90); C702(1.20); C556(0.92)  LDD1540  [12]
 LDCM0302  AC40 PaTu 8988t C86(1.66)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C86(1.58)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C86(2.31)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C86(1.95)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C86(1.69)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C86(1.60)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C651(1.23); C723(0.75)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C651(1.17); C723(1.35)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C651(1.22); C723(1.07)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C651(1.31); C723(1.38)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C448(1.02); C651(1.00); C723(0.87); C702(1.11)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C651(1.68); C723(0.97)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C651(2.20); C723(1.17)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C651(1.55); C723(1.11)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C651(1.29); C723(0.91)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C651(1.50); C723(1.18)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C651(1.26); C723(1.20)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C651(1.09); C723(0.98)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C651(1.07); C702(1.18); C723(0.99)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C651(1.15); C702(1.15); C723(1.01)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C651(1.33); C702(1.13); C723(0.95)  LDD0920  [5]
 LDCM0323  AC6 HCT 116 C702(1.11)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C651(1.27); C702(1.09); C723(1.00)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C651(1.86); C702(1.41); C723(1.01)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C651(1.50); C702(1.36); C723(0.90)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C651(1.67); C702(1.17); C723(0.97)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C651(1.55); C702(1.15); C723(0.92)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C651(1.83); C702(1.08); C723(0.90)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C651(1.33); C702(1.43); C723(0.86)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C651(1.42); C702(1.19); C723(0.87)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C651(0.96); C702(1.01); C723(1.09)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C651(0.90); C702(0.78); C723(0.96)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C702(1.17)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C651(1.15); C702(0.90); C723(1.05)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C651(0.99); C702(1.00); C723(0.99)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C651(1.19); C702(1.23); C723(0.97)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C651(1.14); C702(1.02); C723(0.92)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C651(1.33); C702(1.12); C723(0.74)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C651(0.79); C702(0.80); C723(0.84)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C651(0.93); C702(0.81); C723(0.85)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C651(1.01); C702(0.91); C723(1.10)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C651(1.03); C702(0.84); C723(0.89)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C651(0.86); C702(0.74); C723(0.97)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C702(1.09)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C651(0.90); C702(1.11); C723(0.95)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C651(0.77); C702(1.09); C723(0.84)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C651(0.98); C702(1.07); C723(1.02)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C702(1.36)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C702(1.15)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C702(1.31)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C702(1.19)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C702(1.28)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C702(1.24)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C702(1.31)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C702(1.19)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C702(1.10)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C702(1.20)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C702(1.12)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C702(1.25)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C702(1.09)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C702(1.21)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C702(1.33)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C651(0.98); C702(0.80); C723(1.03)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C651(0.83); C702(0.87); C723(0.93)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C702(1.14)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C702(1.48)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C702(1.16)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C86(1.15); C448(1.05); C651(0.77)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C651(0.97)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C651(2.10)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C448(1.05); C702(0.99); C556(1.02); C688(1.01)  LDD1573  [12]
 LDCM0370  CL101 HCT 116 C702(0.68)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C702(0.60)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C702(0.78)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C702(0.90)  LDD0690  [5]
 LDCM0374  CL105 PaTu 8988t C702(1.80)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C702(3.49)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C702(1.81)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C702(1.52)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C702(2.16)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C651(1.94)  LDD0977  [5]
 LDCM0380  CL110 PaTu 8988t C702(1.75)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C702(1.98)  LDD1260  [5]
 LDCM0382  CL112 HCT 116 C702(0.99)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C702(1.01)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C702(0.97)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C702(1.32)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C702(0.98)  LDD0703  [5]
 LDCM0387  CL117 PaTu 8988t C86(2.68)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C86(2.00)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C86(1.93)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C651(1.21)  LDD0988  [5]
 LDCM0391  CL120 PaTu 8988t C86(2.00)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C651(1.26); C723(0.75)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C651(1.13); C723(1.18)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C651(1.21); C723(0.93)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C651(1.07); C723(1.08)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C651(1.04); C702(1.25); C723(0.97)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C651(1.40); C702(0.99); C723(0.99)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C651(1.07); C702(1.09); C723(0.96)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C651(0.95); C702(1.14); C723(0.88)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C651(1.17)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C651(1.09)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C651(1.33)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C651(0.63); C702(1.00); C723(1.02)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C651(1.06); C702(0.76); C723(0.93)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C651(0.71); C702(0.94); C723(1.03)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C651(1.12); C702(0.87); C723(1.11)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C651(1.23)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C651(1.09); C702(0.89); C723(1.06)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C651(1.05); C702(0.79); C723(1.09)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C651(1.34); C702(1.01); C723(1.08)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C651(1.47); C702(0.85); C723(0.96)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C651(1.25); C702(0.91); C723(1.02)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C651(1.36); C702(0.73); C723(1.16)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C651(1.23); C702(1.00); C723(1.06)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C651(1.40); C702(0.95); C723(1.07)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C651(1.01); C702(0.85); C723(0.99)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C651(1.65); C702(0.93); C723(0.95)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C651(1.31)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C651(1.70); C702(0.99); C723(1.36)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C651(0.69)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C651(1.00)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C651(0.86)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C651(1.00)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C651(1.07)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C651(1.07)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C651(1.14)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C651(1.71)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C651(1.21)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C651(1.27)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C651(1.39)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C651(1.60)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C651(1.65)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C651(1.08)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C651(1.41)  LDD1033  [5]
 LDCM0436  CL46 PaTu 8988t C702(1.15); C86(1.29)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C702(1.75); C86(1.24)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C702(0.98); C86(1.15)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C702(1.03); C86(1.34)  LDD1318  [5]
 LDCM0440  CL5 HEK-293T C651(1.24)  LDD1038  [5]
 LDCM0441  CL50 PaTu 8988t C702(1.21); C86(1.26)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C702(1.27); C86(1.12)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C702(1.35); C86(1.25)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C702(1.59); C86(1.34)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C702(0.90); C86(1.29)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C702(1.03); C86(1.17)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C702(0.42); C86(0.64)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C702(1.09); C86(0.91)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C702(1.33); C86(1.31)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C702(1.15); C86(0.87)  LDD1329  [5]
 LDCM0451  CL6 HEK-293T C651(1.41)  LDD1049  [5]
 LDCM0452  CL60 PaTu 8988t C702(1.08); C86(1.04)  LDD1331  [5]
 LDCM0453  CL61 HCT 116 C702(1.18)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C702(1.00)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C702(0.95)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C702(1.27)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C702(1.20)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C702(1.12)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C702(1.10)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C702(0.91)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C702(0.92)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C651(1.51)  LDD1060  [5]
 LDCM0463  CL70 HCT 116 C702(0.84)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C702(1.19)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C702(1.08)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C702(1.21)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C702(0.99)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C723(1.00)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C723(1.25)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C723(1.09)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C723(1.38)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C651(1.05)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C723(1.18)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C723(1.33)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C723(1.16)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C723(1.07)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C723(1.25)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C723(1.14)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C723(1.51)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C723(1.08)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C723(1.24)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C723(1.29)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C651(1.71)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C723(0.88)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C723(1.00); C556(0.98); C688(1.15); C740(0.96)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C651(1.15); C723(1.12); C702(1.10); C556(1.40)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C448(1.00); C651(1.18); C723(0.90); C702(1.03)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C448(1.06); C723(1.15); C688(0.97)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C448(1.17); C723(1.10); C556(1.41); C688(1.00)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C448(1.02); C723(0.90); C702(1.06); C556(0.97)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C448(1.12); C651(1.02); C723(1.25); C556(1.28)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C723(1.07); C688(0.97)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C651(1.01); C723(1.06); C556(1.08); C688(0.98)  LDD1697  [12]
 LDCM0634  CY-0357 Hep-G2 C740(1.64)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C651(0.97); C723(1.17); C556(1.03); C688(0.94)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C702(1.89)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C702(0.95)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C651(1.14)  LDD1025  [5]
 LDCM0022  KB02 HCT 116 C702(6.15)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C702(1.63)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C702(2.09)  LDD0082  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C257(0.97)  LDD2101  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C651(0.30)  LDD2107  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C448(1.39)  LDD2120  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C448(0.92)  LDD2128  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C257(1.00)  LDD2133  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C651(0.26)  LDD2136  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C651(1.70)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C723(0.32)  LDD2140  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C257(1.16)  LDD2146  [2]
 LDCM0021  THZ1 HCT 116 C86(1.15); C448(1.05); C651(0.77)  LDD2173  [5]
 LDCM0008  Tranylcypromine SH-SY5Y 2.43  LDD0054  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-galactosidase A (GLA) Glycosyl hydrolase 27 family P06280
High affinity nerve growth factor receptor (NTRK1) Tyr protein kinase family P04629
NT-3 growth factor receptor (NTRK3) Tyr protein kinase family Q16288
Thyroglobulin (TG) Type-B carboxylesterase/lipase family P01266
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
ADP-ribosylation factor-binding protein GGA1 (GGA1) GGA protein family Q9UJY5
VPS10 domain-containing receptor SorCS1 (SORCS1) VPS10-related sortilin family Q8WY21
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adhesion G-protein coupled receptor G7 (ADGRG7) G-protein coupled receptor 2 family Q96K78
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliary neurotrophic factor (CNTF) CNTF family P26441
Interleukin-6 (IL6) IL-6 superfamily P05231
Leukemia inhibitory factor receptor (LIFR) Type I cytokine receptor family P42702
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2-macroglobulin receptor-associated protein (LRPAP1) Alpha-2-MRAP family P30533
Protein FAM3C (FAM3C) FAM3 family Q92520
Progranulin (GRN) Granulin family P28799
Beta-nerve growth factor (NGF) NGF-beta family P01138
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Serotransferrin (TF) Transferrin family P02787

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402