Details of the Target

General Information of Target

Target ID LDTP11176
Target Name Protein canopy homolog 3 (CNPY3)
Gene Name CNPY3
Gene ID 10695
Synonyms
CTG4A; ERDA5; PRAT4A; TNRC5; Protein canopy homolog 3; CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEEGTGGTVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQL
SSARTENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAMVLLVGLEELTNIRN
VERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVS
LVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTL
LPSLELCLLCGPSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLL
LLHLELKRCLFTVEPLGDKEPSPEQRRRLLRNFYTLVTSTHFPPEPGPPEKTEDEVYQAQ
LPRACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL
Target Bioclass
Other
Family
Canopy family
Subcellular location
Endoplasmic reticulum
Function
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
Uniprot ID
Q9BT09
Ensemble ID
ENST00000372836.5
HGNC ID
HGNC:11968

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.W180S .
MFE319 SNV: p.D146N .
REH SNV: p.G263D .
SNU1 SNV: p.V176M .
SNU245 SNV: p.D276N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		5.00  LDD0387  [1]
TH211
 Probe Info  		Y54(20.00); Y110(15.47)  LDD0260  [2]
ONAyne
 Probe Info  		K114(1.22)  LDD0274  [3]
STPyne
 Probe Info  		K114(9.70); K202(5.00); K48(1.34); K91(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y110(61.09)  LDD3495  [4]
Alkylaryl probe 2
 Probe Info  		5.00  LDD0392  [1]
DBIA
 Probe Info  		C104(1.79)  LDD3312  [5]
Acrolein
 Probe Info  		C104(0.00); C194(0.00)  LDD0222  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C206(0.00); C104(0.00); C194(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C206(0.00); C194(0.00); C166(0.00); C104(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C206(0.00); C104(0.00); C194(0.00); C166(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
NAIA_5
 Probe Info  		C206(0.00); C104(0.00); C194(0.00); C166(0.00)  LDD2223  [9]
HHS-482
 Probe Info  		Y110(0.44)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [12]
FFF probe13
 Probe Info  		20.00  LDD0476  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C104(0.94)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C206(0.96); C104(1.00)  LDD1508  [14]
 LDCM0237  AC12 HEK-293T C206(0.99); C104(1.04)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C206(0.97)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C104(1.08)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C104(0.93)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C206(0.93); C104(0.89)  LDD1516  [14]
 LDCM0279  AC2 HEK-293T C206(1.01); C104(1.01)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C206(0.90); C104(0.95)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C206(1.00); C104(0.85)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C206(1.03)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C104(0.93)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C206(0.88)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C104(0.94)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C206(1.02); C104(1.04)  LDD1525  [14]
 LDCM0288  AC28 HEK-293T C206(0.98); C104(0.89)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C206(0.96); C104(1.04)  LDD1528  [14]
 LDCM0291  AC30 HEK-293T C206(0.96)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C104(1.08)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C206(1.08)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C104(1.01)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C206(1.08); C104(1.05)  LDD1534  [14]
 LDCM0296  AC35 PaTu 8988t C206(1.05)  LDD1175  [15]
 LDCM0297  AC36 PaTu 8988t C206(1.20)  LDD1176  [15]
 LDCM0298  AC37 PaTu 8988t C206(1.23)  LDD1177  [15]
 LDCM0299  AC38 PaTu 8988t C206(1.45)  LDD1178  [15]
 LDCM0300  AC39 PaTu 8988t C206(1.20)  LDD1179  [15]
 LDCM0301  AC4 HEK-293T C206(0.91); C104(1.02)  LDD1540  [14]
 LDCM0302  AC40 PaTu 8988t C206(1.52)  LDD1181  [15]
 LDCM0303  AC41 PaTu 8988t C206(1.23)  LDD1182  [15]
 LDCM0304  AC42 PaTu 8988t C206(1.28)  LDD1183  [15]
 LDCM0305  AC43 PaTu 8988t C206(1.27)  LDD1184  [15]
 LDCM0306  AC44 PaTu 8988t C206(1.60)  LDD1185  [15]
 LDCM0307  AC45 PaTu 8988t C206(1.38)  LDD1186  [15]
 LDCM0308  AC46 HEK-293T C206(1.02)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C104(1.04)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C206(1.00)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C104(0.94)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C206(1.06); C104(1.02)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C206(1.12); C104(1.08)  LDD1552  [14]
 LDCM0315  AC52 HEK-293T C206(1.08); C104(1.09)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C206(1.06); C104(0.97)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C206(1.09)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C104(1.07)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C206(1.17)  LDD1558  [14]
 LDCM0320  AC57 PaTu 8988t C206(1.17)  LDD1199  [15]
 LDCM0321  AC58 PaTu 8988t C206(1.13)  LDD1200  [15]
 LDCM0322  AC59 PaTu 8988t C206(1.09)  LDD1201  [15]
 LDCM0323  AC6 HEK-293T C206(0.91)  LDD1562  [14]
 LDCM0324  AC60 PaTu 8988t C206(1.01)  LDD1203  [15]
 LDCM0325  AC61 PaTu 8988t C206(1.07)  LDD1204  [15]
 LDCM0326  AC62 PaTu 8988t C206(0.99)  LDD1205  [15]
 LDCM0327  AC63 PaTu 8988t C206(1.05)  LDD1206  [15]
 LDCM0328  AC64 PaTu 8988t C206(1.09)  LDD1207  [15]
 LDCM0329  AC65 PaTu 8988t C206(1.00)  LDD1208  [15]
 LDCM0330  AC66 PaTu 8988t C206(0.99)  LDD1209  [15]
 LDCM0331  AC67 PaTu 8988t C206(1.08)  LDD1210  [15]
 LDCM0332  AC68 PaTu 8988t C206(1.04)  LDD1211  [15]
 LDCM0333  AC69 PaTu 8988t C206(1.07)  LDD1212  [15]
 LDCM0334  AC7 HEK-293T C104(1.18)  LDD1568  [14]
 LDCM0335  AC70 PaTu 8988t C206(1.26)  LDD1214  [15]
 LDCM0336  AC71 PaTu 8988t C206(1.00)  LDD1215  [15]
 LDCM0337  AC72 PaTu 8988t C206(1.09)  LDD1216  [15]
 LDCM0338  AC73 PaTu 8988t C206(0.95)  LDD1217  [15]
 LDCM0339  AC74 PaTu 8988t C206(1.08)  LDD1218  [15]
 LDCM0340  AC75 PaTu 8988t C206(1.17)  LDD1219  [15]
 LDCM0341  AC76 PaTu 8988t C206(1.03)  LDD1220  [15]
 LDCM0342  AC77 PaTu 8988t C206(1.14)  LDD1221  [15]
 LDCM0343  AC78 PaTu 8988t C206(1.13)  LDD1222  [15]
 LDCM0344  AC79 PaTu 8988t C206(1.13)  LDD1223  [15]
 LDCM0345  AC8 HEK-293T C206(0.85)  LDD1569  [14]
 LDCM0346  AC80 PaTu 8988t C206(1.07)  LDD1225  [15]
 LDCM0347  AC81 PaTu 8988t C206(1.16)  LDD1226  [15]
 LDCM0348  AC82 PaTu 8988t C206(1.13)  LDD1227  [15]
 LDCM0349  AC83 PaTu 8988t C206(1.08)  LDD1228  [15]
 LDCM0350  AC84 PaTu 8988t C206(1.14)  LDD1229  [15]
 LDCM0351  AC85 PaTu 8988t C206(1.06)  LDD1230  [15]
 LDCM0352  AC86 PaTu 8988t C206(1.09)  LDD1231  [15]
 LDCM0353  AC87 PaTu 8988t C206(1.03)  LDD1232  [15]
 LDCM0354  AC88 PaTu 8988t C206(1.18)  LDD1233  [15]
 LDCM0355  AC89 PaTu 8988t C206(1.27)  LDD1234  [15]
 LDCM0357  AC90 PaTu 8988t C206(0.95)  LDD1236  [15]
 LDCM0358  AC91 PaTu 8988t C206(0.95)  LDD1237  [15]
 LDCM0359  AC92 PaTu 8988t C206(0.95)  LDD1238  [15]
 LDCM0360  AC93 PaTu 8988t C206(0.90)  LDD1239  [15]
 LDCM0361  AC94 PaTu 8988t C206(1.04)  LDD1240  [15]
 LDCM0362  AC95 PaTu 8988t C206(1.07)  LDD1241  [15]
 LDCM0363  AC96 PaTu 8988t C206(0.92)  LDD1242  [15]
 LDCM0364  AC97 PaTu 8988t C206(1.02)  LDD1243  [15]
 LDCM0248  AKOS034007472 HEK-293T C206(1.11); C104(1.05)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C104(0.94)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C206(0.99)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa C104(0.00); C194(0.00)  LDD0222  [6]
 LDCM0367  CL1 PaTu 8988t C206(1.14)  LDD1246  [15]
 LDCM0368  CL10 PaTu 8988t C206(1.21)  LDD1247  [15]
 LDCM0369  CL100 HEK-293T C206(0.95); C104(1.02)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C206(0.96); C104(0.95)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C206(1.16); C104(1.06)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C206(1.03); C104(1.08)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C206(1.02); C104(0.91)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C206(0.92); C104(1.13)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C206(1.07); C104(0.98)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C206(0.98); C104(1.07)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C206(1.10); C104(0.97)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C206(0.94); C104(0.96)  LDD1582  [14]
 LDCM0379  CL11 PaTu 8988t C206(1.13)  LDD1258  [15]
 LDCM0380  CL110 HEK-293T C206(1.02); C104(1.00)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C206(0.85); C104(1.00)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C206(0.91); C104(1.00)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C206(1.00); C104(1.03)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C206(0.92); C104(1.05)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C206(1.02); C104(1.12)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C206(1.32); C104(1.09)  LDD1590  [14]
 LDCM0387  CL117 PaTu 8988t C206(1.16)  LDD1266  [15]
 LDCM0388  CL118 PaTu 8988t C206(1.33)  LDD1267  [15]
 LDCM0389  CL119 PaTu 8988t C206(1.23)  LDD1268  [15]
 LDCM0390  CL12 PaTu 8988t C206(1.24)  LDD1269  [15]
 LDCM0391  CL120 PaTu 8988t C206(1.11)  LDD1270  [15]
 LDCM0392  CL121 HEK-293T C206(1.03); C104(1.03)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C206(1.10); C104(1.05)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C206(0.95); C104(1.01)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C206(1.04); C104(1.02)  LDD1599  [14]
 LDCM0396  CL125 PaTu 8988t C206(1.03)  LDD1275  [15]
 LDCM0397  CL126 PaTu 8988t C206(1.16)  LDD1276  [15]
 LDCM0398  CL127 PaTu 8988t C206(1.14)  LDD1277  [15]
 LDCM0399  CL128 PaTu 8988t C206(1.10)  LDD1278  [15]
 LDCM0400  CL13 PaTu 8988t C206(1.42)  LDD1279  [15]
 LDCM0401  CL14 PaTu 8988t C206(1.49)  LDD1280  [15]
 LDCM0402  CL15 PaTu 8988t C206(1.26)  LDD1281  [15]
 LDCM0403  CL16 PaTu 8988t C206(0.61)  LDD1282  [15]
 LDCM0404  CL17 PaTu 8988t C206(0.83)  LDD1283  [15]
 LDCM0405  CL18 PaTu 8988t C206(0.88)  LDD1284  [15]
 LDCM0406  CL19 PaTu 8988t C206(0.77)  LDD1285  [15]
 LDCM0407  CL2 PaTu 8988t C206(1.27)  LDD1286  [15]
 LDCM0408  CL20 PaTu 8988t C206(0.80)  LDD1287  [15]
 LDCM0409  CL21 PaTu 8988t C206(0.78)  LDD1288  [15]
 LDCM0410  CL22 PaTu 8988t C206(0.93)  LDD1289  [15]
 LDCM0411  CL23 PaTu 8988t C206(0.82)  LDD1290  [15]
 LDCM0412  CL24 PaTu 8988t C206(0.80)  LDD1291  [15]
 LDCM0413  CL25 PaTu 8988t C206(0.79)  LDD1292  [15]
 LDCM0414  CL26 PaTu 8988t C206(0.77)  LDD1293  [15]
 LDCM0415  CL27 PaTu 8988t C206(0.90)  LDD1294  [15]
 LDCM0416  CL28 PaTu 8988t C206(1.03)  LDD1295  [15]
 LDCM0417  CL29 PaTu 8988t C206(0.79)  LDD1296  [15]
 LDCM0418  CL3 PaTu 8988t C206(1.13)  LDD1297  [15]
 LDCM0419  CL30 PaTu 8988t C206(0.83)  LDD1298  [15]
 LDCM0421  CL32 HEK-293T C206(0.98); C104(1.14)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C206(1.04); C104(1.17)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C206(1.05)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C104(1.11)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C206(0.78)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C206(0.88); C104(1.10)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C206(0.99); C104(1.04)  LDD1632  [14]
 LDCM0429  CL4 PaTu 8988t C206(1.11)  LDD1308  [15]
 LDCM0430  CL40 HEK-293T C206(0.94); C104(1.08)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C104(0.94)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C206(0.85); C104(1.02)  LDD1636  [14]
 LDCM0434  CL44 HEK-293T C206(1.01); C104(1.01)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C206(0.97); C104(1.16)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C206(1.00)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C104(1.11)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C206(1.10)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C206(0.98); C104(0.93)  LDD1643  [14]
 LDCM0440  CL5 PaTu 8988t C206(1.33)  LDD1319  [15]
 LDCM0441  CL50 HEK-293T C206(1.05); C104(1.02)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C206(1.04); C104(1.18)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C104(1.03)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C206(0.90); C104(1.05)  LDD1648  [14]
 LDCM0447  CL56 HEK-293T C206(0.94); C104(1.01)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C206(1.02); C104(1.12)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C206(1.07)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C104(1.28)  LDD1653  [14]
 LDCM0451  CL6 PaTu 8988t C206(1.25)  LDD1330  [15]
 LDCM0452  CL60 HEK-293T C206(1.21)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C206(1.05); C104(1.00)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C206(1.35); C104(1.10)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C206(0.99); C104(1.06)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C206(1.09); C104(1.03)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C104(1.04)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C206(1.02); C104(1.12)  LDD1661  [14]
 LDCM0460  CL68 HEK-293T C206(0.98); C104(0.96)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C206(1.06); C104(1.17)  LDD1664  [14]
 LDCM0462  CL7 PaTu 8988t C206(1.46)  LDD1341  [15]
 LDCM0463  CL70 HEK-293T C206(1.03)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C104(1.48)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C206(1.15)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C206(0.89); C104(0.92)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C206(1.17); C104(1.02)  LDD1670  [14]
 LDCM0469  CL76 PaTu 8988t C206(1.16)  LDD1348  [15]
 LDCM0470  CL77 PaTu 8988t C206(1.13)  LDD1349  [15]
 LDCM0471  CL78 PaTu 8988t C206(1.40)  LDD1350  [15]
 LDCM0472  CL79 PaTu 8988t C206(1.44)  LDD1351  [15]
 LDCM0473  CL8 PaTu 8988t C206(1.03)  LDD1352  [15]
 LDCM0474  CL80 PaTu 8988t C206(1.29)  LDD1353  [15]
 LDCM0475  CL81 PaTu 8988t C206(1.37)  LDD1354  [15]
 LDCM0476  CL82 PaTu 8988t C206(1.57)  LDD1355  [15]
 LDCM0477  CL83 PaTu 8988t C206(1.40)  LDD1356  [15]
 LDCM0478  CL84 PaTu 8988t C206(1.21)  LDD1357  [15]
 LDCM0479  CL85 PaTu 8988t C206(1.16)  LDD1358  [15]
 LDCM0480  CL86 PaTu 8988t C206(1.23)  LDD1359  [15]
 LDCM0481  CL87 PaTu 8988t C206(1.34)  LDD1360  [15]
 LDCM0482  CL88 PaTu 8988t C206(1.43)  LDD1361  [15]
 LDCM0483  CL89 PaTu 8988t C206(1.07)  LDD1362  [15]
 LDCM0484  CL9 PaTu 8988t C206(1.38)  LDD1363  [15]
 LDCM0485  CL90 PaTu 8988t C206(1.32)  LDD1364  [15]
 LDCM0487  CL92 HEK-293T C206(0.89); C104(0.96)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C206(1.04); C104(0.99)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C206(1.04)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C104(1.14)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C206(0.98)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C206(0.97); C104(0.89)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C206(1.05); C104(1.13)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C206(1.02); C104(1.02)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C206(0.99); C104(1.14)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C206(1.13); C104(1.08)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C206(1.17); C104(1.08)  LDD1631  [14]
 LDCM0022  KB02 HEK-293T C104(0.91); C206(0.91)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C104(0.91); C206(0.93)  LDD1497  [14]
 LDCM0024  KB05 HMCB C104(1.79)  LDD3312  [5]
 LDCM0099  Phenelzine MDA-MB-231 5.00  LDD0392  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-5 (CLDN5) Claudin family O00501
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Progranulin (GRN) Granulin family P28799
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.