Details of the Target

General Information of Target

Target ID LDTP09256
Target Name Putative phospholipase B-like 2 (PLBD2)
Gene Name PLBD2
Gene ID 196463
Synonyms
Putative phospholipase B-like 2; EC 3.1.1.-; 76 kDa protein; p76; LAMA-like protein 2; Lamina ancestor homolog 2; Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGAIPAPGGRWARDGQVPPASR
SRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGV
VEAAVSEELIYMHWMNTVVNYCGPFEYEVGYCERLKSFLEANLEWMQEEMESNPDSPYWH
QVRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLG
SGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFREGPWGDYPLVPGNKLVFS
SYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGCVLEWVRNIVANRLASDGA
TWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPGSRVLTILEQIPGMVVVADKTSELYQK
TYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMR
YNDFLHDPLSLCKACNPQPNGENAISARSDLNPANGSYPFQALRQRSHGGIDVKVTSMSL
ARILSLLAASGPTWDQVPPFQWSTSPFSGLLHMGQPDLWKFAPVKVSWD
Target Bioclass
Enzyme
Family
Phospholipase B-like family
Subcellular location
Lysosome lumen
Function Putative phospholipase.
Uniprot ID
Q8NHP8
Ensemble ID
ENST00000280800.5
HGNC ID
HGNC:27283

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A14S .
HCT15 SNV: p.L66M .
HEC1B SNV: p.L159M IA-alkyne    Probe Info 
LNCaP clone FGC SNV: p.Q441H .
NCIH1993 SNV: p.I42V .
NCIH2286 SNV: p.G213R .
NCIH3122 SNV: p.W562C .
OCUG1 SNV: p.H528Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		9.00  LDD0391  [1]
Probe 1
 Probe Info  		Y196(12.24)  LDD3495  [2]
BTD
 Probe Info  		C244(0.60)  LDD2091  [3]
FBPP2
 Probe Info  		5.46  LDD0054  [4]
IPM
 Probe Info  		C492(1.20)  LDD1701  [3]
DBIA
 Probe Info  		C244(1.13); C342(1.12)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C495(0.00); C492(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C495(0.00); C342(0.00); C492(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
NAIA_5
 Probe Info  		C495(0.00); C342(0.00); C309(0.00); C492(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 130 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.73  LDD1711  [10]
C004
 Probe Info  		11.63  LDD1714  [10]
C010
 Probe Info  		7.21  LDD1719  [10]
C011
 Probe Info  		19.29  LDD1720  [10]
C022
 Probe Info  		35.02  LDD1728  [10]
C026
 Probe Info  		7.06  LDD1732  [10]
C036
 Probe Info  		7.62  LDD1736  [10]
C039
 Probe Info  		4.99  LDD1739  [10]
C040
 Probe Info  		7.73  LDD1740  [10]
C041
 Probe Info  		18.00  LDD1741  [10]
C045
 Probe Info  		9.38  LDD1744  [10]
C063
 Probe Info  		16.11  LDD1760  [10]
C064
 Probe Info  		7.52  LDD1761  [10]
C070
 Probe Info  		14.22  LDD1766  [10]
C073
 Probe Info  		9.32  LDD1769  [10]
C078
 Probe Info  		5.43  LDD1771  [10]
C079
 Probe Info  		5.24  LDD1772  [10]
C082
 Probe Info  		6.45  LDD1774  [10]
C085
 Probe Info  		6.92  LDD1777  [10]
C087
 Probe Info  		22.16  LDD1779  [10]
C106
 Probe Info  		34.78  LDD1793  [10]
C107
 Probe Info  		8.69  LDD1794  [10]
C108
 Probe Info  		15.24  LDD1795  [10]
C112
 Probe Info  		18.38  LDD1799  [10]
C115
 Probe Info  		6.19  LDD1802  [10]
C117
 Probe Info  		5.24  LDD1804  [10]
C130
 Probe Info  		6.63  LDD1812  [10]
C134
 Probe Info  		27.28  LDD1816  [10]
C139
 Probe Info  		12.21  LDD1821  [10]
C140
 Probe Info  		11.31  LDD1822  [10]
C141
 Probe Info  		15.78  LDD1823  [10]
C143
 Probe Info  		20.53  LDD1825  [10]
C145
 Probe Info  		15.24  LDD1827  [10]
C147
 Probe Info  		17.39  LDD1829  [10]
C149
 Probe Info  		19.16  LDD1830  [10]
C153
 Probe Info  		22.01  LDD1834  [10]
C159
 Probe Info  		10.20  LDD1839  [10]
C160
 Probe Info  		10.93  LDD1840  [10]
C161
 Probe Info  		22.16  LDD1841  [10]
C163
 Probe Info  		7.01  LDD1843  [10]
C164
 Probe Info  		16.34  LDD1844  [10]
C170
 Probe Info  		43.11  LDD1850  [10]
C171
 Probe Info  		12.47  LDD1851  [10]
C177
 Probe Info  		8.82  LDD1856  [10]
C178
 Probe Info  		29.86  LDD1857  [10]
C183
 Probe Info  		8.11  LDD1861  [10]
C184
 Probe Info  		8.40  LDD1862  [10]
C186
 Probe Info  		36.76  LDD1864  [10]
C187
 Probe Info  		53.82  LDD1865  [10]
C193
 Probe Info  		6.11  LDD1869  [10]
C194
 Probe Info  		17.15  LDD1870  [10]
C197
 Probe Info  		26.91  LDD1873  [10]
C198
 Probe Info  		19.43  LDD1874  [10]
C206
 Probe Info  		15.45  LDD1881  [10]
C208
 Probe Info  		21.56  LDD1883  [10]
C211
 Probe Info  		17.63  LDD1885  [10]
C213
 Probe Info  		17.15  LDD1887  [10]
C220
 Probe Info  		21.26  LDD1894  [10]
C221
 Probe Info  		16.00  LDD1895  [10]
C222
 Probe Info  		5.28  LDD1896  [10]
C223
 Probe Info  		30.27  LDD1897  [10]
C225
 Probe Info  		9.58  LDD1898  [10]
C226
 Probe Info  		10.85  LDD1899  [10]
C228
 Probe Info  		17.03  LDD1901  [10]
C229
 Probe Info  		17.15  LDD1902  [10]
C232
 Probe Info  		78.79  LDD1905  [10]
C233
 Probe Info  		14.93  LDD1906  [10]
C235
 Probe Info  		20.25  LDD1908  [10]
C237
 Probe Info  		13.45  LDD1910  [10]
C239
 Probe Info  		8.75  LDD1912  [10]
C243
 Probe Info  		16.45  LDD1916  [10]
C249
 Probe Info  		15.24  LDD1922  [10]
C258
 Probe Info  		6.02  LDD1931  [10]
C260
 Probe Info  		6.02  LDD1932  [10]
C261
 Probe Info  		8.11  LDD1933  [10]
C264
 Probe Info  		20.68  LDD1935  [10]
C265
 Probe Info  		20.68  LDD1936  [10]
C277
 Probe Info  		8.75  LDD1947  [10]
C280
 Probe Info  		8.94  LDD1950  [10]
C281
 Probe Info  		8.82  LDD1951  [10]
C288
 Probe Info  		10.34  LDD1958  [10]
C293
 Probe Info  		20.97  LDD1963  [10]
C296
 Probe Info  		11.24  LDD1966  [10]
C299
 Probe Info  		6.82  LDD1968  [10]
C302
 Probe Info  		11.96  LDD1971  [10]
C305
 Probe Info  		12.04  LDD1974  [10]
C310
 Probe Info  		21.86  LDD1977  [10]
C314
 Probe Info  		25.28  LDD1981  [10]
C320
 Probe Info  		9.19  LDD1986  [10]
C326
 Probe Info  		31.12  LDD1990  [10]
C334
 Probe Info  		7.84  LDD1997  [10]
C336
 Probe Info  		9.58  LDD1999  [10]
C338
 Probe Info  		17.51  LDD2001  [10]
C339
 Probe Info  		8.63  LDD2002  [10]
C346
 Probe Info  		14.72  LDD2007  [10]
C348
 Probe Info  		16.45  LDD2009  [10]
C349
 Probe Info  		9.32  LDD2010  [10]
C350
 Probe Info  		65.80  LDD2011  [10]
C354
 Probe Info  		13.93  LDD2015  [10]
C355
 Probe Info  		99.73  LDD2016  [10]
C356
 Probe Info  		17.63  LDD2017  [10]
C357
 Probe Info  		11.00  LDD2018  [10]
C361
 Probe Info  		22.01  LDD2022  [10]
C363
 Probe Info  		29.24  LDD2024  [10]
C364
 Probe Info  		21.86  LDD2025  [10]
C369
 Probe Info  		7.52  LDD2030  [10]
C374
 Probe Info  		5.13  LDD2034  [10]
C376
 Probe Info  		7.06  LDD2036  [10]
C378
 Probe Info  		16.45  LDD2037  [10]
C380
 Probe Info  		6.19  LDD2039  [10]
C383
 Probe Info  		16.45  LDD2042  [10]
C386
 Probe Info  		14.12  LDD2045  [10]
C390
 Probe Info  		81.57  LDD2049  [10]
C391
 Probe Info  		20.97  LDD2050  [10]
C393
 Probe Info  		6.06  LDD2052  [10]
C399
 Probe Info  		10.70  LDD2058  [10]
C403
 Probe Info  		24.76  LDD2061  [10]
C419
 Probe Info  		31.12  LDD2074  [10]
C420
 Probe Info  		45.57  LDD2075  [10]
C425
 Probe Info  		22.47  LDD2080  [10]
C428
 Probe Info  		5.10  LDD2083  [10]
C429
 Probe Info  		43.11  LDD2084  [10]
C431
 Probe Info  		35.75  LDD2086  [10]
C433
 Probe Info  		8.11  LDD2088  [10]
FFF probe12
 Probe Info  		20.00  LDD0473  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe4
 Probe Info  		14.11  LDD0466  [11]
FFF probe9
 Probe Info  		20.00  LDD0470  [11]
JN0003
 Probe Info  		20.00  LDD0469  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C244(0.84)  LDD2117  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C244(0.52)  LDD2132  [3]
 LDCM0214  AC1 HCT 116 C244(1.13); C342(1.12)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C244(1.27)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C244(1.15)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C244(0.94)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C244(1.22)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C342(0.84)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C342(0.88)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C342(1.12)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C342(0.74)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C342(1.22)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C342(1.08)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C342(0.63)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C244(1.29)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C342(0.75)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C342(0.91)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C342(0.63)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C342(0.64)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C342(0.79)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C342(0.69)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C342(0.56)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C342(0.86)  LDD2161  [5]
 LDCM0279  AC2 HCT 116 C342(1.07); C244(1.13)  LDD0596  [5]
 LDCM0285  AC25 HCT 116 C342(0.93); C244(1.02)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C342(1.07); C244(1.30)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C342(1.13); C244(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C244(1.14); C342(1.20)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C342(1.25); C244(1.30)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C342(1.06); C244(1.18)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C244(1.05); C342(1.37)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C342(1.06); C244(1.15)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C342(1.25); C244(1.53)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C342(1.12); C244(1.46)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C342(0.95); C244(1.39)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C342(1.00); C244(1.09)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C244(0.86); C342(1.00)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C342(0.81); C244(0.97)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C244(0.89); C342(1.12)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C342(1.10); C244(1.18)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C244(1.20); C342(1.41)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C342(0.98); C244(1.18)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C244(1.08); C342(1.13)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C244(1.16); C342(1.20)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C244(1.23); C342(1.30)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C342(0.88); C244(1.07)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C342(1.00); C244(1.35)  LDD0624  [5]
 LDCM0312  AC5 HCT 116 C244(1.29); C342(1.46)  LDD0629  [5]
 LDCM0323  AC6 HCT 116 C244(1.37)  LDD0640  [5]
 LDCM0332  AC68 HCT 116 C244(1.27)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C244(1.25)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C244(1.19)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C244(1.21)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C244(1.32)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C244(1.29)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C244(1.34)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C244(1.36)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C244(1.19)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C244(1.43)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C244(1.22)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C244(1.17)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C244(1.21)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C244(1.12)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C244(1.34)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C244(1.23)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C244(1.18)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C244(1.60)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C244(1.77)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C244(1.50)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C244(1.41)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C244(1.31)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C244(1.30)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C244(1.35)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C244(1.21)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C244(1.64)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C244(1.67)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C244(1.18)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C244(1.26)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C244(1.33)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C244(1.35)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C244(1.35)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C244(1.06)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C244(1.23)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C244(1.47)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C342(1.08)  LDD2171  [5]
 LDCM0498  BS-3668 MDA-MB-231 C244(0.60)  LDD2091  [3]
 LDCM0369  CL100 HCT 116 C244(1.01); C342(1.06)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C244(1.41)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C244(1.15)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C244(1.09)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C244(1.11)  LDD0690  [5]
 LDCM0382  CL112 HCT 116 C244(1.04); C342(1.04)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C342(1.15); C244(1.35)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C244(1.33); C342(1.57)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C244(1.13); C342(1.27)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C342(1.05); C244(1.25)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C342(1.00); C244(1.44)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C342(1.05); C244(1.06)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C342(1.22); C244(1.24)  LDD0706  [5]
 LDCM0391  CL120 HCT 116 C244(1.18); C342(1.40)  LDD0708  [5]
 LDCM0404  CL17 HCT 116 C342(1.24)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C342(0.95)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C342(1.14)  LDD0723  [5]
 LDCM0408  CL20 HCT 116 C342(0.98)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C342(1.73)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C342(0.93)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C342(1.16)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C342(0.94)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C342(1.04)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C342(0.95)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C342(0.92)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C342(1.23)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C342(0.95)  LDD0734  [5]
 LDCM0419  CL30 HCT 116 C342(0.97)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C342(1.07)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C342(1.04)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C342(1.95)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C342(1.27)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C342(0.90)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C342(1.10)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C342(1.20)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C342(1.52)  LDD0745  [5]
 LDCM0430  CL40 HCT 116 C342(1.06)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C342(1.18)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C342(1.34)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C342(1.18)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C342(1.16)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C342(1.26)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C342(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C342(1.01)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C342(0.86)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C342(0.77)  LDD0756  [5]
 LDCM0441  CL50 HCT 116 C342(0.98)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C342(0.85)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C342(0.89)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C342(1.08)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C342(1.06)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C342(0.91)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C342(1.01)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C342(1.14)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C342(0.83)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C342(0.98)  LDD0767  [5]
 LDCM0452  CL60 HCT 116 C342(0.82)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C342(0.91)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C342(1.02)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C342(0.98)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C342(1.57)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C342(1.08)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C342(1.03)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C342(1.06)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C342(1.09)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C342(1.20)  LDD0778  [5]
 LDCM0463  CL70 HCT 116 C342(0.99)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C342(0.98)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C342(0.84)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C342(1.31)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C342(1.00)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C342(1.07)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C342(1.07)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C342(0.89)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C342(1.42)  LDD0789  [5]
 LDCM0474  CL80 HCT 116 C342(0.99)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C342(1.22)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C342(1.48)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C342(1.53)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C342(1.48)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C342(1.28)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C342(1.14)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C342(1.06)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C342(1.41)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C342(1.26)  LDD0800  [5]
 LDCM0485  CL90 HCT 116 C342(3.43)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C244(1.07); C342(0.97)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C244(1.32); C342(1.87)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C244(1.00); C342(1.12)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C244(1.31); C342(1.42)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C244(1.43); C342(1.39)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C244(1.26); C342(1.09)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C244(1.12); C342(1.29)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C244(1.20); C342(1.19)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C244(1.18); C342(1.22)  LDD0811  [5]
 LDCM0185  Compound 17 HEK-293T 6.23  LDD0512  [11]
 LDCM0468  Fragment33 HCT 116 C342(1.10)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C342(1.24)  LDD0744  [5]
 LDCM0022  KB02 42-MG-BA C342(1.56)  LDD2244  [12]
 LDCM0023  KB03 MDA-MB-231 C492(1.20)  LDD1701  [3]
 LDCM0024  KB05 COLO792 C342(2.15); C492(1.70)  LDD3310  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C244(1.01)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C244(0.92)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C244(0.75)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C244(0.71)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C244(0.86)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C244(2.14)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C244(0.93)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C244(0.79)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C244(0.95)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C244(0.94)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C244(0.55)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C244(1.15)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C244(0.97)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C244(0.64)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C244(0.77)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C244(0.55)  LDD2148  [3]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [1]
 LDCM0021  THZ1 HCT 116 C342(1.08)  LDD2173  [5]
 LDCM0008  Tranylcypromine SH-SY5Y 5.46  LDD0054  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840