Details of the Target

General Information of Target

Target ID LDTP00808
Target Name Density-regulated protein (DENR)
Gene Name DENR
Gene ID 8562
Synonyms
DRP1; Density-regulated protein; DRP; Protein DRP1; Smooth muscle cell-associated protein 3; SMAP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADISESSGADCKGDPRNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKN
FPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKI
PRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQE
KWPEVDDDSIEDLGEVKK
Target Bioclass
Other
Family
DENR family
Function
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Uniprot ID
O43583
Ensemble ID
ENST00000280557.11
HGNC ID
HGNC:2769

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.28  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		5.00  LDD0387  [2]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [2]
STPyne
 Probe Info  		K105(5.01); K22(3.44); K59(1.01); K67(2.89)  LDD0277  [3]
AZ-9
 Probe Info  		D12(1.00)  LDD2208  [4]
Probe 1
 Probe Info  		Y27(67.83)  LDD3495  [5]
DA-P3
 Probe Info  		5.04  LDD0182  [6]
AHL-Pu-1
 Probe Info  		C132(3.38)  LDD0170  [7]
DBIA
 Probe Info  		C37(2.75); C34(1.57); C44(1.57); C132(1.09)  LDD0080  [8]
ATP probe
 Probe Info  		K197(0.00); K198(0.00); K14(0.00); K142(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		C13(0.00); C132(0.00)  LDD0026  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
ENE
 Probe Info  		N.A.  LDD0006  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
PF-06672131
 Probe Info  		N.A.  LDD0017  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		K75(0.00); K22(0.00); K59(0.00); K67(0.00)  LDD0228  [17]
AOyne
 Probe Info  		11.40  LDD0443  [18]
NAIA_5
 Probe Info  		C53(0.00); C132(0.00); C13(0.00)  LDD2223  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C132(3.38)  LDD0170  [7]
 LDCM0214  AC1 HCT 116 C132(1.18)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C132(1.31)  LDD0532  [8]
 LDCM0216  AC100 PaTu 8988t C132(1.15)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C132(1.31)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C132(1.30)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C132(1.27)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C132(1.27)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C132(1.28)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C132(1.30)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C132(1.08)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C132(1.12)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C132(1.23)  LDD1104  [8]
 LDCM0226  AC11 HCT 116 C132(1.41)  LDD0543  [8]
 LDCM0227  AC110 PaTu 8988t C132(1.25)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C132(1.56)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C132(1.09)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C37(1.02); C44(1.02); C132(0.91)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C37(0.94); C44(0.94); C132(1.00)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C37(1.05); C44(1.05); C132(1.05)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C37(0.92); C44(0.92); C132(0.96)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C37(1.04); C44(1.04); C132(0.92)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C37(1.17); C44(1.17); C132(0.99)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C37(0.89); C44(0.89); C132(0.98)  LDD1115  [8]
 LDCM0237  AC12 HCT 116 C132(1.22)  LDD0554  [8]
 LDCM0238  AC120 PaTu 8988t C37(0.94); C44(0.94); C132(0.91)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C37(0.94); C44(0.94); C132(1.01)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C37(0.86); C44(0.86); C132(0.96)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C37(0.95); C44(0.95); C132(0.86)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C37(0.89); C44(0.89); C132(1.05)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C37(1.25); C44(1.25); C132(1.01)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C37(1.29); C44(1.29); C132(0.94)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C37(1.06); C44(1.06); C132(0.91)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C132(1.26)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C132(1.18)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C132(1.04)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C132(1.02)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C132(1.06)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C132(1.17)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C132(1.14)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C132(1.28)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C132(1.29)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C132(1.21)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C132(1.03)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C132(1.16)  LDD1137  [8]
 LDCM0259  AC14 HCT 116 C132(1.41)  LDD0576  [8]
 LDCM0260  AC140 PaTu 8988t C132(1.12)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C132(1.11)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C132(1.09)  LDD1141  [8]
 LDCM0263  AC143 HCT 116 C132(1.07)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C132(1.57)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C132(1.15)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C132(1.29)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C132(1.56)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C132(1.69)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C132(1.43)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C132(1.35)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C132(1.05)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C132(1.08)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C132(1.30)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C132(1.79)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C132(1.37)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C132(1.20)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C132(1.01)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C132(0.87)  LDD2161  [8]
 LDCM0276  AC17 PaTu 8988t C34(1.13); C44(1.13); C132(1.05)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C34(0.62); C44(0.62); C132(1.27)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C34(1.15); C44(1.15); C132(1.58)  LDD1157  [8]
 LDCM0279  AC2 HCT 116 C132(1.15)  LDD0596  [8]
 LDCM0280  AC20 PaTu 8988t C34(0.86); C44(0.86); C132(1.18)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C34(1.22); C44(1.22); C132(1.27)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C34(0.89); C44(0.89); C132(1.31)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C34(1.01); C44(1.01); C132(1.48)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C34(0.98); C44(0.98); C132(1.18)  LDD1163  [8]
 LDCM0285  AC25 PaTu 8988t C37(0.96); C34(0.92); C44(0.96); C132(1.46)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C37(0.91); C34(0.99); C44(0.91); C132(1.64)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C37(0.88); C34(1.10); C44(0.88); C132(1.22)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C37(1.06); C34(1.33); C44(1.06); C132(1.17)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C37(0.96); C34(1.18); C44(0.96); C132(1.34)  LDD1168  [8]
 LDCM0290  AC3 HCT 116 C132(1.11)  LDD0607  [8]
 LDCM0291  AC30 PaTu 8988t C37(0.95); C34(1.01); C44(0.95); C132(1.04)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C37(1.02); C34(0.92); C44(1.02); C132(1.09)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C37(1.11); C34(1.21); C44(1.11); C132(1.87)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C37(1.11); C34(1.11); C44(1.11); C132(1.25)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C37(1.22); C34(1.51); C44(1.22); C132(1.69)  LDD1174  [8]
 LDCM0296  AC35 PaTu 8988t C34(1.05); C44(1.05); C132(1.21)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C34(0.99); C44(0.99); C132(1.51)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C34(1.17); C44(1.17); C132(1.23)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C34(1.09); C44(1.09); C132(1.18)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C34(1.11); C44(1.11); C132(1.29)  LDD1179  [8]
 LDCM0301  AC4 HCT 116 C132(1.22)  LDD0618  [8]
 LDCM0302  AC40 PaTu 8988t C34(1.09); C44(1.09); C132(1.34)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C34(1.18); C44(1.18); C132(0.97)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C34(1.08); C44(1.08); C132(0.92)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C34(1.12); C44(1.12); C132(1.04)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C34(1.39); C44(1.39); C132(1.17)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C34(1.19); C44(1.19); C132(0.94)  LDD1186  [8]
 LDCM0308  AC46 PaTu 8988t C132(1.00)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C132(1.17)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C132(1.32)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C132(1.30)  LDD1190  [8]
 LDCM0312  AC5 HCT 116 C132(1.24)  LDD0629  [8]
 LDCM0313  AC50 PaTu 8988t C132(1.31)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C132(0.79)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C132(1.20)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C132(1.35)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C132(1.58)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C132(1.09)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C132(1.15)  LDD1198  [8]
 LDCM0320  AC57 HCT 116 C132(1.07)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C132(0.99)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C132(0.94)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C132(1.39)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C132(1.01)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C132(1.13)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C132(1.02)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C132(1.01)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C132(0.98)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C132(1.32)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C132(1.21)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C132(1.08)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C132(0.93)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C132(0.84)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C132(1.15)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C132(0.99)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C132(0.83)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C132(0.97)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C132(0.88)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C132(0.87)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C132(1.11)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C132(0.91)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C132(0.92)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C132(0.95)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C132(1.15)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C132(1.18)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C132(0.79)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C132(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C132(0.82)  LDD0665  [8]
 LDCM0349  AC83 PaTu 8988t C34(1.00); C44(1.00); C132(1.05)  LDD1228  [8]
 LDCM0350  AC84 PaTu 8988t C34(0.96); C44(0.96); C132(0.99)  LDD1229  [8]
 LDCM0351  AC85 PaTu 8988t C34(0.98); C44(0.98); C132(1.17)  LDD1230  [8]
 LDCM0352  AC86 PaTu 8988t C34(1.02); C44(1.02); C132(1.01)  LDD1231  [8]
 LDCM0353  AC87 PaTu 8988t C34(1.05); C44(1.05); C132(1.23)  LDD1232  [8]
 LDCM0354  AC88 PaTu 8988t C34(1.04); C44(1.04); C132(0.92)  LDD1233  [8]
 LDCM0355  AC89 PaTu 8988t C34(1.08); C44(1.08); C132(0.99)  LDD1234  [8]
 LDCM0357  AC90 PaTu 8988t C34(1.20); C44(1.20); C132(0.84)  LDD1236  [8]
 LDCM0358  AC91 PaTu 8988t C34(1.12); C44(1.12); C132(0.94)  LDD1237  [8]
 LDCM0359  AC92 PaTu 8988t C34(1.05); C44(1.05); C132(0.98)  LDD1238  [8]
 LDCM0360  AC93 PaTu 8988t C34(0.92); C44(0.92); C132(1.07)  LDD1239  [8]
 LDCM0361  AC94 PaTu 8988t C34(1.06); C44(1.06); C132(0.99)  LDD1240  [8]
 LDCM0362  AC95 PaTu 8988t C34(1.01); C44(1.01); C132(1.08)  LDD1241  [8]
 LDCM0363  AC96 PaTu 8988t C34(0.97); C44(0.97); C132(0.96)  LDD1242  [8]
 LDCM0364  AC97 PaTu 8988t C34(0.96); C44(0.96); C132(0.88)  LDD1243  [8]
 LDCM0365  AC98 PaTu 8988t C132(1.34)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C132(1.24)  LDD1245  [8]
 LDCM0248  AKOS034007472 HCT 116 C132(1.24)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C132(1.19)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C132(1.81)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 14.27  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C44(0.87); C34(0.87); C37(0.87)  LDD2171  [8]
 LDCM0632  CL-Sc Hep-G2 C13(20.00); C13(0.96)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C132(0.87)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C132(1.20)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C132(1.20)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C132(1.49)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C132(1.39)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C132(1.13)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C132(1.06)  LDD0690  [8]
 LDCM0374  CL105 PaTu 8988t C34(0.79); C44(0.79); C132(1.03)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C34(0.81); C44(0.81); C132(1.01)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C34(0.98); C44(0.98); C132(1.02)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C34(1.03); C44(1.03); C132(1.04)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C34(1.42); C44(1.42); C132(1.20)  LDD1257  [8]
 LDCM0379  CL11 HCT 116 C132(1.42)  LDD0696  [8]
 LDCM0380  CL110 PaTu 8988t C34(0.76); C44(0.76); C132(1.44)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C34(1.08); C44(1.08); C132(1.75)  LDD1260  [8]
 LDCM0382  CL112 PaTu 8988t C37(0.96); C34(0.90); C44(0.96); C132(0.78)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C37(1.16); C34(1.40); C44(1.16); C132(1.13)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C37(1.36); C34(1.75); C44(1.36); C132(1.00)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C37(1.14); C34(1.20); C44(1.14); C132(1.32)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C37(0.90); C34(0.81); C44(0.90); C132(1.00)  LDD1265  [8]
 LDCM0387  CL117 PaTu 8988t C34(1.25); C44(1.25); C132(0.99)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C34(1.09); C44(1.09); C132(1.02)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C34(1.15); C44(1.15); C132(1.03)  LDD1268  [8]
 LDCM0390  CL12 HCT 116 C132(1.41)  LDD0707  [8]
 LDCM0391  CL120 PaTu 8988t C34(1.31); C44(1.31); C132(1.03)  LDD1270  [8]
 LDCM0392  CL121 PaTu 8988t C132(1.13)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C132(1.09)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C132(1.26)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C132(1.30)  LDD1274  [8]
 LDCM0396  CL125 HCT 116 C132(1.13)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C132(1.14)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C132(1.13)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C132(1.09)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C132(1.22)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C132(1.02)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C132(1.12)  LDD0719  [8]
 LDCM0403  CL16 PaTu 8988t C37(1.17); C44(1.17); C132(1.14)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C37(0.86); C44(0.86); C132(1.20)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C37(1.09); C44(1.09); C132(1.09)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C37(1.53); C44(1.53); C132(1.33)  LDD1285  [8]
 LDCM0407  CL2 HCT 116 C132(0.98)  LDD0724  [8]
 LDCM0408  CL20 PaTu 8988t C37(1.18); C44(1.18); C132(1.44)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C37(1.47); C44(1.47); C132(1.31)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C37(0.96); C44(0.96); C132(1.26)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C37(0.95); C44(0.95); C132(1.55)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C37(0.87); C44(0.87); C132(1.46)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C37(1.00); C44(1.00); C132(1.24)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C37(0.93); C44(0.93); C132(1.37)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C37(0.71); C44(0.71); C132(1.36)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C37(1.10); C44(1.10); C132(1.54)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C37(0.71); C44(0.71); C132(1.52)  LDD1296  [8]
 LDCM0418  CL3 HCT 116 C132(1.13)  LDD0735  [8]
 LDCM0419  CL30 PaTu 8988t C37(1.01); C44(1.01); C132(1.31)  LDD1298  [8]
 LDCM0420  CL31 HCT 116 C132(0.93)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C132(0.87)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C132(0.70)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C132(1.02)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C132(1.11)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C132(1.13)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C132(1.22)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C132(1.10)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C132(1.08)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C132(1.14)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C132(1.09)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C132(1.32)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C132(1.21)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C132(1.08)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C132(1.20)  LDD0752  [8]
 LDCM0436  CL46 PaTu 8988t C132(1.19)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C132(1.13)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C132(1.12)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C132(1.23)  LDD1318  [8]
 LDCM0440  CL5 HCT 116 C132(1.18)  LDD0757  [8]
 LDCM0441  CL50 PaTu 8988t C132(1.35)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C132(1.05)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C132(1.19)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C132(1.40)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C132(1.13)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C132(1.25)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C132(1.22)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C132(1.07)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C132(1.19)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C132(1.14)  LDD1329  [8]
 LDCM0451  CL6 HCT 116 C132(1.05)  LDD0768  [8]
 LDCM0452  CL60 PaTu 8988t C132(1.09)  LDD1331  [8]
 LDCM0453  CL61 HCT 116 C132(1.06)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C132(1.05)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C132(1.18)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C132(1.28)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C132(1.15)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C132(1.63)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C132(1.28)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C132(1.27)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C132(1.03)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C132(1.31)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C132(1.18)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C132(1.12)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C132(1.04)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C132(1.15)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C132(1.18)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C132(1.11)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C132(0.94)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C132(1.28)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C132(1.53)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C132(1.33)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C132(1.14)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C132(1.20)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C132(1.51)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C132(1.42)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C132(1.66)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C132(1.38)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C132(1.09)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C132(1.28)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C132(1.37)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C132(1.83)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C132(1.16)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C132(0.89)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C132(1.17)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C132(1.00)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C132(1.11)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C132(1.13)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C132(1.14)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C132(1.17)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C132(1.21)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C132(1.20)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C132(1.14)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C13(0.86)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C132(0.97); C154(0.94); C34(1.00); C44(0.96)  LDD1698  [20]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.37  LDD0183  [6]
 LDCM0468  Fragment33 HCT 116 C132(1.15)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C132(1.38)  LDD0744  [8]
 LDCM0022  KB02 HCT 116 C37(2.75); C34(1.57); C44(1.57); C132(1.09)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C37(2.61); C34(1.80); C44(1.80); C132(1.15)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C37(3.62); C34(2.03); C44(2.03); C132(1.02)  LDD0082  [8]
 LDCM0030  Luteolin HEK-293T 5.04  LDD0182  [6]
 LDCM0099  Phenelzine MDA-MB-231 5.00  LDD0392  [2]
 LDCM0021  THZ1 HCT 116 C44(0.87); C34(0.87); C37(0.87)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Malignant T-cell-amplified sequence 1 (MCTS1) MCTS1 family Q9ULC4
Negative elongation factor B (NELFB) NELF-B family Q8WX92
Polyubiquitin-C (UBC) Ubiquitin family P0CG48

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402