Probe Name	Alkylaryl probe 2					Probe Info
Probe concentration	1 mM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	Phenelzine					Competitor Info
Competitor Concentration	10 mM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Breast
	Disease Model		Breast adenocarcinoma [ICD-11:2C60]
	Model Name		Human breast adenocarcinoma cells (MDA-MB-231)

Target ID	Target Name					Binding Ratio
LDTP15408	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2)					20.0
LDTP01372	Carboxypeptidase D (CPD)					15.0
LDTP17022	Secernin-3 (SCRN3)					13.0
LDTP11494	Neurolysin, mitochondrial (NLN)					11.0
LDTP15725	Secernin-2 (SCRN2)					11.0
LDTP04572	Dipeptidyl peptidase 1 (CTSC)					9.0
LDTP00344	Stearoyl-CoA desaturase (SCD)					7.0
LDTP00544	Sphingolipid delta(4)-desaturase DES1 (DEGS1)					6.0
LDTP18414	5'-nucleotidase domain-containing protein 2 (NT5DC2)					5.0
LDTP11595	Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)					5.0
LDTP02223	Cathepsin B (CTSB)					5.0
LDTP13147	Cathepsin Z (CTSZ)					5.0
LDTP01974	Ferritin heavy chain (FTH1)					5.0
LDTP04388	Palmitoyl-protein thioesterase 1 (PPT1)					5.0
LDTP09829	Peroxidasin homolog (PXDN)					5.0
LDTP07065	Phytanoyl-CoA dioxygenase domain-containing protein 1 (PHYHD1)					5.0
LDTP12420	Xaa-Pro aminopeptidase 3 (XPNPEP3)					5.0
LDTP08476	5'-3' exonuclease PLD3 (PLD3)					4.0
LDTP05905	Acid ceramidase (ASAH1)					4.0
LDTP00968	Acyl-CoA (8-3)-desaturase (FADS1)					4.0
LDTP03560	Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)					4.0
LDTP02074	Aldehyde dehydrogenase, mitochondrial (ALDH2)					4.0
LDTP02198	Cathepsin D (CTSD)					4.0
LDTP03455	Cytosol aminopeptidase (LAP3)					4.0
LDTP12868	Endoplasmic reticulum aminopeptidase 1 (ERAP1)					4.0
LDTP04008	Endothelin-converting enzyme 1 (ECE1)					4.0
LDTP02008	Fructose-bisphosphate aldolase A (ALDOA)					4.0
LDTP02386	Fructose-bisphosphate aldolase C (ALDOC)					4.0
LDTP18330	Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5)					4.0
LDTP10888	Legumain (LGMN)					4.0
LDTP02486	Lysosomal alpha-glucosidase (GAA)					4.0
LDTP00338	Lysosomal alpha-mannosidase (MAN2B1)					4.0
LDTP04004	Lysosomal Pro-X carboxypeptidase (PRCP)					4.0
LDTP02505	Lysosomal protective protein (CTSA)					4.0
LDTP01005	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)					4.0
LDTP00325	Pirin (PIR)					4.0
LDTP06501	Ras-related protein Rab-11B (RAB11B)					4.0
LDTP04134	Retinaldehyde dehydrogenase 3 (ALDH1A3)					4.0
LDTP16032	Retinoid-inducible serine carboxypeptidase (SCPEP1)					4.0
LDTP00428	Tripeptidyl-peptidase 1 (TPP1)					4.0
LDTP01699	Acyl-CoA 6-desaturase (FADS2)					3.0
LDTP16274	Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)					3.0
LDTP02883	Alpha-N-acetylgalactosaminidase (NAGA)					3.0
LDTP02888	Aspartate aminotransferase, cytoplasmic (GOT1)					3.0
LDTP02260	Beta-glucuronidase (GUSB)					3.0
LDTP02216	Beta-hexosaminidase subunit beta (HEXB)					3.0
LDTP10215	Carboxymethylenebutenolidase homolog (CMBL)					3.0
LDTP03329	Cathepsin S (CTSS)					3.0
LDTP00697	Cytochrome b5 type B (CYB5B)					3.0
LDTP11225	Deoxyhypusine hydroxylase (DOHH)					3.0
LDTP01374	Glutaredoxin-3 (GLRX3)					3.0
LDTP03540	Heme oxygenase 2 (HMOX2)					3.0
LDTP03858	Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)					3.0
LDTP04352	Matrix metalloproteinase-14 (MMP14)					3.0
LDTP05793	Methanethiol oxidase (SELENBP1)					3.0
LDTP09396	Minor histocompatibility antigen H13 (HM13)					3.0
LDTP10981	Mitochondrial intermediate peptidase (MIPEP)					3.0
LDTP02799	N-acetylglucosamine-6-sulfatase (GNS)					3.0
LDTP06307	Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)					3.0
LDTP05373	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)					3.0
LDTP02679	Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)					3.0
LDTP00645	Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)					3.0
LDTP09256	Putative phospholipase B-like 2 (PLBD2)					3.0
LDTP04901	Ras-related protein Rab-14 (RAB14)					3.0
LDTP04893	Ras-related protein Rab-5B (RAB5B)					3.0
LDTP04398	Ras-related protein Rab-5C (RAB5C)					3.0
LDTP02918	S-adenosylmethionine decarboxylase proenzyme (AMD1)					3.0
LDTP02860	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)					3.0
LDTP10884	Sialidase-1 (NEU1)					3.0
LDTP02067	Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)					3.0
LDTP05348	Sterol 26-hydroxylase, mitochondrial (CYP27A1)					3.0
LDTP04289	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)					3.0

Target ID	Target Name					Binding Ratio
LDTP02215	Prosaposin (PSAP)					5.0
LDTP05511	Cytoskeleton-associated protein 4 (CKAP4)					4.0
LDTP04940	NPC intracellular cholesterol transporter 2 (NPC2)					4.0
LDTP00310	Syntenin-1 (SDCBP)					3.0
LDTP01969	Transferrin receptor protein 1 (TFRC)					3.0
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)					3.0

Target ID	Target Name					Binding Ratio
LDTP01913	HLA class I histocompatibility antigen, B alpha chain (HLA-B)					3.0

Target ID	Target Name					Binding Ratio
LDTP14788	Small ribosomal subunit protein mS35 (MRPS35)					20.0
LDTP13143	Eukaryotic translation initiation factor 3 subunit K (EIF3K)					11.0
LDTP06210	Golgin subfamily B member 1 (GOLGB1)					11.0
LDTP00808	Density-regulated protein (DENR)					5.0
LDTP13606	Mammalian ependymin-related protein 1 (EPDR1)					5.0
LDTP11176	Protein canopy homolog 3 (CNPY3)					5.0
LDTP01973	Ferritin light chain (FTL)					3.0
LDTP05558	Galectin-3-binding protein (LGALS3BP)					3.0
LDTP06051	Kelch-like ECH-associated protein 1 (KEAP1)					3.0
LDTP02085	Plasminogen activator inhibitor 1 (SERPINE1)					3.0
LDTP14085	Protein PRRC2C (PRRC2C)					3.0
LDTP05257	Receptor expression-enhancing protein 5 (REEP5)					3.0
LDTP12412	Reticulon-4 (RTN4)					3.0

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.