Details of the Target

General Information of Target

Target ID LDTP04940
Target Name NPC intracellular cholesterol transporter 2 (NPC2)
Gene Name NPC2
Gene ID 10577
Synonyms
HE1; NPC intracellular cholesterol transporter 2; Epididymal secretory protein E1; Human epididymis-specific protein 1; He1; Niemann-Pick disease type C2 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVT
FTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYP
SIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL
Target Bioclass
Transporter and channel
Family
NPC2 family
Subcellular location
Secreted
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Uniprot ID
P61916
Ensemble ID
ENST00000541064.5
HGNC ID
HGNC:14537

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SH4 SNV: p.P88S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		177.55  LDD0318  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K112(0.84); K116(4.61); K51(10.00)  LDD0277  [3]
Alkylaryl probe 2
 Probe Info  		4.00  LDD0392  [4]
Alkylaryl probe 3
 Probe Info  		3.21  LDD0384  [4]
BTD
 Probe Info  		C27(0.73)  LDD2128  [5]
IPM
 Probe Info  		C99(3.82)  LDD1701  [5]
DBIA
 Probe Info  		C42(1.21); C47(1.21)  LDD0533  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C93(0.00); C99(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C93(0.00); C42(0.00); C99(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C93(0.00); C99(0.00); C27(0.00)  LDD0037  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		7.89  LDD1744  [13]
C070
 Probe Info  		10.56  LDD1766  [13]
C073
 Probe Info  		6.77  LDD1769  [13]
C115
 Probe Info  		5.39  LDD1802  [13]
C140
 Probe Info  		8.22  LDD1822  [13]
C149
 Probe Info  		13.36  LDD1830  [13]
C153
 Probe Info  		18.13  LDD1834  [13]
C161
 Probe Info  		11.55  LDD1841  [13]
C170
 Probe Info  		31.34  LDD1850  [13]
C171
 Probe Info  		17.63  LDD1851  [13]
C184
 Probe Info  		6.28  LDD1862  [13]
C186
 Probe Info  		21.71  LDD1864  [13]
C197
 Probe Info  		11.00  LDD1873  [13]
C201
 Probe Info  		26.72  LDD1877  [13]
C206
 Probe Info  		15.56  LDD1881  [13]
C208
 Probe Info  		8.88  LDD1883  [13]
C213
 Probe Info  		17.03  LDD1887  [13]
C223
 Probe Info  		16.22  LDD1897  [13]
C225
 Probe Info  		6.73  LDD1898  [13]
C237
 Probe Info  		9.92  LDD1910  [13]
C302
 Probe Info  		13.09  LDD1971  [13]
C305
 Probe Info  		13.36  LDD1974  [13]
C310
 Probe Info  		10.85  LDD1977  [13]
C314
 Probe Info  		11.31  LDD1981  [13]
C334
 Probe Info  		5.82  LDD1997  [13]
C346
 Probe Info  		11.31  LDD2007  [13]
C363
 Probe Info  		16.91  LDD2024  [13]
C407
 Probe Info  		12.47  LDD2064  [13]
C420
 Probe Info  		10.06  LDD2075  [13]
C425
 Probe Info  		19.16  LDD2080  [13]
FFF probe12
 Probe Info  		20.00  LDD0473  [14]
FFF probe13
 Probe Info  		15.15  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe4
 Probe Info  		20.00  LDD0466  [14]
FFF probe9
 Probe Info  		20.00  LDD0470  [14]
JN0003
 Probe Info  		20.00  LDD0469  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C27(1.01); C93(0.92); C99(0.85); C47(1.14)  LDD1507  [15]
 LDCM0215  AC10 PaTu 8988t C42(0.89); C47(0.89)  LDD1094  [6]
 LDCM0216  AC100 HCT 116 C42(1.21); C47(1.21)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C42(0.95); C47(0.95)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C42(0.81); C47(0.81)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C42(0.85); C47(0.85)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C42(0.88); C47(0.88)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C42(0.61); C47(0.61)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C42(0.90); C47(0.90)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C42(0.90); C47(0.72)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C42(1.20); C47(0.71)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C42(0.82); C47(0.74)  LDD0542  [6]
 LDCM0226  AC11 PaTu 8988t C42(0.78); C47(0.78)  LDD1105  [6]
 LDCM0227  AC110 HCT 116 C42(0.54); C47(0.72)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C42(0.68); C47(0.67)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C42(0.71); C47(0.69)  LDD0546  [6]
 LDCM0237  AC12 PaTu 8988t C42(0.91); C47(0.91)  LDD1116  [6]
 LDCM0246  AC128 PaTu 8988t C42(0.85); C47(0.85)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C42(0.85); C47(0.85)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C42(0.96); C47(0.96)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C42(1.03); C47(1.03)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C42(1.03); C47(1.03)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C42(0.78); C47(0.78)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C42(0.85); C47(0.85)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C42(0.69); C47(0.69)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C42(0.90); C47(0.90)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C42(0.80); C47(0.80)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C42(0.79); C47(0.79)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C42(0.96); C47(0.96)  LDD1137  [6]
 LDCM0259  AC14 PaTu 8988t C42(0.80); C47(0.80)  LDD1138  [6]
 LDCM0260  AC140 PaTu 8988t C42(0.76); C47(0.76)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C42(1.02); C47(1.02)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C42(0.81); C47(0.81)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C42(1.05); C47(1.05)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C42(0.98); C47(0.98)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C42(1.05); C47(1.05)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C42(0.84); C47(0.84)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C42(0.84); C47(0.84)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C42(0.69); C47(0.69)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C42(0.78); C47(0.78)  LDD0586  [6]
 LDCM0270  AC15 PaTu 8988t C42(0.76); C47(0.76)  LDD1149  [6]
 LDCM0271  AC150 HCT 116 C42(0.89); C47(0.89)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C42(0.94); C47(0.94)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C42(0.91); C47(0.91)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C42(0.62); C47(0.62)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C42(0.95); C47(0.95)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C42(1.02); C47(1.02)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C42(1.26); C47(1.26)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C42(1.35); C47(1.35)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C27(0.98); C93(0.89); C99(0.88); C47(0.86)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C27(1.00); C93(0.98); C140(1.22); C47(0.96)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C27(1.22); C93(1.15); C99(1.00); C47(0.89)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C27(1.02); C93(0.96); C140(0.76); C47(0.98)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C27(1.00); C93(0.97); C99(0.98); C47(0.84)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C27(0.92); C93(1.06); C99(0.95); C47(1.03)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C27(0.96); C93(0.93); C99(1.04); C47(0.90)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C27(0.99); C93(1.01); C47(0.87)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C27(0.95); C93(0.91); C99(0.87); C47(1.00)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C27(1.02); C93(0.96); C99(0.97); C47(1.14)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C27(1.07); C93(1.05); C140(0.99); C47(1.06)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C27(1.03); C93(0.93); C99(1.06); C47(0.91)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C27(1.04); C93(1.17); C99(1.04); C47(1.06)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C27(1.06); C93(1.01); C99(1.01); C47(1.19)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C27(1.01); C93(1.16); C99(1.09); C47(0.75)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C27(1.00); C93(1.11); C99(1.08); C47(1.16)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C27(1.00); C93(1.01); C47(1.06)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C27(0.94); C93(0.97); C99(0.94); C47(1.06)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C27(0.99); C93(0.96); C99(0.85); C47(0.92)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C27(1.09); C93(1.06); C140(1.06); C47(0.95)  LDD1534  [15]
 LDCM0296  AC35 PaTu 8988t C42(0.90); C47(0.90)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C42(0.95); C47(0.95)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C42(0.87); C47(0.87)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C42(0.90); C47(0.90)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C42(0.89); C47(0.89)  LDD1179  [6]
 LDCM0301  AC4 HEK-293T C27(1.00); C93(1.11); C99(1.11); C47(1.05)  LDD1540  [15]
 LDCM0302  AC40 PaTu 8988t C42(0.90); C47(0.90)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C42(0.86); C47(0.86)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C42(0.95); C47(0.95)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C42(0.91); C47(0.91)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C42(0.81); C47(0.81)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C42(0.81); C47(0.81)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C42(1.13); C47(1.13)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C42(0.98); C47(0.98)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C42(0.86); C47(0.86)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C42(0.80); C47(0.80)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C27(0.93); C93(1.17); C99(1.00); C47(1.01)  LDD1551  [15]
 LDCM0313  AC50 HCT 116 C42(0.84); C47(0.84)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C42(1.31); C47(1.31)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C42(0.84); C47(0.84)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C42(1.05); C47(1.05)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C42(1.03); C47(1.03)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C42(0.85); C47(0.85)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C42(0.68); C47(0.68)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C42(0.92); C47(0.92)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C42(0.75); C47(0.75)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C42(0.77); C47(0.77)  LDD0639  [6]
 LDCM0323  AC6 PaTu 8988t C42(1.25); C47(1.25)  LDD1202  [6]
 LDCM0324  AC60 HCT 116 C42(0.80); C47(0.80)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C42(0.93); C47(0.93)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C42(0.83); C47(0.83)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C42(0.82); C47(0.82)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C42(0.75); C47(0.75)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C42(0.61); C47(0.61)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C42(0.63); C47(0.63)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C42(0.38); C47(0.38)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C42(1.06); C47(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C42(0.80); C47(0.80)  LDD0650  [6]
 LDCM0334  AC7 PaTu 8988t C42(0.72); C47(0.72)  LDD1213  [6]
 LDCM0335  AC70 HCT 116 C42(0.82); C47(0.82)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C42(0.87); C47(0.87)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C42(0.81); C47(0.81)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C42(0.59); C47(0.59)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C42(0.61); C47(0.61)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C42(0.44); C47(0.44)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C42(0.77); C47(0.77)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C42(0.72); C47(0.72)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C42(0.86); C47(0.86)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C42(0.79); C47(0.79)  LDD0661  [6]
 LDCM0345  AC8 PaTu 8988t C42(0.75); C47(0.75)  LDD1224  [6]
 LDCM0346  AC80 HCT 116 C42(0.88); C47(0.88)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C42(0.88); C47(0.88)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C42(0.19); C47(0.19)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C42(0.98); C47(0.98)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C42(0.96); C47(0.96)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C42(1.02); C47(1.02)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C42(1.13); C47(1.13)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C42(1.47); C47(1.47)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C42(1.31); C47(1.31)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C42(0.83); C47(0.83)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C42(1.90); C47(1.90)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C42(0.84); C47(0.84)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C42(1.21); C47(1.21)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C42(1.30); C47(1.30)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C42(1.28); C47(1.28)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C42(1.36); C47(1.36)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C42(1.25); C47(1.25)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C42(1.09); C47(1.09)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C42(0.23); C47(0.23)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C42(0.71); C47(0.71)  LDD0683  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C42(0.70); C47(0.70)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C42(1.10); C47(1.10)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C42(0.71); C47(0.71)  LDD1154  [6]
 LDCM0020  ARS-1620 HCC44 C99(0.95)  LDD2171  [6]
 LDCM0108  Chloroacetamide HeLa C93(0.00); C42(0.00)  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C27(1.00); C93(0.98); C99(0.96); C47(0.97)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C27(1.01); C93(0.90); C99(0.99); C47(1.20)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C27(0.95); C93(0.89); C99(1.05); C47(0.99)  LDD1573  [15]
 LDCM0370  CL101 PaTu 8988t C42(1.10); C47(1.10)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C42(0.83); C47(0.83)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C42(0.61); C47(0.61)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C42(0.68); C47(0.68)  LDD1252  [6]
 LDCM0374  CL105 HEK-293T C27(0.97); C93(0.98); C99(0.89); C47(0.92)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C27(1.12); C93(1.05); C99(0.93); C47(1.07)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C27(0.96); C93(1.01); C99(0.97); C47(0.89)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C27(1.06); C93(1.09); C99(0.95); C47(1.04)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C27(1.00); C93(1.02); C99(1.04); C47(1.04)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C27(0.97); C93(0.95); C47(1.01)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C27(0.94); C93(0.98); C99(0.99); C47(1.05)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C27(0.96); C93(1.03); C99(0.97); C47(0.91)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C27(1.01); C93(0.87); C99(0.99); C47(1.09)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C27(1.03); C93(1.06); C99(0.87); C47(0.98)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C27(1.10); C93(1.08); C99(0.95); C47(1.08)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C27(1.00); C93(1.01); C99(0.99); C47(1.07)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C27(1.07); C93(0.99); C99(0.98); C47(0.93)  LDD1590  [15]
 LDCM0387  CL117 PaTu 8988t C42(0.92); C47(0.92)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C42(0.93); C47(0.93)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C42(1.01); C47(1.01)  LDD1268  [6]
 LDCM0390  CL12 HEK-293T C27(1.05); C93(1.20); C99(0.95); C47(0.96)  LDD1594  [15]
 LDCM0391  CL120 PaTu 8988t C42(0.95); C47(0.95)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C42(1.26); C47(1.26)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C42(0.82); C47(0.82)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C42(1.34); C47(1.34)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C42(1.04); C47(1.04)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C42(1.05); C47(1.05)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C42(0.96); C47(0.96)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C42(0.93); C47(0.93)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C42(0.77); C47(0.77)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C27(1.07); C93(0.99); C99(0.92); C47(0.83)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C27(1.02); C93(1.14); C99(0.89); C47(1.00)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C27(0.94); C93(1.07); C99(0.90); C47(0.88)  LDD1606  [15]
 LDCM0403  CL16 PaTu 8988t C42(0.87); C47(0.87)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C42(0.85); C47(0.85)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C42(0.73); C47(0.73)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C42(0.96); C47(0.96)  LDD1285  [6]
 LDCM0407  CL2 HEK-293T C27(1.16); C93(1.17); C99(0.89); C47(0.97)  LDD1611  [15]
 LDCM0408  CL20 PaTu 8988t C42(0.79); C47(0.79)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C42(0.79); C47(0.79)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C42(0.81); C47(0.81)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C42(0.66); C47(0.66)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C42(0.92); C47(0.92)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C42(0.89); C47(0.89)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C42(0.72); C47(0.72)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C42(0.81); C47(0.81)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C42(0.79); C47(0.79)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C42(0.65); C47(0.65)  LDD1296  [6]
 LDCM0418  CL3 HEK-293T C27(0.89); C93(0.98); C99(0.97); C47(0.95)  LDD1622  [15]
 LDCM0419  CL30 PaTu 8988t C42(0.73); C47(0.73)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C27(1.06); C93(1.06); C99(0.99); C47(0.97)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C27(1.01); C93(0.97); C99(1.00); C47(0.89)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C27(0.93); C93(0.93); C99(1.19); C47(0.89)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C27(1.08); C93(0.70); C99(1.02); C47(0.92)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C27(0.98); C93(1.13); C47(0.93)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C27(1.04); C93(0.95); C99(1.03); C47(1.05)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C27(0.92); C93(1.03); C99(0.88); C47(1.02)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C27(0.91); C93(0.97); C99(0.87); C47(0.98)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C27(0.92); C93(0.90); C99(1.09); C47(1.12)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C27(0.97); C93(0.92); C99(0.95); C47(1.00)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C27(1.01); C93(0.94); C99(0.93); C47(0.91)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C27(1.03); C93(0.98); C140(1.04); C47(0.97)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C27(1.06); C93(0.93); C99(1.02); C47(0.91)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C27(1.05); C93(1.02); C99(1.05); C47(1.02)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C27(0.99); C93(1.03); C99(1.05); C47(1.01)  LDD1639  [15]
 LDCM0436  CL46 PaTu 8988t C42(0.81); C47(0.81)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C42(0.86); C47(0.86)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C42(1.04); C47(1.04)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C42(0.80); C47(0.80)  LDD1318  [6]
 LDCM0440  CL5 HEK-293T C27(1.01); C93(0.93); C99(0.87); C47(1.03)  LDD1644  [15]
 LDCM0441  CL50 PaTu 8988t C42(0.80); C47(0.80)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C42(0.80); C47(0.80)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C42(0.90); C47(0.90)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C42(0.87); C47(0.87)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C42(0.69); C47(0.69)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C42(0.79); C47(0.79)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C42(0.85); C47(0.85)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C42(0.83); C47(0.83)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C42(0.84); C47(0.84)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C42(0.75); C47(0.75)  LDD1329  [6]
 LDCM0451  CL6 HEK-293T C27(0.94); C93(0.83); C140(1.02); C47(1.00)  LDD1654  [15]
 LDCM0452  CL60 PaTu 8988t C42(0.76); C47(0.76)  LDD1331  [6]
 LDCM0453  CL61 HCT 116 C42(0.66); C47(0.66)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C42(0.67); C47(0.67)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C42(0.72); C47(0.72)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C42(0.84); C47(0.84)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C42(1.05); C47(1.05)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C42(0.78); C47(0.78)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C42(0.61); C47(0.61)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C42(0.79); C47(0.79)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C42(1.22); C47(1.22)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C27(0.95); C93(0.98); C99(0.92); C47(0.80)  LDD1665  [15]
 LDCM0463  CL70 HCT 116 C42(0.66); C47(0.66)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C42(0.66); C47(0.66)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C42(0.96); C47(0.96)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C42(0.73); C47(0.73)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C42(0.76); C47(0.76)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C27(0.98); C93(1.02); C99(1.06); C47(0.91)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C27(0.98); C93(0.89); C99(0.96); C47(0.94)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C27(0.88); C93(0.95); C140(0.94); C47(0.95)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C27(0.90); C93(0.95); C99(0.99); C47(1.03)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C27(0.96); C93(0.89); C99(1.16); C47(0.79)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C27(0.93); C93(1.16); C99(1.19); C47(1.10)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C27(0.97); C93(1.02); C99(1.06); C47(0.97)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C27(1.05); C93(0.97); C99(0.95); C47(0.99)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C27(1.00); C93(0.98); C47(1.06)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C27(0.97); C93(0.88); C99(1.06); C47(1.03)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C27(0.90); C93(1.01); C99(0.92); C47(0.85)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C27(1.02); C93(1.14); C99(0.89); C47(0.99)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C27(1.00); C93(1.09); C99(0.93); C47(0.92)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C27(1.01); C93(0.98); C99(1.02); C47(1.04)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C27(1.05); C93(0.98); C99(0.87); C47(0.97)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C27(0.96); C93(1.08); C99(1.06); C47(1.07)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C27(0.92); C93(0.87); C140(0.66); C47(0.91)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C27(0.96); C93(0.91); C99(0.94); C47(0.81)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C27(0.96); C93(0.94); C99(0.97); C47(0.88)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C27(0.95); C93(0.96); C99(0.82); C47(0.94)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C27(1.02); C93(0.91); C99(0.90); C47(0.97)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C27(1.08); C93(0.77); C47(0.87)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C27(1.05); C93(1.00); C99(1.02); C47(1.01)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C27(0.96); C93(0.94); C99(0.96); C47(1.02)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C27(0.95); C93(1.11); C99(0.96); C47(1.12)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C27(1.05); C93(1.00); C99(1.03); C47(0.91)  LDD1697  [15]
 LDCM0185  Compound 17 HEK-293T 5.99  LDD0512  [14]
 LDCM0495  E2913 HEK-293T C27(0.89); C93(0.93); C99(0.90); C47(0.86)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C99(2.27)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C42(0.67); C47(0.67)  LDD0785  [6]
 LDCM0427  Fragment51 HEK-293T C27(1.14); C93(1.06); C99(0.93); C47(0.90)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C99(0.83); C93(1.01); C47(0.87)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C99(0.94); C93(0.96); C47(0.97)  LDD1497  [15]
 LDCM0024  KB05 HMCB C27(2.81)  LDD3312  [16]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C27(0.73)  LDD2128  [5]
 LDCM0099  Phenelzine MDA-MB-231 3.21  LDD0384  [4]
 LDCM0021  THZ1 HCT 116 C99(0.95)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NPC intracellular cholesterol transporter 1 (NPC1) Patched family O15118
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal growth regulator 1 (NEGR1) IgLON family Q7Z3B1

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840