Details of the Target

General Information of Target

Target ID LDTP17022
Target Name Secernin-3 (SCRN3)
Gene Name SCRN3
Gene ID 79634
Synonyms
Secernin-3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKYPLMPLVNDLTFSFLVFWFCLPVGLLLLLIIWLRFLLSQDSEENDSSVCLDWEPWSKG
PAEFCWKGTLHGQEKERPCW
Target Bioclass
Enzyme
Family
Peptidase C69 family, Secernin subfamily
Uniprot ID
Q0VDG4
Ensemble ID
ENST00000272732.11
HGNC ID
HGNC:30382

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.S5PfsTer39 DBIA    Probe Info 
HCT116 Deletion: p.S5PfsTer39 .
KMCH1 SNV: p.D333Y DBIA    Probe Info 
MEWO SNV: p.P13L DBIA    Probe Info 
NCIH358 Substitution: p.E397Ter DBIA    Probe Info 
RKO SNV: p.F150C DBIA    Probe Info 
TE4 SNV: p.G274V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0385  [1]
Alkylaryl probe 2
 Probe Info  		15.00  LDD0389  [1]
Probe 1
 Probe Info  		Y173(29.51)  LDD3495  [2]
Alkylaryl probe 3
 Probe Info  		3.12  LDD0382  [1]
P11
 Probe Info  		1.92  LDD0211  [3]
Johansson_61
 Probe Info  		_(4.69)  LDD1485  [4]
HHS-475
 Probe Info  		Y31(1.18)  LDD0264  [5]
DBIA
 Probe Info  		C143(0.95)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C102(0.00); C143(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		C143(0.00); C102(0.00)  LDD2156  [8]
TFBX
 Probe Info  		C143(0.00); C241(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C102(0.00); C143(0.00)  LDD0217  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		9.00  LDD1937  [12]
C270
 Probe Info  		7.84  LDD1940  [12]
C292
 Probe Info  		6.06  LDD1962  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C143(0.73)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C143(0.36); C406(0.75)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C143(1.29)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C143(1.11)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C143(1.54)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C143(1.90)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C143(1.62)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C143(1.19)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C143(1.31)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C143(1.84)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C143(1.39)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C143(1.33)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C143(0.93); C406(0.74)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C143(1.09)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C143(1.11)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C143(1.32)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C406(1.34)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C406(1.34)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C406(1.25)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C406(1.03)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C406(1.01)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C406(1.44)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C406(1.20)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C143(0.98); C406(0.84)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C406(0.80)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C406(1.12)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C406(1.08)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C406(0.97)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C406(0.98)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C406(1.07)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C406(0.42)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C406(0.30)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C143(1.08)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C143(1.21)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C143(0.99)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C143(1.19)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C143(1.52)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C143(1.09)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C143(1.11)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C143(1.12)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C143(1.14)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C143(1.18)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C143(1.21)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C143(1.23)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C143(0.60); C406(0.77)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C143(1.13)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C143(1.15)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C143(1.29)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C143(1.03)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C143(1.06)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C143(1.18)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C143(1.07)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C143(0.87)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C143(0.94)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C143(0.98)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C143(0.43); C406(0.66)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C143(0.88)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C143(1.00)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C143(1.10)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C143(1.04)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C143(1.08)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C143(1.22)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C143(1.23)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C143(1.03)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C143(0.85); C406(0.81)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C143(1.18); C406(0.91)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C143(0.89); C406(0.79)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C143(0.90)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C143(1.07); C406(0.74)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C143(1.02); C406(0.74)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C143(0.71); C406(0.75)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C143(1.84); C406(1.51)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C143(1.11); C406(0.75)  LDD0882  [6]
 LDCM0285  AC25 PaTu 8988t C143(0.96); C406(0.94)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C143(0.71); C406(1.01)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C143(0.81); C406(1.09)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C143(1.43); C406(1.02)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C143(1.25); C406(1.11)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C143(1.34)  LDD0888  [6]
 LDCM0291  AC30 PaTu 8988t C143(0.79); C406(0.92)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C143(1.34); C406(0.88)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C143(1.07); C406(0.91)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C143(1.07); C406(0.83)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C143(0.89); C406(0.75)  LDD1174  [6]
 LDCM0296  AC35 HCT 116 C143(0.99)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C143(1.16)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C143(0.82)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C143(1.02)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C143(1.11)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C143(0.51)  LDD0899  [6]
 LDCM0302  AC40 HCT 116 C143(1.43)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C143(1.20)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C143(1.02)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C143(1.12)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C143(0.89)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C143(0.93)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C143(0.89)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C143(2.56)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C143(1.23)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C143(1.35)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C143(0.89)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C143(1.54)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C143(1.10)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C143(1.07)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C143(1.70)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C143(1.44)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C143(1.74)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C143(2.28)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C143(0.72); C406(1.28)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C143(2.57); C406(1.08)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C143(2.07); C406(1.08)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C143(0.66); C406(0.97)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C143(1.97); C406(1.69)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C143(4.42); C406(1.13)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C143(5.12); C406(1.24)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C143(4.04); C406(1.34)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C143(6.28); C406(1.32)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C143(5.35); C406(1.72)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C143(5.97); C406(1.05)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C143(4.65); C406(1.17)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C143(0.96)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C143(1.00)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C143(0.86); C406(0.99)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C143(0.94)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C143(1.08)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C143(1.00)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C143(1.40)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C143(1.36)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C143(1.45)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C143(0.87)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C143(1.01)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C143(0.77)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C143(1.09)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C143(0.68); C406(1.04)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C143(1.10)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C143(0.59)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C143(1.38)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C406(0.89)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C406(0.99)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C406(0.96)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C406(0.98)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C406(0.92)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C406(1.12)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C406(1.04)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C406(1.09)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C406(0.90)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C406(0.87)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C406(0.95)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C406(1.01)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C406(0.93)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C406(0.83)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C406(0.93)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C143(1.92)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C143(1.28)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C143(0.74); C406(0.72)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C143(0.34); C406(0.90)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C143(0.60); C406(0.72)  LDD0873  [6]
 LDCM0020  ARS-1620 HCC44 C143(0.95)  LDD0078  [6]
 LDCM0088  C45 HEK-293T 1.92  LDD0211  [3]
 LDCM0367  CL1 HCT 116 C143(1.68)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C143(1.46)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C143(0.56)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C143(0.68); C406(1.13)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C143(0.72); C406(1.94)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C143(0.81); C406(1.85)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C143(0.16); C406(1.03)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C143(4.53); C406(1.65)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C143(1.12); C406(0.78)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C143(1.26); C406(0.69)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C143(0.97); C406(0.85)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C143(1.15); C406(0.91)  LDD0976  [6]
 LDCM0379  CL11 HCT 116 C143(2.16)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C143(1.64); C406(2.22)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C143(20.00); C406(1.61)  LDD0979  [6]
 LDCM0382  CL112 PaTu 8988t C143(1.18); C406(1.07)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C143(0.92); C406(1.00)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C143(2.04); C406(1.20)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C143(0.89); C406(0.83)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C143(0.83); C406(0.90)  LDD1265  [6]
 LDCM0387  CL117 HCT 116 C143(1.37)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C143(1.17)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C143(1.37)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C143(1.45)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C143(1.44)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C143(0.98)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C143(3.33)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C143(2.97)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C143(2.11)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C143(1.00); C406(0.96)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C143(1.65); C406(1.27)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C143(1.07); C406(1.15)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C143(1.76); C406(1.15)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C143(2.18)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C143(1.74)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C143(2.69)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C143(1.86)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C143(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C143(1.67)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C143(1.25)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C143(1.41)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C143(2.64)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C143(0.93)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C143(2.81)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C143(1.03)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C143(0.97)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C143(3.06)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C143(2.47)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C143(12.94)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C143(1.31)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C143(1.04)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C143(2.23)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C143(0.86)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C143(2.38)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C143(1.45)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C143(2.37)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C143(2.38)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C143(1.63)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C143(2.64)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C143(3.24)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C143(4.00)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C143(2.01)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C143(1.22)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C143(2.11)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C143(2.80)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C143(2.71)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C143(2.40)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C143(2.39)  LDD0752  [6]
 LDCM0436  CL46 PaTu 8988t C143(3.56)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C143(2.61)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C143(1.71)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C143(5.29)  LDD1318  [6]
 LDCM0440  CL5 HCT 116 C143(1.16)  LDD0757  [6]
 LDCM0441  CL50 PaTu 8988t C143(1.65)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C143(5.33)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C143(2.43)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C143(3.69)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C143(3.40)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C143(3.27)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C143(5.28)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C143(1.51)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C143(1.38)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C143(1.46)  LDD1329  [6]
 LDCM0451  CL6 HCT 116 C143(2.39)  LDD0768  [6]
 LDCM0452  CL60 PaTu 8988t C143(3.62)  LDD1331  [6]
 LDCM0453  CL61 HCT 116 C143(1.19)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C143(1.99)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C143(2.02)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C143(3.50)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C143(1.49)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C143(5.65)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C143(3.69)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C143(4.64)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C143(1.73)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C143(2.46)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C143(3.91)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C143(1.78)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C143(1.38)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C143(4.19)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C143(1.45)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C143(1.65)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C143(1.64)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C143(1.53)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C143(0.99)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C143(1.34)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C143(1.44)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C143(1.47)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C143(1.19)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C143(1.56)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C143(1.52)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C143(1.40)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C143(0.89)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C143(1.29)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C143(1.54)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C143(1.75)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C143(2.79)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C143(2.29)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C143(0.38)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C143(0.25)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C143(0.76)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C143(0.19)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C143(0.30)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C143(0.37)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C143(0.51)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C143(0.38)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C143(0.26)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C143(1.43); C102(1.18)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C143(2.98)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C143(2.22)  LDD0744  [6]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [4]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [4]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [4]
 LDCM0569  Fragment7 Jurkat _(4.69)  LDD1485  [4]
 LDCM0116  HHS-0101 DM93 Y31(1.18)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y31(0.92)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y31(0.90)  LDD0266  [5]
 LDCM0120  HHS-0701 DM93 Y31(1.02)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C143(1.01); C102(0.96)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C143(0.94); C102(0.94)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C143(0.99)  LDD3310  [14]
 LDCM0099  Phenelzine HEK-293T 3.12  LDD0382  [1]
 LDCM0131  RA190 MM1.R C102(1.23)  LDD0304  [15]

References

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4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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Mass spectrometry data entry: PXD028853
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.